Major Facilitator Superfamily, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WW86_LEIDO

TriTrypDb:

LdBPK_210120.1 , LdCL_210006100 , LDHU3_21.0130

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A0A3S7WW86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW86

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	13
GO:0022857	transmembrane transporter activity	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.501
CLV_PCSK_SKI1_1	317	321	PF00082	0.229
CLV_PCSK_SKI1_1	412	416	PF00082	0.592
CLV_PCSK_SKI1_1	73	77	PF00082	0.216
DOC_CDC14_PxL_1	165	173	PF14671	0.348
DOC_CYCLIN_RxL_1	170	181	PF00134	0.317
DOC_CYCLIN_RxL_1	46	58	PF00134	0.253
DOC_MAPK_gen_1	317	325	PF00069	0.429
DOC_MAPK_gen_1	9	19	PF00069	0.418
DOC_MAPK_MEF2A_6	12	21	PF00069	0.411
DOC_MAPK_MEF2A_6	77	85	PF00069	0.490
DOC_PP1_RVXF_1	171	178	PF00149	0.317
DOC_PP1_RVXF_1	318	325	PF00149	0.427
DOC_USP7_MATH_1	105	109	PF00917	0.289
DOC_USP7_MATH_1	223	227	PF00917	0.428
DOC_WW_Pin1_4	123	128	PF00397	0.249
DOC_WW_Pin1_4	338	343	PF00397	0.356
LIG_14-3-3_CanoR_1	146	156	PF00244	0.427
LIG_14-3-3_CanoR_1	440	446	PF00244	0.507
LIG_Actin_WH2_2	67	84	PF00022	0.282
LIG_APCC_ABBA_1	273	278	PF00400	0.348
LIG_BRCT_BRCA1_1	152	156	PF00533	0.414
LIG_BRCT_BRCA1_1	265	269	PF00533	0.302
LIG_BRCT_BRCA1_1	284	288	PF00533	0.154
LIG_BRCT_BRCA1_1	410	414	PF00533	0.382
LIG_FHA_1	107	113	PF00498	0.275
LIG_FHA_1	128	134	PF00498	0.289
LIG_FHA_1	170	176	PF00498	0.283
LIG_FHA_1	426	432	PF00498	0.271
LIG_FHA_2	137	143	PF00498	0.396
LIG_FHA_2	179	185	PF00498	0.289
LIG_FHA_2	339	345	PF00498	0.417
LIG_FHA_2	74	80	PF00498	0.459
LIG_FHA_2	87	93	PF00498	0.314
LIG_LIR_Apic_2	137	143	PF02991	0.290
LIG_LIR_Apic_2	248	253	PF02991	0.517
LIG_LIR_Gen_1	153	163	PF02991	0.336
LIG_LIR_Gen_1	176	185	PF02991	0.195
LIG_LIR_Gen_1	193	203	PF02991	0.217
LIG_LIR_Gen_1	270	280	PF02991	0.342
LIG_LIR_Gen_1	355	363	PF02991	0.429
LIG_LIR_Gen_1	4	14	PF02991	0.522
LIG_LIR_Nem_3	108	113	PF02991	0.234
LIG_LIR_Nem_3	11	17	PF02991	0.460
LIG_LIR_Nem_3	153	159	PF02991	0.355
LIG_LIR_Nem_3	162	168	PF02991	0.281
LIG_LIR_Nem_3	176	180	PF02991	0.151
LIG_LIR_Nem_3	181	186	PF02991	0.239
LIG_LIR_Nem_3	270	275	PF02991	0.379
LIG_LIR_Nem_3	278	283	PF02991	0.223
LIG_LIR_Nem_3	285	291	PF02991	0.212
LIG_LIR_Nem_3	293	298	PF02991	0.307
LIG_LIR_Nem_3	355	359	PF02991	0.356
