Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWD9_LEIDO

TriTrypDb:

LdBPK_210560.1 , LdCL_210010400 , LDHU3_21.0600

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	154	156	PF00082	0.399
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.424
CLV_PCSK_SKI1_1	180	184	PF00082	0.528
CLV_PCSK_SKI1_1	189	193	PF00082	0.381
CLV_PCSK_SKI1_1	7	11	PF00082	0.446
CLV_PCSK_SKI1_1	94	98	PF00082	0.435
DOC_MAPK_gen_1	135	145	PF00069	0.519
DOC_MAPK_JIP1_4	92	98	PF00069	0.390
DOC_MAPK_MEF2A_6	45	53	PF00069	0.393
DOC_MAPK_MEF2A_6	7	14	PF00069	0.389
DOC_PP1_RVXF_1	92	99	PF00149	0.509
DOC_PP2B_LxvP_1	10	13	PF13499	0.377
DOC_USP7_MATH_1	119	123	PF00917	0.524
DOC_USP7_MATH_1	33	37	PF00917	0.421
DOC_WW_Pin1_4	29	34	PF00397	0.452
LIG_14-3-3_CanoR_1	123	128	PF00244	0.403
LIG_14-3-3_CanoR_1	27	33	PF00244	0.472
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_CSL_BTD_1	10	13	PF09270	0.352
LIG_CSL_BTD_1	57	60	PF09270	0.370
LIG_EH1_1	111	119	PF00400	0.386
LIG_FHA_1	108	114	PF00498	0.435
LIG_FHA_2	182	188	PF00498	0.455
LIG_PTB_Apo_2	15	22	PF02174	0.436
LIG_SH2_STAP1	195	199	PF00017	0.471
LIG_SH2_STAT5	158	161	PF00017	0.405
LIG_SUMO_SIM_anti_2	139	148	PF11976	0.461
LIG_SUMO_SIM_par_1	139	148	PF11976	0.418
MOD_CK1_1	107	113	PF00069	0.358
MOD_CK1_1	181	187	PF00069	0.507
MOD_CK1_1	206	212	PF00069	0.455
MOD_CK1_1	3	9	PF00069	0.482
MOD_CK1_1	32	38	PF00069	0.447
MOD_CK2_1	181	187	PF00069	0.521
MOD_Cter_Amidation	152	155	PF01082	0.384
MOD_GlcNHglycan	199	202	PF01048	0.506
MOD_GlcNHglycan	208	211	PF01048	0.675
MOD_GlcNHglycan	74	77	PF01048	0.396
MOD_GSK3_1	100	107	PF00069	0.350
MOD_GSK3_1	119	126	PF00069	0.382
MOD_GSK3_1	28	35	PF00069	0.472
MOD_NEK2_1	100	105	PF00069	0.321
MOD_NEK2_1	208	213	PF00069	0.628
MOD_NEK2_1	21	26	PF00069	0.470
MOD_NEK2_1	28	33	PF00069	0.403
MOD_NEK2_1	63	68	PF00069	0.448
MOD_PK_1	123	129	PF00069	0.400
MOD_PK_1	178	184	PF00069	0.402
MOD_Plk_1	178	184	PF00069	0.419
MOD_Plk_1	94	100	PF00069	0.346
MOD_Plk_4	203	209	PF00069	0.407
MOD_Plk_4	63	69	PF00069	0.509
MOD_ProDKin_1	29	35	PF00069	0.444
MOD_SUMO_for_1	44	47	PF00179	0.406
MOD_SUMO_rev_2	139	144	PF00179	0.371
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.417
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.338
TRG_NES_CRM1_1	61	73	PF08389	0.386
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P855	Leptomonas seymouri	53%	100%
A0A0N0P8I2	Leptomonas seymouri	29%	91%
A0A1X0NXQ6	Trypanosomatidae	26%	93%
A0A1X0NZ15	Trypanosomatidae	30%	99%
A0A422NBM7	Trypanosoma rangeli	32%	100%
A4HBP7	Leishmania braziliensis	78%	99%
A4HZ49	Leishmania infantum	99%	100%
D0A1Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AV17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCG5	Leishmania major	94%	100%