TBC1 domain family member 20/GTPase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TBC1 domain family member 20/GTPase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WWA9_LEIDO

TriTrypDb:

LdBPK_201600.1 , LdCL_200020800 , LDHU3_20.1970

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WWA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWA9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0016192	vesicle-mediated transport	4	7
GO:0043085	positive regulation of catalytic activity	4	7
GO:0043087	regulation of GTPase activity	5	7
GO:0043547	positive regulation of GTPase activity	6	7
GO:0044093	positive regulation of molecular function	3	7
GO:0050790	regulation of catalytic activity	3	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051336	regulation of hydrolase activity	4	7
GO:0051345	positive regulation of hydrolase activity	5	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0009987	cellular process	1	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.742
CLV_C14_Caspase3-7	260	264	PF00656	0.587
CLV_NRD_NRD_1	150	152	PF00675	0.530
CLV_NRD_NRD_1	184	186	PF00675	0.503
CLV_NRD_NRD_1	226	228	PF00675	0.473
CLV_NRD_NRD_1	234	236	PF00675	0.457
CLV_NRD_NRD_1	306	308	PF00675	0.277
CLV_NRD_NRD_1	38	40	PF00675	0.351
CLV_NRD_NRD_1	572	574	PF00675	0.274
CLV_NRD_NRD_1	77	79	PF00675	0.337
CLV_PCSK_FUR_1	359	363	PF00082	0.326
CLV_PCSK_KEX2_1	184	186	PF00082	0.503
CLV_PCSK_KEX2_1	225	227	PF00082	0.493
CLV_PCSK_KEX2_1	234	236	PF00082	0.454
CLV_PCSK_KEX2_1	305	307	PF00082	0.277
CLV_PCSK_KEX2_1	361	363	PF00082	0.317
CLV_PCSK_KEX2_1	37	39	PF00082	0.364
CLV_PCSK_KEX2_1	536	538	PF00082	0.467
CLV_PCSK_KEX2_1	572	574	PF00082	0.274
CLV_PCSK_KEX2_1	79	81	PF00082	0.409
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.326
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.467
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.409
CLV_PCSK_PC7_1	301	307	PF00082	0.274
CLV_PCSK_SKI1_1	226	230	PF00082	0.521
CLV_PCSK_SKI1_1	234	238	PF00082	0.462
CLV_PCSK_SKI1_1	306	310	PF00082	0.274
CLV_PCSK_SKI1_1	314	318	PF00082	0.274
CLV_PCSK_SKI1_1	366	370	PF00082	0.264
CLV_PCSK_SKI1_1	572	576	PF00082	0.277
CLV_PCSK_SKI1_1	79	83	PF00082	0.369
CLV_Separin_Metazoa	192	196	PF03568	0.738
DEG_APCC_DBOX_1	225	233	PF00400	0.689
DEG_APCC_DBOX_1	304	312	PF00400	0.588
DEG_SPOP_SBC_1	19	23	PF00917	0.644
DOC_ANK_TNKS_1	71	78	PF00023	0.506
DOC_CYCLIN_RxL_1	309	321	PF00134	0.474
DOC_CYCLIN_RxL_1	567	578	PF00134	0.613
DOC_MAPK_gen_1	305	315	PF00069	0.506
DOC_MAPK_MEF2A_6	306	315	PF00069	0.482
DOC_MAPK_MEF2A_6	462	469	PF00069	0.618
DOC_PP1_RVXF_1	215	222	PF00149	0.662
DOC_PP1_RVXF_1	571	578	PF00149	0.474
DOC_PP2B_LxvP_1	191	194	PF13499	0.764
DOC_PP4_FxxP_1	124	127	PF00568	0.695
DOC_USP7_MATH_1	13	17	PF00917	0.670
DOC_USP7_MATH_1	179	183	PF00917	0.688
DOC_USP7_MATH_1	19	23	PF00917	0.583
