Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WW49_LEIDO

TriTrypDb:

LdBPK_201010.1 , LdCL_200014800 , LDHU3_20.1250

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WW49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.655
CLV_C14_Caspase3-7	56	60	PF00656	0.639
CLV_NRD_NRD_1	160	162	PF00675	0.585
CLV_NRD_NRD_1	201	203	PF00675	0.674
CLV_NRD_NRD_1	210	212	PF00675	0.609
CLV_NRD_NRD_1	215	217	PF00675	0.565
CLV_NRD_NRD_1	309	311	PF00675	0.669
CLV_NRD_NRD_1	386	388	PF00675	0.627
CLV_NRD_NRD_1	43	45	PF00675	0.607
CLV_NRD_NRD_1	432	434	PF00675	0.691
CLV_NRD_NRD_1	482	484	PF00675	0.704
CLV_PCSK_FUR_1	382	386	PF00082	0.744
CLV_PCSK_KEX2_1	160	162	PF00082	0.585
CLV_PCSK_KEX2_1	210	212	PF00082	0.651
CLV_PCSK_KEX2_1	215	217	PF00082	0.637
CLV_PCSK_KEX2_1	309	311	PF00082	0.657
CLV_PCSK_KEX2_1	384	386	PF00082	0.743
CLV_PCSK_KEX2_1	43	45	PF00082	0.621
CLV_PCSK_KEX2_1	432	434	PF00082	0.691
CLV_PCSK_KEX2_1	570	572	PF00082	0.703
CLV_PCSK_KEX2_1	75	77	PF00082	0.645
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.605
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.743
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.621
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.703
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.645
CLV_PCSK_PC7_1	211	217	PF00082	0.689
CLV_PCSK_PC7_1	382	388	PF00082	0.632
CLV_PCSK_SKI1_1	12	16	PF00082	0.520
CLV_PCSK_SKI1_1	18	22	PF00082	0.441
CLV_PCSK_SKI1_1	215	219	PF00082	0.691
CLV_PCSK_SKI1_1	284	288	PF00082	0.625
CLV_PCSK_SKI1_1	29	33	PF00082	0.406
CLV_PCSK_SKI1_1	410	414	PF00082	0.661
CLV_PCSK_SKI1_1	44	48	PF00082	0.462
CLV_PCSK_SKI1_1	454	458	PF00082	0.643
CLV_PCSK_SKI1_1	526	530	PF00082	0.695
DEG_Nend_UBRbox_2	1	3	PF02207	0.583
DEG_SCF_FBW7_1	421	428	PF00400	0.674
DEG_SCF_FBW7_2	359	366	PF00400	0.564
DEG_SPOP_SBC_1	183	187	PF00917	0.720
DEG_SPOP_SBC_1	411	415	PF00917	0.590
DEG_SPOP_SBC_1	628	632	PF00917	0.714
DOC_CKS1_1	273	278	PF01111	0.614
DOC_CKS1_1	422	427	PF01111	0.675
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.638
DOC_MAPK_gen_1	309	318	PF00069	0.678
DOC_MAPK_gen_1	429	437	PF00069	0.691
DOC_PP1_RVXF_1	10	16	PF00149	0.524
DOC_PP2B_LxvP_1	458	461	PF13499	0.627
DOC_PP4_FxxP_1	234	237	PF00568	0.625
DOC_USP7_MATH_1	123	127	PF00917	0.601
DOC_USP7_MATH_1	143	147	PF00917	0.546
DOC_USP7_MATH_1	148	152	PF00917	0.654
DOC_USP7_MATH_1	183	187	PF00917	0.664
DOC_USP7_MATH_1	370	374	PF00917	0.726
DOC_USP7_MATH_1	398	402	PF00917	0.630
