Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWB2_LEIDO

TriTrypDb:

LdBPK_210340.1 , LdCL_210008200 , LDHU3_21.0360

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.496
CLV_NRD_NRD_1	109	111	PF00675	0.585
CLV_NRD_NRD_1	113	115	PF00675	0.590
CLV_NRD_NRD_1	314	316	PF00675	0.561
CLV_NRD_NRD_1	434	436	PF00675	0.692
CLV_NRD_NRD_1	463	465	PF00675	0.457
CLV_NRD_NRD_1	490	492	PF00675	0.586
CLV_PCSK_FUR_1	312	316	PF00082	0.659
CLV_PCSK_KEX2_1	109	111	PF00082	0.542
CLV_PCSK_KEX2_1	113	115	PF00082	0.543
CLV_PCSK_KEX2_1	314	316	PF00082	0.579
CLV_PCSK_KEX2_1	434	436	PF00082	0.692
CLV_PCSK_KEX2_1	463	465	PF00082	0.457
CLV_PCSK_KEX2_1	490	492	PF00082	0.586
CLV_PCSK_PC7_1	109	115	PF00082	0.555
CLV_PCSK_SKI1_1	11	15	PF00082	0.540
CLV_PCSK_SKI1_1	133	137	PF00082	0.654
CLV_PCSK_SKI1_1	295	299	PF00082	0.462
CLV_PCSK_SKI1_1	322	326	PF00082	0.572
CLV_PCSK_SKI1_1	435	439	PF00082	0.545
CLV_PCSK_SKI1_1	464	468	PF00082	0.459
CLV_PCSK_SKI1_1	499	503	PF00082	0.450
CLV_PCSK_SKI1_1	81	85	PF00082	0.572
CLV_Separin_Metazoa	142	146	PF03568	0.551
DEG_Nend_Nbox_1	1	3	PF02207	0.557
DEG_SPOP_SBC_1	242	246	PF00917	0.647
DEG_SPOP_SBC_1	247	251	PF00917	0.614
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	410	416	PF00134	0.503
DOC_MAPK_gen_1	14	22	PF00069	0.576
DOC_MAPK_gen_1	289	298	PF00069	0.466
DOC_MAPK_gen_1	445	455	PF00069	0.465
DOC_MAPK_gen_1	463	470	PF00069	0.424
DOC_MAPK_gen_1	490	496	PF00069	0.574
DOC_MAPK_MEF2A_6	448	455	PF00069	0.559
DOC_MAPK_MEF2A_6	463	472	PF00069	0.349
DOC_PP1_RVXF_1	293	299	PF00149	0.461
DOC_PP2B_LxvP_1	151	154	PF13499	0.541
DOC_PP2B_LxvP_1	410	413	PF13499	0.472
DOC_PP4_FxxP_1	280	283	PF00568	0.591
DOC_PP4_FxxP_1	437	440	PF00568	0.529
DOC_USP7_MATH_1	122	126	PF00917	0.630
DOC_USP7_MATH_1	131	135	PF00917	0.700
DOC_USP7_MATH_1	209	213	PF00917	0.686
DOC_USP7_MATH_1	221	225	PF00917	0.567
DOC_USP7_MATH_1	227	231	PF00917	0.516
DOC_USP7_MATH_1	242	246	PF00917	0.547
DOC_USP7_MATH_1	252	256	PF00917	0.580
DOC_USP7_MATH_1	340	344	PF00917	0.542
DOC_USP7_MATH_1	38	42	PF00917	0.660
DOC_USP7_MATH_1	397	401	PF00917	0.490
DOC_USP7_MATH_1	474	478	PF00917	0.455
DOC_USP7_MATH_1	528	532	PF00917	0.568
DOC_WW_Pin1_4	212	217	PF00397	0.760
DOC_WW_Pin1_4	279	284	PF00397	0.471
DOC_WW_Pin1_4	28	33	PF00397	0.659
DOC_WW_Pin1_4	436	441	PF00397	0.571
DOC_WW_Pin1_4	81	86	PF00397	0.629
LIG_14-3-3_CanoR_1	113	119	PF00244	0.575
LIG_14-3-3_CanoR_1	133	143	PF00244	0.652
LIG_14-3-3_CanoR_1	186	194	PF00244	0.643
LIG_14-3-3_CanoR_1	289	299	PF00244	0.491