LIG_LIR_Nem_3	4	10	PF02991	0.586
LIG_LIR_Nem_3	444	448	PF02991	0.507
LIG_LIR_Nem_3	57	62	PF02991	0.283
LIG_LIR_Nem_3	67	71	PF02991	0.259
LIG_LIR_Nem_3	76	81	PF02991	0.407
LIG_MLH1_MIPbox_1	410	414	PF16413	0.382
LIG_PDZ_Class_3	452	457	PF00595	0.531
LIG_Pex14_1	272	276	PF04695	0.269
LIG_Pex14_2	64	68	PF04695	0.292
LIG_PTB_Apo_2	331	338	PF02174	0.289
LIG_REV1ctd_RIR_1	4	13	PF16727	0.456
LIG_SH2_CRK	14	18	PF00017	0.227
LIG_SH2_CRK	407	411	PF00017	0.270
LIG_SH2_CRK	78	82	PF00017	0.509
LIG_SH2_NCK_1	376	380	PF00017	0.440
LIG_SH2_PTP2	165	168	PF00017	0.314
LIG_SH2_STAP1	183	187	PF00017	0.270
LIG_SH2_STAP1	280	284	PF00017	0.263
LIG_SH2_STAP1	376	380	PF00017	0.475
LIG_SH2_STAT3	448	451	PF00017	0.602
LIG_SH2_STAT5	165	168	PF00017	0.270
LIG_SH2_STAT5	300	303	PF00017	0.272
LIG_SH2_STAT5	309	312	PF00017	0.240
LIG_SH2_STAT5	314	317	PF00017	0.389
LIG_SH2_STAT5	321	324	PF00017	0.235
LIG_SH2_STAT5	448	451	PF00017	0.542
LIG_SH3_3	121	127	PF00018	0.270
LIG_SH3_3	194	200	PF00018	0.348
LIG_SUMO_SIM_anti_2	238	244	PF11976	0.519
LIG_SxIP_EBH_1	62	73	PF03271	0.240
LIG_TRAF2_1	385	388	PF00917	0.564
LIG_TYR_ITIM	163	168	PF00017	0.270
LIG_TYR_ITIM	260	265	PF00017	0.446
LIG_TYR_ITIM	374	379	PF00017	0.286
LIG_TYR_ITIM	405	410	PF00017	0.314
LIG_WRC_WIRS_1	291	296	PF05994	0.289
LIG_WRC_WIRS_1	65	70	PF05994	0.240
MOD_CDK_SPxxK_3	338	345	PF00069	0.356
MOD_CK1_1	134	140	PF00069	0.270
MOD_CK1_1	178	184	PF00069	0.412
MOD_CK1_1	221	227	PF00069	0.317
MOD_CK1_1	241	247	PF00069	0.321
MOD_CK1_1	248	254	PF00069	0.228
MOD_CK2_1	136	142	PF00069	0.354
MOD_CK2_1	178	184	PF00069	0.270
MOD_CK2_1	393	399	PF00069	0.270
MOD_CK2_1	86	92	PF00069	0.355
MOD_GlcNHglycan	121	124	PF01048	0.326
MOD_GlcNHglycan	133	136	PF01048	0.270
MOD_GlcNHglycan	177	180	PF01048	0.382
MOD_GlcNHglycan	204	207	PF01048	0.366
MOD_GlcNHglycan	220	223	PF01048	0.446
MOD_GlcNHglycan	265	268	PF01048	0.308
MOD_GlcNHglycan	269	272	PF01048	0.321
MOD_GlcNHglycan	390	393	PF01048	0.270
MOD_GSK3_1	119	126	PF00069	0.336
MOD_GSK3_1	127	134	PF00069	0.270
MOD_GSK3_1	155	162	PF00069	0.279
MOD_GSK3_1	169	176	PF00069	0.250
MOD_GSK3_1	209	216	PF00069	0.286
MOD_GSK3_1	241	248	PF00069	0.342
MOD_GSK3_1	263	270	PF00069	0.276
MOD_GSK3_1	278	285	PF00069	0.263
MOD_GSK3_1	408	415	PF00069	0.383
MOD_GSK3_1	417	424	PF00069	0.271
MOD_N-GLC_1	441	446	PF02516	0.359
MOD_NEK2_1	136	141	PF00069	0.335
