Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WW39_LEIDO

TriTrypDb:

LdBPK_201440.1 , LdCL_200019100 , LDHU3_20.1810

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WW39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.571
CLV_C14_Caspase3-7	334	338	PF00656	0.689
CLV_NRD_NRD_1	170	172	PF00675	0.508
CLV_NRD_NRD_1	254	256	PF00675	0.518
CLV_NRD_NRD_1	265	267	PF00675	0.422
CLV_NRD_NRD_1	375	377	PF00675	0.632
CLV_PCSK_FUR_1	168	172	PF00082	0.508
CLV_PCSK_KEX2_1	170	172	PF00082	0.508
CLV_PCSK_KEX2_1	254	256	PF00082	0.566
CLV_PCSK_KEX2_1	265	267	PF00082	0.444
CLV_PCSK_KEX2_1	375	377	PF00082	0.637
CLV_PCSK_PC7_1	166	172	PF00082	0.424
CLV_PCSK_PC7_1	371	377	PF00082	0.557
CLV_PCSK_SKI1_1	89	93	PF00082	0.616
DEG_Nend_UBRbox_1	1	4	PF02207	0.620
DEG_SCF_FBW7_2	234	240	PF00400	0.547
DEG_SPOP_SBC_1	66	70	PF00917	0.604
DOC_CKS1_1	234	239	PF01111	0.548
DOC_CYCLIN_RxL_1	371	381	PF00134	0.554
DOC_MAPK_gen_1	275	283	PF00069	0.517
DOC_MAPK_gen_1	383	392	PF00069	0.507
DOC_MAPK_MEF2A_6	383	392	PF00069	0.507
DOC_USP7_MATH_1	209	213	PF00917	0.699
DOC_USP7_MATH_1	235	239	PF00917	0.586
DOC_USP7_MATH_1	243	247	PF00917	0.501
DOC_USP7_MATH_1	311	315	PF00917	0.678
DOC_USP7_MATH_1	59	63	PF00917	0.630
DOC_USP7_MATH_1	65	69	PF00917	0.603
DOC_WW_Pin1_4	144	149	PF00397	0.653
DOC_WW_Pin1_4	233	238	PF00397	0.597
DOC_WW_Pin1_4	285	290	PF00397	0.745
DOC_WW_Pin1_4	294	299	PF00397	0.720
DOC_WW_Pin1_4	399	404	PF00397	0.622
DOC_WW_Pin1_4	55	60	PF00397	0.587
DOC_WW_Pin1_4	99	104	PF00397	0.679
LIG_14-3-3_CanoR_1	113	118	PF00244	0.545
LIG_14-3-3_CanoR_1	2	9	PF00244	0.595
LIG_14-3-3_CanoR_1	81	85	PF00244	0.635
LIG_14-3-3_CanoR_1	97	103	PF00244	0.607
LIG_APCC_ABBA_1	388	393	PF00400	0.533
LIG_APCC_ABBA_1	395	400	PF00400	0.551
LIG_BIR_III_4	195	199	PF00653	0.604
LIG_BIR_III_4	356	360	PF00653	0.601
LIG_DLG_GKlike_1	113	120	PF00625	0.647
LIG_FHA_1	160	166	PF00498	0.566
LIG_FHA_1	262	268	PF00498	0.550
LIG_FHA_2	135	141	PF00498	0.702
LIG_FHA_2	271	277	PF00498	0.433
LIG_FHA_2	303	309	PF00498	0.823
LIG_FHA_2	338	344	PF00498	0.667
LIG_LIR_Gen_1	180	191	PF02991	0.503
LIG_LIR_Gen_1	44	53	PF02991	0.677
LIG_LIR_Nem_3	180	186	PF02991	0.495
LIG_LIR_Nem_3	44	49	PF02991	0.661
LIG_Pex14_1	179	183	PF04695	0.544
LIG_SH2_NCK_1	138	142	PF00017	0.557
LIG_SH2_STAP1	35	39	PF00017	0.605
LIG_SH2_STAT3	443	446	PF00017	0.542
LIG_SH2_STAT5	138	141	PF00017	0.561
LIG_SH2_STAT5	35	38	PF00017	0.617
LIG_SH3_3	231	237	PF00018	0.666
LIG_SUMO_SIM_anti_2	404	410	PF11976	0.575
MOD_CK1_1	116	122	PF00069	0.657
MOD_CK1_1	226	232	PF00069	0.680
MOD_CK1_1	288	294	PF00069	0.764
MOD_CK1_1	349	355	PF00069	0.699
