LeishMANIAdb
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RNA editing endoribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RNA editing endoribonuclease
Gene product:
RNA-editing nuclease 1
Species:
Leishmania donovani
UniProt:
A0A3S7WW37_LEIDO
TriTrypDb:
LdBPK_200910.1 * , LdCL_200013800 , LDHU3_20.1120
Length:
888

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7WW37
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW37

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 7
GO:0006396 RNA processing 6 7
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0016070 RNA metabolic process 5 7
GO:0034641 cellular nitrogen compound metabolic process 3 7
GO:0043170 macromolecule metabolic process 3 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0046483 heterocycle metabolic process 3 7
GO:0071704 organic substance metabolic process 2 7
GO:0090304 nucleic acid metabolic process 4 7
GO:1901360 organic cyclic compound metabolic process 3 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004518 nuclease activity 4 7
GO:0004519 endonuclease activity 5 7
GO:0004521 RNA endonuclease activity 5 7
GO:0004525 ribonuclease III activity 6 7
GO:0004540 RNA nuclease activity 4 7
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 6 7
GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 7
GO:0032296 double-stranded RNA-specific ribonuclease activity 5 7
GO:0140098 catalytic activity, acting on RNA 3 7
GO:0140640 catalytic activity, acting on a nucleic acid 2 7
GO:0005488 binding 1 1
GO:0008270 zinc ion binding 6 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0046914 transition metal ion binding 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 513 517 PF00656 0.693
CLV_C14_Caspase3-7 812 816 PF00656 0.542
CLV_NRD_NRD_1 254 256 PF00675 0.470
CLV_NRD_NRD_1 3 5 PF00675 0.806
CLV_NRD_NRD_1 686 688 PF00675 0.706
CLV_NRD_NRD_1 868 870 PF00675 0.602
CLV_PCSK_FUR_1 250 254 PF00082 0.489
CLV_PCSK_KEX2_1 213 215 PF00082 0.400
CLV_PCSK_KEX2_1 252 254 PF00082 0.497
CLV_PCSK_KEX2_1 3 5 PF00082 0.806
CLV_PCSK_KEX2_1 411 413 PF00082 0.570
CLV_PCSK_KEX2_1 425 427 PF00082 0.545
CLV_PCSK_KEX2_1 686 688 PF00082 0.706
CLV_PCSK_KEX2_1 867 869 PF00082 0.594
CLV_PCSK_PC1ET2_1 213 215 PF00082 0.399
CLV_PCSK_PC1ET2_1 411 413 PF00082 0.570
CLV_PCSK_PC1ET2_1 425 427 PF00082 0.545
CLV_PCSK_PC7_1 250 256 PF00082 0.504
CLV_PCSK_SKI1_1 202 206 PF00082 0.563
CLV_PCSK_SKI1_1 223 227 PF00082 0.530
CLV_PCSK_SKI1_1 255 259 PF00082 0.561