DOC_USP7_MATH_1	565	569	PF00917	0.692
DOC_WW_Pin1_4	123	128	PF00397	0.696
DOC_WW_Pin1_4	20	25	PF00397	0.656
DOC_WW_Pin1_4	253	258	PF00397	0.725
DOC_WW_Pin1_4	337	342	PF00397	0.474
DOC_WW_Pin1_4	416	421	PF00397	0.436
LIG_14-3-3_CanoR_1	164	169	PF00244	0.716
LIG_14-3-3_CanoR_1	226	236	PF00244	0.659
LIG_14-3-3_CanoR_1	289	295	PF00244	0.526
LIG_14-3-3_CanoR_1	362	368	PF00244	0.477
LIG_14-3-3_CanoR_1	520	524	PF00244	0.570
LIG_14-3-3_CanoR_1	78	87	PF00244	0.591
LIG_APCC_ABBA_1	339	344	PF00400	0.474
LIG_EH1_1	375	383	PF00400	0.499
LIG_FHA_1	198	204	PF00498	0.780
LIG_FHA_1	409	415	PF00498	0.499
LIG_FHA_1	583	589	PF00498	0.332
LIG_FHA_2	341	347	PF00498	0.499
LIG_FHA_2	41	47	PF00498	0.543
LIG_FHA_2	451	457	PF00498	0.505
LIG_LIR_Apic_2	122	127	PF02991	0.691
LIG_LIR_Apic_2	270	275	PF02991	0.642
LIG_LIR_Apic_2	561	565	PF02991	0.634
LIG_LIR_Gen_1	343	351	PF02991	0.575
LIG_LIR_Gen_1	452	461	PF02991	0.523
LIG_LIR_Gen_1	513	523	PF02991	0.522
LIG_LIR_Nem_3	270	274	PF02991	0.648
LIG_LIR_Nem_3	290	295	PF02991	0.383
LIG_LIR_Nem_3	343	348	PF02991	0.582
LIG_LIR_Nem_3	358	363	PF02991	0.444
LIG_LIR_Nem_3	394	398	PF02991	0.474
LIG_LIR_Nem_3	428	432	PF02991	0.526
LIG_LIR_Nem_3	44	50	PF02991	0.535
LIG_LIR_Nem_3	452	458	PF02991	0.517
LIG_LIR_Nem_3	513	518	PF02991	0.551
LIG_MYND_1	189	193	PF01753	0.743
LIG_NRBOX	312	318	PF00104	0.474
LIG_NRBOX	504	510	PF00104	0.528
LIG_Pex14_2	442	446	PF04695	0.427
LIG_Rb_LxCxE_1	27	46	PF01857	0.573
LIG_Rb_pABgroove_1	421	429	PF01858	0.474
LIG_SH2_CRK	325	329	PF00017	0.474
LIG_SH2_CRK	486	490	PF00017	0.514
LIG_SH2_CRK	515	519	PF00017	0.553
LIG_SH2_GRB2like	47	50	PF00017	0.650
LIG_SH2_SRC	413	416	PF00017	0.481
LIG_SH2_STAP1	376	380	PF00017	0.474
LIG_SH2_STAP1	404	408	PF00017	0.526
LIG_SH2_STAP1	50	54	PF00017	0.511
LIG_SH2_STAT5	342	345	PF00017	0.488
LIG_SH2_STAT5	413	416	PF00017	0.499
LIG_SH2_STAT5	429	432	PF00017	0.482
LIG_SH2_STAT5	441	444	PF00017	0.535
LIG_SH2_STAT5	515	518	PF00017	0.566
LIG_SH3_3	190	196	PF00018	0.793
LIG_SH3_3	217	223	PF00018	0.660
LIG_SH3_3	262	268	PF00018	0.693
LIG_SUMO_SIM_anti_2	475	483	PF11976	0.584
LIG_SUMO_SIM_par_1	346	353	PF11976	0.474
LIG_TRAF2_1	461	464	PF00917	0.574
LIG_TRFH_1	337	341	PF08558	0.310
LIG_UBA3_1	454	462	PF00899	0.378
LIG_WRC_WIRS_1	121	126	PF05994	0.616
LIG_WW_3	192	196	PF00397	0.692
MOD_CK1_1	120	126	PF00069	0.676
MOD_CK1_1	155	161	PF00069	0.663
MOD_CK1_1	167	173	PF00069	0.643
MOD_CK1_1	230	236	PF00069	0.677
MOD_CK1_1	290	296	PF00069	0.383
MOD_CK1_1	340	346	PF00069	0.345
MOD_CK1_1	416	422	PF00069	0.293
MOD_CK1_1	9	15	PF00069	0.660
MOD_CK2_1	249	255	PF00069	0.631
MOD_CK2_1	340	346	PF00069	0.340
MOD_CK2_1	347	353	PF00069	0.284
MOD_CK2_1	446	452	PF00069	0.326
MOD_Cter_Amidation	76	79	PF01082	0.389
MOD_GlcNHglycan	11	14	PF01048	0.777
MOD_GlcNHglycan	117	120	PF01048	0.647
MOD_GlcNHglycan	15	18	PF01048	0.608
