Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWF2_LEIDO

TriTrypDb:

LdBPK_210860.1 , LdCL_210013500 , LDHU3_21.0960

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.705
CLV_C14_Caspase3-7	442	446	PF00656	0.622
CLV_C14_Caspase3-7	491	495	PF00656	0.652
CLV_C14_Caspase3-7	731	735	PF00656	0.511
CLV_NRD_NRD_1	236	238	PF00675	0.519
CLV_NRD_NRD_1	277	279	PF00675	0.624
CLV_NRD_NRD_1	374	376	PF00675	0.498
CLV_NRD_NRD_1	380	382	PF00675	0.494
CLV_NRD_NRD_1	503	505	PF00675	0.694
CLV_NRD_NRD_1	513	515	PF00675	0.704
CLV_NRD_NRD_1	517	519	PF00675	0.511
CLV_NRD_NRD_1	563	565	PF00675	0.509
CLV_NRD_NRD_1	567	569	PF00675	0.486
CLV_NRD_NRD_1	625	627	PF00675	0.655
CLV_NRD_NRD_1	96	98	PF00675	0.673
CLV_PCSK_FUR_1	501	505	PF00082	0.715
CLV_PCSK_FUR_1	511	515	PF00082	0.607
CLV_PCSK_FUR_1	94	98	PF00082	0.663
CLV_PCSK_KEX2_1	236	238	PF00082	0.519
CLV_PCSK_KEX2_1	277	279	PF00082	0.624
CLV_PCSK_KEX2_1	374	376	PF00082	0.498
CLV_PCSK_KEX2_1	380	382	PF00082	0.494
CLV_PCSK_KEX2_1	503	505	PF00082	0.724
CLV_PCSK_KEX2_1	513	515	PF00082	0.599
CLV_PCSK_KEX2_1	517	519	PF00082	0.597
CLV_PCSK_KEX2_1	563	565	PF00082	0.506
CLV_PCSK_KEX2_1	567	569	PF00082	0.488
CLV_PCSK_KEX2_1	625	627	PF00082	0.655
CLV_PCSK_KEX2_1	94	96	PF00082	0.665
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.724
CLV_PCSK_PC7_1	513	519	PF00082	0.623
CLV_PCSK_PC7_1	563	569	PF00082	0.619
CLV_PCSK_SKI1_1	215	219	PF00082	0.705
CLV_PCSK_SKI1_1	237	241	PF00082	0.521
CLV_PCSK_SKI1_1	278	282	PF00082	0.537
CLV_PCSK_SKI1_1	380	384	PF00082	0.560
CLV_PCSK_SKI1_1	563	567	PF00082	0.554
CLV_PCSK_SKI1_1	582	586	PF00082	0.705
CLV_PCSK_SKI1_1	764	768	PF00082	0.662
CLV_PCSK_SKI1_1	77	81	PF00082	0.558
DEG_APCC_DBOX_1	190	198	PF00400	0.585
DEG_APCC_DBOX_1	71	79	PF00400	0.601
DEG_APCC_DBOX_1	719	727	PF00400	0.636
DEG_ODPH_VHL_1	571	583	PF01847	0.481
DEG_SPOP_SBC_1	119	123	PF00917	0.675
DEG_SPOP_SBC_1	642	646	PF00917	0.641
DEG_SPOP_SBC_1	713	717	PF00917	0.661
DOC_CKS1_1	242	247	PF01111	0.529
DOC_CKS1_1	434	439	PF01111	0.476
DOC_CKS1_1	765	770	PF01111	0.659
DOC_CYCLIN_RxL_1	374	386	PF00134	0.541
DOC_CYCLIN_RxL_1	560	569	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.552
DOC_MAPK_gen_1	213	220	PF00069	0.597
DOC_MAPK_gen_1	380	387	PF00069	0.609
DOC_MAPK_gen_1	513	523	PF00069	0.633
DOC_MAPK_MEF2A_6	380	387	PF00069	0.550
DOC_MAPK_NFAT4_5	380	388	PF00069	0.558
DOC_PP1_RVXF_1	141	147	PF00149	0.595
DOC_PP1_RVXF_1	75	81	PF00149	0.557
DOC_PP2B_LxvP_1	360	363	PF13499	0.593
DOC_PP2B_LxvP_1	737	740	PF13499	0.631
DOC_USP7_MATH_1	149	153	PF00917	0.627
DOC_USP7_MATH_1	348	352	PF00917	0.697
DOC_USP7_MATH_1	57	61	PF00917	0.568
DOC_USP7_MATH_1	577	581	PF00917	0.543
DOC_USP7_MATH_1	642	646	PF00917	0.742
DOC_WW_Pin1_4	166	171	PF00397	0.650
DOC_WW_Pin1_4	172	177	PF00397	0.637
DOC_WW_Pin1_4	241	246	PF00397	0.524
DOC_WW_Pin1_4	298	303	PF00397	0.709
DOC_WW_Pin1_4	31	36	PF00397	0.603
DOC_WW_Pin1_4	405	410	PF00397	0.622
DOC_WW_Pin1_4	433	438	PF00397	0.477
DOC_WW_Pin1_4	53	58	PF00397	0.470
DOC_WW_Pin1_4	630	635	PF00397	0.720
DOC_WW_Pin1_4	764	769	PF00397	0.655
LIG_14-3-3_CanoR_1	213	220	PF00244	0.681
LIG_14-3-3_CanoR_1	303	313	PF00244	0.554
LIG_14-3-3_CanoR_1	354	363	PF00244	0.669
LIG_14-3-3_CanoR_1	439	447	PF00244	0.632
LIG_14-3-3_CanoR_1	555	565	PF00244	0.544
LIG_14-3-3_CanoR_1	567	573	PF00244	0.611
LIG_14-3-3_CanoR_1	602	608	PF00244	0.540
LIG_14-3-3_CanoR_1	625	635	PF00244	0.699
LIG_14-3-3_CanoR_1	97	107	PF00244	0.665
LIG_Actin_WH2_2	551	569	PF00022	0.595
LIG_Actin_WH2_2	58	74	PF00022	0.450
LIG_Actin_WH2_2	750	766	PF00022	0.606
LIG_BIR_III_2	247	251	PF00653	0.525
LIG_BIR_III_4	125	129	PF00653	0.630
LIG_BRCT_BRCA1_1	579	583	PF00533	0.710
LIG_Clathr_ClatBox_1	471	475	PF01394	0.619
LIG_CSL_BTD_1	322	325	PF09270	0.529
LIG_CtBP_PxDLS_1	672	676	PF00389	0.670
LIG_EVH1_2	324	328	PF00568	0.527
LIG_FHA_1	113	119	PF00498	0.721
LIG_FHA_1	331	337	PF00498	0.570
LIG_FHA_1	368	374	PF00498	0.479
LIG_FHA_1	425	431	PF00498	0.672
LIG_FHA_1	650	656	PF00498	0.714
LIG_FHA_1	66	72	PF00498	0.629
LIG_FHA_1	772	778	PF00498	0.669
LIG_FHA_2	242	248	PF00498	0.557
LIG_FHA_2	306	312	PF00498	0.678
LIG_FHA_2	440	446	PF00498	0.631
LIG_FHA_2	555	561	PF00498	0.669
LIG_FHA_2	652	658	PF00498	0.639
LIG_FHA_2	86	92	PF00498	0.594
LIG_LIR_Gen_1	113	120	PF02991	0.659
LIG_LIR_Gen_1	221	231	PF02991	0.619
LIG_LIR_Gen_1	271	280	PF02991	0.509
LIG_LIR_Gen_1	386	394	PF02991	0.613
LIG_LIR_Gen_1	46	54	PF02991	0.566
LIG_LIR_Nem_3	113	119	PF02991	0.658
LIG_LIR_Nem_3	221	227	PF02991	0.588
LIG_LIR_Nem_3	261	267	PF02991	0.528
LIG_LIR_Nem_3	271	275	PF02991	0.477
LIG_LIR_Nem_3	321	326	PF02991	0.648
LIG_LIR_Nem_3	386	390	PF02991	0.611
LIG_LIR_Nem_3	46	51	PF02991	0.508
LIG_LIR_Nem_3	559	565	PF02991	0.565
LIG_LIR_Nem_3	690	696	PF02991	0.599
LIG_NRBOX	580	586	PF00104	0.622
LIG_OCRL_FandH_1	386	398	PF00620	0.551
LIG_PCNA_PIPBox_1	751	760	PF02747	0.439
LIG_PCNA_yPIPBox_3	251	265	PF02747	0.483
LIG_Pex14_1	76	80	PF04695	0.497
LIG_Pex14_2	14	18	PF04695	0.552
LIG_Pex14_2	80	84	PF04695	0.498
LIG_PTB_Apo_2	78	85	PF02174	0.501
LIG_REV1ctd_RIR_1	11	21	PF16727	0.648
LIG_RPA_C_Fungi	272	284	PF08784	0.538
LIG_RPA_C_Fungi	370	382	PF08784	0.598
LIG_SH2_CRK	264	268	PF00017	0.518
LIG_SH2_CRK	279	283	PF00017	0.456
LIG_SH2_CRK	693	697	PF00017	0.622
LIG_SH2_NCK_1	116	120	PF00017	0.662
LIG_SH2_NCK_1	423	427	PF00017	0.625
LIG_SH2_PTP2	272	275	PF00017	0.518
LIG_SH2_SRC	423	426	PF00017	0.631
LIG_SH2_SRC	460	463	PF00017	0.593
LIG_SH2_STAP1	116	120	PF00017	0.662
