DNA topoisomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA topoisomerase

Gene product:

DNA topoisomerase 1A

Species:

Leishmania donovani

UniProt:

A0A3S7WW83_LEIDO

TriTrypDb:

LdBPK_210180.1 , LdCL_210006600 , LDHU3_21.0180

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WW83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW83

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006265	DNA topological change	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	12
GO:0071103	DNA conformation change	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003916	DNA topoisomerase activity	3	12
GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	4	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.515
CLV_C14_Caspase3-7	238	242	PF00656	0.446
CLV_C14_Caspase3-7	405	409	PF00656	0.401
CLV_C14_Caspase3-7	728	732	PF00656	0.518
CLV_NRD_NRD_1	106	108	PF00675	0.218
CLV_NRD_NRD_1	172	174	PF00675	0.356
CLV_NRD_NRD_1	3	5	PF00675	0.484
CLV_NRD_NRD_1	378	380	PF00675	0.373
CLV_NRD_NRD_1	398	400	PF00675	0.321
CLV_NRD_NRD_1	445	447	PF00675	0.287
CLV_NRD_NRD_1	751	753	PF00675	0.434
CLV_NRD_NRD_1	798	800	PF00675	0.657
CLV_PCSK_KEX2_1	106	108	PF00082	0.218
CLV_PCSK_KEX2_1	172	174	PF00082	0.495
CLV_PCSK_KEX2_1	3	5	PF00082	0.484
CLV_PCSK_KEX2_1	378	380	PF00082	0.310
CLV_PCSK_KEX2_1	383	385	PF00082	0.435
CLV_PCSK_KEX2_1	398	400	PF00082	0.164
CLV_PCSK_KEX2_1	445	447	PF00082	0.311
CLV_PCSK_KEX2_1	698	700	PF00082	0.511
CLV_PCSK_KEX2_1	720	722	PF00082	0.444
CLV_PCSK_KEX2_1	751	753	PF00082	0.434
CLV_PCSK_KEX2_1	798	800	PF00082	0.678
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.459
CLV_PCSK_PC1ET2_1	698	700	PF00082	0.527
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.498
CLV_PCSK_PC7_1	379	385	PF00082	0.310
CLV_PCSK_SKI1_1	148	152	PF00082	0.296
CLV_PCSK_SKI1_1	20	24	PF00082	0.221
CLV_PCSK_SKI1_1	320	324	PF00082	0.310
CLV_PCSK_SKI1_1	383	387	PF00082	0.269
CLV_PCSK_SKI1_1	592	596	PF00082	0.293
CLV_PCSK_SKI1_1	642	646	PF00082	0.385
CLV_PCSK_SKI1_1	67	71	PF00082	0.256
CLV_PCSK_SKI1_1	720	724	PF00082	0.360
CLV_PCSK_SKI1_1	737	741	PF00082	0.377
DEG_MDM2_SWIB_1	96	103	PF02201	0.515
DEG_Nend_Nbox_1	1	3	PF02207	0.557
DEG_SPOP_SBC_1	73	77	PF00917	0.493
DEG_SPOP_SBC_1	763	767	PF00917	0.562
DOC_CDC14_PxL_1	723	731	PF14671	0.402
DOC_CKS1_1	221	226	PF01111	0.246
DOC_CYCLIN_RxL_1	378	390	PF00134	0.371
DOC_CYCLIN_RxL_1	684	697	PF00134	0.388
DOC_MAPK_gen_1	3	14	PF00069	0.433
DOC_MAPK_gen_1	445	451	PF00069	0.357
DOC_MAPK_gen_1	457	465	PF00069	0.209
DOC_MAPK_gen_1	545	551	PF00069	0.406
DOC_MAPK_MEF2A_6	148	156	PF00069	0.411
DOC_MAPK_MEF2A_6	220	228	PF00069	0.261
DOC_MAPK_MEF2A_6	445	453	PF00069	0.435
DOC_MAPK_MEF2A_6	457	465	PF00069	0.321
DOC_MAPK_MEF2A_6	560	567	PF00069	0.360
DOC_MAPK_RevD_3	589	604	PF00069	0.190
DOC_PP1_RVXF_1	65	72	PF00149	0.422
DOC_PP2B_LxvP_1	154	157	PF13499	0.411
DOC_USP7_MATH_1	296	300	PF00917	0.288
DOC_USP7_MATH_1	656	660	PF00917	0.554
