Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWD2_LEIDO

TriTrypDb:

LdBPK_210540.1 , LdCL_210010200 , LDHU3_21.0580

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.497
CLV_C14_Caspase3-7	414	418	PF00656	0.614
CLV_NRD_NRD_1	118	120	PF00675	0.628
CLV_NRD_NRD_1	484	486	PF00675	0.754
CLV_PCSK_KEX2_1	117	119	PF00082	0.632
CLV_PCSK_KEX2_1	484	486	PF00082	0.681
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.632
CLV_PCSK_SKI1_1	253	257	PF00082	0.614
CLV_PCSK_SKI1_1	268	272	PF00082	0.410
CLV_TASPASE1	394	400	PF01112	0.636
DEG_Nend_UBRbox_2	1	3	PF02207	0.640
DOC_ANK_TNKS_1	391	398	PF00023	0.630
DOC_CKS1_1	473	478	PF01111	0.723
DOC_MAPK_gen_1	184	193	PF00069	0.544
DOC_MAPK_MEF2A_6	345	353	PF00069	0.505
DOC_PP1_RVXF_1	260	267	PF00149	0.634
DOC_PP4_FxxP_1	327	330	PF00568	0.623
DOC_USP7_MATH_1	286	290	PF00917	0.754
DOC_USP7_MATH_1	36	40	PF00917	0.723
DOC_USP7_MATH_1	411	415	PF00917	0.525
DOC_USP7_MATH_1	43	47	PF00917	0.665
DOC_USP7_MATH_1	442	446	PF00917	0.529
DOC_WW_Pin1_4	281	286	PF00397	0.674
DOC_WW_Pin1_4	311	316	PF00397	0.634
DOC_WW_Pin1_4	329	334	PF00397	0.683
DOC_WW_Pin1_4	472	477	PF00397	0.679
LIG_14-3-3_CanoR_1	161	169	PF00244	0.551
LIG_14-3-3_CanoR_1	372	376	PF00244	0.583
LIG_Actin_WH2_2	176	194	PF00022	0.521
LIG_Actin_WH2_2	238	255	PF00022	0.558
LIG_BRCT_BRCA1_1	323	327	PF00533	0.650
LIG_FHA_1	108	114	PF00498	0.605
LIG_FHA_1	377	383	PF00498	0.418
LIG_FHA_1	414	420	PF00498	0.490
LIG_FHA_1	488	494	PF00498	0.781
LIG_FHA_1	66	72	PF00498	0.531
LIG_FHA_2	255	261	PF00498	0.494
LIG_FHA_2	282	288	PF00498	0.697
LIG_FHA_2	364	370	PF00498	0.604
LIG_FHA_2	50	56	PF00498	0.653
LIG_LIR_Apic_2	324	330	PF02991	0.627
LIG_LIR_Gen_1	131	141	PF02991	0.444
LIG_LIR_Gen_1	267	277	PF02991	0.685
LIG_LIR_Nem_3	131	137	PF02991	0.444
LIG_LIR_Nem_3	267	273	PF02991	0.572
LIG_LIR_Nem_3	335	341	PF02991	0.556
LIG_MYND_3	339	343	PF01753	0.590
LIG_NRBOX	91	97	PF00104	0.497
LIG_Pex14_1	266	270	PF04695	0.546
LIG_Pex14_2	334	338	PF04695	0.590
LIG_SH2_STAT5	227	230	PF00017	0.495
LIG_SH2_STAT5	235	238	PF00017	0.510
LIG_SH3_3	32	38	PF00018	0.779
LIG_SH3_3	327	333	PF00018	0.731
LIG_SH3_3	470	476	PF00018	0.799
LIG_TRAF2_1	122	125	PF00917	0.536
LIG_TRAF2_1	231	234	PF00917	0.508
LIG_TRAF2_1	289	292	PF00917	0.786
LIG_TRAF2_1	91	94	PF00917	0.633
LIG_UBA3_1	380	385	PF00899	0.508
MOD_CK1_1	111	117	PF00069	0.414
MOD_CK1_1	298	304	PF00069	0.754
MOD_CK1_1	314	320	PF00069	0.501
MOD_CK1_1	371	377	PF00069	0.585
MOD_CK1_1	39	45	PF00069	0.730
MOD_CK1_1	444	450	PF00069	0.680
MOD_CK1_1	459	465	PF00069	0.764
MOD_CK1_1	46	52	PF00069	0.665
MOD_CK1_1	467	473	PF00069	0.660
MOD_CK1_1	478	484	PF00069	0.811
MOD_CK2_1	133	139	PF00069	0.596
