Nucleolar protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nucleolar protein 9

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WW94_LEIDO

TriTrypDb:

LdBPK_210230.1 , LdCL_210007100 , LDHU3_21.0230

Length:

766

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030686	90S preribosome	4	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7WW94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW94

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0000056	ribosomal small subunit export from nucleus	4	1
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000966	RNA 5'-end processing	7	1
GO:0000967	rRNA 5'-end processing	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031503	protein-containing complex localization	2	1
GO:0033750	ribosome localization	3	1
GO:0034470	ncRNA processing	7	1
GO:0034471	ncRNA 5'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0036260	RNA capping	7	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.775
CLV_C14_Caspase3-7	74	78	PF00656	0.482
CLV_NRD_NRD_1	35	37	PF00675	0.541
CLV_NRD_NRD_1	420	422	PF00675	0.518
CLV_NRD_NRD_1	491	493	PF00675	0.532
CLV_NRD_NRD_1	633	635	PF00675	0.402
CLV_NRD_NRD_1	722	724	PF00675	0.484
CLV_NRD_NRD_1	740	742	PF00675	0.439
CLV_NRD_NRD_1	760	762	PF00675	0.326
CLV_PCSK_KEX2_1	34	36	PF00082	0.534
CLV_PCSK_KEX2_1	420	422	PF00082	0.518
CLV_PCSK_KEX2_1	445	447	PF00082	0.454
CLV_PCSK_KEX2_1	625	627	PF00082	0.495
CLV_PCSK_KEX2_1	633	635	PF00082	0.358
CLV_PCSK_KEX2_1	722	724	PF00082	0.563
CLV_PCSK_KEX2_1	760	762	PF00082	0.533
CLV_PCSK_KEX2_1	9	11	PF00082	0.658
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.454
CLV_PCSK_PC1ET2_1	625	627	PF00082	0.603
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.658
CLV_PCSK_SKI1_1	118	122	PF00082	0.389
CLV_PCSK_SKI1_1	309	313	PF00082	0.406
CLV_PCSK_SKI1_1	420	424	PF00082	0.432
CLV_PCSK_SKI1_1	426	430	PF00082	0.396
CLV_PCSK_SKI1_1	446	450	PF00082	0.182
CLV_PCSK_SKI1_1	523	527	PF00082	0.526
CLV_PCSK_SKI1_1	547	551	PF00082	0.421
CLV_PCSK_SKI1_1	664	668	PF00082	0.438
CLV_PCSK_SKI1_1	760	764	PF00082	0.588
CLV_PCSK_SKI1_1	85	89	PF00082	0.497
DEG_APCC_DBOX_1	308	316	PF00400	0.421
DEG_APCC_DBOX_1	568	576	PF00400	0.512
DEG_SCF_FBW7_1	687	692	PF00400	0.611
DOC_CDC14_PxL_1	430	438	PF14671	0.463
DOC_CYCLIN_RxL_1	757	766	PF00134	0.652
DOC_MAPK_DCC_7	500	508	PF00069	0.521
DOC_MAPK_gen_1	209	218	PF00069	0.377
DOC_MAPK_gen_1	566	575	PF00069	0.488
DOC_MAPK_gen_1	625	631	PF00069	0.494
DOC_MAPK_gen_1	741	748	PF00069	0.502
DOC_MAPK_HePTP_8	206	218	PF00069	0.419
DOC_MAPK_MEF2A_6	118	125	PF00069	0.391
DOC_MAPK_MEF2A_6	209	218	PF00069	0.389
