LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WWH4_LEIDO
TriTrypDb:
LdBPK_211050.1 , LdCL_210015500 , LDHU3_21.1250
Length:
855

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7WWH4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWH4

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 5
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0006807 nitrogen compound metabolic process 2 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016310 phosphorylation 5 5
GO:0019538 protein metabolic process 3 5
GO:0036211 protein modification process 4 5
GO:0043170 macromolecule metabolic process 3 5
GO:0043412 macromolecule modification 4 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0071704 organic substance metabolic process 2 5
GO:1901564 organonitrogen compound metabolic process 3 5
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 5
GO:0003824 catalytic activity 1 5
GO:0004672 protein kinase activity 3 5
GO:0005488 binding 1 5
GO:0005524 ATP binding 5 5
GO:0016301 kinase activity 4 5
GO:0016740 transferase activity 2 5
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 5
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 5
GO:0017076 purine nucleotide binding 4 5
GO:0030554 adenyl nucleotide binding 5 5
GO:0032553 ribonucleotide binding 3 5
GO:0032555 purine ribonucleotide binding 4 5
GO:0032559 adenyl ribonucleotide binding 5 5
GO:0035639 purine ribonucleoside triphosphate binding 4 5
GO:0036094 small molecule binding 2 5
GO:0043167 ion binding 2 5
GO:0043168 anion binding 3 5
GO:0097159 organic cyclic compound binding 2 5
GO:0097367 carbohydrate derivative binding 2 5
GO:0140096 catalytic activity, acting on a protein 2 5
GO:1901265 nucleoside phosphate binding 3 5
GO:1901363 heterocyclic compound binding 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 127 129 PF00675 0.506
CLV_NRD_NRD_1 207 209 PF00675 0.373
CLV_NRD_NRD_1 301 303 PF00675 0.461
CLV_NRD_NRD_1 84 86 PF00675 0.432
CLV_NRD_NRD_1 844 846 PF00675 0.639
CLV_PCSK_KEX2_1 127 129 PF00082 0.495
CLV_PCSK_KEX2_1 207 209 PF00082 0.373
CLV_PCSK_KEX2_1 84 86 PF00082 0.335
CLV_PCSK_KEX2_1 844 846 PF00082 0.744
CLV_PCSK_PC7_1 80 86 PF00082 0.301
CLV_PCSK_SKI1_1 118 122 PF00082 0.412
CLV_PCSK_SKI1_1 317 321 PF00082 0.283
CLV_PCSK_SKI1_1 428 432 PF00082 0.440
CLV_PCSK_SKI1_1 533 537 PF00082 0.345
CLV_PCSK_SKI1_1 84 88 PF00082 0.339
CLV_Separin_Metazoa 367 371 PF03568 0.338
DEG_APCC_DBOX_1 354 362 PF00400 0.426
DEG_SCF_FBW7_1 683 690 PF00400 0.622
