Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WWA1_LEIDO

TriTrypDb:

LdBPK_210200.1 , LdCL_210006800 , LDHU3_21.0200

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WWA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WWA1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	619	623	PF00656	0.469
CLV_NRD_NRD_1	155	157	PF00675	0.384
CLV_NRD_NRD_1	413	415	PF00675	0.492
CLV_NRD_NRD_1	565	567	PF00675	0.405
CLV_NRD_NRD_1	570	572	PF00675	0.379
CLV_NRD_NRD_1	632	634	PF00675	0.627
CLV_PCSK_FUR_1	153	157	PF00082	0.464
CLV_PCSK_KEX2_1	155	157	PF00082	0.384
CLV_PCSK_KEX2_1	247	249	PF00082	0.507
CLV_PCSK_KEX2_1	565	567	PF00082	0.369
CLV_PCSK_KEX2_1	570	572	PF00082	0.365
CLV_PCSK_KEX2_1	632	634	PF00082	0.627
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.525
CLV_PCSK_PC7_1	566	572	PF00082	0.387
CLV_PCSK_SKI1_1	104	108	PF00082	0.431
CLV_PCSK_SKI1_1	15	19	PF00082	0.665
CLV_PCSK_SKI1_1	179	183	PF00082	0.375
CLV_PCSK_SKI1_1	209	213	PF00082	0.363
CLV_PCSK_SKI1_1	219	223	PF00082	0.324
CLV_PCSK_SKI1_1	369	373	PF00082	0.385
CLV_PCSK_SKI1_1	459	463	PF00082	0.321
CLV_PCSK_SKI1_1	66	70	PF00082	0.480
CLV_PCSK_SKI1_1	95	99	PF00082	0.439
DEG_APCC_DBOX_1	103	111	PF00400	0.341
DEG_Nend_UBRbox_3	1	3	PF02207	0.515
DEG_SCF_FBW7_1	361	368	PF00400	0.452
DEG_SPOP_SBC_1	327	331	PF00917	0.387
DEG_SPOP_SBC_1	83	87	PF00917	0.495
DOC_CKS1_1	362	367	PF01111	0.449
DOC_CKS1_1	401	406	PF01111	0.435
DOC_CYCLIN_RxL_1	152	162	PF00134	0.353
DOC_CYCLIN_RxL_1	366	377	PF00134	0.501
DOC_MAPK_gen_1	247	253	PF00069	0.481
DOC_MAPK_gen_1	98	107	PF00069	0.428
DOC_PP1_RVXF_1	153	160	PF00149	0.339
DOC_PP1_RVXF_1	207	213	PF00149	0.368
DOC_PP1_RVXF_1	217	223	PF00149	0.323
DOC_PP1_RVXF_1	259	266	PF00149	0.455
DOC_PP1_RVXF_1	367	374	PF00149	0.367
DOC_PP1_RVXF_1	447	454	PF00149	0.411
DOC_PP4_FxxP_1	341	344	PF00568	0.508
DOC_USP7_MATH_1	139	143	PF00917	0.391
DOC_USP7_MATH_1	22	26	PF00917	0.694
DOC_USP7_MATH_1	28	32	PF00917	0.451
DOC_USP7_MATH_1	365	369	PF00917	0.406
DOC_USP7_MATH_1	83	87	PF00917	0.483
DOC_WW_Pin1_4	184	189	PF00397	0.446
DOC_WW_Pin1_4	26	31	PF00397	0.716
DOC_WW_Pin1_4	340	345	PF00397	0.497
DOC_WW_Pin1_4	361	366	PF00397	0.445
DOC_WW_Pin1_4	400	405	PF00397	0.424
DOC_WW_Pin1_4	465	470	PF00397	0.329
DOC_WW_Pin1_4	519	524	PF00397	0.365
LIG_14-3-3_CanoR_1	109	118	PF00244	0.479
LIG_14-3-3_CanoR_1	15	23	PF00244	0.554
LIG_14-3-3_CanoR_1	238	242	PF00244	0.592
LIG_14-3-3_CanoR_1	290	296	PF00244	0.439
LIG_14-3-3_CanoR_1	393	398	PF00244	0.487
LIG_14-3-3_CanoR_1	613	618	PF00244	0.503
LIG_Actin_WH2_2	65	81	PF00022	0.593
LIG_BRCT_BRCA1_1	177	181	PF00533	0.354
LIG_CaM_IQ_9	87	103	PF13499	0.392