DOC_USP7_MATH_1	411	415	PF00917	0.586
DOC_USP7_MATH_1	425	429	PF00917	0.687
DOC_USP7_MATH_1	447	451	PF00917	0.721
DOC_USP7_MATH_1	459	463	PF00917	0.628
DOC_USP7_MATH_1	479	483	PF00917	0.641
DOC_USP7_MATH_1	495	499	PF00917	0.548
DOC_USP7_MATH_1	60	64	PF00917	0.648
DOC_USP7_MATH_1	624	628	PF00917	0.709
DOC_USP7_MATH_1	655	659	PF00917	0.693
DOC_USP7_UBL2_3	43	47	PF12436	0.630
DOC_WD40_RPTOR_TOS_1	696	702	PF00400	0.675
DOC_WW_Pin1_4	134	139	PF00397	0.629
DOC_WW_Pin1_4	241	246	PF00397	0.815
DOC_WW_Pin1_4	272	277	PF00397	0.615
DOC_WW_Pin1_4	293	298	PF00397	0.629
DOC_WW_Pin1_4	359	364	PF00397	0.645
DOC_WW_Pin1_4	417	422	PF00397	0.752
DOC_WW_Pin1_4	474	479	PF00397	0.716
DOC_WW_Pin1_4	512	517	PF00397	0.779
DOC_WW_Pin1_4	533	538	PF00397	0.685
DOC_WW_Pin1_4	569	574	PF00397	0.723
DOC_WW_Pin1_4	578	583	PF00397	0.629
DOC_WW_Pin1_4	612	617	PF00397	0.737
DOC_WW_Pin1_4	636	641	PF00397	0.699
DOC_WW_Pin1_4	677	682	PF00397	0.765
LIG_14-3-3_CanoR_1	111	120	PF00244	0.514
LIG_14-3-3_CanoR_1	18	28	PF00244	0.524
LIG_14-3-3_CanoR_1	252	256	PF00244	0.687
LIG_14-3-3_CanoR_1	309	318	PF00244	0.618
LIG_14-3-3_CanoR_1	403	412	PF00244	0.668
LIG_14-3-3_CanoR_1	483	493	PF00244	0.584
LIG_14-3-3_CanoR_1	571	577	PF00244	0.744
LIG_14-3-3_CanoR_1	589	596	PF00244	0.638
LIG_14-3-3_CanoR_1	626	636	PF00244	0.691
LIG_14-3-3_CanoR_1	644	651	PF00244	0.527
LIG_14-3-3_CanoR_1	81	89	PF00244	0.516
LIG_BIR_III_4	331	335	PF00653	0.639
LIG_BRCT_BRCA1_1	489	493	PF00533	0.586
LIG_FHA_1	20	26	PF00498	0.516
LIG_FHA_1	212	218	PF00498	0.736
LIG_FHA_1	285	291	PF00498	0.738
LIG_FHA_1	311	317	PF00498	0.674
LIG_FHA_1	360	366	PF00498	0.562
LIG_FHA_1	417	423	PF00498	0.708
LIG_FHA_1	455	461	PF00498	0.651
LIG_FHA_1	501	507	PF00498	0.781
LIG_FHA_1	542	548	PF00498	0.798
LIG_FHA_1	579	585	PF00498	0.719
LIG_FHA_1	6	12	PF00498	0.521
LIG_FHA_1	628	634	PF00498	0.755
LIG_FHA_2	231	237	PF00498	0.631
LIG_FHA_2	290	296	PF00498	0.570
LIG_FHA_2	390	396	PF00498	0.794
LIG_FHA_2	463	469	PF00498	0.721
LIG_FHA_2	54	60	PF00498	0.641
LIG_FHA_2	595	601	PF00498	0.687
LIG_FHA_2	689	695	PF00498	0.677
LIG_Integrin_RGD_1	57	59	PF01839	0.612
LIG_LIR_Apic_2	231	237	PF02991	0.617
LIG_LIR_Nem_3	646	651	PF02991	0.665
LIG_MYND_1	512	516	PF01753	0.668
LIG_MYND_1	636	640	PF01753	0.653
LIG_NRBOX	27	33	PF00104	0.523
LIG_SH2_GRB2like	586	589	PF00017	0.724
LIG_SH2_STAT5	38	41	PF00017	0.475
LIG_SH2_STAT5	712	715	PF00017	0.803
LIG_SH2_STAT5	94	97	PF00017	0.489
LIG_SH3_3	117	123	PF00018	0.643