LIG_SH2_STAP1	279	283	PF00017	0.589
LIG_SH2_STAP1	605	609	PF00017	0.498
LIG_SH2_STAT3	605	608	PF00017	0.621
LIG_SH2_STAT3	620	623	PF00017	0.653
LIG_SH2_STAT5	224	227	PF00017	0.509
LIG_SH2_STAT5	241	244	PF00017	0.454
LIG_SH2_STAT5	272	275	PF00017	0.518
LIG_SH2_STAT5	48	51	PF00017	0.597
LIG_SH2_STAT5	749	752	PF00017	0.638
LIG_SH2_STAT5	85	88	PF00017	0.541
LIG_SH3_3	158	164	PF00018	0.667
LIG_SH3_3	29	35	PF00018	0.686
LIG_SH3_3	665	671	PF00018	0.681
LIG_SH3_3	705	711	PF00018	0.591
LIG_SH3_4	772	779	PF00018	0.590
LIG_SUMO_SIM_anti_2	399	405	PF11976	0.655
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.465
LIG_SUMO_SIM_anti_2	614	619	PF11976	0.629
LIG_SUMO_SIM_par_1	265	271	PF11976	0.527
LIG_SUMO_SIM_par_1	60	66	PF11976	0.590
LIG_SUMO_SIM_par_1	671	677	PF11976	0.670
LIG_TRAF2_1	152	155	PF00917	0.619
LIG_TRAF2_1	249	252	PF00917	0.474
LIG_TRAF2_1	466	469	PF00917	0.620
LIG_TRAF2_1	728	731	PF00917	0.582
LIG_UBA3_1	257	265	PF00899	0.570
LIG_UBA3_1	753	760	PF00899	0.477
LIG_WRC_WIRS_1	38	43	PF05994	0.571
LIG_WRC_WIRS_1	48	53	PF05994	0.502
MOD_CDC14_SPxK_1	633	636	PF00782	0.725
MOD_CDK_SPK_2	298	303	PF00069	0.614
MOD_CDK_SPxK_1	433	439	PF00069	0.476
MOD_CDK_SPxK_1	630	636	PF00069	0.719
MOD_CK1_1	121	127	PF00069	0.604
MOD_CK1_1	295	301	PF00069	0.567
MOD_CK1_1	318	324	PF00069	0.714
MOD_CK1_1	367	373	PF00069	0.531
MOD_CK1_1	463	469	PF00069	0.610
MOD_CK1_1	538	544	PF00069	0.635
MOD_CK1_1	715	721	PF00069	0.601
MOD_CK2_1	121	127	PF00069	0.669
MOD_CK2_1	149	155	PF00069	0.579
MOD_CK2_1	246	252	PF00069	0.493
MOD_CK2_1	30	36	PF00069	0.667
MOD_CK2_1	305	311	PF00069	0.736
MOD_CK2_1	324	330	PF00069	0.385
MOD_CK2_1	463	469	PF00069	0.658
MOD_CK2_1	490	496	PF00069	0.760
MOD_CK2_1	523	529	PF00069	0.733
MOD_CK2_1	554	560	PF00069	0.546
MOD_CK2_1	98	104	PF00069	0.624
MOD_Cter_Amidation	501	504	PF01082	0.679
MOD_DYRK1A_RPxSP_1	53	57	PF00069	0.472
MOD_GlcNHglycan	172	175	PF01048	0.751
MOD_GlcNHglycan	176	179	PF01048	0.637
MOD_GlcNHglycan	294	297	PF01048	0.707
MOD_GlcNHglycan	320	323	PF01048	0.728
MOD_GlcNHglycan	350	353	PF01048	0.704
MOD_GlcNHglycan	356	359	PF01048	0.715
MOD_GlcNHglycan	366	369	PF01048	0.655
MOD_GlcNHglycan	465	468	PF01048	0.627
MOD_GlcNHglycan	529	534	PF01048	0.704
MOD_GlcNHglycan	537	540	PF01048	0.570
MOD_GlcNHglycan	59	62	PF01048	0.613
MOD_GlcNHglycan	699	702	PF01048	0.693
MOD_GlcNHglycan	717	720	PF01048	0.418
MOD_GSK3_1	166	173	PF00069	0.668
MOD_GSK3_1	185	192	PF00069	0.431
MOD_GSK3_1	27	34	PF00069	0.773
MOD_GSK3_1	53	60	PF00069	0.584
MOD_GSK3_1	534	541	PF00069	0.621
MOD_GSK3_1	554	561	PF00069	0.463
MOD_GSK3_1	626	633	PF00069	0.654
MOD_GSK3_1	651	658	PF00069	0.736
MOD_N-GLC_1	330	335	PF02516	0.607
MOD_NEK2_1	258	263	PF00069	0.557
MOD_NEK2_1	292	297	PF00069	0.706