LIG_deltaCOP1_diTrp_1	146	154	PF00928	0.299
LIG_deltaCOP1_diTrp_1	434	440	PF00928	0.358
LIG_deltaCOP1_diTrp_1	452	458	PF00928	0.364
LIG_deltaCOP1_diTrp_1	506	514	PF00928	0.495
LIG_EVH1_2	291	295	PF00568	0.491
LIG_FHA_1	111	117	PF00498	0.443
LIG_FHA_1	16	22	PF00498	0.553
LIG_FHA_1	193	199	PF00498	0.354
LIG_FHA_1	216	222	PF00498	0.313
LIG_FHA_1	223	229	PF00498	0.294
LIG_FHA_1	27	33	PF00498	0.686
LIG_FHA_1	304	310	PF00498	0.413
LIG_FHA_1	329	335	PF00498	0.387
LIG_FHA_1	362	368	PF00498	0.505
LIG_FHA_1	85	91	PF00498	0.534
LIG_FHA_2	452	458	PF00498	0.479
LIG_FHA_2	483	489	PF00498	0.494
LIG_FHA_2	539	545	PF00498	0.513
LIG_FHA_2	594	600	PF00498	0.493
LIG_GBD_Chelix_1	64	72	PF00786	0.391
LIG_LIR_Apic_2	557	562	PF02991	0.372
LIG_LIR_Gen_1	146	154	PF02991	0.315
LIG_LIR_Gen_1	168	177	PF02991	0.330
LIG_LIR_Gen_1	396	405	PF02991	0.572
LIG_LIR_Gen_1	452	461	PF02991	0.424
LIG_LIR_Nem_3	146	151	PF02991	0.295
LIG_LIR_Nem_3	168	173	PF02991	0.391
LIG_LIR_Nem_3	396	401	PF02991	0.591
LIG_LIR_Nem_3	452	456	PF02991	0.380
LIG_LIR_Nem_3	457	461	PF02991	0.308
LIG_LIR_Nem_3	506	511	PF02991	0.413
LIG_NRP_CendR_1	638	640	PF00754	0.579
LIG_PCNA_PIPBox_1	296	305	PF02747	0.335
LIG_PCNA_yPIPBox_3	393	401	PF02747	0.573
LIG_Pex14_2	241	245	PF04695	0.504
LIG_REV1ctd_RIR_1	370	380	PF16727	0.426
LIG_SH2_CRK	217	221	PF00017	0.346
LIG_SH2_NCK_1	579	583	PF00017	0.544
LIG_SH2_PTP2	559	562	PF00017	0.362
LIG_SH2_STAP1	112	116	PF00017	0.459
LIG_SH2_STAP1	217	221	PF00017	0.322
LIG_SH2_STAP1	579	583	PF00017	0.449
LIG_SH2_STAT5	112	115	PF00017	0.458
LIG_SH2_STAT5	217	220	PF00017	0.327
LIG_SH2_STAT5	230	233	PF00017	0.384
LIG_SH2_STAT5	303	306	PF00017	0.364
LIG_SH2_STAT5	398	401	PF00017	0.485
LIG_SH2_STAT5	4	7	PF00017	0.611
LIG_SH2_STAT5	44	47	PF00017	0.560
LIG_SH2_STAT5	559	562	PF00017	0.375
LIG_SH3_3	285	291	PF00018	0.419
LIG_SH3_3	341	347	PF00018	0.421
LIG_SH3_3	352	358	PF00018	0.446
LIG_SH3_3	633	639	PF00018	0.587
LIG_SUMO_SIM_par_1	310	318	PF11976	0.379
LIG_SUMO_SIM_par_1	522	528	PF11976	0.339
LIG_TRAF2_1	525	528	PF00917	0.536
LIG_TRAF2_1	86	89	PF00917	0.456
LIG_TRAF2_2	55	60	PF00917	0.495
LIG_TYR_ITIM	215	220	PF00017	0.360
LIG_UBA3_1	617	621	PF00899	0.478
MOD_CDK_SPK_2	465	470	PF00069	0.329
MOD_CK1_1	189	195	PF00069	0.479
MOD_CK1_1	37	43	PF00069	0.614
MOD_CK2_1	237	243	PF00069	0.623
MOD_CK2_1	322	328	PF00069	0.588
MOD_CK2_1	451	457	PF00069	0.489
MOD_CK2_1	538	544	PF00069	0.485
MOD_CK2_1	593	599	PF00069	0.588
MOD_CK2_1	82	88	PF00069	0.544
MOD_GlcNHglycan	24	27	PF01048	0.589
MOD_GlcNHglycan	376	379	PF01048	0.361
MOD_GlcNHglycan	434	438	PF01048	0.462
MOD_GlcNHglycan	48	51	PF01048	0.584
MOD_GlcNHglycan	622	625	PF01048	0.559