LIG_SH3_3	373	379	PF00018	0.799
LIG_SH3_3	394	400	PF00018	0.716
LIG_SH3_3	472	478	PF00018	0.724
LIG_SH3_3	507	513	PF00018	0.709
LIG_SH3_3	590	596	PF00018	0.674
LIG_TRAF2_1	219	222	PF00917	0.664
LIG_TRAF2_1	245	248	PF00917	0.730
LIG_TRAF2_1	292	295	PF00917	0.709
LIG_TRAF2_1	576	579	PF00917	0.651
LIG_WW_3	550	554	PF00397	0.647
MOD_CDK_SPK_2	515	520	PF00069	0.564
MOD_CDK_SPxK_1	421	427	PF00069	0.672
MOD_CDK_SPxxK_3	474	481	PF00069	0.680
MOD_CK1_1	345	351	PF00069	0.662
MOD_CK1_1	428	434	PF00069	0.548
MOD_CK1_1	462	468	PF00069	0.728
MOD_CK1_1	482	488	PF00069	0.620
MOD_CK1_1	515	521	PF00069	0.724
MOD_CK1_1	572	578	PF00069	0.754
MOD_CK1_1	587	593	PF00069	0.560
MOD_CK1_1	615	621	PF00069	0.844
MOD_CK1_1	627	633	PF00069	0.630
MOD_CK1_1	664	670	PF00069	0.665
MOD_CK1_1	69	75	PF00069	0.688
MOD_CK1_1	707	713	PF00069	0.654
MOD_CK2_1	143	149	PF00069	0.717
MOD_CK2_1	236	242	PF00069	0.627
MOD_CK2_1	289	295	PF00069	0.570
MOD_CK2_1	412	418	PF00069	0.723
MOD_CK2_1	464	470	PF00069	0.683
MOD_CK2_1	688	694	PF00069	0.680
MOD_CK2_1	698	704	PF00069	0.469
MOD_Cter_Amidation	382	385	PF01082	0.745
MOD_Cter_Amidation	532	535	PF01082	0.674
MOD_GlcNHglycan	123	126	PF01048	0.760
MOD_GlcNHglycan	169	172	PF01048	0.644
MOD_GlcNHglycan	186	189	PF01048	0.761
MOD_GlcNHglycan	277	280	PF01048	0.628
MOD_GlcNHglycan	337	340	PF01048	0.713
MOD_GlcNHglycan	441	447	PF01048	0.773
MOD_GlcNHglycan	449	452	PF01048	0.804
MOD_GlcNHglycan	461	464	PF01048	0.591
MOD_GlcNHglycan	470	473	PF01048	0.798
MOD_GlcNHglycan	489	492	PF01048	0.529
MOD_GlcNHglycan	574	577	PF01048	0.694
MOD_GlcNHglycan	610	613	PF01048	0.701
MOD_GlcNHglycan	625	629	PF01048	0.657
MOD_GlcNHglycan	666	669	PF01048	0.628
MOD_GlcNHglycan	67	71	PF01048	0.648
MOD_GlcNHglycan	706	709	PF01048	0.680
MOD_GSK3_1	123	130	PF00069	0.644
MOD_GSK3_1	144	151	PF00069	0.644
MOD_GSK3_1	179	186	PF00069	0.678
MOD_GSK3_1	228	235	PF00069	0.701
MOD_GSK3_1	289	296	PF00069	0.591
MOD_GSK3_1	335	342	PF00069	0.711
MOD_GSK3_1	385	392	PF00069	0.701
MOD_GSK3_1	412	419	PF00069	0.726
MOD_GSK3_1	421	428	PF00069	0.589
MOD_GSK3_1	442	449	PF00069	0.741
MOD_GSK3_1	462	469	PF00069	0.617
MOD_GSK3_1	479	486	PF00069	0.584
MOD_GSK3_1	49	56	PF00069	0.704
MOD_GSK3_1	500	507	PF00069	0.761
MOD_GSK3_1	539	546	PF00069	0.783
MOD_GSK3_1	584	591	PF00069	0.768
MOD_GSK3_1	608	615	PF00069	0.732
MOD_GSK3_1	624	631	PF00069	0.562
MOD_GSK3_1	683	690	PF00069	0.741
MOD_GSK3_1	694	701	PF00069	0.687
MOD_GSK3_1	703	710	PF00069	0.585