MOD_NEK2_1	155	160	PF00069	0.140
MOD_NEK2_1	175	180	PF00069	0.120
MOD_NEK2_1	218	223	PF00069	0.412
MOD_NEK2_1	276	281	PF00069	0.307
MOD_NEK2_1	313	318	PF00069	0.291
MOD_NEK2_1	325	330	PF00069	0.224
MOD_NEK2_1	352	357	PF00069	0.382
MOD_NEK2_1	425	430	PF00069	0.287
MOD_NEK2_1	55	60	PF00069	0.320
MOD_NEK2_1	64	69	PF00069	0.302
MOD_NEK2_2	271	276	PF00069	0.282
MOD_NEK2_2	290	295	PF00069	0.120
MOD_PIKK_1	241	247	PF00454	0.396
MOD_PKA_1	173	179	PF00069	0.306
MOD_PKA_2	147	153	PF00069	0.270
MOD_Plk_1	213	219	PF00069	0.405
MOD_Plk_1	343	349	PF00069	0.354
MOD_Plk_1	380	386	PF00069	0.302
MOD_Plk_1	441	447	PF00069	0.363
MOD_Plk_4	136	142	PF00069	0.396
MOD_Plk_4	150	156	PF00069	0.396
MOD_Plk_4	178	184	PF00069	0.299
MOD_Plk_4	290	296	PF00069	0.352
MOD_Plk_4	305	311	PF00069	0.195
MOD_Plk_4	345	351	PF00069	0.305
MOD_Plk_4	352	358	PF00069	0.275
MOD_Plk_4	64	70	PF00069	0.361
MOD_ProDKin_1	123	129	PF00069	0.249
MOD_ProDKin_1	338	344	PF00069	0.356
TRG_DiLeu_BaEn_1	238	243	PF01217	0.348
TRG_DiLeu_BaEn_3	286	292	PF01217	0.306
TRG_ENDOCYTIC_2	14	17	PF00928	0.227
TRG_ENDOCYTIC_2	165	168	PF00928	0.270
TRG_ENDOCYTIC_2	183	186	PF00928	0.261
TRG_ENDOCYTIC_2	262	265	PF00928	0.340
TRG_ENDOCYTIC_2	280	283	PF00928	0.158
TRG_ENDOCYTIC_2	321	324	PF00928	0.305
TRG_ENDOCYTIC_2	376	379	PF00928	0.287
TRG_ENDOCYTIC_2	407	410	PF00928	0.319
TRG_ENDOCYTIC_2	78	81	PF00928	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJH4	Leptomonas seymouri	80%	99%
A0A0S4J692	Bodo saltans	23%	76%
A0A0S4J989	Bodo saltans	49%	92%
A0A1X0NWR8	Trypanosomatidae	24%	95%
A0A1X0NXK8	Trypanosomatidae	65%	100%
A0A3R7NE20	Trypanosoma rangeli	61%	100%
A0A3S7WUW1	Leishmania donovani	23%	100%
A4H9A1	Leishmania braziliensis	23%	100%
A4HBK5	Leishmania braziliensis	90%	100%
A4HXM1	Leishmania infantum	23%	100%
B2RXV4	Mus musculus	23%	82%
E9AGU5	Leishmania infantum	100%	100%
E9ARB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AUX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O01735	Caenorhabditis elegans	23%	78%
P60815	Rattus norvegicus	21%	84%
Q4QCK8	Leishmania major	96%	100%
Q4QE46	Leishmania major	23%	100%
Q6GNV7	Xenopus laevis	21%	100%
Q91X85	Mus musculus	21%	83%
Q9ES43	Mus terricolor	23%	82%
Q9N1F2	Felis catus	23%	82%
Q9UPI3	Homo sapiens	21%	87%
Q9Y5Y0	Homo sapiens	23%	82%
V5BQV3	Trypanosoma cruzi	25%	83%
V5DGX2	Trypanosoma cruzi	60%	100%