Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WW50_LEIDO

TriTrypDb:

LdBPK_201460.1 , LdCL_200019300 , LDHU3_20.1830

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WW50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.648
CLV_C14_Caspase3-7	702	706	PF00656	0.585
CLV_NRD_NRD_1	117	119	PF00675	0.648
CLV_NRD_NRD_1	342	344	PF00675	0.493
CLV_NRD_NRD_1	693	695	PF00675	0.590
CLV_NRD_NRD_1	808	810	PF00675	0.658
CLV_PCSK_FUR_1	113	117	PF00082	0.646
CLV_PCSK_KEX2_1	115	117	PF00082	0.659
CLV_PCSK_KEX2_1	342	344	PF00082	0.493
CLV_PCSK_KEX2_1	693	695	PF00082	0.590
CLV_PCSK_KEX2_1	808	810	PF00082	0.658
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.650
CLV_PCSK_PC7_1	113	119	PF00082	0.715
CLV_PCSK_SKI1_1	129	133	PF00082	0.420
CLV_PCSK_SKI1_1	317	321	PF00082	0.482
CLV_PCSK_SKI1_1	348	352	PF00082	0.467
CLV_Separin_Metazoa	235	239	PF03568	0.392
CLV_Separin_Metazoa	460	464	PF03568	0.625
DEG_APCC_DBOX_1	347	355	PF00400	0.461
DEG_SCF_FBW7_1	698	703	PF00400	0.702
DEG_SCF_TRCP1_1	705	710	PF00400	0.626
DEG_SPOP_SBC_1	513	517	PF00917	0.644
DEG_SPOP_SBC_1	679	683	PF00917	0.662
DEG_SPOP_SBC_1	685	689	PF00917	0.661
DEG_SPOP_SBC_1	834	838	PF00917	0.657
DOC_CYCLIN_RxL_1	314	325	PF00134	0.494
DOC_CYCLIN_RxL_1	843	851	PF00134	0.646
DOC_CYCLIN_RxL_1	891	901	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.376
DOC_MAPK_gen_1	808	815	PF00069	0.639
DOC_MAPK_JIP1_4	924	930	PF00069	0.502
DOC_MAPK_MEF2A_6	238	247	PF00069	0.382
DOC_PP2B_LxvP_1	19	22	PF13499	0.678
DOC_PP2B_LxvP_1	666	669	PF13499	0.473
DOC_USP7_MATH_1	15	19	PF00917	0.553
DOC_USP7_MATH_1	205	209	PF00917	0.530
DOC_USP7_MATH_1	37	41	PF00917	0.561
DOC_USP7_MATH_1	482	486	PF00917	0.709
DOC_USP7_MATH_1	6	10	PF00917	0.583
DOC_USP7_MATH_1	679	683	PF00917	0.567
DOC_USP7_MATH_1	700	704	PF00917	0.754
DOC_USP7_MATH_1	709	713	PF00917	0.618
DOC_USP7_MATH_1	732	736	PF00917	0.578
DOC_USP7_MATH_1	762	766	PF00917	0.628
DOC_USP7_MATH_1	770	774	PF00917	0.686
DOC_USP7_MATH_1	788	792	PF00917	0.690
DOC_USP7_MATH_1	807	811	PF00917	0.537
DOC_USP7_MATH_1	834	838	PF00917	0.630
DOC_USP7_MATH_1	876	880	PF00917	0.517
DOC_USP7_MATH_2	882	888	PF00917	0.550
DOC_WW_Pin1_4	178	183	PF00397	0.777
DOC_WW_Pin1_4	226	231	PF00397	0.542
DOC_WW_Pin1_4	238	243	PF00397	0.355
DOC_WW_Pin1_4	39	44	PF00397	0.637
DOC_WW_Pin1_4	492	497	PF00397	0.739
DOC_WW_Pin1_4	643	648	PF00397	0.718
DOC_WW_Pin1_4	696	701	PF00397	0.685
DOC_WW_Pin1_4	715	720	PF00397	0.672
DOC_WW_Pin1_4	725	730	PF00397	0.798
DOC_WW_Pin1_4	784	789	PF00397	0.665
LIG_14-3-3_CanoR_1	100	106	PF00244	0.654
LIG_14-3-3_CanoR_1	116	124	PF00244	0.472
LIG_14-3-3_CanoR_1	176	185	PF00244	0.637
LIG_14-3-3_CanoR_1	189	198	PF00244	0.543
LIG_14-3-3_CanoR_1	514	519	PF00244	0.647
LIG_14-3-3_CanoR_1	52	58	PF00244	0.638
