RNasePH-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome-associated protein 1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WW44_LEIDO

TriTrypDb:

LdBPK_201400.1 , LdCL_200018700 , LDHU3_20.1760

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0000178	exosome (RNase complex)	4	1
GO:0005730	nucleolus	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905354	exoribonuclease complex	3	1

Expansion

Sequence features

A0A3S7WW44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW44

Function

Biological processes
Term	Name	Level	Count
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	1
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006417	regulation of translation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009896	positive regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0016073	snRNA metabolic process	7	1
GO:0016075	rRNA catabolic process	7	1
GO:0016078	tRNA catabolic process	7	1
GO:0016180	snRNA processing	8	1
GO:0017148	negative regulation of translation	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031331	positive regulation of cellular catabolic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034249	negative regulation of amide metabolic process	6	1
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	9	1
GO:0034470	ncRNA processing	7	1
GO:0034472	snRNA 3'-end processing	8	1
GO:0034473	U1 snRNA 3'-end processing	9	1
GO:0034475	U4 snRNA 3'-end processing	9	1
GO:0034476	U5 snRNA 3'-end processing	9	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034660	ncRNA metabolic process	6	1
GO:0034661	ncRNA catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0043633	polyadenylation-dependent RNA catabolic process	6	1
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	1
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	9	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050779	RNA destabilization	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051248	negative regulation of protein metabolic process	6	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0061014	positive regulation of mRNA catabolic process	7	1
GO:0061157	mRNA destabilization	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071025	RNA surveillance	6	1
GO:0071027	nuclear RNA surveillance	7	1
GO:0071028	nuclear mRNA surveillance	8	1
GO:0071029	nuclear ncRNA surveillance	7	1
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	1
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	1
GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	7	1
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	1
GO:0071047	polyadenylation-dependent mRNA catabolic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:0106354	tRNA surveillance	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903313	positive regulation of mRNA metabolic process	7	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.661
CLV_C14_Caspase3-7	81	85	PF00656	0.550
CLV_NRD_NRD_1	137	139	PF00675	0.509
CLV_NRD_NRD_1	283	285	PF00675	0.503
CLV_NRD_NRD_1	34	36	PF00675	0.403
CLV_NRD_NRD_1	343	345	PF00675	0.469
CLV_PCSK_FUR_1	135	139	PF00082	0.533
CLV_PCSK_KEX2_1	137	139	PF00082	0.534
CLV_PCSK_KEX2_1	34	36	PF00082	0.403
CLV_PCSK_KEX2_1	343	345	PF00082	0.469
CLV_PCSK_SKI1_1	149	153	PF00082	0.426
CLV_PCSK_SKI1_1	29	33	PF00082	0.389
DEG_APCC_DBOX_1	137	145	PF00400	0.451
DEG_SPOP_SBC_1	185	189	PF00917	0.692
DOC_CYCLIN_RxL_1	250	262	PF00134	0.407
DOC_MAPK_DCC_7	254	263	PF00069	0.329
DOC_MAPK_gen_1	107	114	PF00069	0.456
DOC_MAPK_gen_1	135	143	PF00069	0.392
DOC_MAPK_gen_1	254	263	PF00069	0.344
DOC_MAPK_MEF2A_6	107	114	PF00069	0.389
DOC_MAPK_MEF2A_6	254	263	PF00069	0.350
DOC_PP1_RVXF_1	283	290	PF00149	0.394
DOC_PP2B_LxvP_1	256	259	PF13499	0.414
DOC_USP7_MATH_1	185	189	PF00917	0.709
DOC_USP7_MATH_1	192	196	PF00917	0.699
DOC_USP7_MATH_1	201	205	PF00917	0.678
DOC_USP7_MATH_1	271	275	PF00917	0.605
DOC_USP7_MATH_1	353	357	PF00917	0.536
DOC_USP7_MATH_1	56	60	PF00917	0.496
DOC_USP7_MATH_1	78	82	PF00917	0.372