DEG_SIAH_1 686 694 PF03145 0.542
DEG_SPOP_SBC_1 626 630 PF00917 0.723
DEG_SPOP_SBC_1 674 678 PF00917 0.583
DOC_CKS1_1 18 23 PF01111 0.461
DOC_CKS1_1 294 299 PF01111 0.465
DOC_CKS1_1 409 414 PF01111 0.397
DOC_CKS1_1 692 697 PF01111 0.587
DOC_CYCLIN_RxL_1 3 13 PF00134 0.501
DOC_CYCLIN_RxL_1 425 435 PF00134 0.323
DOC_MAPK_gen_1 207 213 PF00069 0.418
DOC_MAPK_gen_1 426 433 PF00069 0.430
DOC_MAPK_gen_1 84 91 PF00069 0.337
DOC_MAPK_MEF2A_6 426 433 PF00069 0.413
DOC_MAPK_MEF2A_6 504 513 PF00069 0.294
DOC_MAPK_NFAT4_5 426 434 PF00069 0.324
DOC_MAPK_RevD_3 113 128 PF00069 0.339
DOC_PP2B_LxvP_1 796 799 PF13499 0.602
DOC_PP2B_LxvP_1 89 92 PF13499 0.347
DOC_PP4_FxxP_1 360 363 PF00568 0.364
DOC_USP7_MATH_1 155 159 PF00917 0.444
DOC_USP7_MATH_1 373 377 PF00917 0.437
DOC_USP7_MATH_1 477 481 PF00917 0.483
DOC_USP7_MATH_1 547 551 PF00917 0.308
DOC_USP7_MATH_1 620 624 PF00917 0.637
DOC_USP7_MATH_1 66 70 PF00917 0.530
DOC_USP7_MATH_1 674 678 PF00917 0.667
DOC_USP7_MATH_1 699 703 PF00917 0.658
DOC_USP7_MATH_1 717 721 PF00917 0.585
DOC_USP7_MATH_1 776 780 PF00917 0.632
DOC_USP7_MATH_1 799 803 PF00917 0.693
DOC_USP7_MATH_2 218 224 PF00917 0.463
DOC_USP7_UBL2_3 842 846 PF12436 0.579
DOC_WW_Pin1_4 17 22 PF00397 0.441
DOC_WW_Pin1_4 195 200 PF00397 0.586
DOC_WW_Pin1_4 293 298 PF00397 0.471
DOC_WW_Pin1_4 30 35 PF00397 0.408
DOC_WW_Pin1_4 408 413 PF00397 0.415
DOC_WW_Pin1_4 516 521 PF00397 0.484
DOC_WW_Pin1_4 569 574 PF00397 0.461
DOC_WW_Pin1_4 628 633 PF00397 0.608
DOC_WW_Pin1_4 678 683 PF00397 0.766
DOC_WW_Pin1_4 691 696 PF00397 0.585
DOC_WW_Pin1_4 765 770 PF00397 0.725
DOC_WW_Pin1_4 786 791 PF00397 0.642
LIG_14-3-3_CanoR_1 262 267 PF00244 0.517
LIG_14-3-3_CanoR_1 28 34 PF00244 0.434
LIG_14-3-3_CanoR_1 280 284 PF00244 0.360
LIG_14-3-3_CanoR_1 35 41 PF00244 0.523
LIG_14-3-3_CanoR_1 80 84 PF00244 0.343
LIG_14-3-3_CanoR_1 85 90 PF00244 0.322
LIG_Actin_WH2_2 263 278 PF00022 0.491
LIG_Actin_WH2_2 379 397 PF00022 0.475
LIG_Actin_WH2_2 522 539 PF00022 0.505
LIG_BIR_II_1 1 5 PF00653 0.454
LIG_BIR_III_4 239 243 PF00653 0.356
LIG_BRCT_BRCA1_1 733 737 PF00533 0.640
LIG_BRCT_BRCA1_2 733 739 PF00533 0.639
LIG_Clathr_ClatBox_1 182 186 PF01394 0.272
LIG_Clathr_ClatBox_1 330 334 PF01394 0.417
LIG_Clathr_ClatBox_1 430 434 PF01394 0.333
LIG_CtBP_PxDLS_1 218 222 PF00389 0.485
LIG_eIF4E_1 409 415 PF01652 0.339
LIG_eIF4E_1 467 473 PF01652 0.345
LIG_FHA_1 104 110 PF00498 0.334
LIG_FHA_1 248 254 PF00498 0.413
LIG_FHA_1 409 415 PF00498 0.395
LIG_FHA_1 506 512 PF00498 0.288
LIG_FHA_1 55 61 PF00498 0.409