MOD_CK1_1	401	407	PF00069	0.618
MOD_CK1_1	58	64	PF00069	0.685
MOD_CK1_1	75	81	PF00069	0.558
MOD_CK2_1	136	142	PF00069	0.623
MOD_CK2_1	171	177	PF00069	0.472
MOD_CK2_1	199	205	PF00069	0.677
MOD_CK2_1	270	276	PF00069	0.433
MOD_CK2_1	302	308	PF00069	0.707
MOD_CK2_1	311	317	PF00069	0.685
MOD_CK2_1	337	343	PF00069	0.669
MOD_CK2_1	65	71	PF00069	0.606
MOD_GlcNHglycan	199	204	PF01048	0.756
MOD_GlcNHglycan	209	212	PF01048	0.753
MOD_GlcNHglycan	226	229	PF01048	0.533
MOD_GlcNHglycan	237	240	PF01048	0.536
MOD_GlcNHglycan	293	296	PF01048	0.641
MOD_GlcNHglycan	320	323	PF01048	0.766
MOD_GlcNHglycan	403	406	PF01048	0.648
MOD_GlcNHglycan	55	58	PF01048	0.734
MOD_GlcNHglycan	75	78	PF01048	0.668
MOD_GSK3_1	112	119	PF00069	0.593
MOD_GSK3_1	216	223	PF00069	0.668
MOD_GSK3_1	285	292	PF00069	0.689
MOD_GSK3_1	311	318	PF00069	0.641
MOD_GSK3_1	55	62	PF00069	0.667
MOD_GSK3_1	65	72	PF00069	0.612
MOD_GSK3_1	75	82	PF00069	0.633
MOD_GSK3_1	99	106	PF00069	0.771
MOD_LATS_1	95	101	PF00433	0.687
MOD_N-GLC_1	302	307	PF02516	0.659
MOD_N-GLC_1	349	354	PF02516	0.631
MOD_NEK2_1	1	6	PF00069	0.594
MOD_NEK2_1	366	371	PF00069	0.557
MOD_NEK2_1	53	58	PF00069	0.744
MOD_NEK2_1	98	103	PF00069	0.655
MOD_NEK2_2	216	221	PF00069	0.637
MOD_NEK2_2	270	275	PF00069	0.433
MOD_PIKK_1	159	165	PF00454	0.566
MOD_PKA_2	1	7	PF00069	0.609
MOD_PKA_2	112	118	PF00069	0.573
MOD_PKA_2	16	22	PF00069	0.613
MOD_PKA_2	220	226	PF00069	0.642
MOD_PKA_2	346	352	PF00069	0.660
MOD_PKA_2	366	372	PF00069	0.584
MOD_PKA_2	398	404	PF00069	0.632
MOD_PKA_2	53	59	PF00069	0.642
MOD_PKA_2	72	78	PF00069	0.536
MOD_PKA_2	80	86	PF00069	0.634
MOD_PKA_2	96	102	PF00069	0.589
MOD_PKB_1	164	172	PF00069	0.427
MOD_Plk_1	270	276	PF00069	0.541
MOD_Plk_1	31	37	PF00069	0.583
MOD_Plk_1	359	365	PF00069	0.559
MOD_Plk_4	220	226	PF00069	0.639
MOD_Plk_4	41	47	PF00069	0.532
MOD_ProDKin_1	144	150	PF00069	0.651
MOD_ProDKin_1	233	239	PF00069	0.594
MOD_ProDKin_1	285	291	PF00069	0.752
MOD_ProDKin_1	294	300	PF00069	0.721
MOD_ProDKin_1	399	405	PF00069	0.618
MOD_ProDKin_1	55	61	PF00069	0.591
MOD_ProDKin_1	99	105	PF00069	0.679
MOD_SUMO_rev_2	185	191	PF00179	0.523
TRG_ENDOCYTIC_2	183	186	PF00928	0.545
TRG_ER_diArg_1	165	168	PF00400	0.501
TRG_ER_diArg_1	170	172	PF00400	0.481
TRG_ER_diArg_1	253	255	PF00400	0.519
TRG_ER_diArg_1	265	267	PF00400	0.415
TRG_ER_diArg_1	375	377	PF00400	0.643
TRG_ER_diArg_1	435	438	PF00400	0.538
TRG_NES_CRM1_1	386	400	PF08389	0.524
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HYY2	Leishmania infantum	99%	100%
E9AIJ6	Leishmania braziliensis	62%	100%
E9AUS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QCQ5	Leishmania major	90%	100%