WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWC6_LEIDO

TriTrypDb:

LdBPK_201770.1 , LdCL_200022600 , LDHU3_20.2160

Length:

1003

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	419	421	PF00675	0.511
CLV_NRD_NRD_1	615	617	PF00675	0.566
CLV_NRD_NRD_1	8	10	PF00675	0.699
CLV_PCSK_FUR_1	6	10	PF00082	0.494
CLV_PCSK_KEX2_1	201	203	PF00082	0.459
CLV_PCSK_KEX2_1	504	506	PF00082	0.606
CLV_PCSK_KEX2_1	615	617	PF00082	0.624
CLV_PCSK_KEX2_1	8	10	PF00082	0.706
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.459
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.606
CLV_PCSK_SKI1_1	411	415	PF00082	0.589
CLV_PCSK_SKI1_1	515	519	PF00082	0.415
CLV_PCSK_SKI1_1	623	627	PF00082	0.521
CLV_PCSK_SKI1_1	712	716	PF00082	0.574
CLV_PCSK_SKI1_1	727	731	PF00082	0.365
CLV_PCSK_SKI1_1	759	763	PF00082	0.556
CLV_PCSK_SKI1_1	88	92	PF00082	0.583
CLV_PCSK_SKI1_1	9	13	PF00082	0.613
CLV_PCSK_SKI1_1	954	958	PF00082	0.414
DEG_APCC_DBOX_1	514	522	PF00400	0.438
DEG_APCC_DBOX_1	622	630	PF00400	0.582
DEG_Nend_Nbox_1	1	3	PF02207	0.668
DOC_MAPK_gen_1	420	427	PF00069	0.485
DOC_MAPK_MEF2A_6	801	808	PF00069	0.533
DOC_MAPK_MEF2A_6	967	975	PF00069	0.595
DOC_PP2B_LxvP_1	369	372	PF13499	0.547
DOC_PP2B_PxIxI_1	801	807	PF00149	0.495
DOC_PP4_FxxP_1	990	993	PF00568	0.508
DOC_USP7_MATH_1	272	276	PF00917	0.584
DOC_USP7_MATH_1	400	404	PF00917	0.484
DOC_USP7_MATH_1	446	450	PF00917	0.550
DOC_USP7_MATH_1	651	655	PF00917	0.623
DOC_USP7_MATH_1	749	753	PF00917	0.459
DOC_USP7_MATH_1	864	868	PF00917	0.391
DOC_USP7_MATH_1	935	939	PF00917	0.650
DOC_USP7_MATH_1	960	964	PF00917	0.568
DOC_USP7_MATH_2	260	266	PF00917	0.547
DOC_WW_Pin1_4	405	410	PF00397	0.464
DOC_WW_Pin1_4	615	620	PF00397	0.590
DOC_WW_Pin1_4	694	699	PF00397	0.678
DOC_WW_Pin1_4	931	936	PF00397	0.566
DOC_WW_Pin1_4	981	986	PF00397	0.436
DOC_WW_Pin1_4	989	994	PF00397	0.414
LIG_14-3-3_CanoR_1	115	123	PF00244	0.480
LIG_14-3-3_CanoR_1	237	243	PF00244	0.663
LIG_14-3-3_CanoR_1	333	340	PF00244	0.413
LIG_14-3-3_CanoR_1	411	418	PF00244	0.565
LIG_14-3-3_CanoR_1	445	451	PF00244	0.558
LIG_14-3-3_CanoR_1	505	509	PF00244	0.604
LIG_14-3-3_CanoR_1	610	615	PF00244	0.607
LIG_14-3-3_CanoR_1	704	709	PF00244	0.553
LIG_14-3-3_CanoR_1	727	732	PF00244	0.591
LIG_14-3-3_CanoR_1	857	864	PF00244	0.489
LIG_14-3-3_CanoR_1	88	93	PF00244	0.582
LIG_Actin_WH2_2	601	617	PF00022	0.541
LIG_AP2alpha_2	748	750	PF02296	0.383
LIG_APCC_ABBA_1	425	430	PF00400	0.502
LIG_BRCT_BRCA1_1	199	203	PF00533	0.522
