Metallo-beta-lactamase_family-like_protein/GeneDB:LmjF.21.0670

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-beta-lactamase family-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WWH9_LEIDO

TriTrypDb:

LdBPK_210730.1 , LdCL_210012200 , LDHU3_21.0790

Length:

336

Annotations

Annotations by Jardim et al.

Drug resistance proteins, Metallo-beta-lactamase family-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.486
CLV_C14_Caspase3-7	308	312	PF00656	0.526
CLV_NRD_NRD_1	101	103	PF00675	0.389
CLV_PCSK_KEX2_1	101	103	PF00082	0.486
CLV_PCSK_KEX2_1	195	197	PF00082	0.370
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.370
CLV_PCSK_PC7_1	191	197	PF00082	0.350
CLV_PCSK_SKI1_1	101	105	PF00082	0.384
CLV_PCSK_SKI1_1	160	164	PF00082	0.409
CLV_PCSK_SKI1_1	224	228	PF00082	0.465
CLV_PCSK_SKI1_1	244	248	PF00082	0.469
CLV_PCSK_SKI1_1	276	280	PF00082	0.392
CLV_PCSK_SKI1_1	298	302	PF00082	0.507
CLV_PCSK_SKI1_1	319	323	PF00082	0.540
CLV_PCSK_SKI1_1	83	87	PF00082	0.459
DEG_SCF_FBW7_1	141	148	PF00400	0.384
DOC_CKS1_1	142	147	PF01111	0.384
DOC_CYCLIN_RxL_1	273	281	PF00134	0.592
DOC_CYCLIN_RxL_1	80	87	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	75	81	PF00134	0.384
DOC_MAPK_gen_1	101	109	PF00069	0.384
DOC_MAPK_gen_1	219	229	PF00069	0.469
DOC_MAPK_MEF2A_6	101	109	PF00069	0.384
DOC_USP7_MATH_1	239	243	PF00917	0.598
DOC_USP7_MATH_1	266	270	PF00917	0.467
DOC_USP7_MATH_1	329	333	PF00917	0.595
DOC_WW_Pin1_4	141	146	PF00397	0.384
LIG_14-3-3_CanoR_1	160	169	PF00244	0.430
LIG_14-3-3_CanoR_1	319	326	PF00244	0.390
LIG_Actin_WH2_2	248	266	PF00022	0.519
LIG_BRCT_BRCA1_1	268	272	PF00533	0.484
LIG_EH1_1	272	280	PF00400	0.536
LIG_eIF4E_1	288	294	PF01652	0.564
LIG_FHA_1	136	142	PF00498	0.384
LIG_FHA_1	207	213	PF00498	0.469
LIG_FHA_1	232	238	PF00498	0.528
LIG_FHA_1	37	43	PF00498	0.377
LIG_FHA_2	117	123	PF00498	0.384
LIG_FHA_2	245	251	PF00498	0.409
LIG_FHA_2	42	48	PF00498	0.384
LIG_LIR_Gen_1	173	183	PF02991	0.384
LIG_LIR_Gen_1	253	263	PF02991	0.513
LIG_LIR_Gen_1	269	279	PF02991	0.569
LIG_LIR_Gen_1	301	310	PF02991	0.474
LIG_LIR_Nem_3	173	179	PF02991	0.384
LIG_LIR_Nem_3	253	259	PF02991	0.513
LIG_LIR_Nem_3	269	275	PF02991	0.569
LIG_LIR_Nem_3	301	306	PF02991	0.463
LIG_LIR_Nem_3	58	63	PF02991	0.397
LIG_PTB_Apo_2	25	32	PF02174	0.567
LIG_PTB_Phospho_1	25	31	PF10480	0.563
LIG_SH2_CRK	256	260	PF00017	0.536
LIG_SH2_CRK	31	35	PF00017	0.576
LIG_SH2_GRB2like	182	185	PF00017	0.389
LIG_SH2_NCK_1	256	260	PF00017	0.536
LIG_SH2_NCK_1	288	292	PF00017	0.491
LIG_SH2_SRC	288	291	PF00017	0.486
LIG_SH2_STAT5	116	119	PF00017	0.389
LIG_SH2_STAT5	256	259	PF00017	0.535
LIG_SH2_STAT5	303	306	PF00017	0.447
LIG_SH2_STAT5	40	43	PF00017	0.384
LIG_SUMO_SIM_anti_2	250	258	PF11976	0.473
LIG_SUMO_SIM_par_1	77	82	PF11976	0.272
LIG_TRAF2_1	44	47	PF00917	0.486
LIG_TYR_ITIM	254	259	PF00017	0.467
LIG_WRC_WIRS_1	176	181	PF05994	0.384
MOD_CK1_1	174	180	PF00069	0.326
MOD_CK2_1	244	250	PF00069	0.397
MOD_CK2_1	41	47	PF00069	0.384
MOD_GlcNHglycan	332	335	PF01048	0.620
MOD_GlcNHglycan	52	55	PF01048	0.326
MOD_GSK3_1	141	148	PF00069	0.384
MOD_GSK3_1	164	171	PF00069	0.384
MOD_GSK3_1	262	269	PF00069	0.523