LIG_14-3-3_CanoR_1	643	647	PF00244	0.617
LIG_14-3-3_CanoR_1	734	744	PF00244	0.707
LIG_14-3-3_CanoR_1	808	813	PF00244	0.646
LIG_14-3-3_CanoR_1	844	849	PF00244	0.623
LIG_14-3-3_CanoR_1	924	929	PF00244	0.497
LIG_APCC_ABBA_1	131	136	PF00400	0.405
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BRCT_BRCA1_1	919	923	PF00533	0.526
LIG_Clathr_ClatBox_1	206	210	PF01394	0.506
LIG_deltaCOP1_diTrp_1	660	664	PF00928	0.508
LIG_FHA_1	102	108	PF00498	0.751
LIG_FHA_1	123	129	PF00498	0.481
LIG_FHA_1	14	20	PF00498	0.656
LIG_FHA_1	163	169	PF00498	0.573
LIG_FHA_1	214	220	PF00498	0.508
LIG_FHA_1	242	248	PF00498	0.375
LIG_FHA_1	381	387	PF00498	0.491
LIG_FHA_1	43	49	PF00498	0.627
LIG_FHA_1	551	557	PF00498	0.488
LIG_FHA_1	589	595	PF00498	0.565
LIG_FHA_1	625	631	PF00498	0.517
LIG_FHA_1	681	687	PF00498	0.567
LIG_FHA_1	748	754	PF00498	0.568
LIG_FHA_1	769	775	PF00498	0.637
LIG_FHA_2	23	29	PF00498	0.647
LIG_FHA_2	816	822	PF00498	0.542
LIG_FHA_2	873	879	PF00498	0.543
LIG_GBD_Chelix_1	614	622	PF00786	0.478
LIG_HCF-1_HBM_1	146	149	PF13415	0.556
LIG_LIR_Gen_1	122	132	PF02991	0.444
LIG_LIR_Gen_1	259	269	PF02991	0.424
LIG_LIR_Gen_1	357	367	PF02991	0.498
LIG_LIR_Gen_1	817	827	PF02991	0.553
LIG_LIR_Nem_3	122	127	PF02991	0.471
LIG_LIR_Nem_3	130	135	PF02991	0.408
LIG_LIR_Nem_3	232	237	PF02991	0.448
LIG_LIR_Nem_3	259	265	PF02991	0.410
LIG_LIR_Nem_3	325	329	PF02991	0.506
LIG_LIR_Nem_3	357	363	PF02991	0.491
LIG_LIR_Nem_3	507	513	PF02991	0.570
LIG_LIR_Nem_3	738	743	PF02991	0.592
LIG_LIR_Nem_3	795	801	PF02991	0.650
LIG_LIR_Nem_3	817	822	PF02991	0.583
LIG_LIR_Nem_3	886	892	PF02991	0.546
LIG_NRBOX	350	356	PF00104	0.467
LIG_NRBOX	661	667	PF00104	0.430
LIG_NRBOX	869	875	PF00104	0.578
LIG_PDZ_Class_2	925	930	PF00595	0.495
LIG_SH2_CRK	262	266	PF00017	0.411
LIG_SH2_CRK	279	283	PF00017	0.328
LIG_SH2_CRK	360	364	PF00017	0.487
LIG_SH2_GRB2like	784	787	PF00017	0.664
LIG_SH2_NCK_1	171	175	PF00017	0.648
LIG_SH2_NCK_1	177	181	PF00017	0.601
LIG_SH2_SRC	134	137	PF00017	0.384
LIG_SH2_SRC	413	416	PF00017	0.519
LIG_SH2_SRC	784	787	PF00017	0.640
LIG_SH2_STAP1	279	283	PF00017	0.441
LIG_SH2_STAP1	819	823	PF00017	0.509
LIG_SH2_STAT5	134	137	PF00017	0.418
LIG_SH2_STAT5	149	152	PF00017	0.626
LIG_SH2_STAT5	171	174	PF00017	0.649
LIG_SH2_STAT5	177	180	PF00017	0.602
LIG_SH2_STAT5	285	288	PF00017	0.367
LIG_SH2_STAT5	62	65	PF00017	0.629
LIG_SH2_STAT5	784	787	PF00017	0.712
LIG_SH3_2	729	734	PF14604	0.582
LIG_SH3_3	100	106	PF00018	0.568
LIG_SH3_3	179	185	PF00018	0.671
LIG_SH3_3	458	464	PF00018	0.632
LIG_SH3_3	549	555	PF00018	0.456
LIG_SH3_3	591	597	PF00018	0.613
LIG_SH3_3	716	722	PF00018	0.613
LIG_SH3_3	723	729	PF00018	0.619
LIG_SH3_3	827	833	PF00018	0.619
LIG_SH3_3	889	895	PF00018	0.542
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.490
