Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WWD4_LEIDO

TriTrypDb:

LdBPK_210650.1 , LdCL_210011500 , LDHU3_21.0700

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWD4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.598
CLV_C14_Caspase3-7	72	76	PF00656	0.603
CLV_NRD_NRD_1	261	263	PF00675	0.602
CLV_NRD_NRD_1	303	305	PF00675	0.631
CLV_NRD_NRD_1	368	370	PF00675	0.628
CLV_NRD_NRD_1	385	387	PF00675	0.660
CLV_NRD_NRD_1	60	62	PF00675	0.561
CLV_PCSK_KEX2_1	263	265	PF00082	0.595
CLV_PCSK_KEX2_1	303	305	PF00082	0.631
CLV_PCSK_KEX2_1	370	372	PF00082	0.628
CLV_PCSK_KEX2_1	385	387	PF00082	0.678
CLV_PCSK_KEX2_1	60	62	PF00082	0.583
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.595
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.614
CLV_PCSK_SKI1_1	279	283	PF00082	0.681
DEG_SCF_TRCP1_1	75	80	PF00400	0.647
DEG_SPOP_SBC_1	47	51	PF00917	0.675
DOC_CKS1_1	71	76	PF01111	0.588
DOC_MAPK_gen_1	262	271	PF00069	0.702
DOC_MAPK_gen_1	303	312	PF00069	0.619
DOC_PP2B_LxvP_1	239	242	PF13499	0.529
DOC_PP2B_LxvP_1	310	313	PF13499	0.678
DOC_PP2B_LxvP_1	87	90	PF13499	0.546
DOC_PP2B_PxIxI_1	89	95	PF00149	0.542
DOC_USP7_MATH_1	176	180	PF00917	0.740
DOC_USP7_MATH_1	20	24	PF00917	0.618
DOC_USP7_MATH_1	208	212	PF00917	0.649
DOC_USP7_MATH_1	320	324	PF00917	0.689
DOC_USP7_MATH_1	355	359	PF00917	0.633
DOC_USP7_MATH_1	47	51	PF00917	0.648
DOC_WW_Pin1_4	181	186	PF00397	0.609
DOC_WW_Pin1_4	204	209	PF00397	0.554
DOC_WW_Pin1_4	70	75	PF00397	0.586
DOC_WW_Pin1_4	99	104	PF00397	0.718
LIG_14-3-3_CanoR_1	225	230	PF00244	0.449
LIG_14-3-3_CanoR_1	262	271	PF00244	0.702
LIG_14-3-3_CanoR_1	303	313	PF00244	0.781
LIG_14-3-3_CanoR_1	356	363	PF00244	0.570
LIG_14-3-3_CanoR_1	4	12	PF00244	0.635
LIG_APCC_ABBA_1	337	342	PF00400	0.581
LIG_FHA_1	121	127	PF00498	0.667
LIG_FHA_1	181	187	PF00498	0.642
LIG_FHA_1	188	194	PF00498	0.484
LIG_FHA_1	26	32	PF00498	0.789
LIG_FHA_1	294	300	PF00498	0.567
LIG_FHA_1	305	311	PF00498	0.749
LIG_FHA_2	232	238	PF00498	0.531
LIG_FHA_2	52	58	PF00498	0.599
LIG_LIR_Apic_2	65	70	PF02991	0.580
LIG_LIR_Gen_1	223	233	PF02991	0.580
LIG_LIR_Nem_3	223	229	PF02991	0.579
LIG_LIR_Nem_3	247	252	PF02991	0.593
LIG_LIR_Nem_3	375	381	PF02991	0.716
LIG_LIR_Nem_3	62	67	PF02991	0.559
LIG_LYPXL_yS_3	249	252	PF13949	0.573
LIG_NRP_CendR_1	385	388	PF00754	0.704
LIG_PCNA_yPIPBox_3	156	167	PF02747	0.657
LIG_PTB_Apo_2	52	59	PF02174	0.643
LIG_PTB_Phospho_1	52	58	PF10480	0.647
LIG_SH2_NCK_1	15	19	PF00017	0.651
LIG_SH2_SRC	221	224	PF00017	0.469
LIG_SH2_STAP1	218	222	PF00017	0.617
LIG_SH2_STAP1	226	230	PF00017	0.542
LIG_SH2_STAT5	340	343	PF00017	0.670
LIG_SH2_STAT5	380	383	PF00017	0.700
LIG_SH3_1	202	208	PF00018	0.619