CLV_PCSK_SKI1_1 276 280 PF00082 0.508
CLV_PCSK_SKI1_1 457 461 PF00082 0.697
CLV_PCSK_SKI1_1 584 588 PF00082 0.719
CLV_PCSK_SKI1_1 686 690 PF00082 0.603
CLV_PCSK_SKI1_1 700 704 PF00082 0.543
CLV_PCSK_SKI1_1 791 795 PF00082 0.588
CLV_PCSK_SKI1_1 860 864 PF00082 0.609
DEG_APCC_DBOX_1 685 693 PF00400 0.595
DEG_APCC_DBOX_1 699 707 PF00400 0.558
DEG_Kelch_Keap1_1 753 758 PF01344 0.583
DEG_SCF_FBW7_1 740 747 PF00400 0.777
DEG_SCF_TRCP1_1 526 531 PF00400 0.611
DEG_SPOP_SBC_1 64 68 PF00917 0.720
DOC_ANK_TNKS_1 769 776 PF00023 0.609
DOC_ANK_TNKS_1 831 838 PF00023 0.654
DOC_CDC14_PxL_1 351 359 PF14671 0.643
DOC_CDC14_PxL_1 579 587 PF14671 0.599
DOC_CKS1_1 559 564 PF01111 0.657
DOC_CKS1_1 586 591 PF01111 0.647
DOC_CYCLIN_RxL_1 595 606 PF00134 0.656
DOC_MAPK_FxFP_2 50 53 PF00069 0.639
DOC_MAPK_gen_1 223 233 PF00069 0.466
DOC_MAPK_gen_1 250 258 PF00069 0.574
DOC_MAPK_gen_1 547 555 PF00069 0.676
DOC_MAPK_MEF2A_6 226 235 PF00069 0.495
DOC_MAPK_MEF2A_6 299 308 PF00069 0.400
DOC_PP1_RVXF_1 252 259 PF00149 0.576
DOC_PP1_RVXF_1 30 36 PF00149 0.740
DOC_PP2B_LxvP_1 688 691 PF13499 0.510
DOC_PP4_FxxP_1 193 196 PF00568 0.478
DOC_PP4_FxxP_1 35 38 PF00568 0.676
DOC_PP4_FxxP_1 420 423 PF00568 0.716
DOC_PP4_FxxP_1 50 53 PF00568 0.436
DOC_PP4_FxxP_1 559 562 PF00568 0.658
DOC_PP4_FxxP_1 586 589 PF00568 0.604
DOC_USP7_MATH_1 13 17 PF00917 0.769
DOC_USP7_MATH_1 38 42 PF00917 0.597
DOC_USP7_MATH_1 443 447 PF00917 0.710
DOC_USP7_MATH_1 477 481 PF00917 0.755
DOC_USP7_MATH_1 522 526 PF00917 0.723
DOC_USP7_MATH_1 607 611 PF00917 0.588
DOC_USP7_MATH_1 64 68 PF00917 0.735
DOC_USP7_MATH_1 714 718 PF00917 0.682
DOC_USP7_MATH_1 831 835 PF00917 0.731
DOC_USP7_MATH_1 839 843 PF00917 0.675
DOC_USP7_MATH_1 848 852 PF00917 0.572
DOC_WW_Pin1_4 2 7 PF00397 0.700
DOC_WW_Pin1_4 488 493 PF00397 0.752
DOC_WW_Pin1_4 553 558 PF00397 0.612
DOC_WW_Pin1_4 57 62 PF00397 0.624
DOC_WW_Pin1_4 585 590 PF00397 0.642
DOC_WW_Pin1_4 644 649 PF00397 0.695
DOC_WW_Pin1_4 706 711 PF00397 0.593
DOC_WW_Pin1_4 715 720 PF00397 0.653
DOC_WW_Pin1_4 721 726 PF00397 0.656
DOC_WW_Pin1_4 740 745 PF00397 0.685
DOC_WW_Pin1_4 820 825 PF00397 0.692
DOC_WW_Pin1_4 844 849 PF00397 0.768
LIG_14-3-3_CanoR_1 147 153 PF00244 0.631
LIG_14-3-3_CanoR_1 157 162 PF00244 0.462
LIG_14-3-3_CanoR_1 200 205 PF00244 0.419
LIG_14-3-3_CanoR_1 291 296 PF00244 0.559
LIG_14-3-3_CanoR_1 584 589 PF00244 0.721
LIG_14-3-3_CanoR_1 624 630 PF00244 0.523
LIG_14-3-3_CanoR_1 761 767 PF00244 0.711
LIG_14-3-3_CanoR_1 867 874 PF00244 0.629