LIG_BRCT_BRCA1_1	229	233	PF00533	0.473
LIG_BRCT_BRCA1_1	646	650	PF00533	0.530
LIG_BRCT_BRCA1_1	949	953	PF00533	0.571
LIG_Clathr_ClatBox_1	311	315	PF01394	0.560
LIG_eIF4E_1	288	294	PF01652	0.499
LIG_FAT_LD_1	489	497	PF03623	0.542
LIG_FHA_1	103	109	PF00498	0.547
LIG_FHA_1	156	162	PF00498	0.508
LIG_FHA_1	244	250	PF00498	0.630
LIG_FHA_1	307	313	PF00498	0.491
LIG_FHA_1	320	326	PF00498	0.375
LIG_FHA_1	378	384	PF00498	0.487
LIG_FHA_1	40	46	PF00498	0.675
LIG_FHA_1	412	418	PF00498	0.457
LIG_FHA_1	438	444	PF00498	0.440
LIG_FHA_1	588	594	PF00498	0.622
LIG_FHA_1	713	719	PF00498	0.495
LIG_FHA_1	786	792	PF00498	0.538
LIG_FHA_1	912	918	PF00498	0.517
LIG_FHA_2	146	152	PF00498	0.547
LIG_FHA_2	73	79	PF00498	0.535
LIG_FHA_2	823	829	PF00498	0.474
LIG_FHA_2	919	925	PF00498	0.519
LIG_HCF-1_HBM_1	316	319	PF13415	0.599
LIG_LIR_Apic_2	302	307	PF02991	0.596
LIG_LIR_Apic_2	989	993	PF02991	0.526
LIG_LIR_Gen_1	262	272	PF02991	0.649
LIG_LIR_Gen_1	379	389	PF02991	0.439
LIG_LIR_Gen_1	423	428	PF02991	0.497
LIG_LIR_Gen_1	553	562	PF02991	0.524
LIG_LIR_Gen_1	673	682	PF02991	0.562
LIG_LIR_Gen_1	697	708	PF02991	0.638
LIG_LIR_Gen_1	748	758	PF02991	0.575
LIG_LIR_Gen_1	818	827	PF02991	0.387
LIG_LIR_LC3C_4	541	546	PF02991	0.637
LIG_LIR_Nem_3	200	206	PF02991	0.508
LIG_LIR_Nem_3	255	261	PF02991	0.643
LIG_LIR_Nem_3	262	267	PF02991	0.674
LIG_LIR_Nem_3	287	291	PF02991	0.508
LIG_LIR_Nem_3	423	427	PF02991	0.497
LIG_LIR_Nem_3	444	450	PF02991	0.536
LIG_LIR_Nem_3	553	559	PF02991	0.468
LIG_LIR_Nem_3	609	614	PF02991	0.600
LIG_LIR_Nem_3	673	678	PF02991	0.569
LIG_LIR_Nem_3	697	703	PF02991	0.651
LIG_LIR_Nem_3	748	753	PF02991	0.572
LIG_LIR_Nem_3	818	823	PF02991	0.429
LIG_LIR_Nem_3	950	956	PF02991	0.539
LIG_NRBOX	457	463	PF00104	0.610
LIG_NRBOX	561	567	PF00104	0.555
LIG_NRBOX	677	683	PF00104	0.511
LIG_PCNA_yPIPBox_3	448	462	PF02747	0.438
LIG_PCNA_yPIPBox_3	770	778	PF02747	0.364
LIG_Pex14_1	26	30	PF04695	0.647
LIG_Pex14_2	169	173	PF04695	0.517
LIG_Pex14_2	607	611	PF04695	0.550
LIG_Pex14_2	807	811	PF04695	0.480
LIG_Pex14_2	978	982	PF04695	0.509
LIG_Pex14_2	990	994	PF04695	0.518
LIG_PTB_Apo_2	811	818	PF02174	0.511
LIG_PTB_Phospho_1	811	817	PF10480	0.513
LIG_SH2_CRK	195	199	PF00017	0.484
LIG_SH2_CRK	245	249	PF00017	0.701
LIG_SH2_CRK	264	268	PF00017	0.406
LIG_SH2_CRK	288	292	PF00017	0.499
LIG_SH2_CRK	304	308	PF00017	0.580
LIG_SH2_CRK	334	338	PF00017	0.519
LIG_SH2_CRK	424	428	PF00017	0.489
LIG_SH2_CRK	475	479	PF00017	0.601
LIG_SH2_NCK_1	304	308	PF00017	0.622