MOD_GlcNHglycan	153	157	PF01048	0.702
MOD_GlcNHglycan	211	214	PF01048	0.598
MOD_GlcNHglycan	363	366	PF01048	0.310
MOD_GlcNHglycan	433	439	PF01048	0.370
MOD_GlcNHglycan	56	59	PF01048	0.506
MOD_GSK3_1	104	111	PF00069	0.576
MOD_GSK3_1	152	159	PF00069	0.685
MOD_GSK3_1	163	170	PF00069	0.611
MOD_GSK3_1	175	182	PF00069	0.605
MOD_GSK3_1	249	256	PF00069	0.586
MOD_GSK3_1	295	302	PF00069	0.389
MOD_GSK3_1	4	11	PF00069	0.671
MOD_GSK3_1	404	411	PF00069	0.395
MOD_GSK3_1	446	453	PF00069	0.276
MOD_GSK3_1	465	472	PF00069	0.645
MOD_GSK3_1	487	494	PF00069	0.390
MOD_GSK3_1	539	546	PF00069	0.469
MOD_GSK3_1	96	103	PF00069	0.585
MOD_LATS_1	110	116	PF00433	0.590
MOD_N-GLC_1	108	113	PF02516	0.623
MOD_N-GLC_1	253	258	PF02516	0.662
MOD_N-GLC_1	48	53	PF02516	0.499
MOD_NEK2_1	163	168	PF00069	0.639
MOD_NEK2_1	261	266	PF00069	0.580
MOD_NEK2_1	355	360	PF00069	0.340
MOD_NEK2_1	446	451	PF00069	0.310
MOD_NEK2_1	465	470	PF00069	0.670
MOD_NEK2_1	48	53	PF00069	0.418
MOD_NEK2_1	54	59	PF00069	0.400
MOD_NEK2_1	575	580	PF00069	0.313
MOD_NEK2_1	8	13	PF00069	0.634
MOD_NEK2_2	179	184	PF00069	0.579
MOD_PIKK_1	227	233	PF00454	0.568
MOD_PIKK_1	446	452	PF00454	0.299
MOD_PKA_1	361	367	PF00069	0.310
MOD_PKA_1	79	85	PF00069	0.480
MOD_PKA_2	163	169	PF00069	0.661
MOD_PKA_2	361	367	PF00069	0.376
MOD_PKA_2	450	456	PF00069	0.291
MOD_PKA_2	519	525	PF00069	0.478
MOD_PKA_2	79	85	PF00069	0.480
MOD_PKB_1	185	193	PF00069	0.640
MOD_PKB_1	225	233	PF00069	0.576
MOD_Plk_1	159	165	PF00069	0.709
MOD_Plk_1	287	293	PF00069	0.310
MOD_Plk_1	48	54	PF00069	0.495
MOD_Plk_1	96	102	PF00069	0.576
MOD_Plk_2-3	347	353	PF00069	0.310
MOD_Plk_4	261	267	PF00069	0.558
MOD_Plk_4	404	410	PF00069	0.501
MOD_Plk_4	450	456	PF00069	0.296
MOD_Plk_4	48	54	PF00069	0.370
MOD_ProDKin_1	123	129	PF00069	0.621
MOD_ProDKin_1	20	26	PF00069	0.558
MOD_ProDKin_1	253	259	PF00069	0.661
MOD_ProDKin_1	337	343	PF00069	0.310
MOD_ProDKin_1	416	422	PF00069	0.258
MOD_SUMO_for_1	461	464	PF00179	0.399
MOD_SUMO_for_1	566	569	PF00179	0.524
MOD_SUMO_rev_2	212	219	PF00179	0.554
TRG_DiLeu_BaEn_2	525	531	PF01217	0.403
TRG_DiLeu_BaEn_4	526	532	PF01217	0.404
TRG_ENDOCYTIC_2	325	328	PF00928	0.310
TRG_ENDOCYTIC_2	429	432	PF00928	0.383
TRG_ENDOCYTIC_2	486	489	PF00928	0.362
TRG_ENDOCYTIC_2	50	53	PF00928	0.343
TRG_ENDOCYTIC_2	515	518	PF00928	0.427
TRG_ER_diArg_1	183	185	PF00400	0.636
TRG_ER_diArg_1	224	227	PF00400	0.597
TRG_ER_diArg_1	234	236	PF00400	0.562
TRG_ER_diArg_1	305	307	PF00400	0.356
TRG_ER_diArg_1	37	39	PF00400	0.413
TRG_ER_diArg_1	571	573	PF00400	0.528
TRG_ER_diArg_1	78	81	PF00400	0.486
TRG_NES_CRM1_1	421	435	PF08389	0.383
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P406	Leptomonas seymouri	55%	100%
A4HYZ3	Leishmania infantum	99%	100%
E9AIL1	Leishmania braziliensis	75%	100%
E9AUU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCN9	Leishmania major	93%	100%