LIG_Actin_WH2_2 378 394 PF00022 0.484
LIG_APCC_ABBA_1 278 283 PF00400 0.420
LIG_BRCT_BRCA1_1 128 132 PF00533 0.606
LIG_BRCT_BRCA1_1 555 559 PF00533 0.733
LIG_BRCT_BRCA1_1 618 622 PF00533 0.633
LIG_Clathr_ClatBox_1 689 693 PF01394 0.535
LIG_CtBP_PxDLS_1 562 566 PF00389 0.654
LIG_EH1_1 178 186 PF00400 0.408
LIG_eIF4E_1 629 635 PF01652 0.513
LIG_eIF4E_2 771 777 PF01652 0.614
LIG_EVH1_2 8 12 PF00568 0.772
LIG_FHA_1 101 107 PF00498 0.789
LIG_FHA_1 111 117 PF00498 0.632
LIG_FHA_1 168 174 PF00498 0.410
LIG_FHA_1 239 245 PF00498 0.525
LIG_FHA_1 292 298 PF00498 0.609
LIG_FHA_1 312 318 PF00498 0.242
LIG_FHA_1 397 403 PF00498 0.539
LIG_FHA_1 574 580 PF00498 0.598
LIG_FHA_1 586 592 PF00498 0.621
LIG_FHA_1 812 818 PF00498 0.625
LIG_FHA_2 149 155 PF00498 0.653
LIG_FHA_2 480 486 PF00498 0.632
LIG_FHA_2 615 621 PF00498 0.557
LIG_FHA_2 745 751 PF00498 0.774
LIG_FHA_2 810 816 PF00498 0.660
LIG_GBD_Chelix_1 338 346 PF00786 0.484
LIG_Integrin_isoDGR_2 759 761 PF01839 0.601
LIG_LIR_Apic_2 190 196 PF02991 0.411
LIG_LIR_Apic_2 417 423 PF02991 0.699
LIG_LIR_Apic_2 49 53 PF02991 0.636
LIG_LIR_Apic_2 556 562 PF02991 0.662
LIG_LIR_Apic_2 769 774 PF02991 0.601
LIG_LIR_Gen_1 129 140 PF02991 0.453
LIG_LIR_Gen_1 186 196 PF02991 0.522
LIG_LIR_Gen_1 293 301 PF02991 0.422
LIG_LIR_Gen_1 309 320 PF02991 0.423
LIG_LIR_Gen_1 383 394 PF02991 0.380
LIG_LIR_Gen_1 619 629 PF02991 0.506
LIG_LIR_Nem_3 129 135 PF02991 0.452
LIG_LIR_Nem_3 186 191 PF02991 0.517
LIG_LIR_Nem_3 293 298 PF02991 0.428
LIG_LIR_Nem_3 309 315 PF02991 0.416
LIG_LIR_Nem_3 316 321 PF02991 0.405
LIG_LIR_Nem_3 340 346 PF02991 0.483
LIG_LIR_Nem_3 383 389 PF02991 0.374
LIG_LIR_Nem_3 628 632 PF02991 0.563
LIG_NRBOX 316 322 PF00104 0.529
LIG_OCRL_FandH_1 342 354 PF00620 0.533
LIG_Rb_pABgroove_1 380 388 PF01858 0.357
LIG_Rb_pABgroove_1 482 490 PF01858 0.744
LIG_RPA_C_Fungi 390 402 PF08784 0.480
LIG_SH2_CRK 351 355 PF00017 0.613
LIG_SH2_CRK 386 390 PF00017 0.374
LIG_SH2_NCK_1 88 92 PF00017 0.688
LIG_SH2_PTP2 771 774 PF00017 0.721
LIG_SH2_SRC 20 23 PF00017 0.653
LIG_SH2_SRC 771 774 PF00017 0.674
LIG_SH2_SRC 88 91 PF00017 0.691
LIG_SH2_STAP1 386 390 PF00017 0.358
LIG_SH2_STAT3 281 284 PF00017 0.427
LIG_SH2_STAT5 263 266 PF00017 0.419
LIG_SH2_STAT5 363 366 PF00017 0.666
LIG_SH2_STAT5 613 616 PF00017 0.548
LIG_SH2_STAT5 644 647 PF00017 0.584
LIG_SH2_STAT5 698 701 PF00017 0.552
LIG_SH2_STAT5 771 774 PF00017 0.721
LIG_SH3_1 3 9 PF00018 0.792
LIG_SH3_1 577 583 PF00018 0.599
LIG_SH3_3 156 162 PF00018 0.612
