Pentatricopeptide_repeat_domain_containing_protei n_putative/Pfam:PF13812

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWD8_LEIDO

TriTrypDb:

LdBPK_210320.1 , LdCL_210008000 , LDHU3_21.0340

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.379
CLV_NRD_NRD_1	358	360	PF00675	0.493
CLV_NRD_NRD_1	398	400	PF00675	0.370
CLV_NRD_NRD_1	423	425	PF00675	0.391
CLV_NRD_NRD_1	47	49	PF00675	0.638
CLV_NRD_NRD_1	89	91	PF00675	0.682
CLV_PCSK_KEX2_1	108	110	PF00082	0.303
CLV_PCSK_KEX2_1	205	207	PF00082	0.419
CLV_PCSK_KEX2_1	398	400	PF00082	0.394
CLV_PCSK_KEX2_1	46	48	PF00082	0.634
CLV_PCSK_KEX2_1	89	91	PF00082	0.697
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.439
CLV_PCSK_SKI1_1	131	135	PF00082	0.437
CLV_PCSK_SKI1_1	14	18	PF00082	0.528
CLV_PCSK_SKI1_1	193	197	PF00082	0.391
CLV_PCSK_SKI1_1	205	209	PF00082	0.428
CLV_PCSK_SKI1_1	271	275	PF00082	0.432
CLV_PCSK_SKI1_1	294	298	PF00082	0.388
CLV_PCSK_SKI1_1	401	405	PF00082	0.501
CLV_PCSK_SKI1_1	424	428	PF00082	0.418
CLV_PCSK_SKI1_1	467	471	PF00082	0.400
DEG_APCC_DBOX_1	423	431	PF00400	0.490
DEG_Nend_UBRbox_1	1	4	PF02207	0.452
DOC_CKS1_1	382	387	PF01111	0.457
DOC_CYCLIN_RxL_1	335	344	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.578
DOC_MAPK_gen_1	205	213	PF00069	0.461
DOC_MAPK_gen_1	398	407	PF00069	0.482
DOC_MAPK_gen_1	587	596	PF00069	0.546
DOC_MAPK_gen_1	9	19	PF00069	0.445
DOC_MAPK_MEF2A_6	12	21	PF00069	0.549
DOC_MAPK_MEF2A_6	318	327	PF00069	0.311
DOC_MAPK_MEF2A_6	511	520	PF00069	0.351
DOC_PP2B_LxvP_1	24	27	PF13499	0.544
DOC_PP2B_LxvP_1	67	70	PF13499	0.699
DOC_USP7_MATH_1	183	187	PF00917	0.393
DOC_USP7_MATH_1	238	242	PF00917	0.742
DOC_USP7_MATH_1	317	321	PF00917	0.298
DOC_USP7_MATH_1	562	566	PF00917	0.516
DOC_USP7_MATH_1	578	582	PF00917	0.344
DOC_WW_Pin1_4	162	167	PF00397	0.639
DOC_WW_Pin1_4	214	219	PF00397	0.616
DOC_WW_Pin1_4	246	251	PF00397	0.745
DOC_WW_Pin1_4	31	36	PF00397	0.708
DOC_WW_Pin1_4	381	386	PF00397	0.479
DOC_WW_Pin1_4	56	61	PF00397	0.715
LIG_14-3-3_CanoR_1	242	250	PF00244	0.687
LIG_14-3-3_CanoR_1	285	293	PF00244	0.522
LIG_14-3-3_CanoR_1	367	371	PF00244	0.572
LIG_14-3-3_CanoR_1	442	447	PF00244	0.304
LIG_14-3-3_CanoR_1	455	461	PF00244	0.274
LIG_14-3-3_CanoR_1	535	541	PF00244	0.438
LIG_14-3-3_CanoR_1	75	85	PF00244	0.639
LIG_Actin_WH2_2	164	179	PF00022	0.530
LIG_Actin_WH2_2	184	199	PF00022	0.389
LIG_Actin_WH2_2	257	273	PF00022	0.415
