ATP-binding cassette protein subfamily E, member 1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily E, member 1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWG1_LEIDO

TriTrypDb:

LdBPK_210770.1 , LdCL_210012600 , LDHU3_21.0830

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWG1

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0006413	translational initiation	3	1
GO:0006415	translational termination	6	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022411	cellular component disassembly	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0033750	ribosome localization	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0005215	transporter activity	1	1
GO:0005506	iron ion binding	6	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043024	ribosomal small subunit binding	4	1
GO:0043169	cation binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0140657	ATP-dependent activity	1	1
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.310
CLV_C14_Caspase3-7	622	626	PF00656	0.791
CLV_NRD_NRD_1	26	28	PF00675	0.420
CLV_NRD_NRD_1	352	354	PF00675	0.639
CLV_NRD_NRD_1	575	577	PF00675	0.438
CLV_PCSK_KEX2_1	351	353	PF00082	0.592
CLV_PCSK_KEX2_1	513	515	PF00082	0.376
CLV_PCSK_KEX2_1	520	522	PF00082	0.386
CLV_PCSK_KEX2_1	575	577	PF00082	0.438
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.592
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.376
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.386
CLV_PCSK_SKI1_1	173	177	PF00082	0.313
CLV_PCSK_SKI1_1	202	206	PF00082	0.325
CLV_PCSK_SKI1_1	268	272	PF00082	0.367
CLV_PCSK_SKI1_1	433	437	PF00082	0.313
CLV_PCSK_SKI1_1	455	459	PF00082	0.313
CLV_PCSK_SKI1_1	510	514	PF00082	0.371
CLV_PCSK_SKI1_1	521	525	PF00082	0.345
CLV_PCSK_SKI1_1	565	569	PF00082	0.405
DOC_ANK_TNKS_1	642	649	PF00023	0.630
DOC_CKS1_1	484	489	PF01111	0.313
DOC_CYCLIN_yClb5_NLxxxL_5	78	87	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	484	490	PF00134	0.313
DOC_MAPK_gen_1	202	211	PF00069	0.356
DOC_MAPK_gen_1	331	339	PF00069	0.433
DOC_MAPK_gen_1	565	574	PF00069	0.402
DOC_MAPK_MEF2A_6	314	321	PF00069	0.362
DOC_MAPK_MEF2A_6	477	484	PF00069	0.313
DOC_MAPK_MEF2A_6	565	574	PF00069	0.402
DOC_PP2B_LxvP_1	105	108	PF13499	0.375
DOC_SPAK_OSR1_1	232	236	PF12202	0.313
DOC_USP7_MATH_1	359	363	PF00917	0.438
DOC_USP7_UBL2_3	132	136	PF12436	0.283
DOC_USP7_UBL2_3	423	427	PF12436	0.313
DOC_USP7_UBL2_3	615	619	PF12436	0.736
DOC_USP7_UBL2_3	633	637	PF12436	0.538
DOC_USP7_UBL2_3	654	658	PF12436	0.751
DOC_WW_Pin1_4	483	488	PF00397	0.313
DOC_WW_Pin1_4	543	548	PF00397	0.414
DOC_WW_Pin1_4	552	557	PF00397	0.398
LIG_14-3-3_CanoR_1	258	267	PF00244	0.386
LIG_14-3-3_CanoR_1	268	278	PF00244	0.396
LIG_14-3-3_CanoR_1	565	571	PF00244	0.476
LIG_AP2alpha_1	320	324	PF02296	0.372
LIG_APCC_ABBA_1	245	250	PF00400	0.313
LIG_APCC_ABBA_1	317	322	PF00400	0.361
LIG_deltaCOP1_diTrp_1	145	155	PF00928	0.334
LIG_FHA_1	272	278	PF00498	0.468
LIG_FHA_1	325	331	PF00498	0.416
LIG_FHA_1	336	342	PF00498	0.454
LIG_FHA_1	392	398	PF00498	0.312
LIG_FHA_1	449	455	PF00498	0.313
LIG_FHA_1	520	526	PF00498	0.355
LIG_FHA_1	544	550	PF00498	0.428
LIG_FHA_2	195	201	PF00498	0.371
LIG_FHA_2	374	380	PF00498	0.367
