Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWC8_LEIDO

TriTrypDb:

LdBPK_210370.1 , LdCL_210008500 , LDHU3_21.0390

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WWC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.540
CLV_MEL_PAP_1	153	159	PF00089	0.648
CLV_NRD_NRD_1	174	176	PF00675	0.667
CLV_NRD_NRD_1	239	241	PF00675	0.679
CLV_PCSK_FUR_1	47	51	PF00082	0.605
CLV_PCSK_KEX2_1	49	51	PF00082	0.622
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.622
CLV_PCSK_SKI1_1	125	129	PF00082	0.652
CLV_PCSK_SKI1_1	280	284	PF00082	0.476
CLV_PCSK_SKI1_1	306	310	PF00082	0.429
CLV_Separin_Metazoa	86	90	PF03568	0.554
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.707
DOC_CYCLIN_yCln2_LP_2	112	115	PF00134	0.520
DOC_MAPK_gen_1	104	112	PF00069	0.454
DOC_MAPK_gen_1	49	59	PF00069	0.503
DOC_MAPK_JIP1_4	89	95	PF00069	0.525
DOC_MAPK_MEF2A_6	261	268	PF00069	0.451
DOC_MAPK_RevD_3	34	50	PF00069	0.483
DOC_PP1_RVXF_1	230	236	PF00149	0.420
DOC_PP2B_LxvP_1	112	115	PF13499	0.524
DOC_PP2B_LxvP_1	93	96	PF13499	0.559
DOC_SPAK_OSR1_1	120	124	PF12202	0.444
DOC_SPAK_OSR1_1	156	160	PF12202	0.408
DOC_USP7_MATH_1	138	142	PF00917	0.430
DOC_WW_Pin1_4	115	120	PF00397	0.515
DOC_WW_Pin1_4	254	259	PF00397	0.428
DOC_WW_Pin1_4	26	31	PF00397	0.504
LIG_14-3-3_CanoR_1	156	160	PF00244	0.408
LIG_14-3-3_CanoR_1	232	236	PF00244	0.371
LIG_14-3-3_CanoR_1	280	285	PF00244	0.395
LIG_14-3-3_CanoR_1	53	57	PF00244	0.490
LIG_Actin_WH2_2	123	138	PF00022	0.424
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_BIR_III_4	74	78	PF00653	0.447
LIG_BRCT_BRCA1_1	117	121	PF00533	0.517
LIG_CSL_BTD_1	168	171	PF09270	0.364
LIG_FHA_1	177	183	PF00498	0.443
LIG_FHA_2	81	87	PF00498	0.580
LIG_LIR_Gen_1	55	64	PF02991	0.456
LIG_LIR_Nem_3	166	172	PF02991	0.353
LIG_LIR_Nem_3	234	239	PF02991	0.335
LIG_LIR_Nem_3	55	59	PF02991	0.554
LIG_REV1ctd_RIR_1	234	245	PF16727	0.414
LIG_SH2_STAP1	178	182	PF00017	0.468
LIG_SH2_STAT3	178	181	PF00017	0.416
LIG_SH2_STAT5	178	181	PF00017	0.471
LIG_SH2_STAT5	229	232	PF00017	0.330
LIG_SH2_STAT5	45	48	PF00017	0.459
LIG_SH3_2	275	280	PF14604	0.481
LIG_SH3_3	272	278	PF00018	0.454
LIG_SH3_3	297	303	PF00018	0.408
LIG_SH3_3	84	90	PF00018	0.525
LIG_Sin3_3	287	294	PF02671	0.480
LIG_SUMO_SIM_anti_2	286	293	PF11976	0.356
LIG_TRAF2_1	141	144	PF00917	0.456
LIG_WRC_WIRS_1	247	252	PF05994	0.369
MOD_CDK_SPK_2	115	120	PF00069	0.516
MOD_CDK_SPxxK_3	254	261	PF00069	0.426
MOD_CK1_1	180	186	PF00069	0.449
MOD_CK1_1	231	237	PF00069	0.390
MOD_CK1_1	26	32	PF00069	0.545
MOD_CK1_1	293	299	PF00069	0.397
MOD_CK1_1	304	310	PF00069	0.615
MOD_CK1_1	55	61	PF00069	0.511
MOD_CK2_1	138	144	PF00069	0.439
MOD_CK2_1	80	86	PF00069	0.529
MOD_GlcNHglycan	25	28	PF01048	0.734
MOD_GlcNHglycan	285	288	PF01048	0.386
MOD_GSK3_1	176	183	PF00069	0.399
MOD_GSK3_1	94	101	PF00069	0.549
MOD_N-GLC_1	131	136	PF02516	0.652
MOD_NEK2_1	155	160	PF00069	0.408
MOD_NEK2_1	182	187	PF00069	0.443
MOD_NEK2_1	215	220	PF00069	0.542
MOD_NEK2_1	309	314	PF00069	0.661
MOD_NEK2_1	98	103	PF00069	0.548
MOD_NEK2_2	131	136	PF00069	0.453
MOD_PIKK_1	177	183	PF00454	0.448
MOD_PIKK_1	309	315	PF00454	0.673
MOD_PK_1	28	34	PF00069	0.520
MOD_PKA_1	176	182	PF00069	0.460
MOD_PKA_2	155	161	PF00069	0.440
MOD_PKA_2	231	237	PF00069	0.368
MOD_PKA_2	52	58	PF00069	0.516
MOD_Plk_1	131	137	PF00069	0.433
MOD_Plk_1	143	149	PF00069	0.472
MOD_Plk_1	165	171	PF00069	0.440
MOD_Plk_4	125	131	PF00069	0.440
MOD_Plk_4	165	171	PF00069	0.422
MOD_Plk_4	231	237	PF00069	0.381
MOD_Plk_4	290	296	PF00069	0.377
MOD_Plk_4	40	46	PF00069	0.414
MOD_Plk_4	52	58	PF00069	0.499
MOD_ProDKin_1	115	121	PF00069	0.518
MOD_ProDKin_1	254	260	PF00069	0.429
MOD_ProDKin_1	26	32	PF00069	0.503
MOD_SUMO_rev_2	257	262	PF00179	0.418
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.487
TRG_NES_CRM1_1	243	255	PF08389	0.392
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H6	Leptomonas seymouri	50%	90%
A0A1X0NXE2	Trypanosomatidae	29%	100%
A0A3S5IR94	Trypanosoma rangeli	27%	100%
A4HBM9	Leishmania braziliensis	76%	100%
A4HZB8	Leishmania infantum	100%	100%
D0A1M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AUZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCI4	Leishmania major	93%	100%
V5B0L2	Trypanosoma cruzi	28%	100%