LIG_14-3-3_CanoR_1	322	327	PF00244	0.597
LIG_14-3-3_CanoR_1	70	76	PF00244	0.495
LIG_Actin_WH2_2	132	147	PF00022	0.583
LIG_BRCT_BRCA1_1	214	218	PF00533	0.549
LIG_BRCT_BRCA1_1	254	258	PF00533	0.546
LIG_CSL_BTD_1	213	216	PF09270	0.617
LIG_FHA_1	100	106	PF00498	0.478
LIG_FHA_1	134	140	PF00498	0.638
LIG_FHA_1	248	254	PF00498	0.616
LIG_FHA_1	291	297	PF00498	0.474
LIG_FHA_1	342	348	PF00498	0.504
LIG_FHA_1	396	402	PF00498	0.573
LIG_FHA_1	405	411	PF00498	0.448
LIG_FHA_1	520	526	PF00498	0.477
LIG_FHA_1	66	72	PF00498	0.489
LIG_FHA_1	88	94	PF00498	0.531
LIG_FHA_2	119	125	PF00498	0.624
LIG_FHA_2	223	229	PF00498	0.692
LIG_FHA_2	234	240	PF00498	0.627
LIG_FHA_2	315	321	PF00498	0.644
LIG_FHA_2	323	329	PF00498	0.642
LIG_GBD_Chelix_1	451	459	PF00786	0.424
LIG_LIR_Apic_2	74	80	PF02991	0.535
LIG_LIR_Gen_1	376	385	PF02991	0.547
LIG_LIR_Gen_1	481	487	PF02991	0.568
LIG_LIR_Gen_1	535	543	PF02991	0.417
LIG_LIR_LC3C_4	536	541	PF02991	0.354
LIG_LIR_Nem_3	376	380	PF02991	0.553
LIG_LIR_Nem_3	515	521	PF02991	0.462
LIG_LIR_Nem_3	535	540	PF02991	0.293
LIG_MYND_1	6	10	PF01753	0.446
LIG_Pex14_1	214	218	PF04695	0.549
LIG_SH2_CRK	77	81	PF00017	0.555
LIG_SH2_NCK_1	46	50	PF00017	0.560
LIG_SH2_PTP2	377	380	PF00017	0.545
LIG_SH2_STAP1	406	410	PF00017	0.460
LIG_SH2_STAP1	46	50	PF00017	0.560
LIG_SH2_STAT5	377	380	PF00017	0.577
LIG_SH2_STAT5	395	398	PF00017	0.634
LIG_SH2_STAT5	406	409	PF00017	0.424
LIG_SH2_STAT5	46	49	PF00017	0.482
LIG_SH3_3	140	146	PF00018	0.670
LIG_SH3_3	164	170	PF00018	0.600
LIG_SH3_3	195	201	PF00018	0.679
LIG_SH3_3	260	266	PF00018	0.628
LIG_SH3_3	4	10	PF00018	0.422
LIG_SH3_3	410	416	PF00018	0.503
LIG_SUMO_SIM_anti_2	102	109	PF11976	0.511
LIG_SUMO_SIM_anti_2	538	544	PF11976	0.421
LIG_SUMO_SIM_par_1	538	544	PF11976	0.416
LIG_TRAF2_1	188	191	PF00917	0.566
LIG_TRAF2_1	317	320	PF00917	0.619
LIG_TRAF2_1	417	420	PF00917	0.686
LIG_WRC_WIRS_1	469	474	PF05994	0.406
MOD_CDC14_SPxK_1	439	442	PF00782	0.505
MOD_CDK_SPK_2	212	217	PF00069	0.683
MOD_CDK_SPxK_1	436	442	PF00069	0.523
MOD_CK1_1	125	131	PF00069	0.752
MOD_CK1_1	134	140	PF00069	0.680
MOD_CK1_1	174	180	PF00069	0.560
MOD_CK1_1	212	218	PF00069	0.684
MOD_CK1_1	243	249	PF00069	0.706
MOD_CK1_1	282	288	PF00069	0.460
MOD_CK1_1	31	37	PF00069	0.631
MOD_CK1_1	430	436	PF00069	0.674
MOD_CK1_1	478	484	PF00069	0.490
MOD_CK1_1	535	541	PF00069	0.418
MOD_CK1_1	87	93	PF00069	0.532
MOD_CK2_1	185	191	PF00069	0.563
MOD_CK2_1	233	239	PF00069	0.752
MOD_CK2_1	297	303	PF00069	0.461
MOD_CK2_1	314	320	PF00069	0.575