MOD_CK2_1	191	197	PF00069	0.510
MOD_CK2_1	227	233	PF00069	0.489
MOD_CK2_1	254	260	PF00069	0.497
MOD_CK2_1	286	292	PF00069	0.746
MOD_CK2_1	88	94	PF00069	0.528
MOD_GlcNHglycan	193	196	PF01048	0.616
MOD_GlcNHglycan	229	232	PF01048	0.525
MOD_GlcNHglycan	272	276	PF01048	0.563
MOD_GlcNHglycan	296	300	PF01048	0.737
MOD_GlcNHglycan	301	304	PF01048	0.661
MOD_GlcNHglycan	316	319	PF01048	0.647
MOD_GlcNHglycan	38	41	PF01048	0.782
MOD_GlcNHglycan	444	447	PF01048	0.627
MOD_GlcNHglycan	45	48	PF01048	0.674
MOD_GlcNHglycan	458	461	PF01048	0.735
MOD_GlcNHglycan	477	480	PF01048	0.735
MOD_GlcNHglycan	7	11	PF01048	0.580
MOD_GlcNHglycan	77	80	PF01048	0.650
MOD_GSK3_1	107	114	PF00069	0.487
MOD_GSK3_1	156	163	PF00069	0.638
MOD_GSK3_1	295	302	PF00069	0.675
MOD_GSK3_1	371	378	PF00069	0.581
MOD_GSK3_1	39	46	PF00069	0.712
MOD_GSK3_1	438	445	PF00069	0.654
MOD_N-GLC_1	25	30	PF02516	0.692
MOD_NEK2_1	179	184	PF00069	0.577
MOD_NEK2_1	191	196	PF00069	0.443
MOD_NEK2_1	375	380	PF00069	0.607
MOD_NEK2_1	41	46	PF00069	0.614
MOD_NEK2_1	480	485	PF00069	0.739
MOD_PIKK_1	108	114	PF00454	0.633
MOD_PIKK_1	148	154	PF00454	0.633
MOD_PIKK_1	254	260	PF00454	0.497
MOD_PIKK_1	432	438	PF00454	0.632
MOD_PIKK_1	478	484	PF00454	0.811
MOD_PKA_2	160	166	PF00069	0.552
MOD_PKA_2	191	197	PF00069	0.519
MOD_PKA_2	371	377	PF00069	0.585
MOD_PKA_2	464	470	PF00069	0.714
MOD_PKB_1	485	493	PF00069	0.787
MOD_Plk_1	25	31	PF00069	0.678
MOD_Plk_1	368	374	PF00069	0.633
MOD_Plk_1	376	382	PF00069	0.473
MOD_Plk_1	467	473	PF00069	0.755
MOD_Plk_1	6	12	PF00069	0.584
MOD_Plk_2-3	287	293	PF00069	0.709
MOD_Plk_2-3	88	94	PF00069	0.591
MOD_Plk_4	376	382	PF00069	0.571
MOD_Plk_4	383	389	PF00069	0.522
MOD_ProDKin_1	281	287	PF00069	0.675
MOD_ProDKin_1	311	317	PF00069	0.635
MOD_ProDKin_1	329	335	PF00069	0.681
MOD_ProDKin_1	472	478	PF00069	0.685
MOD_SUMO_rev_2	170	177	PF00179	0.629
MOD_SUMO_rev_2	97	107	PF00179	0.559
TRG_DiLeu_BaEn_1	164	169	PF01217	0.625
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.601
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.532
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.438
TRG_ENDOCYTIC_2	134	137	PF00928	0.528
TRG_ER_diArg_1	183	186	PF00400	0.623
TRG_ER_diArg_1	204	207	PF00400	0.553
TRG_ER_diArg_1	484	487	PF00400	0.698
TRG_ER_diArg_1	488	491	PF00400	0.675
TRG_NES_CRM1_1	7	19	PF08389	0.663
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	408	413	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF17	Leptomonas seymouri	39%	88%
A4HBP6	Leishmania braziliensis	79%	100%
A4HZ47	Leishmania infantum	99%	100%
E9AV15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QCG7	Leishmania major	94%	100%