Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WW58_LEIDO

TriTrypDb:

LdBPK_201630.1 , LdCL_200021100 , LDHU3_20.2000

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7WW58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW58

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	241	243	PF00675	0.408
CLV_NRD_NRD_1	388	390	PF00675	0.586
CLV_PCSK_FUR_1	239	243	PF00082	0.469
CLV_PCSK_KEX2_1	241	243	PF00082	0.408
CLV_PCSK_KEX2_1	387	389	PF00082	0.588
CLV_PCSK_SKI1_1	50	54	PF00082	0.603
DEG_Nend_UBRbox_3	1	3	PF02207	0.712
DEG_SCF_FBW7_1	331	338	PF00400	0.658
DEG_SPOP_SBC_1	370	374	PF00917	0.761
DOC_CKS1_1	225	230	PF01111	0.678
DOC_CKS1_1	332	337	PF01111	0.753
DOC_MAPK_gen_1	10	18	PF00069	0.663
DOC_PP2B_LxvP_1	278	281	PF13499	0.757
DOC_PP2B_LxvP_1	321	324	PF13499	0.802
DOC_PP4_MxPP_1	340	343	PF00568	0.734
DOC_PP4_MxPP_1	362	365	PF00568	0.684
DOC_USP7_MATH_1	369	373	PF00917	0.780
DOC_USP7_MATH_1	392	396	PF00917	0.786
DOC_WW_Pin1_4	224	229	PF00397	0.672
DOC_WW_Pin1_4	331	336	PF00397	0.772
DOC_WW_Pin1_4	354	359	PF00397	0.781
DOC_WW_Pin1_4	371	376	PF00397	0.794
DOC_WW_Pin1_4	390	395	PF00397	0.640
DOC_WW_Pin1_4	62	67	PF00397	0.452
LIG_APCC_ABBA_1	22	27	PF00400	0.485
LIG_BRCT_BRCA1_1	48	52	PF00533	0.421
LIG_CaM_NSCaTE_8	145	152	PF13499	0.591
LIG_EH1_1	207	215	PF00400	0.369
LIG_EH1_1	39	47	PF00400	0.485
LIG_FHA_1	117	123	PF00498	0.414
LIG_FHA_1	150	156	PF00498	0.389
LIG_FHA_1	192	198	PF00498	0.398
LIG_FHA_1	205	211	PF00498	0.463
LIG_FHA_1	275	281	PF00498	0.729
LIG_FHA_1	34	40	PF00498	0.435
LIG_FHA_1	366	372	PF00498	0.817
LIG_FHA_1	41	47	PF00498	0.463
LIG_FHA_1	51	57	PF00498	0.336
LIG_FHA_1	63	69	PF00498	0.428
LIG_FHA_2	225	231	PF00498	0.650
LIG_GBD_Chelix_1	121	129	PF00786	0.369
LIG_LIR_Gen_1	31	42	PF02991	0.310
LIG_LIR_Gen_1	357	367	PF02991	0.815
LIG_LIR_Gen_1	74	85	PF02991	0.460
LIG_LIR_Nem_3	187	191	PF02991	0.352
LIG_LIR_Nem_3	31	37	PF02991	0.310
LIG_LIR_Nem_3	74	80	PF02991	0.444
LIG_Pex14_2	135	139	PF04695	0.599
LIG_SH2_CRK	305	309	PF00017	0.732
LIG_SH2_GRB2like	215	218	PF00017	0.555
LIG_SH2_NCK_1	305	309	PF00017	0.683
LIG_SH2_SRC	305	308	PF00017	0.695
LIG_SH2_STAP1	84	88	PF00017	0.450
LIG_SH2_STAT3	159	162	PF00017	0.444
LIG_SH2_STAT5	143	146	PF00017	0.633
LIG_SH2_STAT5	159	162	PF00017	0.444
LIG_SH2_STAT5	177	180	PF00017	0.326
LIG_SH2_STAT5	188	191	PF00017	0.320
LIG_SH2_STAT5	205	208	PF00017	0.251
LIG_SH2_STAT5	215	218	PF00017	0.458
LIG_SH3_1	294	300	PF00018	0.711
LIG_SH3_3	164	170	PF00018	0.491
LIG_SH3_3	222	228	PF00018	0.722
LIG_SH3_3	284	290	PF00018	0.730
LIG_SH3_3	294	300	PF00018	0.719
LIG_SH3_3	304	310	PF00018	0.677
LIG_SH3_3	316	322	PF00018	0.695
LIG_SH3_3	350	356	PF00018	0.769
LIG_SH3_3	376	382	PF00018	0.781
LIG_SH3_3	388	394	PF00018	0.781
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.400
LIG_TRAF2_1	227	230	PF00917	0.640
LIG_TRAF2_1	243	246	PF00917	0.521
LIG_TRFH_1	62	66	PF08558	0.389
LIG_Vh1_VBS_1	114	132	PF01044	0.374
LIG_WRC_WIRS_1	34	39	PF05994	0.485
LIG_WW_1	399	402	PF00397	0.749
MOD_CK1_1	311	317	PF00069	0.775
MOD_CK1_1	76	82	PF00069	0.450
MOD_CK2_1	147	153	PF00069	0.369
MOD_CK2_1	224	230	PF00069	0.615
MOD_CK2_1	354	360	PF00069	0.820
MOD_GlcNHglycan	149	152	PF01048	0.380
MOD_GlcNHglycan	313	316	PF01048	0.568
MOD_GlcNHglycan	86	89	PF01048	0.630
MOD_GSK3_1	310	317	PF00069	0.755
MOD_GSK3_1	331	338	PF00069	0.779
MOD_GSK3_1	365	372	PF00069	0.783
MOD_GSK3_1	46	53	PF00069	0.342
MOD_GSK3_1	69	76	PF00069	0.392
MOD_GSK3_1	89	96	PF00069	0.333
MOD_N-GLC_1	265	270	PF02516	0.543
MOD_N-GLC_1	274	279	PF02516	0.478
MOD_NEK2_1	191	196	PF00069	0.362
MOD_NEK2_1	28	33	PF00069	0.412
MOD_NEK2_1	38	43	PF00069	0.345
MOD_NEK2_1	52	57	PF00069	0.303
MOD_NEK2_1	91	96	PF00069	0.402
MOD_PIKK_1	392	398	PF00454	0.784
MOD_PIKK_1	91	97	PF00454	0.459
MOD_PKA_2	14	20	PF00069	0.679
MOD_Plk_1	274	280	PF00069	0.729
MOD_Plk_1	73	79	PF00069	0.460
MOD_Plk_1	89	95	PF00069	0.295
MOD_Plk_4	116	122	PF00069	0.406
MOD_Plk_4	184	190	PF00069	0.402
MOD_Plk_4	204	210	PF00069	0.389
MOD_Plk_4	280	286	PF00069	0.779
MOD_Plk_4	33	39	PF00069	0.355
MOD_Plk_4	341	347	PF00069	0.753
MOD_Plk_4	41	47	PF00069	0.417
MOD_Plk_4	64	70	PF00069	0.413
MOD_ProDKin_1	224	230	PF00069	0.668
MOD_ProDKin_1	331	337	PF00069	0.774
MOD_ProDKin_1	354	360	PF00069	0.782
MOD_ProDKin_1	371	377	PF00069	0.795
MOD_ProDKin_1	390	396	PF00069	0.641
MOD_ProDKin_1	62	68	PF00069	0.447
MOD_SUMO_rev_2	230	236	PF00179	0.620
MOD_SUMO_rev_2	253	258	PF00179	0.664
TRG_DiLeu_BaEn_2	130	136	PF01217	0.624
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.380
TRG_ENDOCYTIC_2	188	191	PF00928	0.343
TRG_ENDOCYTIC_2	223	226	PF00928	0.648
TRG_ENDOCYTIC_2	305	308	PF00928	0.702
TRG_ENDOCYTIC_2	359	362	PF00928	0.798
TRG_ER_diArg_1	238	241	PF00400	0.632
TRG_ER_diArg_1	386	389	PF00400	0.790
TRG_NLS_MonoExtN_4	10	16	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH38	Leptomonas seymouri	72%	99%
A0A1X0NHW5	Trypanosomatidae	24%	96%
C9ZIN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AGU2	Leishmania infantum	99%	100%
E9AIL4	Leishmania braziliensis	77%	99%
E9AUU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCN6	Leishmania major	96%	100%
V5ASX9	Trypanosoma cruzi	44%	100%