LIG_Actin_WH2_2	538	555	PF00022	0.495
LIG_eIF4E_1	287	293	PF01652	0.422
LIG_FHA_1	171	177	PF00498	0.428
LIG_FHA_1	198	204	PF00498	0.487
LIG_FHA_1	287	293	PF00498	0.492
LIG_FHA_1	317	323	PF00498	0.386
LIG_FHA_1	382	388	PF00498	0.394
LIG_FHA_1	407	413	PF00498	0.377
LIG_FHA_1	478	484	PF00498	0.280
LIG_FHA_1	80	86	PF00498	0.677
LIG_LIR_Gen_1	135	144	PF02991	0.342
LIG_LIR_Gen_1	151	162	PF02991	0.439
LIG_LIR_Gen_1	344	352	PF02991	0.434
LIG_LIR_Gen_1	443	450	PF02991	0.274
LIG_LIR_LC3C_4	184	189	PF02991	0.427
LIG_LIR_Nem_3	135	139	PF02991	0.333
LIG_LIR_Nem_3	278	282	PF02991	0.419
LIG_LIR_Nem_3	344	348	PF02991	0.407
LIG_LIR_Nem_3	443	449	PF02991	0.274
LIG_LIR_Nem_3	480	484	PF02991	0.276
LIG_LIR_Nem_3	505	510	PF02991	0.483
LIG_LIR_Nem_3	97	102	PF02991	0.428
LIG_LYPXL_yS_3	507	510	PF13949	0.365
LIG_MAD2	177	185	PF02301	0.538
LIG_MYND_3	518	522	PF01753	0.388
LIG_PDZ_Class_2	591	596	PF00595	0.515
LIG_Pex14_2	99	103	PF04695	0.421
LIG_PTB_Apo_2	97	104	PF02174	0.420
LIG_SH2_CRK	136	140	PF00017	0.346
LIG_SH2_CRK	4	8	PF00017	0.570
LIG_SH2_CRK	446	450	PF00017	0.289
LIG_SH2_GRB2like	4	7	PF00017	0.568
LIG_SH2_STAT3	351	354	PF00017	0.477
LIG_SH2_STAT5	102	105	PF00017	0.347
LIG_SH2_STAT5	138	141	PF00017	0.340
LIG_SH2_STAT5	282	285	PF00017	0.545
LIG_SH2_STAT5	287	290	PF00017	0.496
LIG_SH2_STAT5	351	354	PF00017	0.467
LIG_SH2_STAT5	368	371	PF00017	0.325
LIG_SH2_STAT5	374	377	PF00017	0.406
LIG_SH2_STAT5	4	7	PF00017	0.606
LIG_SH2_STAT5	500	503	PF00017	0.413
LIG_SH3_3	216	222	PF00018	0.574
LIG_SH3_3	24	30	PF00018	0.552
LIG_SUMO_SIM_anti_2	319	327	PF11976	0.328
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.295
LIG_SUMO_SIM_anti_2	565	570	PF11976	0.417
LIG_SUMO_SIM_par_1	186	192	PF11976	0.383
LIG_SUMO_SIM_par_1	264	269	PF11976	0.444
LIG_SUMO_SIM_par_1	305	312	PF11976	0.508
LIG_SUMO_SIM_par_1	403	409	PF11976	0.371
LIG_TRAF2_1	113	116	PF00917	0.460
LIG_TYR_ITIM	134	139	PF00017	0.354
LIG_TYR_ITIM	36	41	PF00017	0.704
LIG_UBA3_1	342	349	PF00899	0.345
LIG_WRC_WIRS_1	171	176	PF05994	0.453
LIG_WRC_WIRS_1	478	483	PF05994	0.350
MOD_CDC14_SPxK_1	217	220	PF00782	0.573
MOD_CDK_SPxK_1	214	220	PF00069	0.530
MOD_CDK_SPxK_1	56	62	PF00069	0.598
MOD_CK1_1	228	234	PF00069	0.799
MOD_CK1_1	246	252	PF00069	0.686
MOD_CK1_1	537	543	PF00069	0.448
MOD_CK1_1	79	85	PF00069	0.596
MOD_CK2_1	428	434	PF00069	0.491
MOD_GlcNHglycan	181	184	PF01048	0.559