LIG_SH2_NCK_1	579	583	PF00017	0.558
LIG_SH2_PTP2	803	806	PF00017	0.500
LIG_SH2_SRC	127	130	PF00017	0.535
LIG_SH2_SRC	803	806	PF00017	0.541
LIG_SH2_STAP1	195	199	PF00017	0.484
LIG_SH2_STAP1	245	249	PF00017	0.701
LIG_SH2_STAP1	334	338	PF00017	0.463
LIG_SH2_STAP1	483	487	PF00017	0.578
LIG_SH2_STAP1	510	514	PF00017	0.554
LIG_SH2_STAP1	691	695	PF00017	0.655
LIG_SH2_STAT3	691	694	PF00017	0.559
LIG_SH2_STAT5	245	248	PF00017	0.676
LIG_SH2_STAT5	612	615	PF00017	0.592
LIG_SH2_STAT5	789	792	PF00017	0.487
LIG_SH2_STAT5	803	806	PF00017	0.344
LIG_SH2_STAT5	820	823	PF00017	0.321
LIG_SH3_3	136	142	PF00018	0.495
LIG_SH3_3	212	218	PF00018	0.583
LIG_SH3_3	406	412	PF00018	0.448
LIG_SH3_3	44	50	PF00018	0.685
LIG_SH3_3	524	530	PF00018	0.550
LIG_SH3_3	660	666	PF00018	0.662
LIG_SH3_3	956	962	PF00018	0.419
LIG_SH3_3	997	1003	PF00018	0.569
LIG_SUMO_SIM_anti_2	104	112	PF11976	0.643
LIG_SUMO_SIM_anti_2	275	280	PF11976	0.565
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.525
LIG_SUMO_SIM_anti_2	969	975	PF11976	0.543
LIG_SUMO_SIM_par_1	104	112	PF11976	0.651
LIG_SUMO_SIM_par_1	259	265	PF11976	0.689
LIG_SUMO_SIM_par_1	275	280	PF11976	0.410
LIG_SUMO_SIM_par_1	309	316	PF11976	0.579
LIG_SUMO_SIM_par_1	914	921	PF11976	0.521
LIG_TRAF2_1	313	316	PF00917	0.489
LIG_TRAF2_1	765	768	PF00917	0.551
LIG_TYR_ITIM	193	198	PF00017	0.486
LIG_TYR_ITIM	422	427	PF00017	0.504
LIG_TYR_ITIM	473	478	PF00017	0.588
LIG_UBA3_1	368	373	PF00899	0.506
LIG_UBA3_1	581	588	PF00899	0.582
LIG_WRC_WIRS_1	750	755	PF05994	0.482
LIG_WRC_WIRS_1	941	946	PF05994	0.645
MOD_CDC14_SPxK_1	408	411	PF00782	0.551
MOD_CDK_SPxK_1	405	411	PF00069	0.541
MOD_CK1_1	107	113	PF00069	0.634
MOD_CK1_1	238	244	PF00069	0.729
MOD_CK1_1	270	276	PF00069	0.576
MOD_CK1_1	384	390	PF00069	0.428
MOD_CK1_1	39	45	PF00069	0.683
MOD_CK1_1	468	474	PF00069	0.602
MOD_CK1_1	491	497	PF00069	0.627
MOD_CK1_1	567	573	PF00069	0.471
MOD_CK1_1	634	640	PF00069	0.543
MOD_CK1_1	66	72	PF00069	0.534
MOD_CK1_1	737	743	PF00069	0.492
MOD_CK1_1	832	838	PF00069	0.472
MOD_CK1_1	862	868	PF00069	0.544
MOD_CK1_1	893	899	PF00069	0.444
MOD_CK1_1	911	917	PF00069	0.358
MOD_CK1_1	939	945	PF00069	0.575
MOD_CK1_1	97	103	PF00069	0.627
MOD_CK2_1	145	151	PF00069	0.533
MOD_CK2_1	248	254	PF00069	0.648
MOD_CK2_1	292	298	PF00069	0.493
MOD_CK2_1	503	509	PF00069	0.651
MOD_CK2_1	577	583	PF00069	0.484
MOD_CK2_1	703	709	PF00069	0.595
MOD_CK2_1	762	768	PF00069	0.539
MOD_CK2_1	918	924	PF00069	0.495
MOD_GlcNHglycan	229	232	PF01048	0.589