DOC_MAPK_MEF2A_6	375	384	PF00069	0.510
DOC_MAPK_MEF2A_6	420	429	PF00069	0.407
DOC_MAPK_MEF2A_6	500	508	PF00069	0.486
DOC_PP2B_LxvP_1	329	332	PF13499	0.447
DOC_PP2B_LxvP_1	407	410	PF13499	0.398
DOC_PP2B_LxvP_1	594	597	PF13499	0.561
DOC_PP4_FxxP_1	431	434	PF00568	0.509
DOC_PP4_FxxP_1	457	460	PF00568	0.568
DOC_USP7_MATH_1	135	139	PF00917	0.395
DOC_USP7_MATH_1	210	214	PF00917	0.410
DOC_USP7_MATH_1	274	278	PF00917	0.409
DOC_USP7_MATH_1	348	352	PF00917	0.616
DOC_USP7_MATH_1	396	400	PF00917	0.516
DOC_USP7_MATH_1	448	452	PF00917	0.501
DOC_USP7_MATH_1	554	558	PF00917	0.426
DOC_USP7_MATH_1	610	614	PF00917	0.660
DOC_USP7_MATH_1	621	625	PF00917	0.354
DOC_USP7_MATH_1	687	691	PF00917	0.735
DOC_USP7_MATH_1	695	699	PF00917	0.713
DOC_USP7_MATH_1	71	75	PF00917	0.524
DOC_USP7_MATH_1	89	93	PF00917	0.351
DOC_USP7_MATH_2	11	17	PF00917	0.690
DOC_USP7_UBL2_3	489	493	PF12436	0.466
DOC_WW_Pin1_4	131	136	PF00397	0.395
DOC_WW_Pin1_4	156	161	PF00397	0.312
DOC_WW_Pin1_4	24	29	PF00397	0.594
DOC_WW_Pin1_4	259	264	PF00397	0.480
DOC_WW_Pin1_4	456	461	PF00397	0.668
DOC_WW_Pin1_4	499	504	PF00397	0.519
DOC_WW_Pin1_4	683	688	PF00397	0.769
DOC_WW_Pin1_4	715	720	PF00397	0.597
LIG_14-3-3_CanoR_1	209	215	PF00244	0.482
LIG_14-3-3_CanoR_1	22	28	PF00244	0.556
LIG_14-3-3_CanoR_1	285	293	PF00244	0.463
LIG_14-3-3_CanoR_1	633	643	PF00244	0.448
LIG_14-3-3_CanoR_1	679	687	PF00244	0.645
LIG_14-3-3_CterR_2	761	766	PF00244	0.672
LIG_Actin_RPEL_3	96	115	PF02755	0.418
LIG_Actin_WH2_2	199	214	PF00022	0.508
LIG_APCC_ABBA_1	672	677	PF00400	0.494
LIG_eIF4E_1	139	145	PF01652	0.476
LIG_eIF4E_1	306	312	PF01652	0.529
LIG_eIF4E_1	400	406	PF01652	0.399
LIG_FAT_LD_1	141	149	PF03623	0.438
LIG_FHA_1	274	280	PF00498	0.505
LIG_FHA_1	333	339	PF00498	0.553
LIG_FHA_1	379	385	PF00498	0.557
LIG_FHA_1	396	402	PF00498	0.281
LIG_FHA_1	471	477	PF00498	0.722
LIG_FHA_2	156	162	PF00498	0.569
LIG_FHA_2	239	245	PF00498	0.438
LIG_FHA_2	470	476	PF00498	0.517
LIG_FHA_2	711	717	PF00498	0.674
LIG_IRF3_LxIS_1	128	134	PF10401	0.488
LIG_LIR_Gen_1	119	128	PF02991	0.381
LIG_LIR_Gen_1	17	28	PF02991	0.617
LIG_LIR_Gen_1	327	336	PF02991	0.509
LIG_LIR_Gen_1	645	655	PF02991	0.488
LIG_LIR_Gen_1	743	749	PF02991	0.400
LIG_LIR_Gen_1	77	87	PF02991	0.414
LIG_LIR_LC3C_4	276	280	PF02991	0.482
LIG_LIR_Nem_3	119	125	PF02991	0.374
LIG_LIR_Nem_3	17	23	PF02991	0.618
LIG_LIR_Nem_3	327	331	PF02991	0.449
LIG_LIR_Nem_3	641	647	PF02991	0.452
LIG_LIR_Nem_3	743	748	PF02991	0.435
LIG_LIR_Nem_3	77	83	PF02991	0.411
LIG_LIR_Nem_3	90	96	PF02991	0.442
LIG_MYND_1	434	438	PF01753	0.527
LIG_NRBOX	140	146	PF00104	0.471
LIG_NRBOX	311	317	PF00104	0.381
LIG_NRBOX	82	88	PF00104	0.424
