Leucine Rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWC7_LEIDO

TriTrypDb:

LdBPK_210220.1 , LdCL_210007000 , LDHU3_21.0220

Length:

747

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7WWC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.409
CLV_C14_Caspase3-7	565	569	PF00656	0.443
CLV_NRD_NRD_1	166	168	PF00675	0.536
CLV_NRD_NRD_1	5	7	PF00675	0.556
CLV_NRD_NRD_1	521	523	PF00675	0.531
CLV_NRD_NRD_1	727	729	PF00675	0.484
CLV_PCSK_KEX2_1	165	167	PF00082	0.515
CLV_PCSK_KEX2_1	5	7	PF00082	0.556
CLV_PCSK_KEX2_1	521	523	PF00082	0.531
CLV_PCSK_KEX2_1	727	729	PF00082	0.484
CLV_PCSK_SKI1_1	225	229	PF00082	0.524
CLV_PCSK_SKI1_1	276	280	PF00082	0.451
CLV_PCSK_SKI1_1	359	363	PF00082	0.394
CLV_PCSK_SKI1_1	62	66	PF00082	0.428
CLV_PCSK_SKI1_1	694	698	PF00082	0.384
DEG_Nend_UBRbox_1	1	4	PF02207	0.551
DEG_ODPH_VHL_1	544	557	PF01847	0.411
DEG_SCF_FBW7_1	612	619	PF00400	0.417
DOC_CDC14_PxL_1	396	404	PF14671	0.353
DOC_CDC14_PxL_1	599	607	PF14671	0.562
DOC_CKS1_1	104	109	PF01111	0.476
DOC_CKS1_1	118	123	PF01111	0.477
DOC_CKS1_1	613	618	PF01111	0.423
DOC_CYCLIN_RxL_1	559	569	PF00134	0.440
DOC_MAPK_gen_1	736	745	PF00069	0.434
DOC_MAPK_MEF2A_6	739	747	PF00069	0.422
DOC_PP1_RVXF_1	223	229	PF00149	0.307
DOC_PP1_RVXF_1	608	614	PF00149	0.342
DOC_USP7_MATH_1	10	14	PF00917	0.595
DOC_USP7_MATH_1	137	141	PF00917	0.496
DOC_USP7_MATH_1	168	172	PF00917	0.673
DOC_USP7_MATH_1	26	30	PF00917	0.420
DOC_USP7_MATH_1	31	35	PF00917	0.506
DOC_USP7_MATH_1	479	483	PF00917	0.709
DOC_USP7_MATH_1	663	667	PF00917	0.503
DOC_USP7_MATH_1	674	678	PF00917	0.229
DOC_WW_Pin1_4	103	108	PF00397	0.587
DOC_WW_Pin1_4	117	122	PF00397	0.478
DOC_WW_Pin1_4	231	236	PF00397	0.478
DOC_WW_Pin1_4	46	51	PF00397	0.566
DOC_WW_Pin1_4	469	474	PF00397	0.406
DOC_WW_Pin1_4	612	617	PF00397	0.475
DOC_WW_Pin1_4	67	72	PF00397	0.515
LIG_14-3-3_CanoR_1	167	176	PF00244	0.584
LIG_14-3-3_CanoR_1	20	25	PF00244	0.526
LIG_14-3-3_CanoR_1	243	249	PF00244	0.449
LIG_14-3-3_CanoR_1	280	285	PF00244	0.443
LIG_14-3-3_CanoR_1	355	363	PF00244	0.420
LIG_14-3-3_CanoR_1	437	445	PF00244	0.389
LIG_14-3-3_CanoR_1	62	67	PF00244	0.503
LIG_14-3-3_CanoR_1	653	658	PF00244	0.317
LIG_14-3-3_CanoR_1	80	86	PF00244	0.544
LIG_BRCT_BRCA1_1	52	56	PF00533	0.377
LIG_DLG_GKlike_1	614	621	PF00625	0.363
LIG_EH1_1	150	158	PF00400	0.487
LIG_FAT_LD_1	698	706	PF03623	0.426
LIG_FHA_1	118	124	PF00498	0.447
LIG_FHA_1	188	194	PF00498	0.649
LIG_FHA_1	46	52	PF00498	0.390
LIG_FHA_1	491	497	PF00498	0.597
LIG_FHA_1	613	619	PF00498	0.449
LIG_FHA_1	654	660	PF00498	0.423
LIG_FHA_1	721	727	PF00498	0.512
LIG_FHA_2	287	293	PF00498	0.450
LIG_FHA_2	429	435	PF00498	0.412
LIG_FHA_2	513	519	PF00498	0.499
LIG_GBD_Chelix_1	81	89	PF00786	0.454