MOD_GlcNHglycan	237	240	PF01048	0.693
MOD_GlcNHglycan	264	267	PF01048	0.732
MOD_GlcNHglycan	272	275	PF01048	0.585
MOD_GlcNHglycan	467	470	PF01048	0.542
MOD_GlcNHglycan	493	496	PF01048	0.634
MOD_GlcNHglycan	511	514	PF01048	0.308
MOD_GlcNHglycan	670	673	PF01048	0.599
MOD_GlcNHglycan	764	767	PF01048	0.576
MOD_GlcNHglycan	831	834	PF01048	0.504
MOD_GlcNHglycan	838	841	PF01048	0.588
MOD_GlcNHglycan	901	904	PF01048	0.523
MOD_GlcNHglycan	910	913	PF01048	0.443
MOD_GlcNHglycan	945	948	PF01048	0.600
MOD_GlcNHglycan	949	952	PF01048	0.536
MOD_GlcNHglycan	96	99	PF01048	0.678
MOD_GSK3_1	37	44	PF00069	0.578
MOD_GSK3_1	377	384	PF00069	0.456
MOD_GSK3_1	407	414	PF00069	0.465
MOD_GSK3_1	504	511	PF00069	0.555
MOD_GSK3_1	521	528	PF00069	0.478
MOD_GSK3_1	544	551	PF00069	0.603
MOD_GSK3_1	577	584	PF00069	0.479
MOD_GSK3_1	606	613	PF00069	0.580
MOD_GSK3_1	66	73	PF00069	0.594
MOD_GSK3_1	694	701	PF00069	0.556
MOD_GSK3_1	785	792	PF00069	0.504
MOD_GSK3_1	818	825	PF00069	0.492
MOD_GSK3_1	832	839	PF00069	0.507
MOD_GSK3_1	84	91	PF00069	0.345
MOD_GSK3_1	864	871	PF00069	0.519
MOD_GSK3_1	908	915	PF00069	0.453
MOD_GSK3_1	918	925	PF00069	0.405
MOD_GSK3_1	931	938	PF00069	0.486
MOD_GSK3_1	939	946	PF00069	0.642
MOD_N-GLC_1	374	379	PF02516	0.590
MOD_N-GLC_1	88	93	PF02516	0.509
MOD_N-GLC_1	912	917	PF02516	0.437
MOD_N-GLC_1	935	940	PF02516	0.568
MOD_NEK2_1	12	17	PF00069	0.608
MOD_NEK2_1	154	159	PF00069	0.566
MOD_NEK2_1	165	170	PF00069	0.543
MOD_NEK2_1	248	253	PF00069	0.614
MOD_NEK2_1	381	386	PF00069	0.482
MOD_NEK2_1	508	513	PF00069	0.519
MOD_NEK2_1	521	526	PF00069	0.370
MOD_NEK2_1	544	549	PF00069	0.549
MOD_NEK2_1	589	594	PF00069	0.549
MOD_NEK2_1	614	619	PF00069	0.599
MOD_NEK2_1	628	633	PF00069	0.351
MOD_NEK2_1	644	649	PF00069	0.252
MOD_NEK2_1	668	673	PF00069	0.542
MOD_NEK2_1	703	708	PF00069	0.603
MOD_NEK2_1	734	739	PF00069	0.539
MOD_NEK2_1	785	790	PF00069	0.404
MOD_NEK2_1	856	861	PF00069	0.469
MOD_NEK2_1	868	873	PF00069	0.518
MOD_NEK2_1	945	950	PF00069	0.653
MOD_NEK2_2	299	304	PF00069	0.476
MOD_NEK2_2	949	954	PF00069	0.610
MOD_OFUCOSY	520	525	PF10250	0.559
MOD_PIKK_1	683	689	PF00454	0.595
MOD_PIKK_1	70	76	PF00454	0.602
MOD_PIKK_1	850	856	PF00454	0.451
MOD_PK_1	890	896	PF00069	0.579
MOD_PK_1	967	973	PF00069	0.444
MOD_PKA_1	504	510	PF00069	0.554
MOD_PKA_2	114	120	PF00069	0.618
MOD_PKA_2	243	249	PF00069	0.686
MOD_PKA_2	267	273	PF00069	0.667
MOD_PKA_2	332	338	PF00069	0.491
MOD_PKA_2	504	510	PF00069	0.595
MOD_PKA_2	567	573	PF00069	0.491