LIG_PCNA_yPIPBox_3	630	643	PF02747	0.494
LIG_PCNA_yPIPBox_3	751	763	PF02747	0.518
LIG_Rb_pABgroove_1	425	433	PF01858	0.502
LIG_SH2_CRK	501	505	PF00017	0.515
LIG_SH2_NCK_1	501	505	PF00017	0.495
LIG_SH2_NCK_1	656	660	PF00017	0.502
LIG_SH2_PTP2	122	125	PF00017	0.404
LIG_SH2_PTP2	588	591	PF00017	0.488
LIG_SH2_SRC	603	606	PF00017	0.518
LIG_SH2_STAP1	644	648	PF00017	0.445
LIG_SH2_STAT3	400	403	PF00017	0.409
LIG_SH2_STAT5	122	125	PF00017	0.404
LIG_SH2_STAT5	139	142	PF00017	0.394
LIG_SH2_STAT5	328	331	PF00017	0.370
LIG_SH2_STAT5	400	403	PF00017	0.431
LIG_SH2_STAT5	51	54	PF00017	0.439
LIG_SH2_STAT5	531	534	PF00017	0.418
LIG_SH2_STAT5	588	591	PF00017	0.402
LIG_SH2_STAT5	738	741	PF00017	0.501
LIG_SH2_STAT5	94	97	PF00017	0.491
LIG_SH3_3	226	232	PF00018	0.562
LIG_SH3_3	268	274	PF00018	0.517
LIG_SH3_3	328	334	PF00018	0.409
LIG_SH3_3	419	425	PF00018	0.470
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.410
LIG_SUMO_SIM_anti_2	570	577	PF11976	0.533
LIG_SUMO_SIM_par_1	380	385	PF11976	0.515
LIG_TRAF2_1	249	252	PF00917	0.518
LIG_TRAF2_1	351	354	PF00917	0.678
LIG_TRAF2_1	58	61	PF00917	0.471
LIG_TRFH_1	452	456	PF08558	0.585
LIG_TYR_ITIM	120	125	PF00017	0.393
LIG_TYR_ITIM	499	504	PF00017	0.433
LIG_UBA3_1	572	580	PF00899	0.476
LIG_UBA3_1	83	88	PF00899	0.449
LIG_WRC_WIRS_1	449	454	PF05994	0.587
MOD_CDK_SPxxK_3	24	31	PF00069	0.592
MOD_CDK_SPxxK_3	715	722	PF00069	0.564
MOD_CK1_1	182	188	PF00069	0.418
MOD_CK1_1	24	30	PF00069	0.589
MOD_CK1_1	349	355	PF00069	0.703
MOD_CK1_1	613	619	PF00069	0.637
MOD_CK1_1	638	644	PF00069	0.499
MOD_CK1_1	682	688	PF00069	0.734
MOD_CK1_1	698	704	PF00069	0.712
MOD_CK2_1	155	161	PF00069	0.578
MOD_CK2_1	186	192	PF00069	0.512
MOD_CK2_1	238	244	PF00069	0.477
MOD_CK2_1	259	265	PF00069	0.548
MOD_CK2_1	348	354	PF00069	0.676
MOD_CK2_1	469	475	PF00069	0.707
MOD_Cter_Amidation	7	10	PF01082	0.710
MOD_GlcNHglycan	152	155	PF01048	0.474
MOD_GlcNHglycan	177	180	PF01048	0.518
MOD_GlcNHglycan	182	185	PF01048	0.414
MOD_GlcNHglycan	3	6	PF01048	0.706
MOD_GlcNHglycan	348	351	PF01048	0.594
MOD_GlcNHglycan	63	66	PF01048	0.584
MOD_GlcNHglycan	682	685	PF01048	0.753
MOD_GlcNHglycan	689	692	PF01048	0.705
MOD_GlcNHglycan	700	703	PF01048	0.619
MOD_GSK3_1	131	138	PF00069	0.386
MOD_GSK3_1	140	147	PF00069	0.367
MOD_GSK3_1	175	182	PF00069	0.509
MOD_GSK3_1	284	291	PF00069	0.517
MOD_GSK3_1	348	355	PF00069	0.658
MOD_GSK3_1	356	363	PF00069	0.727
MOD_GSK3_1	367	374	PF00069	0.497
MOD_GSK3_1	378	385	PF00069	0.435
MOD_GSK3_1	470	477	PF00069	0.691
MOD_GSK3_1	634	641	PF00069	0.517
MOD_GSK3_1	679	686	PF00069	0.708
MOD_N-GLC_1	710	715	PF02516	0.686
MOD_N-GLC_1	97	102	PF02516	0.430
