Actin-like protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-like protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWF5_LEIDO

TriTrypDb:

LdBPK_210290.1 , LdCL_210007700 , LDHU3_21.0290

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0000118	histone deacetylase complex	3	1
GO:0000812	Swr1 complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070603	SWI/SNF superfamily-type complex	3	1
GO:0097346	INO80-type complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1904949	ATPase complex	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7WWF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWF5

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	10
GO:0006338	chromatin remodeling	5	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1
GO:0031491	nucleosome binding	3	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.496
CLV_C14_Caspase3-7	477	481	PF00656	0.670
CLV_NRD_NRD_1	184	186	PF00675	0.310
CLV_NRD_NRD_1	285	287	PF00675	0.306
CLV_NRD_NRD_1	314	316	PF00675	0.336
CLV_NRD_NRD_1	94	96	PF00675	0.244
CLV_PCSK_KEX2_1	186	188	PF00082	0.310
CLV_PCSK_KEX2_1	285	287	PF00082	0.331
CLV_PCSK_KEX2_1	314	316	PF00082	0.274
CLV_PCSK_KEX2_1	482	484	PF00082	0.584
CLV_PCSK_KEX2_1	94	96	PF00082	0.215
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.310
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.584
CLV_PCSK_SKI1_1	246	250	PF00082	0.271
CLV_PCSK_SKI1_1	424	428	PF00082	0.247
CLV_PCSK_SKI1_1	435	439	PF00082	0.244
CLV_PCSK_SKI1_1	552	556	PF00082	0.410
CLV_Separin_Metazoa	553	557	PF03568	0.391
DEG_APCC_DBOX_1	349	357	PF00400	0.429
DEG_APCC_DBOX_1	423	431	PF00400	0.447
DEG_SPOP_SBC_1	24	28	PF00917	0.488
DOC_CDC14_PxL_1	353	361	PF14671	0.429
DOC_CKS1_1	400	405	PF01111	0.510
DOC_CYCLIN_RxL_1	421	431	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	400	406	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.461
DOC_MAPK_DCC_7	393	401	PF00069	0.510
DOC_MAPK_gen_1	151	160	PF00069	0.433
DOC_MAPK_gen_1	251	258	PF00069	0.446
DOC_MAPK_MEF2A_6	393	401	PF00069	0.521
DOC_PP2B_LxvP_1	131	134	PF13499	0.446
DOC_PP2B_LxvP_1	18	21	PF13499	0.363
DOC_PP2B_LxvP_1	61	64	PF13499	0.461
DOC_PP4_FxxP_1	135	138	PF00568	0.418
DOC_PP4_FxxP_1	394	397	PF00568	0.415
DOC_SPAK_OSR1_1	393	397	PF12202	0.510
DOC_USP7_MATH_1	200	204	PF00917	0.563
DOC_USP7_MATH_1	233	237	PF00917	0.454
DOC_USP7_MATH_1	24	28	PF00917	0.580
DOC_USP7_MATH_1	284	288	PF00917	0.429
DOC_USP7_MATH_1	374	378	PF00917	0.556
DOC_USP7_UBL2_3	482	486	PF12436	0.506
DOC_WW_Pin1_4	196	201	PF00397	0.532
DOC_WW_Pin1_4	325	330	PF00397	0.492
DOC_WW_Pin1_4	341	346	PF00397	0.511
DOC_WW_Pin1_4	399	404	PF00397	0.471
DOC_WW_Pin1_4	466	471	PF00397	0.565
DOC_WW_Pin1_4	505	510	PF00397	0.430
LIG_14-3-3_CanoR_1	175	180	PF00244	0.570
LIG_14-3-3_CanoR_1	187	193	PF00244	0.430
LIG_14-3-3_CanoR_1	285	289	PF00244	0.461
LIG_14-3-3_CanoR_1	29	38	PF00244	0.563
LIG_14-3-3_CanoR_1	501	509	PF00244	0.491
LIG_14-3-3_CanoR_1	576	580	PF00244	0.522
LIG_APCC_ABBA_1	4	9	PF00400	0.357
LIG_APCC_ABBAyCdc20_2	3	9	PF00400	0.439
LIG_BRCT_BRCA1_1	151	155	PF00533	0.441