DOC_USP7_MATH_1	73	77	PF00917	0.474
DOC_USP7_MATH_1	763	767	PF00917	0.637
DOC_USP7_UBL2_3	791	795	PF12436	0.708
DOC_USP7_UBL2_3	805	809	PF12436	0.755
DOC_WW_Pin1_4	14	19	PF00397	0.416
DOC_WW_Pin1_4	220	225	PF00397	0.271
DOC_WW_Pin1_4	267	272	PF00397	0.415
DOC_WW_Pin1_4	303	308	PF00397	0.321
DOC_WW_Pin1_4	313	318	PF00397	0.286
DOC_WW_Pin1_4	498	503	PF00397	0.287
DOC_WW_Pin1_4	559	564	PF00397	0.391
DOC_WW_Pin1_4	607	612	PF00397	0.261
DOC_WW_Pin1_4	69	74	PF00397	0.440
DOC_WW_Pin1_4	701	706	PF00397	0.585
DOC_WW_Pin1_4	793	798	PF00397	0.656
LIG_14-3-3_CanoR_1	262	269	PF00244	0.397
LIG_14-3-3_CanoR_1	3	7	PF00244	0.476
LIG_14-3-3_CanoR_1	445	450	PF00244	0.267
LIG_14-3-3_CanoR_1	583	588	PF00244	0.279
LIG_14-3-3_CanoR_1	597	603	PF00244	0.329
LIG_14-3-3_CanoR_1	621	625	PF00244	0.326
LIG_14-3-3_CanoR_1	684	694	PF00244	0.506
LIG_14-3-3_CanoR_1	721	730	PF00244	0.425
LIG_14-3-3_CanoR_1	737	746	PF00244	0.391
LIG_14-3-3_CanoR_1	81	88	PF00244	0.515
LIG_BRCT_BRCA1_1	489	493	PF00533	0.391
LIG_Clathr_ClatBox_1	12	16	PF01394	0.411
LIG_CSL_BTD_1	70	73	PF09270	0.457
LIG_deltaCOP1_diTrp_1	36	39	PF00928	0.411
LIG_deltaCOP1_diTrp_1	486	493	PF00928	0.261
LIG_EH1_1	321	329	PF00400	0.339
LIG_EVH1_2	318	322	PF00568	0.261
LIG_EVH1_2	563	567	PF00568	0.310
LIG_FHA_1	122	128	PF00498	0.432
LIG_FHA_1	221	227	PF00498	0.246
LIG_FHA_1	244	250	PF00498	0.290
LIG_FHA_1	446	452	PF00498	0.328
LIG_FHA_1	456	462	PF00498	0.289
LIG_FHA_1	607	613	PF00498	0.261
LIG_FHA_1	687	693	PF00498	0.486
LIG_FHA_1	717	723	PF00498	0.356
LIG_FHA_2	128	134	PF00498	0.435
LIG_FHA_2	361	367	PF00498	0.261
LIG_FHA_2	419	425	PF00498	0.456
LIG_FHA_2	47	53	PF00498	0.515
LIG_FHA_2	502	508	PF00498	0.333
LIG_FHA_2	81	87	PF00498	0.472
LIG_LIR_Apic_2	651	655	PF02991	0.342
LIG_LIR_Gen_1	372	380	PF02991	0.282
LIG_LIR_Gen_1	60	69	PF02991	0.436
LIG_LIR_Gen_1	738	746	PF02991	0.344
LIG_LIR_Gen_1	97	108	PF02991	0.435
LIG_LIR_Nem_3	149	154	PF02991	0.417
LIG_LIR_Nem_3	197	203	PF02991	0.246
LIG_LIR_Nem_3	372	377	PF02991	0.282
LIG_LIR_Nem_3	525	531	PF02991	0.282
LIG_LIR_Nem_3	585	590	PF02991	0.246
LIG_LIR_Nem_3	60	66	PF02991	0.461
LIG_LIR_Nem_3	623	627	PF02991	0.268
LIG_LIR_Nem_3	670	675	PF02991	0.351
LIG_LIR_Nem_3	735	739	PF02991	0.361
LIG_LIR_Nem_3	97	103	PF02991	0.422
LIG_LYPXL_yS_3	587	590	PF13949	0.246
LIG_PCNA_PIPBox_1	196	205	PF02747	0.261
LIG_PCNA_PIPBox_1	743	752	PF02747	0.348
LIG_PCNA_yPIPBox_3	106	116	PF02747	0.435
LIG_PCNA_yPIPBox_3	737	750	PF02747	0.356
LIG_Pex14_1	333	337	PF04695	0.135
LIG_Pex14_1	489	493	PF04695	0.261
LIG_Pex14_2	632	636	PF04695	0.246
LIG_Pex14_2	668	672	PF04695	0.338
LIG_Pex14_2	96	100	PF04695	0.515
LIG_SH2_CRK	210	214	PF00017	0.410
LIG_SH2_CRK	374	378	PF00017	0.261
LIG_SH2_CRK	441	445	PF00017	0.315
LIG_SH2_GRB2like	210	213	PF00017	0.391
LIG_SH2_NCK_1	184	188	PF00017	0.280
LIG_SH2_NCK_1	210	214	PF00017	0.391
LIG_SH2_PTP2	599	602	PF00017	0.246
LIG_SH2_SRC	210	213	PF00017	0.391
LIG_SH2_SRC	239	242	PF00017	0.310
