Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWE9_LEIDO

TriTrypDb:

LdBPK_210420.1 , LdCL_210009000 , LDHU3_21.0440

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.740
CLV_NRD_NRD_1	10	12	PF00675	0.650
CLV_NRD_NRD_1	120	122	PF00675	0.629
CLV_NRD_NRD_1	146	148	PF00675	0.657
CLV_NRD_NRD_1	219	221	PF00675	0.848
CLV_NRD_NRD_1	36	38	PF00675	0.519
CLV_PCSK_FUR_1	120	124	PF00082	0.603
CLV_PCSK_KEX2_1	10	12	PF00082	0.649
CLV_PCSK_KEX2_1	120	122	PF00082	0.627
CLV_PCSK_KEX2_1	146	148	PF00082	0.657
CLV_PCSK_KEX2_1	198	200	PF00082	0.662
CLV_PCSK_KEX2_1	219	221	PF00082	0.848
CLV_PCSK_KEX2_1	36	38	PF00082	0.562
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.681
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.662
DOC_MAPK_gen_1	91	99	PF00069	0.699
DOC_PP2B_LxvP_1	114	117	PF13499	0.629
DOC_PP4_FxxP_1	268	271	PF00568	0.692
DOC_USP7_MATH_1	2	6	PF00917	0.599
DOC_USP7_MATH_1	218	222	PF00917	0.804
DOC_WW_Pin1_4	128	133	PF00397	0.634
DOC_WW_Pin1_4	178	183	PF00397	0.742
DOC_WW_Pin1_4	206	211	PF00397	0.842
LIG_14-3-3_CanoR_1	49	53	PF00244	0.537
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_FHA_1	245	251	PF00498	0.607
LIG_FHA_2	14	20	PF00498	0.503
LIG_FHA_2	146	152	PF00498	0.746
LIG_LIR_Apic_2	266	271	PF02991	0.798
LIG_LIR_Gen_1	17	27	PF02991	0.521
LIG_LIR_Nem_3	17	23	PF02991	0.522
LIG_MYND_1	271	275	PF01753	0.669
LIG_SH2_NCK_1	192	196	PF00017	0.819
LIG_SH2_SRC	192	195	PF00017	0.818
LIG_SH2_STAP1	20	24	PF00017	0.530
LIG_SH2_STAT5	63	66	PF00017	0.537
LIG_SH3_1	78	84	PF00018	0.483
LIG_SH3_2	215	220	PF14604	0.760
LIG_SH3_2	271	276	PF14604	0.613
LIG_SH3_3	165	171	PF00018	0.664
LIG_SH3_3	179	185	PF00018	0.764
LIG_SH3_3	212	218	PF00018	0.684
LIG_SH3_3	268	274	PF00018	0.571
LIG_SH3_3	78	84	PF00018	0.499
LIG_WRC_WIRS_1	102	107	PF05994	0.501
LIG_WW_1	189	192	PF00397	0.642
LIG_WW_3	188	192	PF00397	0.639
MOD_CK1_1	166	172	PF00069	0.727
MOD_CK1_1	177	183	PF00069	0.672
MOD_CK1_1	221	227	PF00069	0.690
MOD_CK2_1	13	19	PF00069	0.504
MOD_CK2_1	145	151	PF00069	0.745
MOD_CK2_1	252	258	PF00069	0.733
MOD_Cter_Amidation	196	199	PF01082	0.650
MOD_GlcNHglycan	159	162	PF01048	0.731
MOD_GlcNHglycan	164	168	PF01048	0.646
MOD_GlcNHglycan	176	179	PF01048	0.473
MOD_GlcNHglycan	220	223	PF01048	0.846
MOD_GlcNHglycan	224	227	PF01048	0.807
MOD_GlcNHglycan	244	247	PF01048	0.797
MOD_GlcNHglycan	254	257	PF01048	0.687
MOD_GlcNHglycan	265	268	PF01048	0.730
MOD_GSK3_1	172	179	PF00069	0.758
MOD_GSK3_1	180	187	PF00069	0.672
MOD_GSK3_1	218	225	PF00069	0.747
MOD_GSK3_1	238	245	PF00069	0.697
MOD_NEK2_1	176	181	PF00069	0.727
MOD_NEK2_1	263	268	PF00069	0.804
MOD_PIKK_1	125	131	PF00454	0.767
MOD_PKA_2	145	151	PF00069	0.665
MOD_PKA_2	218	224	PF00069	0.838
MOD_PKA_2	48	54	PF00069	0.597
MOD_PKB_1	123	131	PF00069	0.771
MOD_Plk_4	98	104	PF00069	0.525
MOD_ProDKin_1	128	134	PF00069	0.627
MOD_ProDKin_1	178	184	PF00069	0.742
MOD_ProDKin_1	206	212	PF00069	0.842
TRG_ENDOCYTIC_2	20	23	PF00928	0.500
TRG_ER_diArg_1	120	123	PF00400	0.620
TRG_ER_diArg_1	137	140	PF00400	0.592
TRG_ER_diArg_1	218	220	PF00400	0.846
TRG_ER_diArg_1	9	11	PF00400	0.661
TRG_NLS_MonoExtC_3	120	125	PF00514	0.779
TRG_NLS_MonoExtN_4	120	126	PF00514	0.778
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD3	Leptomonas seymouri	51%	100%
A4HBN4	Leishmania braziliensis	74%	98%
A4HZ35	Leishmania infantum	99%	100%
E9AV03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q4QCH9	Leishmania major	85%	97%