LIG_BRCT_BRCA1_1	161	165	PF00533	0.388
LIG_deltaCOP1_diTrp_1	128	135	PF00928	0.510
LIG_FHA_1	221	227	PF00498	0.430
LIG_FHA_1	247	253	PF00498	0.471
LIG_FHA_1	265	271	PF00498	0.471
LIG_FHA_1	374	380	PF00498	0.509
LIG_FHA_1	416	422	PF00498	0.510
LIG_FHA_1	429	435	PF00498	0.491
LIG_FHA_1	506	512	PF00498	0.407
LIG_FHA_2	341	347	PF00498	0.565
LIG_FHA_2	400	406	PF00498	0.510
LIG_FHA_2	41	47	PF00498	0.604
LIG_LIR_Apic_2	132	138	PF02991	0.399
LIG_LIR_Apic_2	392	397	PF02991	0.415
LIG_LIR_Gen_1	128	138	PF02991	0.487
LIG_LIR_Gen_1	162	173	PF02991	0.415
LIG_LIR_Gen_1	254	263	PF02991	0.437
LIG_LIR_Nem_3	128	133	PF02991	0.487
LIG_LIR_Nem_3	152	158	PF02991	0.445
LIG_LIR_Nem_3	162	168	PF02991	0.397
LIG_LIR_Nem_3	254	258	PF02991	0.436
LIG_MYND_1	357	361	PF01753	0.429
LIG_NRBOX	143	149	PF00104	0.510
LIG_NRBOX	383	389	PF00104	0.471
LIG_NRBOX	429	435	PF00104	0.461
LIG_PCNA_PIPBox_1	423	432	PF02747	0.461
LIG_PCNA_yPIPBox_3	576	590	PF02747	0.601
LIG_PTB_Apo_2	7	14	PF02174	0.291
LIG_PTB_Phospho_1	7	13	PF10480	0.290
LIG_SH2_CRK	88	92	PF00017	0.471
LIG_SH2_GRB2like	228	231	PF00017	0.510
LIG_SH2_PTP2	231	234	PF00017	0.430
LIG_SH2_SRC	19	22	PF00017	0.475
LIG_SH2_SRC	231	234	PF00017	0.430
LIG_SH2_STAP1	13	17	PF00017	0.311
LIG_SH2_STAP1	291	295	PF00017	0.515
LIG_SH2_STAT5	19	22	PF00017	0.383
LIG_SH2_STAT5	228	231	PF00017	0.415
LIG_SH2_STAT5	255	258	PF00017	0.518
LIG_SH2_STAT5	352	355	PF00017	0.429
LIG_SH3_1	351	357	PF00018	0.415
LIG_SH3_2	345	350	PF14604	0.461
LIG_SH3_3	331	337	PF00018	0.539
LIG_SH3_3	342	348	PF00018	0.356
LIG_SH3_3	351	357	PF00018	0.390
LIG_SH3_3	464	470	PF00018	0.518
LIG_SH3_3	506	512	PF00018	0.550
LIG_SH3_3	90	96	PF00018	0.471
LIG_SUMO_SIM_anti_2	157	164	PF11976	0.445
LIG_TRAF2_1	123	126	PF00917	0.461
LIG_TYR_ITIM	229	234	PF00017	0.461
LIG_UBA3_1	426	432	PF00899	0.430
LIG_WRC_WIRS_1	255	260	PF05994	0.446
LIG_WRC_WIRS_1	579	584	PF05994	0.566
MOD_CDK_SPK_2	325	330	PF00069	0.391
MOD_CK1_1	120	126	PF00069	0.430
MOD_CK1_1	164	170	PF00069	0.471
MOD_CK1_1	178	184	PF00069	0.471
MOD_CK1_1	203	209	PF00069	0.538
MOD_CK1_1	221	227	PF00069	0.350
MOD_CK1_1	23	29	PF00069	0.561
MOD_CK1_1	30	36	PF00069	0.542
MOD_CK1_1	328	334	PF00069	0.429
MOD_CK1_1	481	487	PF00069	0.697
MOD_CK2_1	120	126	PF00069	0.452
MOD_CK2_1	40	46	PF00069	0.605
MOD_CK2_1	547	553	PF00069	0.577
MOD_CK2_1	562	568	PF00069	0.525
MOD_GlcNHglycan	177	180	PF01048	0.345
MOD_GlcNHglycan	181	184	PF01048	0.241
MOD_GlcNHglycan	202	205	PF01048	0.280
MOD_GlcNHglycan	22	25	PF01048	0.477
MOD_GlcNHglycan	220	223	PF01048	0.149
MOD_GlcNHglycan	236	239	PF01048	0.191
MOD_GlcNHglycan	29	32	PF01048	0.526
MOD_GlcNHglycan	35	38	PF01048	0.511
MOD_GlcNHglycan	376	379	PF01048	0.335
MOD_GlcNHglycan	505	508	PF01048	0.442
MOD_GlcNHglycan	537	540	PF01048	0.419
MOD_GlcNHglycan	564	567	PF01048	0.504
MOD_GSK3_1	156	163	PF00069	0.446
MOD_GSK3_1	175	182	PF00069	0.446
MOD_GSK3_1	187	194	PF00069	0.482
MOD_GSK3_1	196	203	PF00069	0.464
MOD_GSK3_1	20	27	PF00069	0.518
MOD_GSK3_1	36	43	PF00069	0.626
MOD_GSK3_1	478	485	PF00069	0.746
MOD_GSK3_1	519	526	PF00069	0.519
MOD_N-GLC_1	39	44	PF02516	0.508