LIG_SH2_STAP1	337	341	PF00017	0.391
LIG_SH2_STAT5	115	118	PF00017	0.515
LIG_SH2_STAT5	239	242	PF00017	0.348
LIG_SH2_STAT5	254	257	PF00017	0.307
LIG_SH2_STAT5	354	357	PF00017	0.370
LIG_SH2_STAT5	599	602	PF00017	0.246
LIG_SH2_STAT5	663	666	PF00017	0.300
LIG_SH2_STAT5	675	678	PF00017	0.310
LIG_SH2_STAT5	749	752	PF00017	0.432
LIG_SH3_1	560	566	PF00018	0.262
LIG_SH3_1	801	807	PF00018	0.513
LIG_SH3_2	804	809	PF14604	0.507
LIG_SH3_3	12	18	PF00018	0.435
LIG_SH3_3	218	224	PF00018	0.277
LIG_SH3_3	312	318	PF00018	0.282
LIG_SH3_3	430	436	PF00018	0.391
LIG_SH3_3	481	487	PF00018	0.257
LIG_SH3_3	515	521	PF00018	0.316
LIG_SH3_3	558	564	PF00018	0.246
LIG_SH3_3	578	584	PF00018	0.246
LIG_SH3_3	702	708	PF00018	0.429
LIG_SH3_3	801	807	PF00018	0.513
LIG_SUMO_SIM_anti_2	10	17	PF11976	0.275
LIG_SUMO_SIM_anti_2	458	465	PF11976	0.267
LIG_SUMO_SIM_par_1	10	17	PF11976	0.259
LIG_SUMO_SIM_par_1	225	231	PF11976	0.246
LIG_TRAF2_1	174	177	PF00917	0.386
LIG_TRAF2_1	426	429	PF00917	0.310
LIG_UBA3_1	226	230	PF00899	0.190
LIG_UBA3_1	453	457	PF00899	0.317
LIG_UBA3_1	572	577	PF00899	0.261
LIG_WRC_WIRS_1	665	670	PF05994	0.350
LIG_WRC_WIRS_1	736	741	PF05994	0.488
LIG_WRC_WIRS_1	93	98	PF05994	0.515
LIG_WW_2	563	566	PF00397	0.305
MOD_CDC14_SPxK_1	17	20	PF00782	0.411
MOD_CDK_SPK_2	793	798	PF00069	0.712
MOD_CDK_SPxK_1	14	20	PF00069	0.411
MOD_CDK_SPxK_1	793	799	PF00069	0.561
MOD_CDK_SPxxK_3	267	274	PF00069	0.391
MOD_CDK_SPxxK_3	303	310	PF00069	0.288
MOD_CDK_SPxxK_3	313	320	PF00069	0.239
MOD_CDK_SPxxK_3	607	614	PF00069	0.261
MOD_CDK_SPxxK_3	74	81	PF00069	0.371
MOD_CK1_1	242	248	PF00069	0.449
MOD_CK1_1	298	304	PF00069	0.308
MOD_CK1_1	397	403	PF00069	0.272
MOD_CK1_1	496	502	PF00069	0.347
MOD_CK1_1	620	626	PF00069	0.410
MOD_CK1_1	667	673	PF00069	0.396
MOD_CK1_1	72	78	PF00069	0.471
MOD_CK1_1	735	741	PF00069	0.370
MOD_CK1_1	766	772	PF00069	0.681
MOD_CK1_1	775	781	PF00069	0.678
MOD_CK1_1	80	86	PF00069	0.450
MOD_CK2_1	242	248	PF00069	0.348
MOD_CK2_1	422	428	PF00069	0.275
MOD_CK2_1	46	52	PF00069	0.518
MOD_CK2_1	521	527	PF00069	0.284
MOD_CK2_1	62	68	PF00069	0.403
MOD_CK2_1	631	637	PF00069	0.310
MOD_CK2_1	645	651	PF00069	0.640
MOD_Cter_Amidation	104	107	PF01082	0.222
MOD_Cter_Amidation	381	384	PF01082	0.365
MOD_DYRK1A_RPxSP_1	220	224	PF00069	0.246
MOD_GlcNHglycan	298	301	PF01048	0.353
MOD_GlcNHglycan	394	397	PF01048	0.259
MOD_GlcNHglycan	433	436	PF01048	0.422
MOD_GlcNHglycan	489	492	PF01048	0.377
MOD_GlcNHglycan	552	555	PF01048	0.362
MOD_GlcNHglycan	633	636	PF01048	0.310
MOD_GlcNHglycan	647	650	PF01048	0.505
MOD_GlcNHglycan	756	759	PF01048	0.641
MOD_GlcNHglycan	766	769	PF01048	0.645
MOD_GSK3_1	235	242	PF00069	0.357
MOD_GSK3_1	280	287	PF00069	0.362
MOD_GSK3_1	336	343	PF00069	0.286
MOD_GSK3_1	35	42	PF00069	0.533
MOD_GSK3_1	353	360	PF00069	0.273
MOD_GSK3_1	365	372	PF00069	0.406
MOD_GSK3_1	394	401	PF00069	0.291
MOD_GSK3_1	418	425	PF00069	0.346
MOD_GSK3_1	616	623	PF00069	0.265
MOD_GSK3_1	663	670	PF00069	0.299