MOD_N-GLC_1	587	592	PF02516	0.714
MOD_NEK2_1	127	132	PF00069	0.666
MOD_NEK2_1	141	146	PF00069	0.613
MOD_NEK2_1	229	234	PF00069	0.730
MOD_NEK2_1	412	417	PF00069	0.664
MOD_NEK2_1	48	53	PF00069	0.674
MOD_NEK2_1	661	666	PF00069	0.646
MOD_NEK2_1	683	688	PF00069	0.688
MOD_PIKK_1	127	133	PF00454	0.662
MOD_PIKK_1	243	249	PF00454	0.684
MOD_PIKK_1	370	376	PF00454	0.730
MOD_PIKK_1	404	410	PF00454	0.666
MOD_PIKK_1	615	621	PF00454	0.746
MOD_PIKK_1	643	649	PF00454	0.659
MOD_PIKK_1	683	689	PF00454	0.688
MOD_PK_1	75	81	PF00069	0.588
MOD_PKA_1	211	217	PF00069	0.689
MOD_PKA_1	310	316	PF00069	0.673
MOD_PKA_1	385	391	PF00069	0.627
MOD_PKA_1	483	489	PF00069	0.715
MOD_PKA_1	75	81	PF00069	0.588
MOD_PKA_2	251	257	PF00069	0.687
MOD_PKA_2	342	348	PF00069	0.642
MOD_PKA_2	385	391	PF00069	0.627
MOD_PKA_2	482	488	PF00069	0.664
MOD_PKA_2	588	594	PF00069	0.823
MOD_PKA_2	643	649	PF00069	0.599
MOD_PKA_2	75	81	PF00069	0.588
MOD_Plk_1	454	460	PF00069	0.663
MOD_Plk_1	694	700	PF00069	0.676
MOD_Plk_2-3	236	242	PF00069	0.590
MOD_Plk_2-3	694	700	PF00069	0.676
MOD_Plk_4	123	129	PF00069	0.791
MOD_Plk_4	629	635	PF00069	0.708
MOD_Plk_4	661	667	PF00069	0.645
MOD_Plk_4	75	81	PF00069	0.588
MOD_ProDKin_1	134	140	PF00069	0.624
MOD_ProDKin_1	241	247	PF00069	0.814
MOD_ProDKin_1	272	278	PF00069	0.614
MOD_ProDKin_1	293	299	PF00069	0.625
MOD_ProDKin_1	359	365	PF00069	0.642
MOD_ProDKin_1	417	423	PF00069	0.751
MOD_ProDKin_1	474	480	PF00069	0.718
MOD_ProDKin_1	512	518	PF00069	0.781
MOD_ProDKin_1	533	539	PF00069	0.685
MOD_ProDKin_1	569	575	PF00069	0.724
MOD_ProDKin_1	578	584	PF00069	0.629
MOD_ProDKin_1	612	618	PF00069	0.736
MOD_ProDKin_1	636	642	PF00069	0.701
MOD_ProDKin_1	677	683	PF00069	0.763
MOD_SUMO_for_1	106	109	PF00179	0.501
MOD_SUMO_rev_2	319	328	PF00179	0.656
TRG_DiLeu_BaLyEn_6	633	638	PF01217	0.695
TRG_DiLeu_LyEn_5	225	230	PF01217	0.563
TRG_ENDOCYTIC_2	101	104	PF00928	0.464
TRG_ER_diArg_1	215	217	PF00400	0.647
TRG_ER_diArg_1	385	387	PF00400	0.631
TRG_NLS_MonoCore_2	383	388	PF00514	0.631
TRG_NLS_MonoExtC_3	383	389	PF00514	0.689
TRG_NLS_MonoExtN_4	309	314	PF00514	0.660
TRG_NLS_MonoExtN_4	382	388	PF00514	0.741
TRG_NLS_MonoExtN_4	43	48	PF00514	0.604
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	659	663	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HYU1	Leishmania infantum	99%	100%
E9AIF0	Leishmania braziliensis	61%	98%
E9AUN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QCU6	Leishmania major	84%	100%