LIG_SH3_3 193 199 PF00018 0.431
LIG_SH3_3 3 9 PF00018 0.762
LIG_SH3_3 551 557 PF00018 0.667
LIG_SH3_3 577 583 PF00018 0.599
LIG_SH3_3 593 599 PF00018 0.568
LIG_SH3_3 642 648 PF00018 0.638
LIG_SH3_3 665 671 PF00018 0.606
LIG_SH3_3 707 713 PF00018 0.720
LIG_SH3_3 821 827 PF00018 0.691
LIG_SUMO_SIM_anti_2 169 175 PF11976 0.413
LIG_SUMO_SIM_anti_2 387 392 PF11976 0.364
LIG_SUMO_SIM_anti_2 519 527 PF11976 0.681
LIG_SUMO_SIM_par_1 373 379 PF11976 0.547
LIG_SUMO_SIM_par_1 560 566 PF11976 0.650
LIG_SxIP_EBH_1 601 614 PF03271 0.646
LIG_SxIP_EBH_1 641 655 PF03271 0.505
LIG_TYR_ITIM 627 632 PF00017 0.469
LIG_UBA3_1 221 226 PF00899 0.392
LIG_UBA3_1 388 392 PF00899 0.484
LIG_WW_3 27 31 PF00397 0.760
MOD_CDK_SPK_2 844 849 PF00069 0.672
MOD_CDK_SPxK_1 740 746 PF00069 0.713
MOD_CK1_1 148 154 PF00069 0.511
MOD_CK1_1 246 252 PF00069 0.528
MOD_CK1_1 293 299 PF00069 0.540
MOD_CK1_1 480 486 PF00069 0.658
MOD_CK1_1 491 497 PF00069 0.749
MOD_CK1_1 67 73 PF00069 0.749
MOD_CK1_1 709 715 PF00069 0.559
MOD_CK1_1 724 730 PF00069 0.586
MOD_CK1_1 762 768 PF00069 0.705
MOD_CK1_1 820 826 PF00069 0.705
MOD_CK1_1 870 876 PF00069 0.632
MOD_CK1_1 878 884 PF00069 0.633
MOD_CK2_1 479 485 PF00069 0.659
MOD_CK2_1 752 758 PF00069 0.608
MOD_CK2_1 830 836 PF00069 0.784
MOD_DYRK1A_RPxSP_1 4 8 PF00069 0.728
MOD_GlcNHglycan 116 119 PF01048 0.671
MOD_GlcNHglycan 330 333 PF01048 0.541
MOD_GlcNHglycan 399 402 PF01048 0.498
MOD_GlcNHglycan 445 448 PF01048 0.658
MOD_GlcNHglycan 449 452 PF01048 0.629
MOD_GlcNHglycan 500 504 PF01048 0.765
MOD_GlcNHglycan 507 510 PF01048 0.646
MOD_GlcNHglycan 526 529 PF01048 0.665
MOD_GlcNHglycan 567 570 PF01048 0.718
MOD_GlcNHglycan 605 608 PF01048 0.577
MOD_GlcNHglycan 681 684 PF01048 0.676
MOD_GlcNHglycan 755 758 PF01048 0.643
MOD_GlcNHglycan 761 764 PF01048 0.700
MOD_GlcNHglycan 78 81 PF01048 0.670
MOD_GlcNHglycan 819 822 PF01048 0.660
MOD_GlcNHglycan 833 836 PF01048 0.710
MOD_GlcNHglycan 841 844 PF01048 0.682
MOD_GlcNHglycan 850 853 PF01048 0.540
MOD_GlcNHglycan 877 880 PF01048 0.670
MOD_GSK3_1 110 117 PF00069 0.695
MOD_GSK3_1 122 129 PF00069 0.725
MOD_GSK3_1 234 241 PF00069 0.501
MOD_GSK3_1 286 293 PF00069 0.592
MOD_GSK3_1 320 327 PF00069 0.554
MOD_GSK3_1 38 45 PF00069 0.601
MOD_GSK3_1 443 450 PF00069 0.711
MOD_GSK3_1 457 464 PF00069 0.728
MOD_GSK3_1 469 476 PF00069 0.598
MOD_GSK3_1 524 531 PF00069 0.791
MOD_GSK3_1 553 560 PF00069 0.623
MOD_GSK3_1 561 568 PF00069 0.661
MOD_GSK3_1 603 610 PF00069 0.647
MOD_GSK3_1 63 70 PF00069 0.755
MOD_GSK3_1 72 79 PF00069 0.643