MOD_GSK3_1	69	76	PF00069	0.505
MOD_GSK3_1	762	769	PF00069	0.602
MOD_GSK3_1	772	779	PF00069	0.675
MOD_N-GLC_1	121	126	PF02516	0.213
MOD_N-GLC_1	39	44	PF02516	0.289
MOD_N-GLC_1	656	661	PF02516	0.411
MOD_NEK2_1	146	151	PF00069	0.529
MOD_NEK2_1	2	7	PF00069	0.480
MOD_NEK2_1	202	207	PF00069	0.246
MOD_NEK2_1	39	44	PF00069	0.555
MOD_NEK2_1	493	498	PF00069	0.295
MOD_NEK2_1	57	62	PF00069	0.455
MOD_NEK2_1	616	621	PF00069	0.248
MOD_NEK2_1	742	747	PF00069	0.457
MOD_NEK2_1	92	97	PF00069	0.457
MOD_PIKK_1	261	267	PF00454	0.264
MOD_PIKK_1	721	727	PF00454	0.394
MOD_PKA_1	398	404	PF00069	0.241
MOD_PKA_1	445	451	PF00069	0.286
MOD_PKA_1	545	551	PF00069	0.374
MOD_PKA_1	782	788	PF00069	0.614
MOD_PKA_2	2	8	PF00069	0.468
MOD_PKA_2	261	267	PF00069	0.397
MOD_PKA_2	397	403	PF00069	0.318
MOD_PKA_2	418	424	PF00069	0.275
MOD_PKA_2	445	451	PF00069	0.308
MOD_PKA_2	493	499	PF00069	0.283
MOD_PKA_2	582	588	PF00069	0.279
MOD_PKA_2	620	626	PF00069	0.391
MOD_PKA_2	80	86	PF00069	0.483
MOD_Plk_1	284	290	PF00069	0.411
MOD_Plk_1	35	41	PF00069	0.425
MOD_Plk_1	360	366	PF00069	0.261
MOD_Plk_1	423	429	PF00069	0.310
MOD_Plk_1	67	73	PF00069	0.471
MOD_Plk_4	203	209	PF00069	0.246
MOD_Plk_4	235	241	PF00069	0.324
MOD_Plk_4	323	329	PF00069	0.339
MOD_Plk_4	365	371	PF00069	0.385
MOD_Plk_4	590	596	PF00069	0.259
MOD_Plk_4	623	629	PF00069	0.261
MOD_Plk_4	664	670	PF00069	0.290
MOD_ProDKin_1	14	20	PF00069	0.416
MOD_ProDKin_1	220	226	PF00069	0.271
MOD_ProDKin_1	267	273	PF00069	0.415
MOD_ProDKin_1	303	309	PF00069	0.321
MOD_ProDKin_1	313	319	PF00069	0.286
MOD_ProDKin_1	498	504	PF00069	0.287
MOD_ProDKin_1	559	565	PF00069	0.391
MOD_ProDKin_1	607	613	PF00069	0.261
MOD_ProDKin_1	69	75	PF00069	0.440
MOD_ProDKin_1	701	707	PF00069	0.580
MOD_ProDKin_1	793	799	PF00069	0.658
MOD_SUMO_for_1	22	25	PF00179	0.422
MOD_SUMO_for_1	456	459	PF00179	0.317
MOD_SUMO_rev_2	113	120	PF00179	0.478
MOD_SUMO_rev_2	231	236	PF00179	0.260
MOD_SUMO_rev_2	25	34	PF00179	0.457
MOD_SUMO_rev_2	522	531	PF00179	0.304
MOD_SUMO_rev_2	634	640	PF00179	0.309
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.310
TRG_ENDOCYTIC_2	374	377	PF00928	0.261
TRG_ENDOCYTIC_2	441	444	PF00928	0.279
TRG_ENDOCYTIC_2	587	590	PF00928	0.246
TRG_ENDOCYTIC_2	599	602	PF00928	0.246
TRG_ENDOCYTIC_2	736	739	PF00928	0.376
TRG_ER_diArg_1	106	108	PF00400	0.418
TRG_ER_diArg_1	171	173	PF00400	0.494
TRG_ER_diArg_1	2	4	PF00400	0.497
TRG_ER_diArg_1	377	379	PF00400	0.310
TRG_ER_diArg_1	444	446	PF00400	0.311
TRG_ER_diArg_1	750	752	PF00400	0.421
TRG_ER_diArg_1	797	799	PF00400	0.685
TRG_ER_diLys_1	805	809	PF00400	0.585
TRG_NLS_Bipartite_1	794	809	PF00514	0.589
TRG_NLS_MonoCore_2	804	809	PF00514	0.717
TRG_NLS_MonoExtC_3	602	608	PF00514	0.190
TRG_NLS_MonoExtC_3	804	809	PF00514	0.679
TRG_NLS_MonoExtN_4	803	809	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.222