MOD_GSK3_1	30	37	PF00069	0.409
MOD_NEK2_1	34	39	PF00069	0.330
MOD_NEK2_1	41	46	PF00069	0.333
MOD_NEK2_1	84	89	PF00069	0.351
MOD_NEK2_2	182	187	PF00069	0.384
MOD_NEK2_2	96	101	PF00069	0.384
MOD_PIKK_1	111	117	PF00454	0.328
MOD_PKA_2	218	224	PF00069	0.497
MOD_Plk_1	301	307	PF00069	0.507
MOD_Plk_1	70	76	PF00069	0.384
MOD_Plk_4	164	170	PF00069	0.384
MOD_Plk_4	171	177	PF00069	0.384
MOD_Plk_4	301	307	PF00069	0.616
MOD_Plk_4	36	42	PF00069	0.384
MOD_ProDKin_1	141	147	PF00069	0.384
MOD_SUMO_for_1	132	135	PF00179	0.409
MOD_SUMO_rev_2	308	317	PF00179	0.504
TRG_DiLeu_BaEn_4	70	76	PF01217	0.409
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.486
TRG_ENDOCYTIC_2	256	259	PF00928	0.520
TRG_ENDOCYTIC_2	303	306	PF00928	0.505
TRG_ENDOCYTIC_2	31	34	PF00928	0.580
TRG_ENDOCYTIC_2	60	63	PF00928	0.384
TRG_ER_diArg_1	100	102	PF00400	0.384
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A067XMV3	Pestalotiopsis fici (strain W106-1 / CGMCC3.15140)	39%	100%
A0A0N1I2E5	Leptomonas seymouri	66%	96%
A0A0S4JM93	Bodo saltans	42%	97%
A0A1L9WLF1	Aspergillus aculeatus (strain ATCC 16872 / CBS 172.66 / WB 5094)	37%	100%
A0A2I1C3U0	Aspergillus novofumigatus (strain IBT 16806)	38%	100%
A0A411PQM3	Paecilomyces divaricatus	37%	100%
A0A4P8DJU1	Cryptosporiopsis sp. (strain 8999)	40%	100%
A0A5B8YUX5	Pestalotiopsis microspora	36%	100%
A1D8J2	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	38%	100%
A2QX23	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	36%	100%
A4HZ66	Leishmania infantum	100%	100%
C5FM60	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	36%	98%
D4AWH0	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	38%	77%
D4CZZ5	Trichophyton verrucosum (strain HKI 0517)	36%	100%
D7PHZ8	Penicillium aethiopicum	35%	100%
E1ACR1	Aspergillus sp. (strain MF297-2)	34%	100%
E4V2N5	Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)	37%	100%
E9AIQ1	Leishmania braziliensis	86%	100%
E9AV33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
F2PWS8	Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97)	39%	100%
F2S702	Trichophyton tonsurans (strain CBS 112818)	39%	100%
F2T0M3	Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892)	36%	100%
G3KLH5	Aspergillus niger	36%	100%
M1WCF7	Claviceps purpurea (strain 20.1)	38%	100%
M3ANL0	Pseudocercospora fijiensis (strain CIRAD86)	36%	100%
P0CU68	Passalora fulva	35%	100%
Q0CCY4	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	37%	100%
Q0V9A9	Xenopus tropicalis	42%	100%
Q1LZ83	Bos taurus	42%	100%
Q4QCE8	Leishmania major	96%	100%
Q4W945	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	41%	100%
Q4WA58	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	38%	100%
Q4WQZ6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	80%
Q53H82	Homo sapiens	42%	100%
Q561R9	Rattus norvegicus	41%	100%
Q5B0C9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	100%
Q5XGR8	Xenopus laevis	43%	100%
Q6NC62	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	27%	100%
Q6NYF0	Danio rerio	42%	100%
Q95Q18	Caenorhabditis elegans	38%	100%
Q99KR3	Mus musculus	41%	100%
Q9VLS9	Drosophila melanogaster	38%	100%