Calcium uniporter protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function, DUF607, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWG8_LEIDO

TriTrypDb:

LdBPK_210410.1 , LdCL_210008900 , LDHU3_21.0430

Length:

121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	5
GO:0016020	membrane	2	5
GO:0019866	organelle inner membrane	4	5
GO:0031090	organelle membrane	3	5
GO:0031966	mitochondrial membrane	4	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7WWG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWG8

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	5
GO:0006874	intracellular calcium ion homeostasis	7	5
GO:0006875	obsolete intracellular metal ion homeostasis	6	5
GO:0009987	cellular process	1	5
GO:0019725	cellular homeostasis	2	5
GO:0030003	intracellular monoatomic cation homeostasis	5	5
GO:0042592	homeostatic process	3	5
GO:0048878	chemical homeostasis	4	5
GO:0050801	monoatomic ion homeostasis	5	5
GO:0051560	mitochondrial calcium ion homeostasis	8	5
GO:0055065	obsolete metal ion homeostasis	7	5
GO:0055074	calcium ion homeostasis	8	5
GO:0055080	monoatomic cation homeostasis	6	5
GO:0055082	intracellular chemical homeostasis	3	5
GO:0065007	biological regulation	1	5
GO:0065008	regulation of biological quality	2	5
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	5
GO:0072507	obsolete divalent inorganic cation homeostasis	7	5
GO:0098771	inorganic ion homeostasis	6	5

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	5
GO:0005216	monoatomic ion channel activity	4	5
GO:0005261	monoatomic cation channel activity	5	5
GO:0005262	calcium channel activity	6	5
GO:0008324	monoatomic cation transmembrane transporter activity	4	5
GO:0015075	monoatomic ion transmembrane transporter activity	3	5
GO:0015085	calcium ion transmembrane transporter activity	6	5
GO:0015267	channel activity	4	5
GO:0015291	secondary active transmembrane transporter activity	4	5
GO:0015292	uniporter activity	5	5
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	5
GO:0022803	passive transmembrane transporter activity	3	5
GO:0022804	active transmembrane transporter activity	3	5
GO:0022857	transmembrane transporter activity	2	5
GO:0022890	inorganic cation transmembrane transporter activity	4	5
GO:0046873	metal ion transmembrane transporter activity	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	86	88	PF00082	0.284
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.279
CLV_PCSK_SKI1_1	21	25	PF00082	0.311
DEG_Nend_UBRbox_2	1	3	PF02207	0.500
DOC_MAPK_FxFP_2	13	16	PF00069	0.500
DOC_PP4_FxxP_1	13	16	PF00568	0.500
DOC_PP4_FxxP_1	46	49	PF00568	0.300
LIG_deltaCOP1_diTrp_1	36	44	PF00928	0.300
LIG_FHA_1	49	55	PF00498	0.494
LIG_LIR_Apic_2	10	16	PF02991	0.500
LIG_LIR_Apic_2	43	49	PF02991	0.300
LIG_LIR_Gen_1	36	47	PF02991	0.300
LIG_LIR_Gen_1	57	68	PF02991	0.339
LIG_LIR_Gen_1	72	82	PF02991	0.515
LIG_LIR_Nem_3	36	42	PF02991	0.300
LIG_LIR_Nem_3	43	47	PF02991	0.265
LIG_LIR_Nem_3	57	63	PF02991	0.339
LIG_LIR_Nem_3	72	78	PF02991	0.515
LIG_LYPXL_yS_3	15	18	PF13949	0.480
LIG_PCNA_PIPBox_1	20	29	PF02747	0.311
LIG_PDZ_Class_3	116	121	PF00595	0.585
LIG_Pex14_2	42	46	PF04695	0.300
LIG_SH2_STAP1	56	60	PF00017	0.339
LIG_SH2_STAT5	39	42	PF00017	0.325
LIG_SH2_STAT5	52	55	PF00017	0.249
LIG_Sin3_3	25	32	PF02671	0.327
MOD_CK1_1	74	80	PF00069	0.459
MOD_GlcNHglycan	56	59	PF01048	0.412
MOD_NEK2_1	35	40	PF00069	0.300
MOD_Plk_1	35	41	PF00069	0.300
MOD_Plk_1	71	77	PF00069	0.459
MOD_Plk_4	56	62	PF00069	0.412
MOD_SUMO_for_1	4	7	PF00179	0.518
MOD_SUMO_for_1	85	88	PF00179	0.480
TRG_ENDOCYTIC_2	101	104	PF00928	0.500
TRG_ENDOCYTIC_2	15	18	PF00928	0.480
TRG_ENDOCYTIC_2	39	42	PF00928	0.300
TRG_ENDOCYTIC_2	66	69	PF00928	0.339
TRG_ENDOCYTIC_2	75	78	PF00928	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HZ34	Leishmania infantum	100%	100%
E9AV02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCI0	Leishmania major	94%	100%