Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWD6_LEIDO

TriTrypDb:

LdBPK_210630.1 , LdCL_210011300 , LDHU3_21.0680

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.639
CLV_NRD_NRD_1	162	164	PF00675	0.548
CLV_NRD_NRD_1	203	205	PF00675	0.650
CLV_NRD_NRD_1	213	215	PF00675	0.585
CLV_NRD_NRD_1	267	269	PF00675	0.692
CLV_NRD_NRD_1	338	340	PF00675	0.816
CLV_NRD_NRD_1	428	430	PF00675	0.513
CLV_NRD_NRD_1	432	434	PF00675	0.554
CLV_NRD_NRD_1	52	54	PF00675	0.604
CLV_NRD_NRD_1	66	68	PF00675	0.434
CLV_PCSK_FUR_1	433	437	PF00082	0.500
CLV_PCSK_KEX2_1	202	204	PF00082	0.775
CLV_PCSK_KEX2_1	213	215	PF00082	0.568
CLV_PCSK_KEX2_1	267	269	PF00082	0.735
CLV_PCSK_KEX2_1	302	304	PF00082	0.779
CLV_PCSK_KEX2_1	338	340	PF00082	0.655
CLV_PCSK_KEX2_1	402	404	PF00082	0.705
CLV_PCSK_KEX2_1	432	434	PF00082	0.550
CLV_PCSK_KEX2_1	435	437	PF00082	0.521
CLV_PCSK_KEX2_1	52	54	PF00082	0.604
CLV_PCSK_KEX2_1	66	68	PF00082	0.434
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.771
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.779
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.705
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.579
CLV_PCSK_SKI1_1	268	272	PF00082	0.714
CLV_PCSK_SKI1_1	299	303	PF00082	0.724
CLV_PCSK_SKI1_1	365	369	PF00082	0.635
CLV_PCSK_SKI1_1	403	407	PF00082	0.689
CLV_PCSK_SKI1_1	45	49	PF00082	0.410
CLV_PCSK_SKI1_1	92	96	PF00082	0.587
DEG_APCC_DBOX_1	87	95	PF00400	0.495
DEG_Nend_UBRbox_1	1	4	PF02207	0.599
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.452
DOC_MAPK_DCC_7	141	150	PF00069	0.518
DOC_MAPK_gen_1	406	416	PF00069	0.554
DOC_MAPK_MEF2A_6	141	150	PF00069	0.442
DOC_MAPK_MEF2A_6	409	416	PF00069	0.537
DOC_MAPK_RevD_3	148	164	PF00069	0.508
DOC_PP2B_LxvP_1	142	145	PF13499	0.463
DOC_PP2B_LxvP_1	358	361	PF13499	0.597
DOC_PP2B_LxvP_1	383	386	PF13499	0.564
DOC_PP4_FxxP_1	387	390	PF00568	0.601
DOC_USP7_MATH_1	240	244	PF00917	0.643
DOC_USP7_MATH_1	270	274	PF00917	0.678
DOC_USP7_MATH_1	280	284	PF00917	0.757
DOC_USP7_MATH_1	318	322	PF00917	0.609
DOC_USP7_MATH_1	372	376	PF00917	0.461
DOC_USP7_MATH_1	401	405	PF00917	0.654
DOC_USP7_UBL2_3	402	406	PF12436	0.697
DOC_WW_Pin1_4	104	109	PF00397	0.487
DOC_WW_Pin1_4	247	252	PF00397	0.663
DOC_WW_Pin1_4	283	288	PF00397	0.645
DOC_WW_Pin1_4	386	391	PF00397	0.587
DOC_WW_Pin1_4	404	409	PF00397	0.601
LIG_14-3-3_CanoR_1	192	200	PF00244	0.584
LIG_14-3-3_CanoR_1	2	8	PF00244	0.622
LIG_14-3-3_CanoR_1	267	277	PF00244	0.660
LIG_14-3-3_CanoR_1	317	323	PF00244	0.661
LIG_14-3-3_CanoR_1	325	330	PF00244	0.631
LIG_14-3-3_CanoR_1	45	54	PF00244	0.495
LIG_Clathr_ClatBox_1	68	72	PF01394	0.511
LIG_EH1_1	129	137	PF00400	0.336
LIG_eIF4E_1	130	136	PF01652	0.332
LIG_FHA_1	126	132	PF00498	0.450
LIG_FHA_1	154	160	PF00498	0.503
LIG_FHA_1	195	201	PF00498	0.684
LIG_FHA_2	93	99	PF00498	0.592
LIG_LIR_Gen_1	154	162	PF02991	0.435
LIG_LIR_Gen_1	166	175	PF02991	0.443
LIG_LIR_Gen_1	366	376	PF02991	0.471
LIG_LIR_Gen_1	41	50	PF02991	0.418
LIG_LIR_Nem_3	112	117	PF02991	0.434
LIG_LIR_Nem_3	125	130	PF02991	0.394
LIG_LIR_Nem_3	154	160	PF02991	0.426
LIG_LIR_Nem_3	166	171	PF02991	0.447
LIG_LIR_Nem_3	366	371	PF02991	0.473
LIG_LIR_Nem_3	41	46	PF02991	0.424
LIG_LIR_Nem_3	418	422	PF02991	0.490
LIG_MYND_1	177	181	PF01753	0.532
LIG_PCNA_yPIPBox_3	406	420	PF02747	0.613