MOD_GlcNHglycan	95	98	PF01048	0.615
MOD_GSK3_1	189	196	PF00069	0.383
MOD_GSK3_1	22	29	PF00069	0.625
MOD_GSK3_1	222	229	PF00069	0.349
MOD_GSK3_1	318	325	PF00069	0.572
MOD_GSK3_1	33	40	PF00069	0.594
MOD_GSK3_1	361	368	PF00069	0.427
MOD_GSK3_1	44	51	PF00069	0.581
MOD_N-GLC_1	393	398	PF02516	0.477
MOD_N-GLC_1	519	524	PF02516	0.427
MOD_NEK2_1	159	164	PF00069	0.362
MOD_NEK2_1	222	227	PF00069	0.319
MOD_NEK2_1	32	37	PF00069	0.629
MOD_NEK2_1	372	377	PF00069	0.386
MOD_NEK2_1	38	43	PF00069	0.592
MOD_NEK2_1	443	448	PF00069	0.456
MOD_NEK2_1	531	536	PF00069	0.349
MOD_NEK2_1	575	580	PF00069	0.411
MOD_NEK2_1	620	625	PF00069	0.455
MOD_NEK2_1	93	98	PF00069	0.538
MOD_NEK2_2	169	174	PF00069	0.438
MOD_NEK2_2	74	79	PF00069	0.475
MOD_PIKK_1	587	593	PF00454	0.547
MOD_PK_1	393	399	PF00069	0.478
MOD_PKA_2	237	243	PF00069	0.568
MOD_PKB_1	184	192	PF00069	0.447
MOD_Plk_1	365	371	PF00069	0.378
MOD_Plk_1	393	399	PF00069	0.478
MOD_Plk_1	451	457	PF00069	0.479
MOD_Plk_2-3	593	599	PF00069	0.496
MOD_Plk_4	186	192	PF00069	0.511
MOD_Plk_4	222	228	PF00069	0.301
MOD_Plk_4	28	34	PF00069	0.600
MOD_Plk_4	393	399	PF00069	0.478
MOD_Plk_4	531	537	PF00069	0.365
MOD_Plk_4	555	561	PF00069	0.378
MOD_Plk_4	613	619	PF00069	0.497
MOD_ProDKin_1	184	190	PF00069	0.436
MOD_ProDKin_1	26	32	PF00069	0.718
MOD_ProDKin_1	340	346	PF00069	0.488
MOD_ProDKin_1	361	367	PF00069	0.434
MOD_ProDKin_1	400	406	PF00069	0.418
MOD_ProDKin_1	465	471	PF00069	0.325
MOD_ProDKin_1	519	525	PF00069	0.361
MOD_SUMO_rev_2	468	477	PF00179	0.368
MOD_SUMO_rev_2	616	623	PF00179	0.480
TRG_DiLeu_BaEn_1	473	478	PF01217	0.346
TRG_DiLeu_BaEn_1	599	604	PF01217	0.456
TRG_DiLeu_BaEn_2	456	462	PF01217	0.329
TRG_DiLeu_BaEn_2	485	491	PF01217	0.378
TRG_DiLeu_BaEn_3	88	94	PF01217	0.440
TRG_DiLeu_BaEn_4	424	430	PF01217	0.455
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.446
TRG_DiLeu_BaLyEn_6	494	499	PF01217	0.318
TRG_ENDOCYTIC_2	217	220	PF00928	0.351
TRG_ENDOCYTIC_2	398	401	PF00928	0.575
TRG_ER_diArg_1	154	156	PF00400	0.370
TRG_ER_diArg_1	565	567	PF00400	0.389
TRG_ER_diArg_1	570	572	PF00400	0.359
TRG_ER_diArg_1	637	640	PF00400	0.705
TRG_NES_CRM1_1	544	557	PF08389	0.479
TRG_NLS_MonoExtN_4	411	418	PF00514	0.478
TRG_NLS_MonoExtN_4	509	516	PF00514	0.392
TRG_Pf-PMV_PEXEL_1	354	359	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X2	Leptomonas seymouri	72%	96%
A0A0S4IQX1	Bodo saltans	44%	100%
A0A1X0NXS1	Trypanosomatidae	64%	94%
A4HBL3	Leishmania braziliensis	93%	100%
A4HZJ6	Leishmania infantum	100%	100%
D0A1K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	99%
E9AUY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QCK1	Leishmania major	98%	100%
V5DGX7	Trypanosoma cruzi	61%	95%