MOD_NEK2_1	383	388	PF00069	0.615
MOD_NEK2_1	535	540	PF00069	0.609
MOD_NEK2_1	558	563	PF00069	0.531
MOD_NEK2_1	566	571	PF00069	0.576
MOD_NEK2_2	577	582	PF00069	0.547
MOD_PIKK_1	258	264	PF00454	0.601
MOD_PIKK_1	521	527	PF00454	0.692
MOD_PIKK_1	619	625	PF00454	0.625
MOD_PIKK_1	772	778	PF00454	0.702
MOD_PKA_2	198	204	PF00069	0.679
MOD_PKA_2	554	560	PF00069	0.489
MOD_PKA_2	566	572	PF00069	0.553
MOD_PKA_2	603	609	PF00069	0.562
MOD_Plk_1	112	118	PF00069	0.704
MOD_Plk_1	132	138	PF00069	0.709
MOD_Plk_1	330	336	PF00069	0.585
MOD_Plk_1	460	466	PF00069	0.601
MOD_Plk_1	477	483	PF00069	0.583
MOD_Plk_1	495	501	PF00069	0.604
MOD_Plk_1	65	71	PF00069	0.574
MOD_Plk_2-3	651	657	PF00069	0.735
MOD_Plk_4	185	191	PF00069	0.650
MOD_Plk_4	37	43	PF00069	0.567
MOD_Plk_4	399	405	PF00069	0.680
MOD_Plk_4	449	455	PF00069	0.475
MOD_Plk_4	47	53	PF00069	0.516
MOD_Plk_4	477	483	PF00069	0.566
MOD_Plk_4	85	91	PF00069	0.613
MOD_ProDKin_1	166	172	PF00069	0.651
MOD_ProDKin_1	241	247	PF00069	0.526
MOD_ProDKin_1	298	304	PF00069	0.711
MOD_ProDKin_1	31	37	PF00069	0.597
MOD_ProDKin_1	405	411	PF00069	0.619
MOD_ProDKin_1	433	439	PF00069	0.476
MOD_ProDKin_1	53	59	PF00069	0.463
MOD_ProDKin_1	630	636	PF00069	0.724
MOD_ProDKin_1	764	770	PF00069	0.657
MOD_SUMO_rev_2	124	134	PF00179	0.783
MOD_SUMO_rev_2	651	661	PF00179	0.791
MOD_SUMO_rev_2	724	733	PF00179	0.472
TRG_DiLeu_BaEn_1	399	404	PF01217	0.693
TRG_DiLeu_BaEn_1	66	71	PF01217	0.568
TRG_DiLeu_BaEn_2	578	584	PF01217	0.632
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.649
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.508
TRG_DiLeu_BaLyEn_6	561	566	PF01217	0.598
TRG_ENDOCYTIC_2	116	119	PF00928	0.661
TRG_ENDOCYTIC_2	224	227	PF00928	0.527
TRG_ENDOCYTIC_2	264	267	PF00928	0.510
TRG_ENDOCYTIC_2	272	275	PF00928	0.480
TRG_ENDOCYTIC_2	279	282	PF00928	0.469
TRG_ENDOCYTIC_2	423	426	PF00928	0.522
TRG_ENDOCYTIC_2	48	51	PF00928	0.597
TRG_ENDOCYTIC_2	693	696	PF00928	0.615
TRG_ER_diArg_1	235	237	PF00400	0.509
TRG_ER_diArg_1	277	279	PF00400	0.624
TRG_ER_diArg_1	373	375	PF00400	0.509
TRG_ER_diArg_1	379	381	PF00400	0.497
TRG_ER_diArg_1	512	514	PF00400	0.660
TRG_ER_diArg_1	516	518	PF00400	0.672
TRG_ER_diArg_1	562	564	PF00400	0.493
TRG_ER_diArg_1	566	568	PF00400	0.482
TRG_ER_diArg_1	94	97	PF00400	0.670
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	582	586	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ90	Leptomonas seymouri	57%	72%
A0A3R7K7W4	Trypanosoma rangeli	30%	83%
A4HBS5	Leishmania braziliensis	80%	100%
A4HZ79	Leishmania infantum	99%	100%
D0A1F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	96%
E9AV46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QCD5	Leishmania major	93%	100%
V5DEN0	Trypanosoma cruzi	30%	83%