MOD_PKA_2	614	620	PF00069	0.638
MOD_PKA_2	703	709	PF00069	0.594
MOD_PKA_2	762	768	PF00069	0.539
MOD_PKA_2	856	862	PF00069	0.538
MOD_Plk_1	377	383	PF00069	0.541
MOD_Plk_1	689	695	PF00069	0.611
MOD_Plk_1	720	726	PF00069	0.650
MOD_Plk_1	88	94	PF00069	0.534
MOD_Plk_1	912	918	PF00069	0.546
MOD_Plk_2-3	918	924	PF00069	0.495
MOD_Plk_4	104	110	PF00069	0.592
MOD_Plk_4	272	278	PF00069	0.545
MOD_Plk_4	299	305	PF00069	0.450
MOD_Plk_4	306	312	PF00069	0.471
MOD_Plk_4	377	383	PF00069	0.502
MOD_Plk_4	41	47	PF00069	0.635
MOD_Plk_4	468	474	PF00069	0.602
MOD_Plk_4	488	494	PF00069	0.508
MOD_Plk_4	577	583	PF00069	0.425
MOD_Plk_4	676	682	PF00069	0.454
MOD_Plk_4	727	733	PF00069	0.569
MOD_Plk_4	749	755	PF00069	0.454
MOD_Plk_4	785	791	PF00069	0.524
MOD_Plk_4	818	824	PF00069	0.447
MOD_Plk_4	88	94	PF00069	0.548
MOD_Plk_4	890	896	PF00069	0.502
MOD_Plk_4	940	946	PF00069	0.611
MOD_Plk_4	969	975	PF00069	0.477
MOD_ProDKin_1	405	411	PF00069	0.470
MOD_ProDKin_1	615	621	PF00069	0.584
MOD_ProDKin_1	694	700	PF00069	0.670
MOD_ProDKin_1	931	937	PF00069	0.576
MOD_ProDKin_1	981	987	PF00069	0.431
MOD_ProDKin_1	989	995	PF00069	0.418
MOD_SUMO_for_1	161	164	PF00179	0.499
MOD_SUMO_rev_2	251	258	PF00179	0.612
MOD_SUMO_rev_2	765	772	PF00179	0.589
MOD_SUMO_rev_2	880	885	PF00179	0.470
MOD_SUMO_rev_2	924	931	PF00179	0.532
TRG_DiLeu_BaEn_1	104	109	PF01217	0.504
TRG_DiLeu_BaEn_1	151	156	PF01217	0.614
TRG_DiLeu_BaEn_1	969	974	PF01217	0.549
TRG_DiLeu_BaEn_2	228	234	PF01217	0.622
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.558
TRG_DiLeu_BaLyEn_6	664	669	PF01217	0.635
TRG_ENDOCYTIC_2	195	198	PF00928	0.485
TRG_ENDOCYTIC_2	245	248	PF00928	0.696
TRG_ENDOCYTIC_2	264	267	PF00928	0.404
TRG_ENDOCYTIC_2	288	291	PF00928	0.501
TRG_ENDOCYTIC_2	334	337	PF00928	0.522
TRG_ENDOCYTIC_2	424	427	PF00928	0.488
TRG_ENDOCYTIC_2	475	478	PF00928	0.637
TRG_ENDOCYTIC_2	579	582	PF00928	0.460
TRG_ENDOCYTIC_2	803	806	PF00928	0.470
TRG_ENDOCYTIC_2	820	823	PF00928	0.262
TRG_ER_diArg_1	614	616	PF00400	0.646
TRG_ER_diArg_1	645	648	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	99	104	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY6	Leptomonas seymouri	53%	100%
A0A1X0NXF3	Trypanosomatidae	25%	88%
A4HZ14	Leishmania infantum	100%	100%
C9ZIL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	85%
E9AIM8	Leishmania braziliensis	76%	100%
E9AUW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCM1	Leishmania major	91%	100%
V5BHE3	Trypanosoma cruzi	26%	100%