LIG_FHA_1 583 589 PF00498 0.521
LIG_FHA_1 778 784 PF00498 0.680
LIG_FHA_1 827 833 PF00498 0.718
LIG_FHA_2 252 258 PF00498 0.458
LIG_FHA_2 42 48 PF00498 0.453
LIG_FHA_2 577 583 PF00498 0.505
LIG_Integrin_isoDGR_2 260 262 PF01839 0.457
LIG_IRF3_LxIS_1 392 397 PF10401 0.324
LIG_LIR_Apic_2 29 34 PF02991 0.526
LIG_LIR_Apic_2 407 412 PF02991 0.363
LIG_LIR_Nem_3 177 183 PF02991 0.282
LIG_LIR_Nem_3 318 323 PF02991 0.427
LIG_LIR_Nem_3 404 409 PF02991 0.393
LIG_LIR_Nem_3 643 649 PF02991 0.689
LIG_NRBOX 326 332 PF00104 0.399
LIG_Pex14_2 179 183 PF04695 0.350
LIG_PTAP_UEV_1 744 749 PF05743 0.585
LIG_PTB_Apo_2 308 315 PF02174 0.380
LIG_REV1ctd_RIR_1 1 10 PF16727 0.512
LIG_SH2_CRK 215 219 PF00017 0.350
LIG_SH2_CRK 31 35 PF00017 0.456
LIG_SH2_CRK 427 431 PF00017 0.329
LIG_SH2_CRK 459 463 PF00017 0.469
LIG_SH2_CRK 531 535 PF00017 0.393
LIG_SH2_NCK_1 248 252 PF00017 0.393
LIG_SH2_PTP2 409 412 PF00017 0.313
LIG_SH2_STAP1 138 142 PF00017 0.434
LIG_SH2_STAP1 467 471 PF00017 0.343
LIG_SH2_STAT5 108 111 PF00017 0.286
LIG_SH2_STAT5 130 133 PF00017 0.531
LIG_SH2_STAT5 31 34 PF00017 0.501
LIG_SH2_STAT5 409 412 PF00017 0.359
LIG_SH2_STAT5 531 534 PF00017 0.399
LIG_SH3_2 837 842 PF14604 0.507
LIG_SH3_3 12 18 PF00018 0.414
LIG_SH3_3 607 613 PF00018 0.563
LIG_SH3_3 668 674 PF00018 0.594
LIG_SH3_3 679 685 PF00018 0.505
LIG_SH3_3 742 748 PF00018 0.763
LIG_SH3_3 788 794 PF00018 0.751
LIG_SH3_3 834 840 PF00018 0.769
LIG_Sin3_3 469 476 PF02671 0.384
LIG_SUMO_SIM_anti_2 328 334 PF11976 0.414
LIG_SUMO_SIM_par_1 233 239 PF11976 0.376
LIG_SUMO_SIM_par_1 572 577 PF11976 0.383
LIG_SUMO_SIM_par_1 794 800 PF11976 0.511
LIG_SUMO_SIM_par_1 821 826 PF11976 0.502
LIG_TRAF2_1 254 257 PF00917 0.479
LIG_TYR_ITIM 246 251 PF00017 0.269
LIG_TYR_ITIM 425 430 PF00017 0.364
MOD_CDC14_SPxK_1 681 684 PF00782 0.575
MOD_CDK_SPK_2 30 35 PF00069 0.392
MOD_CDK_SPxK_1 678 684 PF00069 0.576
MOD_CDK_SPxxK_3 293 300 PF00069 0.352
MOD_CK1_1 174 180 PF00069 0.372
MOD_CK1_1 376 382 PF00069 0.517
MOD_CK1_1 397 403 PF00069 0.368
MOD_CK1_1 54 60 PF00069 0.385
MOD_CK1_1 572 578 PF00069 0.474
MOD_CK1_1 580 586 PF00069 0.401
MOD_CK1_1 61 67 PF00069 0.513
MOD_CK1_1 627 633 PF00069 0.685
MOD_CK1_1 656 662 PF00069 0.607
MOD_CK1_1 677 683 PF00069 0.598
MOD_CK1_1 708 714 PF00069 0.689
MOD_CK1_1 746 752 PF00069 0.631
MOD_CK1_1 758 764 PF00069 0.698
MOD_CK1_1 779 785 PF00069 0.700
MOD_CK1_1 789 795 PF00069 0.739
MOD_CK1_1 802 808 PF00069 0.598
MOD_CK1_1 826 832 PF00069 0.662
MOD_CK1_1 835 841 PF00069 0.589