LIG_FHA_2	429	435	PF00498	0.313
LIG_FHA_2	456	462	PF00498	0.313
LIG_FHA_2	604	610	PF00498	0.627
LIG_IRF3_LxIS_1	412	418	PF10401	0.313
LIG_LIR_Apic_2	442	447	PF02991	0.313
LIG_LIR_Gen_1	145	155	PF02991	0.315
LIG_LIR_Gen_1	206	214	PF02991	0.333
LIG_LIR_Gen_1	252	261	PF02991	0.381
LIG_LIR_Gen_1	273	284	PF02991	0.356
LIG_LIR_Gen_1	291	301	PF02991	0.352
LIG_LIR_Gen_1	394	404	PF02991	0.313
LIG_LIR_Nem_3	145	151	PF02991	0.315
LIG_LIR_Nem_3	206	211	PF02991	0.333
LIG_LIR_Nem_3	252	257	PF02991	0.381
LIG_LIR_Nem_3	273	279	PF02991	0.366
LIG_LIR_Nem_3	291	296	PF02991	0.339
LIG_LIR_Nem_3	438	444	PF02991	0.300
LIG_LYPXL_yS_3	358	361	PF13949	0.391
LIG_PCNA_yPIPBox_3	183	195	PF02747	0.425
LIG_PCNA_yPIPBox_3	423	436	PF02747	0.313
LIG_Pex14_2	320	324	PF04695	0.372
LIG_SH2_CRK	298	302	PF00017	0.385
LIG_SH2_CRK	304	308	PF00017	0.341
LIG_SH2_CRK	75	79	PF00017	0.333
LIG_SH2_GRB2like	142	145	PF00017	0.380
LIG_SH2_NCK_1	248	252	PF00017	0.458
LIG_SH2_PTP2	276	279	PF00017	0.338
LIG_SH2_SRC	248	251	PF00017	0.344
LIG_SH2_SRC	254	257	PF00017	0.352
LIG_SH2_SRC	276	279	PF00017	0.411
LIG_SH2_SRC	499	502	PF00017	0.385
LIG_SH2_STAT3	419	422	PF00017	0.313
LIG_SH2_STAT5	154	157	PF00017	0.313
LIG_SH2_STAT5	163	166	PF00017	0.313
LIG_SH2_STAT5	180	183	PF00017	0.313
LIG_SH2_STAT5	207	210	PF00017	0.380
LIG_SH2_STAT5	254	257	PF00017	0.383
LIG_SH2_STAT5	276	279	PF00017	0.338
LIG_SH2_STAT5	444	447	PF00017	0.425
LIG_SH2_STAT5	491	494	PF00017	0.313
LIG_SH2_STAT5	499	502	PF00017	0.385
LIG_SH2_STAT5	535	538	PF00017	0.364
LIG_SH2_STAT5	602	605	PF00017	0.452
LIG_SH3_3	304	310	PF00018	0.353
LIG_SH3_3	407	413	PF00018	0.425
LIG_SH3_3	450	456	PF00018	0.313
LIG_SH3_4	615	622	PF00018	0.731
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.313
LIG_SUMO_SIM_anti_2	14	22	PF11976	0.313
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.412
LIG_SUMO_SIM_anti_2	378	388	PF11976	0.313
LIG_SUMO_SIM_par_1	276	281	PF11976	0.338
LIG_SUMO_SIM_par_1	378	388	PF11976	0.341
LIG_SUMO_SIM_par_1	455	461	PF11976	0.327
LIG_TRAF2_1	458	461	PF00917	0.313
LIG_TYR_ITSM	272	279	PF00017	0.482
LIG_UBA3_1	559	568	PF00899	0.394
LIG_WRC_WIRS_1	365	370	PF05994	0.454
MOD_CK1_1	11	17	PF00069	0.313
MOD_CK1_1	269	275	PF00069	0.503
MOD_CK1_1	50	56	PF00069	0.441
MOD_CK1_1	519	525	PF00069	0.474
MOD_CK2_1	223	229	PF00069	0.313
MOD_CK2_1	375	381	PF00069	0.313
MOD_CK2_1	455	461	PF00069	0.313
MOD_CK2_1	603	609	PF00069	0.667
MOD_CK2_1	82	88	PF00069	0.466
MOD_Cter_Amidation	612	615	PF01082	0.781
MOD_Cter_Amidation	652	655	PF01082	0.764
MOD_GlcNHglycan	225	228	PF01048	0.313
MOD_GlcNHglycan	470	473	PF01048	0.303
MOD_GlcNHglycan	494	499	PF01048	0.311
MOD_GlcNHglycan	598	601	PF01048	0.549
MOD_GSK3_1	119	126	PF00069	0.313
MOD_GSK3_1	364	371	PF00069	0.475
MOD_GSK3_1	373	380	PF00069	0.270
MOD_GSK3_1	47	54	PF00069	0.469
MOD_GSK3_1	566	573	PF00069	0.397
MOD_N-GLC_1	119	124	PF02516	0.313
MOD_N-GLC_1	468	473	PF02516	0.325
MOD_N-GLC_1	549	554	PF02516	0.513
MOD_N-GLC_1	570	575	PF02516	0.475
MOD_N-GLC_2	389	391	PF02516	0.313
MOD_NEK2_1	271	276	PF00069	0.485
MOD_NEK2_1	415	420	PF00069	0.297
MOD_NEK2_1	428	433	PF00069	0.313
MOD_NEK2_1	435	440	PF00069	0.313
MOD_NEK2_1	566	571	PF00069	0.402
