USP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WW51_LEIDO

TriTrypDb:

LdBPK_201670.1 , LdCL_200021500 , LDHU3_20.2040

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WW51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	37	39	PF00082	0.781
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.781
CLV_PCSK_SKI1_1	97	101	PF00082	0.524
DEG_COP1_1	63	73	PF00400	0.594
DEG_SCF_FBW7_2	62	68	PF00400	0.623
DEG_SPOP_SBC_1	151	155	PF00917	0.752
DOC_CKS1_1	212	217	PF01111	0.672
DOC_CKS1_1	62	67	PF01111	0.702
DOC_CKS1_1	70	75	PF01111	0.614
DOC_CKS1_1	98	103	PF01111	0.529
DOC_CYCLIN_yClb5_NLxxxL_5	7	13	PF00134	0.710
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.606
DOC_MAPK_gen_1	37	43	PF00069	0.782
DOC_PP2B_LxvP_1	50	53	PF13499	0.598
DOC_USP7_MATH_1	3	7	PF00917	0.538
DOC_USP7_MATH_1	39	43	PF00917	0.777
DOC_USP7_MATH_1	60	64	PF00917	0.728
DOC_WW_Pin1_4	16	21	PF00397	0.751
DOC_WW_Pin1_4	211	216	PF00397	0.668
DOC_WW_Pin1_4	61	66	PF00397	0.759
DOC_WW_Pin1_4	69	74	PF00397	0.666
DOC_WW_Pin1_4	97	102	PF00397	0.522
LIG_14-3-3_CanoR_1	195	203	PF00244	0.669
LIG_14-3-3_CanoR_1	218	228	PF00244	0.667
LIG_14-3-3_CanoR_1	38	44	PF00244	0.779
LIG_BIR_II_1	1	5	PF00653	0.723
LIG_FHA_2	29	35	PF00498	0.724
LIG_FHA_2	98	104	PF00498	0.533
LIG_LIR_Apic_2	211	215	PF02991	0.668
LIG_LIR_Gen_1	229	239	PF02991	0.563
LIG_LIR_Gen_1	80	91	PF02991	0.719
LIG_LIR_Nem_3	80	86	PF02991	0.730
LIG_PCNA_yPIPBox_3	170	179	PF02747	0.708
LIG_RPA_C_Insects	2	17	PF08784	0.716
LIG_SH2_CRK	169	173	PF00017	0.641
LIG_SH2_CRK	212	216	PF00017	0.672
LIG_SH2_CRK	83	87	PF00017	0.787
LIG_SH2_NCK_1	83	87	PF00017	0.723
LIG_SH2_STAP1	221	225	PF00017	0.761
LIG_SH2_STAP1	231	235	PF00017	0.601
LIG_SH2_STAT3	203	206	PF00017	0.734
LIG_SH2_STAT3	239	242	PF00017	0.749
LIG_SH2_STAT5	83	86	PF00017	0.730
LIG_SH3_1	257	263	PF00018	0.728
LIG_SH3_2	256	261	PF14604	0.738
LIG_SH3_3	107	113	PF00018	0.660
LIG_SH3_3	136	142	PF00018	0.750
LIG_SH3_3	161	167	PF00018	0.713
LIG_SH3_3	20	26	PF00018	0.601
LIG_SH3_3	204	210	PF00018	0.735
LIG_SH3_3	253	259	PF00018	0.785
LIG_SH3_3	33	39	PF00018	0.781
LIG_SH3_3	42	48	PF00018	0.700
LIG_SH3_3	59	65	PF00018	0.721
LIG_SH3_3	67	73	PF00018	0.626
LIG_SH3_3	86	92	PF00018	0.706
LIG_SH3_5	172	176	PF00018	0.646
LIG_TYR_ITIM	81	86	PF00017	0.790
LIG_WW_1	255	258	PF00397	0.738
LIG_WW_3	258	262	PF00397	0.740
MOD_CDK_SPxxK_3	211	218	PF00069	0.672
MOD_CK1_1	19	25	PF00069	0.710
MOD_CK1_1	2	8	PF00069	0.713
MOD_CK1_1	219	225	PF00069	0.631
MOD_CK1_1	63	69	PF00069	0.770
MOD_CK2_1	74	80	PF00069	0.646
MOD_CK2_1	97	103	PF00069	0.555
MOD_GlcNHglycan	1	4	PF01048	0.736
MOD_GlcNHglycan	218	221	PF01048	0.767
MOD_GlcNHglycan	223	226	PF01048	0.729
MOD_GSK3_1	147	154	PF00069	0.768
MOD_GSK3_1	216	223	PF00069	0.699
MOD_NEK2_1	234	239	PF00069	0.685
MOD_Plk_4	19	25	PF00069	0.679
MOD_ProDKin_1	16	22	PF00069	0.756
MOD_ProDKin_1	211	217	PF00069	0.669
MOD_ProDKin_1	61	67	PF00069	0.761
MOD_ProDKin_1	69	75	PF00069	0.662
MOD_ProDKin_1	97	103	PF00069	0.524
MOD_SUMO_rev_2	27	31	PF00179	0.619
MOD_SUMO_rev_2	42	48	PF00179	0.700
TRG_ENDOCYTIC_2	231	234	PF00928	0.671
TRG_ENDOCYTIC_2	83	86	PF00928	0.794

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HYZ9	Leishmania infantum	99%	100%
E9AIL8	Leishmania braziliensis	68%	97%
E9AUV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCN2	Leishmania major	86%	100%