MOD_CK2_1 251 257 PF00069 0.457
MOD_CK2_1 268 274 PF00069 0.500
MOD_CK2_1 341 347 PF00069 0.525
MOD_CK2_1 576 582 PF00069 0.467
MOD_GlcNHglycan 173 176 PF01048 0.355
MOD_GlcNHglycan 188 191 PF01048 0.295
MOD_GlcNHglycan 204 207 PF01048 0.415
MOD_GlcNHglycan 230 233 PF01048 0.528
MOD_GlcNHglycan 270 273 PF01048 0.467
MOD_GlcNHglycan 317 320 PF01048 0.394
MOD_GlcNHglycan 327 330 PF01048 0.464
MOD_GlcNHglycan 375 378 PF01048 0.516
MOD_GlcNHglycan 419 422 PF01048 0.496
MOD_GlcNHglycan 459 462 PF01048 0.375
MOD_GlcNHglycan 466 470 PF01048 0.339
MOD_GlcNHglycan 558 561 PF01048 0.353
MOD_GlcNHglycan 579 582 PF01048 0.532
MOD_GlcNHglycan 60 63 PF01048 0.511
MOD_GlcNHglycan 605 608 PF01048 0.623
MOD_GlcNHglycan 613 616 PF01048 0.671
MOD_GlcNHglycan 655 658 PF01048 0.567
MOD_GlcNHglycan 671 674 PF01048 0.648
MOD_GlcNHglycan 677 680 PF01048 0.635
MOD_GlcNHglycan 68 71 PF01048 0.543
MOD_GlcNHglycan 707 710 PF01048 0.685
MOD_GlcNHglycan 745 748 PF01048 0.639
MOD_GlcNHglycan 757 760 PF01048 0.594
MOD_GlcNHglycan 825 828 PF01048 0.667
MOD_GlcNHglycan 834 837 PF01048 0.560
MOD_GSK3_1 167 174 PF00069 0.404
MOD_GSK3_1 247 254 PF00069 0.388
MOD_GSK3_1 26 33 PF00069 0.428
MOD_GSK3_1 279 286 PF00069 0.415
MOD_GSK3_1 341 348 PF00069 0.437
MOD_GSK3_1 512 519 PF00069 0.450
MOD_GSK3_1 54 61 PF00069 0.382
MOD_GSK3_1 547 554 PF00069 0.362
MOD_GSK3_1 572 579 PF00069 0.514
MOD_GSK3_1 582 589 PF00069 0.491
MOD_GSK3_1 616 623 PF00069 0.617
MOD_GSK3_1 62 69 PF00069 0.494
MOD_GSK3_1 624 631 PF00069 0.678
MOD_GSK3_1 652 659 PF00069 0.583
MOD_GSK3_1 669 676 PF00069 0.678
MOD_GSK3_1 683 690 PF00069 0.701
MOD_GSK3_1 761 768 PF00069 0.687
MOD_GSK3_1 777 784 PF00069 0.599
MOD_GSK3_1 785 792 PF00069 0.695
MOD_GSK3_1 826 833 PF00069 0.732
MOD_LATS_1 601 607 PF00433 0.457
MOD_N-GLC_1 268 273 PF02516 0.397
MOD_N-GLC_1 505 510 PF02516 0.282
MOD_N-GLC_1 591 596 PF02516 0.297
MOD_N-GLC_1 620 625 PF02516 0.653
MOD_N-GLC_2 277 279 PF02516 0.460
MOD_NEK2_1 10 15 PF00069 0.425
MOD_NEK2_1 202 207 PF00069 0.349
MOD_NEK2_1 221 226 PF00069 0.543
MOD_NEK2_1 247 252 PF00069 0.341
MOD_NEK2_1 301 306 PF00069 0.383
MOD_NEK2_1 333 338 PF00069 0.485
MOD_NEK2_1 341 346 PF00069 0.474
MOD_NEK2_1 36 41 PF00069 0.384
MOD_NEK2_1 368 373 PF00069 0.370
MOD_NEK2_1 440 445 PF00069 0.477
MOD_NEK2_1 457 462 PF00069 0.354
MOD_NEK2_1 479 484 PF00069 0.419
MOD_NEK2_1 56 61 PF00069 0.483
MOD_NEK2_1 563 568 PF00069 0.405
MOD_NEK2_1 591 596 PF00069 0.430
MOD_NEK2_1 652 657 PF00069 0.639
MOD_NEK2_1 731 736 PF00069 0.705