MOD_CK2_1	340	346	PF00069	0.486
MOD_GlcNHglycan	127	130	PF01048	0.657
MOD_GlcNHglycan	173	176	PF01048	0.557
MOD_GlcNHglycan	211	214	PF01048	0.719
MOD_GlcNHglycan	219	222	PF01048	0.632
MOD_GlcNHglycan	231	234	PF01048	0.534
MOD_GlcNHglycan	245	248	PF01048	0.551
MOD_GlcNHglycan	250	253	PF01048	0.552
MOD_GlcNHglycan	328	332	PF01048	0.609
MOD_GlcNHglycan	40	43	PF01048	0.668
MOD_GlcNHglycan	428	432	PF01048	0.658
MOD_GlcNHglycan	530	533	PF01048	0.528
MOD_GlcNHglycan	86	89	PF01048	0.555
MOD_GSK3_1	114	121	PF00069	0.666
MOD_GSK3_1	212	219	PF00069	0.656
MOD_GSK3_1	229	236	PF00069	0.612
MOD_GSK3_1	237	244	PF00069	0.647
MOD_GSK3_1	248	255	PF00069	0.587
MOD_GSK3_1	27	34	PF00069	0.624
MOD_GSK3_1	298	305	PF00069	0.663
MOD_GSK3_1	40	47	PF00069	0.599
MOD_GSK3_1	468	475	PF00069	0.411
MOD_GSK3_1	528	535	PF00069	0.523
MOD_N-GLC_1	125	130	PF02516	0.550
MOD_NEK2_1	327	332	PF00069	0.521
MOD_NEK2_1	468	473	PF00069	0.504
MOD_NEK2_1	71	76	PF00069	0.532
MOD_NEK2_2	458	463	PF00069	0.441
MOD_NEK2_2	65	70	PF00069	0.496
MOD_OFUCOSY	279	286	PF10250	0.516
MOD_PIKK_1	453	459	PF00454	0.437
MOD_PIKK_1	485	491	PF00454	0.481
MOD_PKA_1	109	115	PF00069	0.555
MOD_PKA_1	314	320	PF00069	0.579
MOD_PKA_2	109	115	PF00069	0.597
MOD_PKA_2	144	150	PF00069	0.579
MOD_PKA_2	185	191	PF00069	0.636
MOD_PKA_2	216	222	PF00069	0.683
MOD_PKA_2	228	234	PF00069	0.586
MOD_PKA_2	314	320	PF00069	0.579
MOD_PKB_1	312	320	PF00069	0.617
MOD_Plk_1	327	333	PF00069	0.500
MOD_Plk_2-3	21	27	PF00069	0.583
MOD_Plk_4	114	120	PF00069	0.625
MOD_Plk_4	268	274	PF00069	0.715
MOD_Plk_4	31	37	PF00069	0.601
MOD_Plk_4	322	328	PF00069	0.506
MOD_Plk_4	373	379	PF00069	0.582
MOD_Plk_4	468	474	PF00069	0.405
MOD_Plk_4	478	484	PF00069	0.467
MOD_ProDKin_1	212	218	PF00069	0.761
MOD_ProDKin_1	279	285	PF00069	0.470
MOD_ProDKin_1	28	34	PF00069	0.661
MOD_ProDKin_1	436	442	PF00069	0.569
MOD_ProDKin_1	81	87	PF00069	0.625
MOD_SUMO_rev_2	493	501	PF00179	0.532
TRG_DiLeu_BaEn_1	103	108	PF01217	0.515
TRG_DiLeu_BaEn_4	319	325	PF01217	0.599
TRG_ENDOCYTIC_2	2	5	PF00928	0.520
TRG_ENDOCYTIC_2	377	380	PF00928	0.545
TRG_ENDOCYTIC_2	483	486	PF00928	0.504
TRG_ER_diArg_1	108	110	PF00400	0.529
TRG_ER_diArg_1	311	314	PF00400	0.610
TRG_ER_diArg_1	462	464	PF00400	0.447
TRG_NES_CRM1_1	97	111	PF08389	0.511
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7K7	Leptomonas seymouri	53%	94%
A4HBM6	Leishmania braziliensis	77%	99%
E9AUZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCI7	Leishmania major	92%	100%