MOD_PIKK_1	638	644	PF00454	0.669
MOD_PK_1	587	593	PF00069	0.461
MOD_PKA_2	11	17	PF00069	0.458
MOD_PKA_2	155	161	PF00069	0.313
MOD_PKA_2	231	237	PF00069	0.333
MOD_PKA_2	259	265	PF00069	0.368
MOD_PKA_2	88	94	PF00069	0.560
MOD_Plk_1	200	206	PF00069	0.471
MOD_Plk_1	218	224	PF00069	0.254
MOD_Plk_1	282	288	PF00069	0.341
MOD_Plk_1	570	576	PF00069	0.406
MOD_Plk_1	8	14	PF00069	0.695
MOD_Plk_2-3	200	206	PF00069	0.458
MOD_Plk_2-3	250	256	PF00069	0.376
MOD_Plk_2-3	373	379	PF00069	0.310
MOD_Plk_4	126	132	PF00069	0.313
MOD_Plk_4	250	256	PF00069	0.393
MOD_Plk_4	282	288	PF00069	0.414
MOD_Plk_4	392	398	PF00069	0.313
MOD_Plk_4	531	537	PF00069	0.350
MOD_ProDKin_1	483	489	PF00069	0.313
MOD_ProDKin_1	543	549	PF00069	0.417
MOD_ProDKin_1	552	558	PF00069	0.402
MOD_SUMO_rev_2	210	217	PF00179	0.425
MOD_SUMO_rev_2	589	599	PF00179	0.467
MOD_SUMO_rev_2	625	635	PF00179	0.800
TRG_DiLeu_BaEn_1	381	386	PF01217	0.313
TRG_DiLeu_BaEn_4	8	14	PF01217	0.550
TRG_ENDOCYTIC_2	254	257	PF00928	0.383
TRG_ENDOCYTIC_2	276	279	PF00928	0.338
TRG_ENDOCYTIC_2	304	307	PF00928	0.341
TRG_ENDOCYTIC_2	358	361	PF00928	0.391
TRG_ENDOCYTIC_2	602	605	PF00928	0.452
TRG_ENDOCYTIC_2	75	78	PF00928	0.333
TRG_ER_diArg_1	257	260	PF00400	0.373
TRG_ER_diArg_1	574	576	PF00400	0.417
TRG_ER_diArg_1	581	584	PF00400	0.422
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7M4	Leptomonas seymouri	90%	99%
A0A1X0NXL9	Trypanosomatidae	82%	100%
A0A422NHA0	Trypanosoma rangeli	82%	100%
A4HBR7	Leishmania braziliensis	93%	100%
A4HZ70	Leishmania infantum	100%	100%
D0A1G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9AV37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
G0SEV9	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	63%	100%
O60102	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	61%	100%
P33916	Escherichia coli (strain K12)	25%	100%
P36947	Bacillus subtilis (strain 168)	24%	100%
P61221	Homo sapiens	63%	100%
P61222	Mus musculus	63%	100%
P9WQK2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	23%	100%
P9WQK3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	23%	100%
Q03195	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	64%	100%
Q322L1	Shigella boydii serotype 4 (strain Sb227)	24%	100%
Q3K3R2	Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)	22%	100%
Q3Z2S7	Shigella sonnei (strain Ss046)	24%	100%
Q4QCE4	Leishmania major	98%	100%
Q58129	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	47%	100%
Q6HI76	Bacillus thuringiensis subsp. konkukian (strain 97-27)	25%	100%
Q73R11	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	24%	100%
Q81PZ8	Bacillus anthracis	25%	100%
Q87FK7	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	24%	100%
Q8E7N9	Streptococcus agalactiae serotype III (strain NEM316)	22%	100%
Q8G838	Bifidobacterium longum (strain NCC 2705)	24%	84%
Q8LPJ4	Arabidopsis thaliana	65%	100%
Q8SRV5	Encephalitozoon cuniculi (strain GB-M1)	23%	100%
Q97X60	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	23%	100%
Q9LID6	Arabidopsis thaliana	62%	100%
Q9VSS1	Drosophila melanogaster	65%	100%
Q9WXX0	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	22%	100%
V5BDT2	Trypanosoma cruzi	84%	100%