LIG_Integrin_isoDGR_2	489	491	PF01839	0.605
LIG_LIR_Apic_2	467	473	PF02991	0.506
LIG_LIR_Gen_1	171	178	PF02991	0.508
LIG_LIR_Gen_1	247	256	PF02991	0.382
LIG_LIR_Gen_1	53	64	PF02991	0.381
LIG_LIR_Gen_1	666	676	PF02991	0.438
LIG_LIR_LC3C_4	128	133	PF02991	0.427
LIG_LIR_Nem_3	171	176	PF02991	0.519
LIG_LIR_Nem_3	247	251	PF02991	0.377
LIG_LIR_Nem_3	53	59	PF02991	0.335
LIG_LIR_Nem_3	622	628	PF02991	0.452
LIG_LIR_Nem_3	666	672	PF02991	0.388
LIG_MYND_3	343	347	PF01753	0.291
LIG_NRBOX	607	613	PF00104	0.310
LIG_NRBOX	653	659	PF00104	0.417
LIG_NRBOX	697	703	PF00104	0.443
LIG_PCNA_yPIPBox_3	301	311	PF02747	0.362
LIG_PCNA_yPIPBox_3	32	43	PF02747	0.485
LIG_PDZ_Class_2	742	747	PF00595	0.381
LIG_Pex14_1	52	56	PF04695	0.375
LIG_PTAP_UEV_1	11	16	PF05743	0.557
LIG_PTB_Apo_2	593	600	PF02174	0.357
LIG_SH2_NCK_1	499	503	PF00017	0.579
LIG_SH2_SRC	499	502	PF00017	0.593
LIG_SH3_3	508	514	PF00018	0.631
LIG_SH3_3	540	546	PF00018	0.580
LIG_SH3_3	9	15	PF00018	0.700
LIG_SH3_3	99	105	PF00018	0.454
LIG_SUMO_SIM_anti_2	127	134	PF11976	0.452
LIG_SUMO_SIM_anti_2	254	259	PF11976	0.522
LIG_SUMO_SIM_anti_2	617	622	PF11976	0.405
LIG_SUMO_SIM_anti_2	693	700	PF11976	0.510
LIG_SUMO_SIM_par_1	256	261	PF11976	0.414
LIG_SUMO_SIM_par_1	562	569	PF11976	0.455
LIG_SUMO_SIM_par_1	619	624	PF11976	0.421
LIG_SUMO_SIM_par_1	655	660	PF11976	0.410
LIG_SUMO_SIM_par_1	704	710	PF11976	0.543
LIG_TRAF2_1	140	143	PF00917	0.579
LIG_TRAF2_1	587	590	PF00917	0.438
LIG_WRC_WIRS_1	346	351	PF05994	0.270
MOD_CDK_SPxxK_3	67	74	PF00069	0.372
MOD_CK1_1	125	131	PF00069	0.471
MOD_CK1_1	13	19	PF00069	0.708
MOD_CK1_1	171	177	PF00069	0.585
MOD_CK1_1	180	186	PF00069	0.552
MOD_CK1_1	247	253	PF00069	0.458
MOD_CK1_1	388	394	PF00069	0.470
MOD_CK1_1	444	450	PF00069	0.294
MOD_CK1_1	472	478	PF00069	0.546
MOD_CK1_1	556	562	PF00069	0.412
MOD_CK1_1	677	683	PF00069	0.466
MOD_CK1_1	70	76	PF00069	0.523
MOD_CK1_1	710	716	PF00069	0.516
MOD_CK1_1	722	728	PF00069	0.460
MOD_CK2_1	137	143	PF00069	0.673
MOD_CK2_1	286	292	PF00069	0.421
MOD_CK2_1	479	485	PF00069	0.663
MOD_CK2_1	512	518	PF00069	0.497
MOD_CK2_1	87	93	PF00069	0.598
MOD_CMANNOS	19	22	PF00535	0.393
MOD_CMANNOS	8	11	PF00535	0.541
MOD_GlcNHglycan	12	15	PF01048	0.554
MOD_GlcNHglycan	182	186	PF01048	0.642
MOD_GlcNHglycan	211	214	PF01048	0.481
MOD_GlcNHglycan	28	31	PF01048	0.462
MOD_GlcNHglycan	351	354	PF01048	0.453
MOD_GlcNHglycan	477	480	PF01048	0.602
MOD_GlcNHglycan	55	59	PF01048	0.442
MOD_GlcNHglycan	568	571	PF01048	0.501
MOD_GlcNHglycan	659	662	PF01048	0.507
MOD_GlcNHglycan	89	92	PF01048	0.588
MOD_GSK3_1	10	17	PF00069	0.605
MOD_GSK3_1	168	175	PF00069	0.561
MOD_GSK3_1	177	184	PF00069	0.431
MOD_GSK3_1	247	254	PF00069	0.447
MOD_GSK3_1	276	283	PF00069	0.451