MOD_NEK2_1	144	149	PF00069	0.423
MOD_NEK2_1	155	160	PF00069	0.473
MOD_NEK2_1	186	191	PF00069	0.507
MOD_NEK2_1	316	321	PF00069	0.497
MOD_NEK2_1	635	640	PF00069	0.495
MOD_NEK2_1	667	672	PF00069	0.463
MOD_NEK2_2	219	224	PF00069	0.441
MOD_NEK2_2	89	94	PF00069	0.483
MOD_PIKK_1	146	152	PF00454	0.489
MOD_PIKK_1	677	683	PF00454	0.658
MOD_PIKK_1	717	723	PF00454	0.536
MOD_PKA_2	21	27	PF00069	0.550
MOD_PKA_2	284	290	PF00069	0.478
MOD_PKA_2	346	352	PF00069	0.590
MOD_Plk_1	45	51	PF00069	0.464
MOD_Plk_1	89	95	PF00069	0.477
MOD_Plk_2-3	13	19	PF00069	0.674
MOD_Plk_2-3	288	294	PF00069	0.468
MOD_Plk_4	116	122	PF00069	0.384
MOD_Plk_4	140	146	PF00069	0.379
MOD_Plk_4	182	188	PF00069	0.420
MOD_Plk_4	274	280	PF00069	0.393
MOD_Plk_4	288	294	PF00069	0.420
MOD_Plk_4	324	330	PF00069	0.455
MOD_Plk_4	396	402	PF00069	0.532
MOD_Plk_4	478	484	PF00069	0.564
MOD_Plk_4	555	561	PF00069	0.447
MOD_Plk_4	579	585	PF00069	0.397
MOD_Plk_4	638	644	PF00069	0.439
MOD_Plk_4	667	673	PF00069	0.484
MOD_Plk_4	71	77	PF00069	0.454
MOD_Plk_4	89	95	PF00069	0.505
MOD_ProDKin_1	131	137	PF00069	0.390
MOD_ProDKin_1	156	162	PF00069	0.304
MOD_ProDKin_1	24	30	PF00069	0.594
MOD_ProDKin_1	259	265	PF00069	0.479
MOD_ProDKin_1	456	462	PF00069	0.669
MOD_ProDKin_1	499	505	PF00069	0.517
MOD_ProDKin_1	683	689	PF00069	0.772
MOD_ProDKin_1	715	721	PF00069	0.590
TRG_DiLeu_BaEn_1	383	388	PF01217	0.521
TRG_DiLeu_BaEn_1	82	87	PF01217	0.415
TRG_DiLeu_BaEn_2	543	549	PF01217	0.511
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.476
TRG_DiLeu_BaLyEn_6	754	759	PF01217	0.502
TRG_ENDOCYTIC_2	122	125	PF00928	0.385
TRG_ENDOCYTIC_2	328	331	PF00928	0.370
TRG_ENDOCYTIC_2	501	504	PF00928	0.430
TRG_ENDOCYTIC_2	531	534	PF00928	0.430
TRG_ENDOCYTIC_2	588	591	PF00928	0.488
TRG_ENDOCYTIC_2	647	650	PF00928	0.487
TRG_ENDOCYTIC_2	675	678	PF00928	0.435
TRG_ENDOCYTIC_2	727	730	PF00928	0.501
TRG_ER_diArg_1	297	300	PF00400	0.410
TRG_ER_diArg_1	34	36	PF00400	0.549
TRG_ER_diArg_1	419	421	PF00400	0.472
TRG_ER_diArg_1	521	524	PF00400	0.478
TRG_ER_diArg_1	632	634	PF00400	0.405
TRG_ER_diArg_1	722	724	PF00400	0.482
TRG_ER_diArg_1	759	761	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	761	766	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K4	Leptomonas seymouri	67%	97%
A0A0S4J166	Bodo saltans	34%	100%
A0A1X0NXL8	Trypanosomatidae	42%	96%
A0A3S5IR95	Trypanosoma rangeli	40%	100%
A4HBL6	Leishmania braziliensis	83%	100%
A4HZA4	Leishmania infantum	100%	100%
D0A1L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AUY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCJ8	Leishmania major	93%	100%
V5B0J8	Trypanosoma cruzi	44%	100%