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	614	618	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	690	695	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	721	725	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P1	Leptomonas seymouri	23%	94%
A0A0N1PDE4	Leptomonas seymouri	67%	94%
A0A0S4JDQ6	Bodo saltans	37%	99%
A0A1X0NXB2	Trypanosomatidae	51%	95%
A0A3S7X1K1	Leishmania donovani	23%	93%
A0A3S7XB89	Leishmania donovani	22%	85%
A0A422N774	Trypanosoma rangeli	51%	97%
A0R5D9	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	26%	86%
A0R979	Bacillus thuringiensis (strain Al Hakam)	26%	100%
A4HBL0	Leishmania braziliensis	85%	99%
A4HGN1	Leishmania braziliensis	23%	100%
A4HPI6	Leishmania braziliensis	23%	85%
A4HZ99	Leishmania infantum	98%	100%
A4I3Q5	Leishmania infantum	23%	100%
A4IDA8	Leishmania infantum	22%	85%
D0A1K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D0A8E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	88%
E9AT98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	85%
E9AUX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AZZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
O27661	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	24%	100%
O28469	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	26%	100%
O34204	Fervidobacterium islandicum	25%	100%
O58356	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	23%	100%
O67037	Aquifex aeolicus (strain VF5)	25%	71%
O67226	Aquifex aeolicus (strain VF5)	25%	70%
O69548	Mycobacterium leprae (strain TN)	26%	85%
O70157	Mus musculus	21%	81%
O83409	Treponema pallidum (strain Nichols)	25%	100%
P06612	Escherichia coli (strain K12)	25%	94%
P0A2I1	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	25%	94%
P0A2I2	Salmonella typhi	25%	94%
P0A621	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	27%	87%
P0C2W6	Staphylococcus aureus (strain bovine RF122 / ET3-1)	20%	100%
P14294	Escherichia coli (strain K12)	22%	100%
P34184	Alkalihalophilus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4)	23%	100%
P34185	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	26%	92%
P39814	Bacillus subtilis (strain 168)	27%	100%
P40114	Bacillus anthracis	23%	93%
P40687	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	23%	100%
P43012	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	93%
P46799	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	25%	100%
P47368	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	24%	100%
P55991	Helicobacter pylori (strain ATCC 700392 / 26695)	26%	100%
P57371	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	25%	94%
P73810	Synechocystis sp. (strain PCC 6803 / Kazusa)	28%	90%
P78032	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	26%	100%
P95479	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	24%	67%
P96583	Bacillus subtilis (strain 168)	25%	100%
P9WG48	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	87%
P9WG49	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	87%
Q1RIM1	Rickettsia bellii (strain RML369-C)	26%	100%