LIG_SUMO_SIM_anti_2	382	390	PF11976	0.568
LIG_SUMO_SIM_par_1	349	357	PF11976	0.468
LIG_SUMO_SIM_par_1	382	390	PF11976	0.568
LIG_TRAF2_1	875	878	PF00917	0.586
LIG_WW_3	460	464	PF00397	0.625
MOD_CDK_SPK_2	643	648	PF00069	0.552
MOD_CK1_1	123	129	PF00069	0.439
MOD_CK1_1	137	143	PF00069	0.438
MOD_CK1_1	170	176	PF00069	0.767
MOD_CK1_1	192	198	PF00069	0.566
MOD_CK1_1	241	247	PF00069	0.355
MOD_CK1_1	32	38	PF00069	0.654
MOD_CK1_1	379	385	PF00069	0.530
MOD_CK1_1	42	48	PF00069	0.549
MOD_CK1_1	680	686	PF00069	0.643
MOD_CK1_1	703	709	PF00069	0.676
MOD_CK1_1	712	718	PF00069	0.707
MOD_CK1_1	733	739	PF00069	0.783
MOD_CK1_1	773	779	PF00069	0.635
MOD_CK1_1	838	844	PF00069	0.799
MOD_CK1_1	916	922	PF00069	0.531
MOD_CK2_1	651	657	PF00069	0.422
MOD_CK2_1	872	878	PF00069	0.546
MOD_CMANNOS	50	53	PF00535	0.678
MOD_CMANNOS	661	664	PF00535	0.501
MOD_Cter_Amidation	113	116	PF01082	0.674
MOD_GlcNHglycan	109	112	PF01048	0.691
MOD_GlcNHglycan	150	153	PF01048	0.601
MOD_GlcNHglycan	178	181	PF01048	0.600
MOD_GlcNHglycan	193	198	PF01048	0.706
MOD_GlcNHglycan	31	34	PF01048	0.668
MOD_GlcNHglycan	37	40	PF01048	0.611
MOD_GlcNHglycan	449	452	PF01048	0.606
MOD_GlcNHglycan	520	523	PF01048	0.603
MOD_GlcNHglycan	569	573	PF01048	0.533
MOD_GlcNHglycan	584	587	PF01048	0.633
MOD_GlcNHglycan	611	614	PF01048	0.516
MOD_GlcNHglycan	683	686	PF01048	0.604
MOD_GlcNHglycan	705	708	PF01048	0.658
MOD_GlcNHglycan	709	712	PF01048	0.615
MOD_GlcNHglycan	735	738	PF01048	0.621
MOD_GlcNHglycan	788	791	PF01048	0.644
MOD_GlcNHglycan	837	840	PF01048	0.608
MOD_GlcNHglycan	856	859	PF01048	0.497
MOD_GSK3_1	116	123	PF00069	0.573
MOD_GSK3_1	134	141	PF00069	0.528
MOD_GSK3_1	158	165	PF00069	0.623
MOD_GSK3_1	172	179	PF00069	0.657
MOD_GSK3_1	189	196	PF00069	0.535
MOD_GSK3_1	277	284	PF00069	0.429
MOD_GSK3_1	28	35	PF00069	0.596
MOD_GSK3_1	372	379	PF00069	0.605
MOD_GSK3_1	514	521	PF00069	0.638
MOD_GSK3_1	597	604	PF00069	0.655
MOD_GSK3_1	605	612	PF00069	0.454
MOD_GSK3_1	624	631	PF00069	0.413
MOD_GSK3_1	677	684	PF00069	0.574
MOD_GSK3_1	685	692	PF00069	0.646
MOD_GSK3_1	696	703	PF00069	0.743
MOD_GSK3_1	714	721	PF00069	0.639
MOD_GSK3_1	753	760	PF00069	0.615
MOD_GSK3_1	768	775	PF00069	0.633
MOD_GSK3_1	784	791	PF00069	0.653
MOD_GSK3_1	834	841	PF00069	0.766
MOD_GSK3_1	844	851	PF00069	0.625
MOD_GSK3_1	872	879	PF00069	0.489
MOD_GSK3_1	912	919	PF00069	0.545
MOD_N-GLC_1	329	334	PF02516	0.540
MOD_N-GLC_1	379	384	PF02516	0.538
MOD_N-GLC_1	643	648	PF02516	0.613
MOD_N-GLC_1	753	758	PF02516	0.688
MOD_N-GLC_1	853	858	PF02516	0.562
MOD_N-GLC_1	912	917	PF02516	0.550
MOD_NEK2_1	101	106	PF00069	0.574
MOD_NEK2_1	162	167	PF00069	0.757
MOD_NEK2_1	247	252	PF00069	0.366
MOD_NEK2_1	27	32	PF00069	0.667
MOD_NEK2_1	329	334	PF00069	0.540
MOD_NEK2_1	376	381	PF00069	0.558
MOD_NEK2_1	387	392	PF00069	0.599
