Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWF0_LEIDO

TriTrypDb:

LdBPK_210660.1 , LdCL_210011600 , LDHU3_21.0710

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	27	29	PF00675	0.553
CLV_NRD_NRD_1	4	6	PF00675	0.551
CLV_NRD_NRD_1	68	70	PF00675	0.559
CLV_NRD_NRD_1	95	97	PF00675	0.462
CLV_PCSK_KEX2_1	27	29	PF00082	0.553
CLV_PCSK_KEX2_1	4	6	PF00082	0.579
CLV_PCSK_KEX2_1	67	69	PF00082	0.565
CLV_PCSK_SKI1_1	386	390	PF00082	0.508
CLV_PCSK_SKI1_1	402	406	PF00082	0.413
CLV_PCSK_SKI1_1	422	426	PF00082	0.317
CLV_PCSK_SKI1_1	508	512	PF00082	0.415
CLV_Separin_Metazoa	99	103	PF03568	0.471
DEG_APCC_DBOX_1	26	34	PF00400	0.572
DEG_Nend_Nbox_1	1	3	PF02207	0.563
DEG_SPOP_SBC_1	141	145	PF00917	0.528
DEG_SPOP_SBC_1	49	53	PF00917	0.584
DOC_CKS1_1	493	498	PF01111	0.567
DOC_CKS1_1	527	532	PF01111	0.439
DOC_MAPK_gen_1	177	186	PF00069	0.433
DOC_MAPK_gen_1	96	103	PF00069	0.434
DOC_MAPK_MEF2A_6	395	403	PF00069	0.525
DOC_PP2B_LxvP_1	45	48	PF13499	0.593
DOC_USP7_MATH_1	26	30	PF00917	0.573
DOC_USP7_MATH_1	278	282	PF00917	0.669
DOC_USP7_MATH_1	38	42	PF00917	0.544
DOC_USP7_MATH_1	48	52	PF00917	0.565
DOC_USP7_MATH_1	75	79	PF00917	0.596
DOC_USP7_MATH_1	8	12	PF00917	0.549
DOC_WW_Pin1_4	221	226	PF00397	0.375
DOC_WW_Pin1_4	274	279	PF00397	0.614
DOC_WW_Pin1_4	489	494	PF00397	0.700
DOC_WW_Pin1_4	526	531	PF00397	0.426
DOC_WW_Pin1_4	53	58	PF00397	0.595
LIG_14-3-3_CanoR_1	140	149	PF00244	0.518
LIG_14-3-3_CanoR_1	179	184	PF00244	0.417
LIG_14-3-3_CanoR_1	243	251	PF00244	0.494
LIG_14-3-3_CanoR_1	27	37	PF00244	0.616
LIG_14-3-3_CanoR_1	336	341	PF00244	0.573
LIG_14-3-3_CanoR_1	59	65	PF00244	0.698
LIG_14-3-3_CanoR_1	69	79	PF00244	0.518
LIG_FHA_1	10	16	PF00498	0.562
LIG_FHA_1	154	160	PF00498	0.431
LIG_FHA_1	162	168	PF00498	0.367
LIG_FHA_1	255	261	PF00498	0.555
LIG_FHA_1	32	38	PF00498	0.761
LIG_FHA_1	351	357	PF00498	0.516
LIG_FHA_2	134	140	PF00498	0.636
LIG_FHA_2	164	170	PF00498	0.461
LIG_FHA_2	203	209	PF00498	0.490
LIG_FHA_2	315	321	PF00498	0.574
LIG_FHA_2	337	343	PF00498	0.567
LIG_FHA_2	418	424	PF00498	0.508
LIG_FHA_2	427	433	PF00498	0.417
LIG_Integrin_isoDGR_2	170	172	PF01839	0.553
LIG_LIR_Gen_1	357	365	PF02991	0.541
LIG_LIR_Gen_1	443	454	PF02991	0.380
LIG_LIR_Gen_1	509	519	PF02991	0.461
LIG_LIR_Nem_3	151	157	PF02991	0.357
LIG_LIR_Nem_3	215	220	PF02991	0.474
LIG_LIR_Nem_3	222	226	PF02991	0.448
LIG_LIR_Nem_3	228	234	PF02991	0.441
LIG_LIR_Nem_3	357	362	PF02991	0.541
LIG_LIR_Nem_3	443	449	PF02991	0.375
LIG_LIR_Nem_3	509	514	PF02991	0.492
LIG_NRBOX	384	390	PF00104	0.452
LIG_PAM2_1	140	152	PF00658	0.500
LIG_Pex14_1	227	231	PF04695	0.430
LIG_Pex14_1	340	344	PF04695	0.555
LIG_SH2_CRK	231	235	PF00017	0.486
LIG_SH2_PTP2	359	362	PF00017	0.529
LIG_SH2_STAT5	162	165	PF00017	0.360
LIG_SH2_STAT5	18	21	PF00017	0.562
LIG_SH2_STAT5	223	226	PF00017	0.401
LIG_SH2_STAT5	359	362	PF00017	0.529
LIG_SH3_3	487	493	PF00018	0.749
LIG_SH3_3	524	530	PF00018	0.448
LIG_SUMO_SIM_anti_2	164	169	PF11976	0.426
LIG_SUMO_SIM_par_1	163	169	PF11976	0.415
LIG_SUMO_SIM_par_1	246	252	PF11976	0.412
LIG_TRAF2_1	205	208	PF00917	0.449
LIG_TRAF2_1	339	342	PF00917	0.564
LIG_TYR_ITSM	227	234	PF00017	0.494
MOD_CDK_SPK_2	526	531	PF00069	0.369
MOD_CDK_SPxK_1	53	59	PF00069	0.596
