RNA helicase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA helicase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWF8_LEIDO

TriTrypDb:

LdBPK_210670.1 , LdCL_210011700 , LDHU3_21.0720

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWF8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.543
CLV_C14_Caspase3-7	7	11	PF00656	0.558
CLV_MEL_PAP_1	307	313	PF00089	0.353
CLV_NRD_NRD_1	16	18	PF00675	0.647
CLV_NRD_NRD_1	243	245	PF00675	0.725
CLV_NRD_NRD_1	316	318	PF00675	0.342
CLV_NRD_NRD_1	325	327	PF00675	0.405
CLV_NRD_NRD_1	52	54	PF00675	0.488
CLV_PCSK_FUR_1	14	18	PF00082	0.573
CLV_PCSK_KEX2_1	16	18	PF00082	0.669
CLV_PCSK_KEX2_1	165	167	PF00082	0.260
CLV_PCSK_KEX2_1	238	240	PF00082	0.636
CLV_PCSK_KEX2_1	316	318	PF00082	0.336
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.236
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.636
CLV_PCSK_SKI1_1	101	105	PF00082	0.208
CLV_PCSK_SKI1_1	130	134	PF00082	0.334
CLV_PCSK_SKI1_1	165	169	PF00082	0.215
CLV_PCSK_SKI1_1	17	21	PF00082	0.606
CLV_PCSK_SKI1_1	316	320	PF00082	0.365
CLV_PCSK_SKI1_1	401	405	PF00082	0.462
CLV_PCSK_SKI1_1	420	424	PF00082	0.408
CLV_PCSK_SKI1_1	484	488	PF00082	0.276
CLV_PCSK_SKI1_1	535	539	PF00082	0.334
CLV_PCSK_SKI1_1	558	562	PF00082	0.355
CLV_PCSK_SKI1_1	656	660	PF00082	0.451
CLV_PCSK_SKI1_1	71	75	PF00082	0.505
CLV_PCSK_SKI1_1	90	94	PF00082	0.289
DEG_SPOP_SBC_1	442	446	PF00917	0.685
DOC_CYCLIN_RxL_1	127	135	PF00134	0.497
DOC_CYCLIN_RxL_1	515	526	PF00134	0.430
DOC_CYCLIN_RxL_1	653	661	PF00134	0.454
DOC_CYCLIN_yClb1_LxF_4	319	325	PF00134	0.364
DOC_CYCLIN_yClb5_NLxxxL_5	646	655	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	651	657	PF00134	0.396
DOC_MAPK_gen_1	16	27	PF00069	0.533
DOC_MAPK_gen_1	316	324	PF00069	0.386
DOC_MAPK_gen_1	552	562	PF00069	0.584
DOC_MAPK_gen_1	632	640	PF00069	0.589
DOC_MAPK_MEF2A_6	174	182	PF00069	0.468
DOC_MAPK_MEF2A_6	632	640	PF00069	0.518
DOC_PP1_RVXF_1	410	417	PF00149	0.325
DOC_PP1_RVXF_1	46	52	PF00149	0.475
DOC_PP1_RVXF_1	516	523	PF00149	0.430
DOC_PP2B_LxvP_1	531	534	PF13499	0.430
DOC_PP4_FxxP_1	675	678	PF00568	0.340
DOC_USP7_MATH_1	265	269	PF00917	0.756
DOC_USP7_MATH_1	328	332	PF00917	0.439
DOC_USP7_MATH_1	468	472	PF00917	0.715
DOC_USP7_MATH_1	537	541	PF00917	0.503
DOC_USP7_MATH_1	593	597	PF00917	0.576
DOC_USP7_MATH_1	613	617	PF00917	0.672
DOC_USP7_MATH_1	619	623	PF00917	0.454
DOC_USP7_UBL2_3	319	323	PF12436	0.405
DOC_USP7_UBL2_3	452	456	PF12436	0.811
DOC_USP7_UBL2_3	457	461	PF12436	0.585
DOC_USP7_UBL2_3	635	639	PF12436	0.596
DOC_USP7_UBL2_3	656	660	PF12436	0.383
DOC_USP7_UBL2_3	81	85	PF12436	0.382