MOD_NEK2_1	432	437	PF00069	0.632
MOD_NEK2_1	518	523	PF00069	0.576
MOD_NEK2_1	568	573	PF00069	0.529
MOD_NEK2_1	753	758	PF00069	0.611
MOD_NEK2_1	815	820	PF00069	0.646
MOD_NEK2_1	912	917	PF00069	0.626
MOD_NEK2_2	876	881	PF00069	0.523
MOD_PIKK_1	138	144	PF00454	0.475
MOD_PIKK_1	22	28	PF00454	0.661
MOD_PIKK_1	601	607	PF00454	0.606
MOD_PIKK_1	62	68	PF00454	0.658
MOD_PIKK_1	709	715	PF00454	0.690
MOD_PK_1	304	310	PF00069	0.562
MOD_PKA_1	116	122	PF00069	0.683
MOD_PKA_1	808	814	PF00069	0.640
MOD_PKA_2	116	122	PF00069	0.541
MOD_PKA_2	175	181	PF00069	0.636
MOD_PKA_2	213	219	PF00069	0.366
MOD_PKA_2	405	411	PF00069	0.560
MOD_PKA_2	513	519	PF00069	0.623
MOD_PKA_2	642	648	PF00069	0.618
MOD_PKA_2	703	709	PF00069	0.581
MOD_PKA_2	733	739	PF00069	0.613
MOD_PKA_2	807	813	PF00069	0.689
MOD_PKA_2	99	105	PF00069	0.636
MOD_PKB_1	302	310	PF00069	0.503
MOD_Plk_1	119	125	PF00069	0.539
MOD_Plk_1	379	385	PF00069	0.530
MOD_Plk_1	589	595	PF00069	0.565
MOD_Plk_1	624	630	PF00069	0.555
MOD_Plk_1	753	759	PF00069	0.625
MOD_Plk_1	793	799	PF00069	0.557
MOD_Plk_1	883	889	PF00069	0.560
MOD_Plk_1	912	918	PF00069	0.549
MOD_Plk_2-3	651	657	PF00069	0.404
MOD_Plk_2-3	884	890	PF00069	0.744
MOD_Plk_4	123	129	PF00069	0.439
MOD_Plk_4	277	283	PF00069	0.380
MOD_Plk_4	372	378	PF00069	0.601
MOD_Plk_4	380	386	PF00069	0.463
MOD_Plk_4	387	393	PF00069	0.443
MOD_Plk_4	494	500	PF00069	0.688
MOD_Plk_4	514	520	PF00069	0.666
MOD_Plk_4	808	814	PF00069	0.712
MOD_Plk_4	884	890	PF00069	0.624
MOD_ProDKin_1	178	184	PF00069	0.778
MOD_ProDKin_1	226	232	PF00069	0.534
MOD_ProDKin_1	238	244	PF00069	0.346
MOD_ProDKin_1	39	45	PF00069	0.635
MOD_ProDKin_1	492	498	PF00069	0.741
MOD_ProDKin_1	643	649	PF00069	0.712
MOD_ProDKin_1	696	702	PF00069	0.685
MOD_ProDKin_1	715	721	PF00069	0.672
MOD_ProDKin_1	725	731	PF00069	0.798
MOD_ProDKin_1	784	790	PF00069	0.664
TRG_DiLeu_BaEn_1	235	240	PF01217	0.405
TRG_DiLeu_BaEn_1	907	912	PF01217	0.622
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.566
TRG_DiLeu_LyEn_5	235	240	PF01217	0.405
TRG_ENDOCYTIC_2	262	265	PF00928	0.384
TRG_ENDOCYTIC_2	279	282	PF00928	0.355
TRG_ENDOCYTIC_2	360	363	PF00928	0.479
TRG_ENDOCYTIC_2	619	622	PF00928	0.495
TRG_ENDOCYTIC_2	819	822	PF00928	0.540
TRG_ER_diArg_1	116	118	PF00400	0.663
TRG_ER_diArg_1	287	290	PF00400	0.509
TRG_ER_diArg_1	342	344	PF00400	0.493
TRG_ER_diArg_1	807	809	PF00400	0.668
TRG_ER_diArg_1	923	926	PF00400	0.531
TRG_NLS_MonoCore_2	114	119	PF00514	0.713
TRG_NLS_MonoExtC_3	114	120	PF00514	0.637
TRG_NLS_MonoExtN_4	113	119	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y6	Leptomonas seymouri	44%	88%
A4HYY4	Leishmania infantum	99%	100%
E9AIJ8	Leishmania braziliensis	73%	100%
E9AUT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QCQ3	Leishmania major	92%	100%