MOD_GlcNHglycan	226	230	PF01048	0.806
MOD_GlcNHglycan	251	254	PF01048	0.711
MOD_GlcNHglycan	43	46	PF01048	0.747
MOD_GlcNHglycan	430	433	PF01048	0.533
MOD_GlcNHglycan	471	474	PF01048	0.417
MOD_GlcNHglycan	81	85	PF01048	0.621
MOD_GSK3_1	179	186	PF00069	0.456
MOD_GSK3_1	224	231	PF00069	0.748
MOD_GSK3_1	244	251	PF00069	0.768
MOD_GSK3_1	296	303	PF00069	0.512
MOD_GSK3_1	362	369	PF00069	0.580
MOD_GSK3_1	451	458	PF00069	0.328
MOD_GSK3_1	465	472	PF00069	0.249
MOD_GSK3_1	547	554	PF00069	0.425
MOD_GSK3_1	76	83	PF00069	0.550
MOD_N-GLC_1	51	56	PF02516	0.584
MOD_NEK2_1	243	248	PF00069	0.682
MOD_NEK2_1	41	46	PF00069	0.700
MOD_NEK2_1	469	474	PF00069	0.338
MOD_NEK2_2	403	408	PF00069	0.366
MOD_PIKK_1	277	283	PF00454	0.558
MOD_PIKK_1	328	334	PF00454	0.467
MOD_PIKK_1	534	540	PF00454	0.487
MOD_PKA_1	89	95	PF00069	0.484
MOD_PKA_2	233	239	PF00069	0.678
MOD_PKA_2	366	372	PF00069	0.589
MOD_PKA_2	456	462	PF00069	0.372
MOD_PKA_2	534	540	PF00069	0.344
MOD_PKA_2	89	95	PF00069	0.575
MOD_Plk_1	502	508	PF00069	0.346
MOD_Plk_1	80	86	PF00069	0.643
MOD_Plk_4	170	176	PF00069	0.394
MOD_Plk_4	183	189	PF00069	0.350
MOD_Plk_4	456	462	PF00069	0.393
MOD_Plk_4	547	553	PF00069	0.388
MOD_Plk_4	89	95	PF00069	0.458
MOD_ProDKin_1	162	168	PF00069	0.637
MOD_ProDKin_1	214	220	PF00069	0.633
MOD_ProDKin_1	246	252	PF00069	0.740
MOD_ProDKin_1	31	37	PF00069	0.710
MOD_ProDKin_1	381	387	PF00069	0.475
MOD_ProDKin_1	56	62	PF00069	0.714
MOD_SUMO_rev_2	23	33	PF00179	0.461
MOD_SUMO_rev_2	422	427	PF00179	0.420
TRG_DiLeu_BaEn_1	321	326	PF01217	0.365
TRG_DiLeu_BaEn_2	114	120	PF01217	0.521
TRG_DiLeu_BaEn_4	422	428	PF01217	0.426
TRG_ENDOCYTIC_2	136	139	PF00928	0.333
TRG_ENDOCYTIC_2	38	41	PF00928	0.723
TRG_ENDOCYTIC_2	4	7	PF00928	0.537
TRG_ENDOCYTIC_2	446	449	PF00928	0.301
TRG_ENDOCYTIC_2	466	469	PF00928	0.175
TRG_ENDOCYTIC_2	507	510	PF00928	0.365
TRG_ER_diArg_1	46	48	PF00400	0.634
TRG_ER_diArg_1	579	582	PF00400	0.452
TRG_ER_diArg_1	88	90	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2C5	Leptomonas seymouri	69%	78%
A0A0S4J3H1	Bodo saltans	40%	100%
A0A1X0NYY0	Trypanosomatidae	52%	96%
A0A422NII4	Trypanosoma rangeli	51%	100%
A4HBM4	Leishmania braziliensis	89%	100%
A4HZB3	Leishmania infantum	100%	100%
D0A1L8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
E9AUZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QCI9	Leishmania major	96%	100%
V5BG17	Trypanosoma cruzi	52%	100%