DOC_WW_Pin1_4	288	293	PF00397	0.423
DOC_WW_Pin1_4	445	450	PF00397	0.728
LIG_14-3-3_CanoR_1	239	246	PF00244	0.761
LIG_14-3-3_CanoR_1	310	318	PF00244	0.495
LIG_14-3-3_CanoR_1	395	403	PF00244	0.390
LIG_14-3-3_CanoR_1	484	493	PF00244	0.515
LIG_14-3-3_CanoR_1	546	556	PF00244	0.438
LIG_14-3-3_CanoR_1	66	71	PF00244	0.447
LIG_14-3-3_CanoR_1	676	685	PF00244	0.426
LIG_Actin_WH2_2	164	181	PF00022	0.500
LIG_Actin_WH2_2	192	207	PF00022	0.393
LIG_Actin_WH2_2	644	662	PF00022	0.374
LIG_APCC_ABBA_1	379	384	PF00400	0.395
LIG_BIR_II_1	1	5	PF00653	0.722
LIG_BRCT_BRCA1_1	539	543	PF00533	0.534
LIG_EH_1	628	632	PF12763	0.421
LIG_FHA_1	162	168	PF00498	0.439
LIG_FHA_1	175	181	PF00498	0.430
LIG_FHA_1	20	26	PF00498	0.571
LIG_FHA_1	387	393	PF00498	0.429
LIG_FHA_1	548	554	PF00498	0.501
LIG_FHA_1	576	582	PF00498	0.544
LIG_FHA_1	77	83	PF00498	0.433
LIG_FHA_2	219	225	PF00498	0.537
LIG_FHA_2	33	39	PF00498	0.512
LIG_FHA_2	421	427	PF00498	0.495
LIG_FHA_2	521	527	PF00498	0.534
LIG_FHA_2	647	653	PF00498	0.413
LIG_FHA_2	691	697	PF00498	0.465
LIG_GBD_Chelix_1	196	204	PF00786	0.209
LIG_Integrin_isoDGR_2	105	107	PF01839	0.334
LIG_Integrin_isoDGR_2	410	412	PF01839	0.513
LIG_LIR_Apic_2	120	126	PF02991	0.430
LIG_LIR_Gen_1	34	45	PF02991	0.385
LIG_LIR_Gen_1	521	530	PF02991	0.460
LIG_LIR_LC3C_4	622	627	PF02991	0.391
LIG_LIR_Nem_3	34	40	PF02991	0.361
LIG_LIR_Nem_3	521	525	PF02991	0.435
LIG_LIR_Nem_3	86	92	PF02991	0.381
LIG_Pex14_2	150	154	PF04695	0.430
LIG_RPA_C_Fungi	48	60	PF08784	0.466
LIG_SH2_CRK	100	104	PF00017	0.264
LIG_SH2_CRK	123	127	PF00017	0.264
LIG_SH2_CRK	369	373	PF00017	0.409
LIG_SH2_CRK	633	637	PF00017	0.528
LIG_SH2_NCK_1	633	637	PF00017	0.528
LIG_SH2_STAT3	172	175	PF00017	0.449
LIG_SH2_STAT3	367	370	PF00017	0.410
LIG_SH2_STAT3	692	695	PF00017	0.525
LIG_SH2_STAT5	345	348	PF00017	0.341
LIG_SH2_STAT5	633	636	PF00017	0.531
LIG_SH2_STAT5	692	695	PF00017	0.442
LIG_SH3_3	550	556	PF00018	0.357
LIG_SH3_3	624	630	PF00018	0.368
LIG_SH3_3	635	641	PF00018	0.477
LIG_SH3_4	635	642	PF00018	0.495
LIG_SUMO_SIM_par_1	370	376	PF11976	0.406
LIG_TRAF2_1	222	225	PF00917	0.473
LIG_TRAF2_1	253	256	PF00917	0.692
LIG_TRAF2_1	693	696	PF00917	0.464
LIG_UBA3_1	321	327	PF00899	0.362
MOD_CDC14_SPxK_1	291	294	PF00782	0.395
MOD_CDK_SPxK_1	288	294	PF00069	0.399
MOD_CDK_SPxxK_3	445	452	PF00069	0.572
MOD_CK1_1	117	123	PF00069	0.264
MOD_CK1_1	2	8	PF00069	0.698
MOD_CK1_1	447	453	PF00069	0.708
MOD_CK1_1	471	477	PF00069	0.571
MOD_CK1_1	596	602	PF00069	0.563
MOD_CK1_1	69	75	PF00069	0.431
MOD_CK2_1	218	224	PF00069	0.521
MOD_CK2_1	420	426	PF00069	0.504
MOD_CK2_1	49	55	PF00069	0.512
MOD_CK2_1	665	671	PF00069	0.506
MOD_CK2_1	690	696	PF00069	0.537
MOD_Cter_Amidation	235	238	PF01082	0.750
MOD_Cter_Amidation	314	317	PF01082	0.347
MOD_Cter_Amidation	454	457	PF01082	0.714
MOD_GlcNHglycan	10	13	PF01048	0.657
MOD_GlcNHglycan	116	119	PF01048	0.264
MOD_GlcNHglycan	241	244	PF01048	0.755
MOD_GlcNHglycan	311	314	PF01048	0.591
MOD_GlcNHglycan	375	378	PF01048	0.599
MOD_GlcNHglycan	449	452	PF01048	0.788
MOD_GlcNHglycan	461	464	PF01048	0.658
MOD_GlcNHglycan	595	598	PF01048	0.671
MOD_GlcNHglycan	607	610	PF01048	0.547
MOD_GlcNHglycan	641	644	PF01048	0.379
MOD_GSK3_1	110	117	PF00069	0.264
MOD_GSK3_1	428	435	PF00069	0.490
MOD_GSK3_1	437	444	PF00069	0.621
MOD_GSK3_1	470	477	PF00069	0.576
MOD_GSK3_1	520	527	PF00069	0.378
MOD_GSK3_1	69	76	PF00069	0.518
MOD_LATS_1	112	118	PF00433	0.264
MOD_LATS_1	64	70	PF00433	0.459
MOD_N-GLC_1	328	333	PF02516	0.417
MOD_NEK2_1	200	205	PF00069	0.298
MOD_NEK2_1	311	316	PF00069	0.341
MOD_NEK2_1	386	391	PF00069	0.554
MOD_NEK2_1	475	480	PF00069	0.547
MOD_NEK2_1	49	54	PF00069	0.579
MOD_NEK2_1	631	636	PF00069	0.525
MOD_NEK2_1	75	80	PF00069	0.434
MOD_NEK2_1	83	88	PF00069	0.386
MOD_NEK2_2	619	624	PF00069	0.417
MOD_OFUCOSY	385	390	PF10250	0.349
MOD_PIKK_1	485	491	PF00454	0.258
MOD_PK_1	66	72	PF00069	0.426
MOD_PKA_2	309	315	PF00069	0.355
MOD_PKA_2	631	637	PF00069	0.554
MOD_Plk_1	303	309	PF00069	0.358
MOD_Plk_1	404	410	PF00069	0.561
MOD_Plk_4	21	27	PF00069	0.518
MOD_Plk_4	388	394	PF00069	0.481
MOD_Plk_4	477	483	PF00069	0.483
MOD_Plk_4	524	530	PF00069	0.346
MOD_Plk_4	539	545	PF00069	0.314
MOD_ProDKin_1	288	294	PF00069	0.422
MOD_ProDKin_1	445	451	PF00069	0.729
TRG_DiLeu_BaEn_1	129	134	PF01217	0.409
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.326
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.358
TRG_ENDOCYTIC_2	100	103	PF00928	0.264
TRG_ENDOCYTIC_2	368	371	PF00928	0.419
TRG_ER_diArg_1	14	17	PF00400	0.571
TRG_ER_diArg_1	316	318	PF00400	0.336
TRG_NLS_MonoCore_2	237	242	PF00514	0.677
TRG_NLS_MonoExtC_3	16	21	PF00514	0.624
TRG_NLS_MonoExtC_3	236	241	PF00514	0.678
TRG_NLS_MonoExtN_4	14	21	PF00514	0.690
TRG_NLS_MonoExtN_4	235	242	PF00514	0.636
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	401	405	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P856	Leptomonas seymouri	65%	100%
A0A0S4J214	Bodo saltans	45%	100%
A0A1X0NXJ9	Trypanosomatidae	48%	100%
A0A3R7MLR3	Trypanosoma rangeli	49%	100%
A4HBQ8	Leishmania braziliensis	82%	100%
A4HZ60	Leishmania infantum	99%	100%
D0A1I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AV28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4QCF4	Leishmania major	94%	100%
V5BDT6	Trypanosoma cruzi	48%	100%