MOD_NEK2_1 737 742 PF00069 0.682
MOD_NEK2_1 753 758 PF00069 0.546
MOD_NEK2_2 26 31 PF00069 0.409
MOD_NEK2_2 547 552 PF00069 0.357
MOD_NEK2_2 79 84 PF00069 0.445
MOD_PIKK_1 333 339 PF00454 0.395
MOD_PIKK_1 41 47 PF00454 0.500
MOD_PIKK_1 519 525 PF00454 0.471
MOD_PIKK_1 732 738 PF00454 0.614
MOD_PIKK_1 789 795 PF00454 0.606
MOD_PK_1 262 268 PF00069 0.492
MOD_PKA_2 279 285 PF00069 0.423
MOD_PKA_2 301 307 PF00069 0.387
MOD_PKA_2 51 57 PF00069 0.403
MOD_PKA_2 731 737 PF00069 0.681
MOD_PKA_2 79 85 PF00069 0.423
MOD_PKA_2 802 808 PF00069 0.524
MOD_PKB_1 463 471 PF00069 0.246
MOD_Plk_1 505 511 PF00069 0.282
MOD_Plk_1 591 597 PF00069 0.374
MOD_Plk_1 732 738 PF00069 0.727
MOD_Plk_4 103 109 PF00069 0.315
MOD_Plk_4 167 173 PF00069 0.295
MOD_Plk_4 405 411 PF00069 0.357
MOD_Plk_4 479 485 PF00069 0.460
MOD_Plk_4 51 57 PF00069 0.335
MOD_Plk_4 563 569 PF00069 0.363
MOD_Plk_4 586 592 PF00069 0.503
MOD_Plk_4 687 693 PF00069 0.656
MOD_Plk_4 809 815 PF00069 0.717
MOD_Plk_4 85 91 PF00069 0.333
MOD_ProDKin_1 17 23 PF00069 0.452
MOD_ProDKin_1 195 201 PF00069 0.574
MOD_ProDKin_1 293 299 PF00069 0.468
MOD_ProDKin_1 30 36 PF00069 0.404
MOD_ProDKin_1 408 414 PF00069 0.411
MOD_ProDKin_1 516 522 PF00069 0.486
MOD_ProDKin_1 569 575 PF00069 0.462
MOD_ProDKin_1 628 634 PF00069 0.607
MOD_ProDKin_1 678 684 PF00069 0.768
MOD_ProDKin_1 691 697 PF00069 0.592
MOD_ProDKin_1 765 771 PF00069 0.726
MOD_ProDKin_1 786 792 PF00069 0.642
MOD_SUMO_for_1 596 599 PF00179 0.355
TRG_DiLeu_BaEn_2 309 315 PF01217 0.389
TRG_ENDOCYTIC_2 248 251 PF00928 0.263
TRG_ENDOCYTIC_2 427 430 PF00928 0.318
TRG_ER_diArg_1 126 128 PF00400 0.407
TRG_ER_diArg_1 299 302 PF00400 0.484
TRG_ER_diArg_1 462 465 PF00400 0.261
TRG_ER_diArg_1 83 85 PF00400 0.433
TRG_ER_diArg_1 843 845 PF00400 0.637
TRG_NES_CRM1_1 322 334 PF08389 0.398
TRG_Pf-PMV_PEXEL_1 561 565 PF00026 0.451
TRG_Pf-PMV_PEXEL_1 72 77 PF00026 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PER2 Leptomonas seymouri 54% 96%
A0A0S4KHN7 Bodo saltans 33% 100%
A0A1X0NY37 Trypanosomatidae 38% 100%
A0A3S5IS35 Trypanosoma rangeli 37% 100%
A4HBU3 Leishmania braziliensis 78% 99%
D0A1C9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AGU9 Leishmania infantum 100% 100%
E9AV65 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 99%
O13733 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
Q4QCB6 Leishmania major 93% 100%
Q55GS2 Dictyostelium discoideum 25% 100%
Q96KG9 Homo sapiens 27% 100%
Q9EQC5 Mus musculus 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS