Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7WW52_LEIDO

TriTrypDb:

LdBPK_201500.1 , LdCL_200019700 , LDHU3_20.1870

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WW52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.605
CLV_C14_Caspase3-7	77	81	PF00656	0.474
CLV_NRD_NRD_1	141	143	PF00675	0.584
CLV_NRD_NRD_1	151	153	PF00675	0.610
CLV_NRD_NRD_1	192	194	PF00675	0.552
CLV_PCSK_KEX2_1	141	143	PF00082	0.584
CLV_PCSK_KEX2_1	151	153	PF00082	0.610
CLV_PCSK_KEX2_1	191	193	PF00082	0.495
CLV_PCSK_KEX2_1	375	377	PF00082	0.521
CLV_PCSK_KEX2_1	99	101	PF00082	0.506
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.521
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.506
CLV_PCSK_SKI1_1	129	133	PF00082	0.462
CLV_PCSK_SKI1_1	151	155	PF00082	0.505
DEG_SPOP_SBC_1	315	319	PF00917	0.601
DOC_ANK_TNKS_1	141	148	PF00023	0.418
DOC_CKS1_1	18	23	PF01111	0.479
DOC_CYCLIN_RxL_1	363	373	PF00134	0.518
DOC_CYCLIN_RxL_1	43	54	PF00134	0.407
DOC_MAPK_gen_1	57	66	PF00069	0.330
DOC_MAPK_gen_1	76	86	PF00069	0.371
DOC_MAPK_gen_1	99	106	PF00069	0.463
DOC_MAPK_MEF2A_6	273	280	PF00069	0.587
DOC_MAPK_MEF2A_6	57	66	PF00069	0.330
DOC_MAPK_MEF2A_6	87	94	PF00069	0.382
DOC_MAPK_MEF2A_6	99	106	PF00069	0.347
DOC_PP1_RVXF_1	159	165	PF00149	0.344
DOC_USP7_MATH_1	200	204	PF00917	0.612
DOC_USP7_MATH_1	235	239	PF00917	0.754
DOC_USP7_MATH_1	279	283	PF00917	0.576
DOC_USP7_MATH_1	315	319	PF00917	0.604
DOC_USP7_MATH_1	327	331	PF00917	0.412
DOC_USP7_MATH_1	44	48	PF00917	0.412
DOC_USP7_MATH_1	74	78	PF00917	0.420
DOC_WW_Pin1_4	10	15	PF00397	0.524
DOC_WW_Pin1_4	17	22	PF00397	0.485
DOC_WW_Pin1_4	201	206	PF00397	0.697
DOC_WW_Pin1_4	233	238	PF00397	0.779
DOC_WW_Pin1_4	244	249	PF00397	0.630
DOC_WW_Pin1_4	256	261	PF00397	0.581
LIG_14-3-3_CanoR_1	151	160	PF00244	0.488
LIG_14-3-3_CanoR_1	179	186	PF00244	0.498
LIG_14-3-3_CanoR_1	191	197	PF00244	0.679
LIG_14-3-3_CanoR_1	255	261	PF00244	0.499
LIG_APCC_ABBAyCdc20_2	69	75	PF00400	0.509
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BIR_III_4	266	270	PF00653	0.573
LIG_BIR_III_4	29	33	PF00653	0.443
LIG_CaM_IQ_9	335	351	PF13499	0.454
LIG_FHA_1	10	16	PF00498	0.526
LIG_FHA_1	112	118	PF00498	0.380
LIG_FHA_1	18	24	PF00498	0.382
LIG_FHA_1	180	186	PF00498	0.461
LIG_FHA_1	321	327	PF00498	0.493
LIG_FHA_2	122	128	PF00498	0.327
LIG_FHA_2	315	321	PF00498	0.592
LIG_FHA_2	35	41	PF00498	0.473
LIG_FHA_2	4	10	PF00498	0.604
LIG_LIR_Apic_2	224	230	PF02991	0.646
LIG_LIR_Apic_2	282	287	PF02991	0.608
LIG_LIR_Gen_1	89	98	PF02991	0.337
LIG_LIR_Nem_3	174	180	PF02991	0.349
LIG_LIR_Nem_3	53	58	PF02991	0.456
LIG_LIR_Nem_3	89	94	PF02991	0.338
LIG_NRBOX	93	99	PF00104	0.404
LIG_PCNA_PIPBox_1	49	58	PF02747	0.453
LIG_PCNA_yPIPBox_3	46	56	PF02747	0.457
LIG_SH2_CRK	284	288	PF00017	0.687
LIG_SH2_CRK	301	305	PF00017	0.613
LIG_SH2_NCK_1	264	268	PF00017	0.652
LIG_SH2_NCK_1	284	288	PF00017	0.606
LIG_SH2_PTP2	91	94	PF00017	0.348
LIG_SH2_STAP1	264	268	PF00017	0.635
LIG_SH2_STAT5	115	118	PF00017	0.426
LIG_SH2_STAT5	264	267	PF00017	0.552
LIG_SH2_STAT5	284	287	PF00017	0.737
LIG_SH2_STAT5	34	37	PF00017	0.471
LIG_SH2_STAT5	55	58	PF00017	0.454
LIG_SH2_STAT5	91	94	PF00017	0.348
LIG_SH3_2	21	26	PF14604	0.411
LIG_SH3_3	18	24	PF00018	0.509
LIG_SH3_3	303	309	PF00018	0.647
LIG_SH3_4	59	66	PF00018	0.446
LIG_Sin3_3	377	384	PF02671	0.449
LIG_SUMO_SIM_par_1	317	325	PF11976	0.505
LIG_SUMO_SIM_par_1	366	373	PF11976	0.513
LIG_TYR_ITIM	175	180	PF00017	0.352
LIG_UBA3_1	367	375	PF00899	0.457
MOD_CDK_SPxxK_3	201	208	PF00069	0.548
MOD_CK1_1	204	210	PF00069	0.712
MOD_CK1_1	236	242	PF00069	0.704
MOD_CK1_1	247	253	PF00069	0.578
MOD_CK1_1	282	288	PF00069	0.745
MOD_CK2_1	121	127	PF00069	0.342
MOD_CK2_1	247	253	PF00069	0.634
MOD_CK2_1	256	262	PF00069	0.619
MOD_CK2_1	3	9	PF00069	0.700
MOD_CK2_1	314	320	PF00069	0.609
MOD_GlcNHglycan	1	4	PF01048	0.659
MOD_GlcNHglycan	233	236	PF01048	0.651
MOD_GlcNHglycan	238	241	PF01048	0.571
MOD_GlcNHglycan	281	284	PF01048	0.663
MOD_GSK3_1	147	154	PF00069	0.703
MOD_GSK3_1	200	207	PF00069	0.656
MOD_GSK3_1	231	238	PF00069	0.594
MOD_GSK3_1	316	323	PF00069	0.626
MOD_GSK3_1	9	16	PF00069	0.633
MOD_LATS_1	190	196	PF00433	0.547
MOD_N-GLC_1	212	217	PF02516	0.771
MOD_N-GLC_2	81	83	PF02516	0.354
MOD_NEK2_1	212	217	PF00069	0.714
MOD_NEK2_1	370	375	PF00069	0.515
MOD_NEK2_2	74	79	PF00069	0.390
MOD_PIKK_1	282	288	PF00454	0.618
MOD_PKA_1	151	157	PF00069	0.516
MOD_PKA_1	192	198	PF00069	0.701
MOD_PKA_2	151	157	PF00069	0.516
MOD_PKA_2	178	184	PF00069	0.390
MOD_PKA_2	192	198	PF00069	0.657
MOD_PKA_2	207	213	PF00069	0.559
MOD_PKA_2	254	260	PF00069	0.526
MOD_PKA_2	356	362	PF00069	0.446
MOD_Plk_1	212	218	PF00069	0.636
MOD_Plk_1	370	376	PF00069	0.534
MOD_Plk_1	74	80	PF00069	0.371
MOD_Plk_2-3	121	127	PF00069	0.448
MOD_Plk_4	121	127	PF00069	0.326
MOD_Plk_4	287	293	PF00069	0.573
MOD_ProDKin_1	10	16	PF00069	0.523
MOD_ProDKin_1	17	23	PF00069	0.469
MOD_ProDKin_1	201	207	PF00069	0.698
MOD_ProDKin_1	233	239	PF00069	0.780
MOD_ProDKin_1	244	250	PF00069	0.631
MOD_ProDKin_1	256	262	PF00069	0.582
MOD_SUMO_for_1	58	61	PF00179	0.444
MOD_SUMO_rev_2	121	131	PF00179	0.452
TRG_DiLeu_BaEn_1	158	163	PF01217	0.463
TRG_DiLeu_BaEn_1	61	66	PF01217	0.452
TRG_DiLeu_LyEn_5	158	163	PF01217	0.463
TRG_ENDOCYTIC_2	166	169	PF00928	0.366
TRG_ENDOCYTIC_2	177	180	PF00928	0.359
TRG_ENDOCYTIC_2	55	58	PF00928	0.454
TRG_ENDOCYTIC_2	91	94	PF00928	0.348
TRG_ER_diArg_1	151	153	PF00400	0.544
TRG_ER_diArg_1	159	162	PF00400	0.295
TRG_ER_diArg_1	191	193	PF00400	0.511
TRG_NES_CRM1_1	158	171	PF08389	0.472
TRG_NES_CRM1_1	40	54	PF08389	0.385
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	329	334	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV9	Leptomonas seymouri	54%	96%
A0A1X0NWT1	Trypanosomatidae	37%	100%
A0A422N975	Trypanosoma rangeli	37%	100%
A4HYY8	Leishmania infantum	99%	100%
C9ZIJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
E9AIK2	Leishmania braziliensis	79%	96%
E9AUT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCP9	Leishmania major	94%	100%