Hypothetical_protein_conserved

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WW97_LEIDO

TriTrypDb:

LdBPK_201490.1 , LdCL_200019600 , LDHU3_20.1860

Length:

145

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WW97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.475
CLV_NRD_NRD_1	133	135	PF00675	0.553
CLV_NRD_NRD_1	39	41	PF00675	0.472
CLV_NRD_NRD_1	48	50	PF00675	0.462
CLV_PCSK_KEX2_1	100	102	PF00082	0.397
CLV_PCSK_KEX2_1	132	134	PF00082	0.551
CLV_PCSK_KEX2_1	82	84	PF00082	0.561
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.561
DEG_ODPH_VHL_1	14	27	PF01847	0.447
DEG_SIAH_1	113	121	PF03145	0.499
DOC_MAPK_gen_1	100	109	PF00069	0.433
DOC_USP7_MATH_1	141	145	PF00917	0.707
DOC_USP7_MATH_1	42	46	PF00917	0.624
DOC_WW_Pin1_4	18	23	PF00397	0.550
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_FHA_1	121	127	PF00498	0.537
LIG_FHA_1	19	25	PF00498	0.610
LIG_FHA_1	30	36	PF00498	0.620
LIG_FHA_2	21	27	PF00498	0.511
LIG_GBD_Chelix_1	68	76	PF00786	0.537
LIG_SH3_3	111	117	PF00018	0.611
LIG_SH3_3	59	65	PF00018	0.514
LIG_TRAF2_1	10	13	PF00917	0.486
LIG_TRAF2_1	53	56	PF00917	0.536
LIG_TRAF2_1	77	80	PF00917	0.527
LIG_TRAF2_1	93	96	PF00917	0.338
LIG_UBA3_1	72	81	PF00899	0.569
LIG_WRC_WIRS_1	121	126	PF05994	0.396
LIG_WW_3	46	50	PF00397	0.594
MOD_CK2_1	20	26	PF00069	0.517
MOD_CK2_1	72	78	PF00069	0.480
MOD_GlcNHglycan	1	4	PF01048	0.658
MOD_GlcNHglycan	91	94	PF01048	0.574
MOD_GSK3_1	64	71	PF00069	0.517
MOD_N-GLC_1	109	114	PF02516	0.530
MOD_NEK2_1	72	77	PF00069	0.470
MOD_PIKK_1	91	97	PF00454	0.589
MOD_Plk_1	127	133	PF00069	0.452
MOD_Plk_4	120	126	PF00069	0.585
MOD_Plk_4	20	26	PF00069	0.469
MOD_Plk_4	64	70	PF00069	0.532
MOD_ProDKin_1	18	24	PF00069	0.552
MOD_SUMO_rev_2	75	84	PF00179	0.477
TRG_ER_diArg_1	131	134	PF00400	0.544
TRG_ER_diArg_1	99	101	PF00400	0.534
TRG_NLS_MonoCore_2	39	44	PF00514	0.483
TRG_NLS_MonoExtN_4	37	44	PF00514	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD35	Leptomonas seymouri	69%	100%
A0A0S4ISW9	Bodo saltans	38%	74%
A0A1X0NW52	Trypanosomatidae	43%	78%
A0A3R7N8A8	Trypanosoma rangeli	42%	81%
A4HYY7	Leishmania infantum	100%	100%
C9ZIJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	86%
E9AIK1	Leishmania braziliensis	80%	100%
E9AUT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QCQ0	Leishmania major	94%	100%