MOD_CK1_1	187	193	PF00069	0.321
MOD_CK1_1	22	28	PF00069	0.668
MOD_CK1_1	247	253	PF00069	0.457
MOD_CK1_1	254	260	PF00069	0.450
MOD_CK1_1	281	287	PF00069	0.591
MOD_CK1_1	29	35	PF00069	0.553
MOD_CK1_1	327	333	PF00069	0.492
MOD_CK1_1	379	385	PF00069	0.434
MOD_CK1_1	492	498	PF00069	0.486
MOD_CK1_1	53	59	PF00069	0.592
MOD_CK1_1	71	77	PF00069	0.781
MOD_CK2_1	133	139	PF00069	0.639
MOD_CK2_1	163	169	PF00069	0.439
MOD_CK2_1	202	208	PF00069	0.501
MOD_CK2_1	336	342	PF00069	0.575
MOD_CK2_1	378	384	PF00069	0.486
MOD_CK2_1	417	423	PF00069	0.495
MOD_CK2_1	426	432	PF00069	0.426
MOD_Cter_Amidation	94	97	PF01082	0.466
MOD_GlcNHglycan	231	234	PF01048	0.427
MOD_GlcNHglycan	24	27	PF01048	0.675
MOD_GlcNHglycan	253	256	PF01048	0.490
MOD_GlcNHglycan	279	283	PF01048	0.646
MOD_GlcNHglycan	287	290	PF01048	0.574
MOD_GlcNHglycan	295	299	PF01048	0.398
MOD_GlcNHglycan	326	329	PF01048	0.513
MOD_GlcNHglycan	381	384	PF01048	0.450
MOD_GlcNHglycan	462	465	PF01048	0.635
MOD_GlcNHglycan	73	76	PF01048	0.601
MOD_GlcNHglycan	79	82	PF01048	0.601
MOD_GSK3_1	128	135	PF00069	0.609
MOD_GSK3_1	184	191	PF00069	0.313
MOD_GSK3_1	22	29	PF00069	0.691
MOD_GSK3_1	221	228	PF00069	0.446
MOD_GSK3_1	229	236	PF00069	0.386
MOD_GSK3_1	243	250	PF00069	0.383
MOD_GSK3_1	262	269	PF00069	0.495
MOD_GSK3_1	270	277	PF00069	0.563
MOD_GSK3_1	281	288	PF00069	0.519
MOD_GSK3_1	33	40	PF00069	0.623
MOD_GSK3_1	375	382	PF00069	0.441
MOD_GSK3_1	488	495	PF00069	0.635
MOD_GSK3_1	49	56	PF00069	0.528
MOD_GSK3_1	69	76	PF00069	0.593
MOD_NEK2_1	128	133	PF00069	0.534
MOD_NEK2_1	163	168	PF00069	0.422
MOD_NEK2_1	249	254	PF00069	0.410
MOD_NEK2_1	350	355	PF00069	0.487
MOD_NEK2_2	397	402	PF00069	0.436
MOD_NEK2_2	417	422	PF00069	0.303
MOD_PIKK_1	194	200	PF00454	0.434
MOD_PIKK_1	281	287	PF00454	0.638
MOD_PK_1	179	185	PF00069	0.414
MOD_PKA_1	68	74	PF00069	0.555
MOD_PKA_2	229	235	PF00069	0.405
MOD_PKA_2	26	32	PF00069	0.573
MOD_PKA_2	335	341	PF00069	0.570
MOD_PKA_2	350	356	PF00069	0.389
MOD_PKA_2	68	74	PF00069	0.598
MOD_PKB_1	67	75	PF00069	0.593
MOD_Plk_1	375	381	PF00069	0.375
MOD_Plk_1	468	474	PF00069	0.662
MOD_Plk_1	57	63	PF00069	0.615
MOD_Plk_2-3	202	208	PF00069	0.501
MOD_Plk_4	163	169	PF00069	0.559
MOD_Plk_4	179	185	PF00069	0.462
MOD_Plk_4	244	250	PF00069	0.478
MOD_Plk_4	426	432	PF00069	0.608
MOD_ProDKin_1	221	227	PF00069	0.374
MOD_ProDKin_1	274	280	PF00069	0.615
MOD_ProDKin_1	489	495	PF00069	0.646
MOD_ProDKin_1	526	532	PF00069	0.440
MOD_ProDKin_1	53	59	PF00069	0.600
TRG_DiLeu_BaEn_1	384	389	PF01217	0.490
TRG_DiLeu_BaEn_1	99	104	PF01217	0.467
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.551
TRG_DiLeu_LyEn_5	99	104	PF01217	0.467
TRG_ENDOCYTIC_2	162	165	PF00928	0.387
TRG_ENDOCYTIC_2	223	226	PF00928	0.484
TRG_ENDOCYTIC_2	231	234	PF00928	0.481
TRG_ENDOCYTIC_2	242	245	PF00928	0.369
TRG_ENDOCYTIC_2	359	362	PF00928	0.529
TRG_ER_diArg_1	3	5	PF00400	0.586
TRG_ER_diArg_1	360	363	PF00400	0.571
TRG_ER_diArg_1	67	69	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM65	Leptomonas seymouri	38%	88%
A4HBQ7	Leishmania braziliensis	76%	100%
A4HZ59	Leishmania infantum	100%	100%
E9AV27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCF5	Leishmania major	93%	100%