Q2FEN5	Staphylococcus aureus (strain USA300)	20%	100%
Q2FW03	Staphylococcus aureus (strain NCTC 8325 / PS 47)	20%	100%
Q49ZH2	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	21%	100%
Q4L8B8	Staphylococcus haemolyticus (strain JCSC1435)	22%	100%
Q4Q199	Leishmania major	22%	85%
Q4Q888	Leishmania major	23%	100%
Q4QCK3	Leishmania major	95%	100%
Q4UM42	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	27%	100%
Q59046	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	24%	100%
Q5HDV4	Staphylococcus aureus (strain COL)	20%	100%
Q5HLZ4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	21%	100%
Q5UQB5	Acanthamoeba polyphaga mimivirus	23%	95%
Q5WAX6	Alkalihalobacillus clausii (strain KSM-K16)	24%	100%
Q63GK5	Bacillus cereus (strain ZK / E33L)	26%	100%
Q65N90	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	27%	100%
Q68X45	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	25%	100%
Q6G767	Staphylococcus aureus (strain MSSA476)	20%	100%
Q6GEH9	Staphylococcus aureus (strain MRSA252)	20%	100%
Q6HP19	Bacillus thuringiensis subsp. konkukian (strain 97-27)	26%	100%
Q73E74	Bacillus cereus (strain ATCC 10987 / NRS 248)	26%	100%
Q7A075	Staphylococcus aureus (strain MW2)	20%	100%
Q7A455	Staphylococcus aureus (strain N315)	20%	100%
Q81IH1	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	25%	100%
Q81Z97	Bacillus anthracis	26%	100%
Q87AQ6	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	28%	99%
Q8CRF7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	21%	100%
Q8K9P7	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	25%	95%
Q8Z6F5	Salmonella typhi	23%	100%
Q92IH1	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	26%	100%
Q97ZF5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	25%	69%
Q99S17	Staphylococcus aureus (strain Mu50 / ATCC 700699)	20%	100%
Q9CG80	Lactococcus lactis subsp. lactis (strain IL1403)	25%	100%
Q9CN30	Pasteurella multocida (strain Pm70)	26%	93%
Q9HM08	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	24%	100%
Q9HZJ5	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	25%	93%
Q9JN65	Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))	24%	100%
Q9KQF5	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	23%	100%
Q9KRB2	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	27%	92%
Q9PEV8	Xylella fastidiosa (strain 9a5c)	27%	99%
Q9PHK2	Xylella fastidiosa (strain 9a5c)	26%	100%
Q9PLZ2	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	26%	100%
Q9UYS8	Pyrococcus abyssi (strain GE5 / Orsay)	24%	100%
Q9X3X7	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	26%	67%
Q9X909	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	26%	85%
Q9YB01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	22%	100%
Q9YC75	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	24%	67%
Q9ZDK2	Rickettsia prowazekii (strain Madrid E)	25%	100%
Q9ZMV7	Helicobacter pylori (strain J99 / ATCC 700824)	26%	100%
V5BG04	Trypanosoma cruzi	53%	99%