MOD_GSK3_1	345	352	PF00069	0.438
MOD_GSK3_1	453	460	PF00069	0.524
MOD_GSK3_1	46	53	PF00069	0.443
MOD_GSK3_1	474	481	PF00069	0.596
MOD_GSK3_1	531	538	PF00069	0.579
MOD_GSK3_1	612	619	PF00069	0.484
MOD_GSK3_1	649	656	PF00069	0.403
MOD_GSK3_1	674	681	PF00069	0.532
MOD_GSK3_1	706	713	PF00069	0.483
MOD_GSK3_1	89	96	PF00069	0.440
MOD_NEK2_1	100	105	PF00069	0.413
MOD_NEK2_1	145	150	PF00069	0.607
MOD_NEK2_1	258	263	PF00069	0.381
MOD_NEK2_1	269	274	PF00069	0.399
MOD_NEK2_1	345	350	PF00069	0.367
MOD_NEK2_1	369	374	PF00069	0.447
MOD_NEK2_1	376	381	PF00069	0.350
MOD_NEK2_1	433	438	PF00069	0.377
MOD_NEK2_1	566	571	PF00069	0.351
MOD_NEK2_1	598	603	PF00069	0.475
MOD_NEK2_1	621	626	PF00069	0.375
MOD_NEK2_1	631	636	PF00069	0.394
MOD_NEK2_1	657	662	PF00069	0.352
MOD_NEK2_2	354	359	PF00069	0.359
MOD_PIKK_1	286	292	PF00454	0.469
MOD_PIKK_1	556	562	PF00454	0.469
MOD_PIKK_1	674	680	PF00454	0.437
MOD_PKA_2	180	186	PF00069	0.595
MOD_PKA_2	279	285	PF00069	0.464
MOD_PKA_2	354	360	PF00069	0.554
MOD_PKA_2	438	444	PF00069	0.394
MOD_PKA_2	490	496	PF00069	0.607
MOD_PKA_2	690	696	PF00069	0.460
MOD_PKB_1	179	187	PF00069	0.562
MOD_Plk_1	54	60	PF00069	0.355
MOD_Plk_1	621	627	PF00069	0.442
MOD_Plk_4	152	158	PF00069	0.512
MOD_Plk_4	326	332	PF00069	0.381
MOD_Plk_4	616	622	PF00069	0.497
MOD_Plk_4	631	637	PF00069	0.307
MOD_Plk_4	653	659	PF00069	0.441
MOD_Plk_4	84	90	PF00069	0.461
MOD_ProDKin_1	103	109	PF00069	0.583
MOD_ProDKin_1	117	123	PF00069	0.473
MOD_ProDKin_1	231	237	PF00069	0.479
MOD_ProDKin_1	46	52	PF00069	0.560
MOD_ProDKin_1	469	475	PF00069	0.412
MOD_ProDKin_1	612	618	PF00069	0.468
MOD_ProDKin_1	67	73	PF00069	0.508
TRG_DiLeu_BaEn_1	127	132	PF01217	0.434
TRG_DiLeu_BaEn_1	152	157	PF01217	0.478
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.399
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.483
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.370
TRG_ER_diArg_1	138	141	PF00400	0.518
TRG_ER_diArg_1	165	167	PF00400	0.484
TRG_ER_diArg_1	178	181	PF00400	0.381
TRG_ER_diArg_1	238	241	PF00400	0.470
TRG_ER_diArg_1	373	376	PF00400	0.454
TRG_ER_diArg_1	4	6	PF00400	0.561
TRG_ER_diArg_1	437	440	PF00400	0.435
TRG_ER_diArg_1	528	531	PF00400	0.626
TRG_ER_diArg_1	726	728	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	727	731	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	736	740	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I3	Leptomonas seymouri	49%	97%
A0A1X0NYX0	Trypanosomatidae	32%	100%
A4HBL5	Leishmania braziliensis	81%	100%
A4HZA3	Leishmania infantum	100%	100%
D0A1K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AUY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCJ9	Leishmania major	93%	100%