LIG_SH3_3	122	128	PF00018	0.739
LIG_SH3_3	179	185	PF00018	0.674
LIG_SH3_3	202	208	PF00018	0.542
LIG_SH3_3	235	241	PF00018	0.539
LIG_SH3_3	247	253	PF00018	0.595
LIG_SH3_3	26	32	PF00018	0.632
LIG_SH3_3	314	320	PF00018	0.692
LIG_SH3_3	68	74	PF00018	0.631
LIG_SUMO_SIM_par_1	242	247	PF11976	0.565
LIG_SUMO_SIM_par_1	90	95	PF11976	0.541
LIG_TRAF2_1	283	286	PF00917	0.602
LIG_TYR_ITSM	245	252	PF00017	0.574
LIG_WRC_WIRS_1	226	231	PF05994	0.581
MOD_CDK_SPK_2	99	104	PF00069	0.575
MOD_CK1_1	102	108	PF00069	0.733
MOD_CK1_1	111	117	PF00069	0.660
MOD_CK1_1	120	126	PF00069	0.521
MOD_CK1_1	207	213	PF00069	0.534
MOD_CK1_1	228	234	PF00069	0.636
MOD_CK1_1	321	327	PF00069	0.679
MOD_CK1_1	329	335	PF00069	0.571
MOD_CK1_1	8	14	PF00069	0.678
MOD_CK2_1	113	119	PF00069	0.812
MOD_Cter_Amidation	383	386	PF01082	0.599
MOD_GlcNHglycan	320	323	PF01048	0.679
MOD_GlcNHglycan	350	353	PF01048	0.665
MOD_GlcNHglycan	357	360	PF01048	0.730
MOD_GlcNHglycan	7	10	PF01048	0.705
MOD_GlcNHglycan	75	78	PF01048	0.781
MOD_GlcNHglycan	83	86	PF01048	0.517
MOD_GlcNHglycan	87	90	PF01048	0.451
MOD_GSK3_1	113	120	PF00069	0.760
MOD_GSK3_1	176	183	PF00069	0.587
MOD_GSK3_1	187	194	PF00069	0.673
MOD_GSK3_1	20	27	PF00069	0.780
MOD_GSK3_1	204	211	PF00069	0.604
MOD_GSK3_1	224	231	PF00069	0.438
MOD_GSK3_1	244	251	PF00069	0.488
MOD_GSK3_1	265	272	PF00069	0.572
MOD_GSK3_1	318	325	PF00069	0.699
MOD_GSK3_1	47	54	PF00069	0.649
MOD_GSK3_1	69	76	PF00069	0.683
MOD_GSK3_1	77	84	PF00069	0.727
MOD_N-GLC_1	346	351	PF02516	0.565
MOD_NEK2_1	180	185	PF00069	0.584
MOD_NEK2_1	244	249	PF00069	0.578
MOD_NEK2_1	269	274	PF00069	0.619
MOD_NEK2_1	293	298	PF00069	0.745
MOD_NEK2_2	113	118	PF00069	0.588
MOD_PIKK_1	228	234	PF00454	0.582
MOD_PKA_1	262	268	PF00069	0.707
MOD_PKA_2	117	123	PF00069	0.759
MOD_PKA_2	224	230	PF00069	0.521
MOD_PKA_2	355	361	PF00069	0.706
MOD_Plk_1	20	26	PF00069	0.620
MOD_Plk_1	277	283	PF00069	0.679
MOD_Plk_4	21	27	PF00069	0.711
MOD_Plk_4	225	231	PF00069	0.527
MOD_Plk_4	244	250	PF00069	0.579
MOD_Plk_4	277	283	PF00069	0.679
MOD_ProDKin_1	181	187	PF00069	0.599
MOD_ProDKin_1	204	210	PF00069	0.544
MOD_ProDKin_1	70	76	PF00069	0.587
MOD_ProDKin_1	99	105	PF00069	0.718
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.627
TRG_ENDOCYTIC_2	226	229	PF00928	0.578
TRG_ENDOCYTIC_2	249	252	PF00928	0.573
TRG_ENDOCYTIC_2	378	381	PF00928	0.599
TRG_ER_diArg_1	302	304	PF00400	0.634
TRG_ER_diArg_1	385	388	PF00400	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I5	Leptomonas seymouri	39%	81%
A4HBQ6	Leishmania braziliensis	65%	98%
A4HZ58	Leishmania infantum	100%	100%
E9AV26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QCF6	Leishmania major	88%	100%