MOD_N-GLC_2	441	443	PF02516	0.262
MOD_NEK2_1	147	152	PF00069	0.492
MOD_NEK2_1	220	225	PF00069	0.421
MOD_NEK2_1	264	269	PF00069	0.472
MOD_NEK2_1	38	43	PF00069	0.602
MOD_NEK2_1	478	483	PF00069	0.731
MOD_NEK2_1	514	519	PF00069	0.489
MOD_NEK2_2	11	16	PF00069	0.341
MOD_NEK2_2	149	154	PF00069	0.510
MOD_OFUCOSY	498	504	PF10250	0.485
MOD_PIKK_1	256	262	PF00454	0.429
MOD_PIKK_1	328	334	PF00454	0.446
MOD_PIKK_1	447	453	PF00454	0.461
MOD_PIKK_1	547	553	PF00454	0.444
MOD_PK_1	154	160	PF00069	0.454
MOD_PKA_1	482	488	PF00069	0.582
MOD_PKA_2	188	194	PF00069	0.430
MOD_PKA_2	284	290	PF00069	0.536
MOD_PKA_2	482	488	PF00069	0.678
MOD_PKA_2	500	506	PF00069	0.327
MOD_PKA_2	575	581	PF00069	0.571
MOD_PKB_1	185	193	PF00069	0.430
MOD_Plk_1	264	270	PF00069	0.471
MOD_Plk_1	523	529	PF00069	0.457
MOD_Plk_4	156	162	PF00069	0.415
MOD_Plk_4	164	170	PF00069	0.415
MOD_Plk_4	221	227	PF00069	0.429
MOD_Plk_4	264	270	PF00069	0.489
MOD_ProDKin_1	196	202	PF00069	0.532
MOD_ProDKin_1	325	331	PF00069	0.492
MOD_ProDKin_1	341	347	PF00069	0.511
MOD_ProDKin_1	399	405	PF00069	0.471
MOD_ProDKin_1	466	472	PF00069	0.565
MOD_ProDKin_1	505	511	PF00069	0.424
MOD_SUMO_rev_2	471	481	PF00179	0.559
TRG_DiLeu_BaEn_1	265	270	PF01217	0.429
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.561
TRG_DiLeu_BaLyEn_6	526	531	PF01217	0.425
TRG_ENDOCYTIC_2	231	234	PF00928	0.423
TRG_ENDOCYTIC_2	255	258	PF00928	0.505
TRG_ENDOCYTIC_2	291	294	PF00928	0.495
TRG_ENDOCYTIC_2	88	91	PF00928	0.471
TRG_ER_diArg_1	185	188	PF00400	0.461
TRG_ER_diArg_1	284	286	PF00400	0.564
TRG_ER_diArg_1	313	315	PF00400	0.547
TRG_ER_diArg_1	555	558	PF00400	0.388
TRG_ER_diArg_1	93	95	PF00400	0.415
TRG_NLS_MonoCore_2	185	190	PF00514	0.461
TRG_NLS_MonoExtC_3	184	189	PF00514	0.510
TRG_NLS_MonoExtN_4	185	190	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	393	398	PF00026	0.310
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.273
TRG_Pf-PMV_PEXEL_1	558	563	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I4	Leptomonas seymouri	53%	94%
A0A0S4IXC8	Bodo saltans	34%	100%
A0A3R7KCE3	Trypanosoma rangeli	38%	100%
A4HBM2	Leishmania braziliensis	79%	99%
A4HZB0	Leishmania infantum	99%	100%
D0A1L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AUZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
O94241	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
P0CM04	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	100%
P0CM05	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	100%
P45890	Drosophila melanogaster	26%	100%
Q09443	Caenorhabditis elegans	26%	100%
Q4QCJ2	Leishmania major	94%	99%
Q4W9M3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	100%
Q5AXH1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q6CJF4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	21%	100%
Q6FKE7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	22%	100%
Q74ZV8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	100%
Q7S6X6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
Q9D864	Mus musculus	25%	100%
Q9DEE9	Gallus gallus	26%	100%
Q9GZN1	Homo sapiens	26%	100%
V5B0N4	Trypanosoma cruzi	41%	100%