DOC_USP7_MATH_1	91	95	PF00917	0.588
DOC_USP7_UBL2_3	281	285	PF12436	0.351
DOC_WW_Pin1_4	186	191	PF00397	0.594
DOC_WW_Pin1_4	298	303	PF00397	0.334
DOC_WW_Pin1_4	41	46	PF00397	0.589
DOC_WW_Pin1_4	76	81	PF00397	0.363
LIG_14-3-3_CanoR_1	284	290	PF00244	0.440
LIG_APCC_ABBA_1	225	230	PF00400	0.452
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_BIR_III_2	115	119	PF00653	0.388
LIG_FHA_1	3	9	PF00498	0.526
LIG_FHA_1	70	76	PF00498	0.366
LIG_FHA_1	77	83	PF00498	0.361
LIG_FHA_2	309	315	PF00498	0.348
LIG_FHA_2	398	404	PF00498	0.433
LIG_FHA_2	95	101	PF00498	0.619
LIG_LIR_Apic_2	195	199	PF02991	0.553
LIG_LIR_Apic_2	262	267	PF02991	0.501
LIG_LIR_Apic_2	314	319	PF02991	0.490
LIG_LIR_Apic_2	364	368	PF02991	0.553
LIG_LIR_Gen_1	139	148	PF02991	0.473
LIG_LIR_Gen_1	288	297	PF02991	0.347
LIG_LIR_Gen_1	376	385	PF02991	0.499
LIG_LIR_Gen_1	63	69	PF02991	0.487
LIG_LIR_Nem_3	139	143	PF02991	0.496
LIG_LIR_Nem_3	376	381	PF02991	0.510
LIG_LIR_Nem_3	63	67	PF02991	0.506
LIG_NRBOX	294	300	PF00104	0.322
LIG_PDZ_Class_3	400	405	PF00595	0.506
LIG_SH2_CRK	264	268	PF00017	0.579
LIG_SH2_CRK	337	341	PF00017	0.411
LIG_SH2_PTP2	365	368	PF00017	0.558
LIG_SH2_PTP2	64	67	PF00017	0.484
LIG_SH2_SRC	64	67	PF00017	0.484
LIG_SH2_STAP1	124	128	PF00017	0.389
LIG_SH2_STAP1	247	251	PF00017	0.413
LIG_SH2_STAT5	140	143	PF00017	0.436
LIG_SH2_STAT5	218	221	PF00017	0.399
LIG_SH2_STAT5	334	337	PF00017	0.476
LIG_SH2_STAT5	365	368	PF00017	0.602
LIG_SH2_STAT5	38	41	PF00017	0.363
LIG_SH2_STAT5	64	67	PF00017	0.503
LIG_SH3_1	42	48	PF00018	0.477
LIG_SH3_3	304	310	PF00018	0.341
LIG_SH3_3	363	369	PF00018	0.625
LIG_SH3_3	42	48	PF00018	0.581
LIG_SH3_4	281	288	PF00018	0.403
LIG_SUMO_SIM_par_1	296	301	PF11976	0.353
MOD_CK1_1	186	192	PF00069	0.728
MOD_CK1_1	2	8	PF00069	0.650
MOD_CK1_1	356	362	PF00069	0.550
MOD_CK1_1	370	376	PF00069	0.578
MOD_CK1_1	41	47	PF00069	0.630
MOD_CK1_1	94	100	PF00069	0.728
MOD_CK2_1	308	314	PF00069	0.334
MOD_CK2_1	397	403	PF00069	0.412
MOD_CK2_1	6	12	PF00069	0.412
MOD_CK2_1	60	66	PF00069	0.406
MOD_CK2_1	94	100	PF00069	0.716
MOD_GlcNHglycan	125	128	PF01048	0.522
MOD_GlcNHglycan	190	193	PF01048	0.728
MOD_GlcNHglycan	203	206	PF01048	0.527
MOD_GlcNHglycan	236	239	PF01048	0.528
MOD_GlcNHglycan	356	359	PF01048	0.577
MOD_GlcNHglycan	369	372	PF01048	0.530
MOD_GlcNHglycan	69	72	PF01048	0.566
MOD_GlcNHglycan	93	96	PF01048	0.720
MOD_GSK3_1	181	188	PF00069	0.674
MOD_GSK3_1	2	9	PF00069	0.531
MOD_GSK3_1	349	356	PF00069	0.607
MOD_GSK3_1	37	44	PF00069	0.509
MOD_GSK3_1	397	404	PF00069	0.421
MOD_GSK3_1	56	63	PF00069	0.508
MOD_GSK3_1	90	97	PF00069	0.650
MOD_N-GLC_1	60	65	PF02516	0.509
MOD_N-GLC_1	67	72	PF02516	0.500
MOD_N-GLC_1	91	96	PF02516	0.649
MOD_N-GLC_2	375	377	PF02516	0.410
MOD_NEK2_1	143	148	PF00069	0.312
MOD_NEK2_1	183	188	PF00069	0.539
MOD_NEK2_1	234	239	PF00069	0.495
MOD_NEK2_2	259	264	PF00069	0.347
MOD_PIKK_1	397	403	PF00454	0.307
MOD_PKA_2	100	106	PF00069	0.682
MOD_Plk_4	259	265	PF00069	0.342
MOD_Plk_4	361	367	PF00069	0.601
MOD_Plk_4	60	66	PF00069	0.428
MOD_Plk_4	69	75	PF00069	0.319
MOD_Plk_4	78	84	PF00069	0.289
MOD_ProDKin_1	186	192	PF00069	0.593
MOD_ProDKin_1	298	304	PF00069	0.341
MOD_ProDKin_1	41	47	PF00069	0.595
MOD_ProDKin_1	76	82	PF00069	0.366
TRG_DiLeu_BaEn_2	220	226	PF01217	0.445
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.458
TRG_ENDOCYTIC_2	140	143	PF00928	0.461
TRG_ENDOCYTIC_2	337	340	PF00928	0.440
TRG_ENDOCYTIC_2	64	67	PF00928	0.503
TRG_ER_diArg_1	107	110	PF00400	0.339
TRG_ER_diArg_1	136	138	PF00400	0.448
TRG_ER_diArg_1	34	36	PF00400	0.408
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD98	Leptomonas seymouri	69%	95%
A0A0S4JA55	Bodo saltans	28%	100%
A0A1X0NWT9	Trypanosomatidae	44%	100%
A0A3R7M9T9	Trypanosoma rangeli	49%	100%
A4HYX8	Leishmania infantum	100%	100%
C9ZII6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AIJ0	Leishmania braziliensis	82%	100%
E9AUS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCR0	Leishmania major	93%	100%
V5D565	Trypanosoma cruzi	45%	100%