LIG_SH2_CRK	117	121	PF00017	0.420
LIG_SH2_STAT5	130	133	PF00017	0.453
LIG_SH2_STAT5	43	46	PF00017	0.419
LIG_SH2_STAT5	93	96	PF00017	0.515
LIG_SH3_1	327	333	PF00018	0.581
LIG_SH3_2	177	182	PF14604	0.542
LIG_SH3_2	334	339	PF14604	0.585
LIG_SH3_3	103	109	PF00018	0.522
LIG_SH3_3	133	139	PF00018	0.505
LIG_SH3_3	141	147	PF00018	0.442
LIG_SH3_3	174	180	PF00018	0.614
LIG_SH3_3	274	280	PF00018	0.725
LIG_SH3_3	327	333	PF00018	0.641
LIG_SH3_CIN85_PxpxPR_1	333	338	PF14604	0.581
LIG_SUMO_SIM_par_1	146	152	PF11976	0.557
LIG_TRAF2_1	36	39	PF00917	0.510
LIG_TRAF2_1	423	426	PF00917	0.478
LIG_TYR_ITIM	115	120	PF00017	0.513
LIG_WW_3	160	164	PF00397	0.534
LIG_WW_3	179	183	PF00397	0.508
MOD_CDK_SPK_2	404	409	PF00069	0.601
MOD_CK1_1	107	113	PF00069	0.441
MOD_CK1_1	125	131	PF00069	0.378
MOD_CK1_1	283	289	PF00069	0.787
MOD_CK1_1	321	327	PF00069	0.662
MOD_CK1_1	389	395	PF00069	0.598
MOD_CK1_1	396	402	PF00069	0.809
MOD_CK1_1	404	410	PF00069	0.645
MOD_CK2_1	372	378	PF00069	0.469
MOD_GlcNHglycan	124	127	PF01048	0.400
MOD_GlcNHglycan	20	23	PF01048	0.598
MOD_GlcNHglycan	217	220	PF01048	0.653
MOD_GlcNHglycan	242	245	PF01048	0.697
MOD_GlcNHglycan	257	260	PF01048	0.538
MOD_GlcNHglycan	272	275	PF01048	0.599
MOD_GlcNHglycan	29	32	PF01048	0.502
MOD_GlcNHglycan	299	302	PF01048	0.714
MOD_GlcNHglycan	3	6	PF01048	0.653
MOD_GlcNHglycan	304	308	PF01048	0.666
MOD_GlcNHglycan	395	398	PF01048	0.626
MOD_GlcNHglycan	403	406	PF01048	0.700
MOD_GSK3_1	100	107	PF00069	0.559
MOD_GSK3_1	191	198	PF00069	0.632
MOD_GSK3_1	205	212	PF00069	0.788
MOD_GSK3_1	23	30	PF00069	0.639
MOD_GSK3_1	240	247	PF00069	0.741
MOD_GSK3_1	266	273	PF00069	0.801
MOD_GSK3_1	279	286	PF00069	0.633
MOD_GSK3_1	289	296	PF00069	0.700
MOD_GSK3_1	303	310	PF00069	0.583
MOD_GSK3_1	317	324	PF00069	0.641
MOD_GSK3_1	389	396	PF00069	0.581
MOD_LATS_1	90	96	PF00433	0.584
MOD_NEK2_1	1	6	PF00069	0.643
MOD_NEK2_1	100	105	PF00069	0.500
MOD_NEK2_1	153	158	PF00069	0.492
MOD_NEK2_1	209	214	PF00069	0.791
MOD_NEK2_2	372	377	PF00069	0.464
MOD_PIKK_1	100	106	PF00454	0.494
MOD_PIKK_1	289	295	PF00454	0.739
MOD_PIKK_1	325	331	PF00454	0.705
MOD_PKA_1	213	219	PF00069	0.565
MOD_PKA_2	1	7	PF00069	0.634
MOD_PKA_2	191	197	PF00069	0.604
MOD_PKA_2	213	219	PF00069	0.660
MOD_PKA_2	266	272	PF00069	0.632
MOD_PKA_2	393	399	PF00069	0.622
MOD_PKA_2	428	434	PF00069	0.499
MOD_Plk_1	372	378	PF00069	0.610
MOD_Plk_4	318	324	PF00069	0.595
MOD_ProDKin_1	104	110	PF00069	0.481
MOD_ProDKin_1	247	253	PF00069	0.660
MOD_ProDKin_1	283	289	PF00069	0.648
MOD_ProDKin_1	386	392	PF00069	0.590
MOD_ProDKin_1	404	410	PF00069	0.594
MOD_SUMO_for_1	301	304	PF00179	0.695
TRG_ENDOCYTIC_2	117	120	PF00928	0.503
TRG_ENDOCYTIC_2	168	171	PF00928	0.520
TRG_ENDOCYTIC_2	43	46	PF00928	0.423
TRG_ER_diArg_1	203	205	PF00400	0.576
TRG_ER_diArg_1	223	226	PF00400	0.796
TRG_ER_diArg_1	337	339	PF00400	0.722
TRG_ER_diArg_1	52	54	PF00400	0.434
TRG_ER_diArg_1	65	67	PF00400	0.428
TRG_NLS_MonoExtC_3	428	433	PF00514	0.490
TRG_NLS_MonoExtN_4	201	206	PF00514	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U2	Leptomonas seymouri	44%	100%
A4HBQ4	Leishmania braziliensis	76%	100%
A4HZ56	Leishmania infantum	100%	100%
E9AV24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QCF8	Leishmania major	92%	100%