MOD_GSK3_1 721 728 PF00069 0.735
MOD_GSK3_1 736 743 PF00069 0.797
MOD_GSK3_1 762 769 PF00069 0.688
MOD_GSK3_1 811 818 PF00069 0.710
MOD_GSK3_1 826 833 PF00069 0.561
MOD_GSK3_1 844 851 PF00069 0.744
MOD_GSK3_1 878 885 PF00069 0.662
MOD_LATS_1 326 332 PF00433 0.506
MOD_N-GLC_1 271 276 PF02516 0.516
MOD_N-GLC_1 477 482 PF02516 0.745
MOD_N-GLC_1 57 62 PF02516 0.745
MOD_N-GLC_1 64 69 PF02516 0.731
MOD_N-GLC_1 875 880 PF02516 0.588
MOD_N-GLC_2 788 790 PF02516 0.569
MOD_NEK2_1 320 325 PF00069 0.553
MOD_NEK2_1 397 402 PF00069 0.390
MOD_NEK2_1 563 568 PF00069 0.607
MOD_NEK2_1 573 578 PF00069 0.571
MOD_NEK2_1 656 661 PF00069 0.502
MOD_PIKK_1 867 873 PF00454 0.662
MOD_PKA_1 867 873 PF00069 0.590
MOD_PKA_2 136 142 PF00069 0.518
MOD_PKA_2 207 213 PF00069 0.554
MOD_PKA_2 290 296 PF00069 0.571
MOD_PKA_2 831 837 PF00069 0.800
MOD_PKA_2 867 873 PF00069 0.669
MOD_PKB_1 155 163 PF00069 0.616
MOD_PKB_1 200 208 PF00069 0.553
MOD_PKB_1 431 439 PF00069 0.774
MOD_PKB_1 867 875 PF00069 0.637
MOD_Plk_1 477 483 PF00069 0.742
MOD_Plk_1 882 888 PF00069 0.696
MOD_Plk_4 169 175 PF00069 0.513
MOD_Plk_4 183 189 PF00069 0.311
MOD_Plk_4 217 223 PF00069 0.427
MOD_Plk_4 656 662 PF00069 0.626
MOD_ProDKin_1 2 8 PF00069 0.698
MOD_ProDKin_1 488 494 PF00069 0.750
MOD_ProDKin_1 553 559 PF00069 0.612
MOD_ProDKin_1 57 63 PF00069 0.626
MOD_ProDKin_1 585 591 PF00069 0.644
MOD_ProDKin_1 644 650 PF00069 0.691
MOD_ProDKin_1 706 712 PF00069 0.595
MOD_ProDKin_1 715 721 PF00069 0.653
MOD_ProDKin_1 740 746 PF00069 0.777
MOD_ProDKin_1 820 826 PF00069 0.693
MOD_ProDKin_1 844 850 PF00069 0.765
TRG_DiLeu_BaEn_1 169 174 PF01217 0.529
TRG_DiLeu_BaEn_1 316 321 PF01217 0.523
TRG_DiLeu_BaEn_1 384 389 PF01217 0.356
TRG_DiLeu_BaEn_1 630 635 PF01217 0.632
TRG_DiLeu_BaEn_1 684 689 PF01217 0.650
TRG_DiLeu_BaLyEn_6 598 603 PF01217 0.644
TRG_DiLeu_LyEn_5 684 689 PF01217 0.650
TRG_ENDOCYTIC_2 351 354 PF00928 0.605
TRG_ENDOCYTIC_2 386 389 PF00928 0.373
TRG_ENDOCYTIC_2 629 632 PF00928 0.531
TRG_ER_diArg_1 199 202 PF00400 0.602
TRG_ER_diArg_1 251 254 PF00400 0.483
TRG_ER_diArg_1 416 419 PF00400 0.668
TRG_ER_diArg_1 686 688 PF00400 0.706
TRG_ER_diArg_1 866 869 PF00400 0.692
TRG_Pf-PMV_PEXEL_1 223 227 PF00026 0.418

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEA0 Leptomonas seymouri 42% 86%
A4HYT2 Leishmania infantum 100% 100%
E9AIE1 Leishmania braziliensis 76% 100%
E9AUM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QCV6 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS