Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WW32_LEIDO

TriTrypDb:

LdBPK_201480.1 , LdCL_200019500 , LDHU3_20.1850

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WW32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	331	337	PF00089	0.482
CLV_NRD_NRD_1	189	191	PF00675	0.444
CLV_NRD_NRD_1	249	251	PF00675	0.626
CLV_PCSK_FUR_1	246	250	PF00082	0.688
CLV_PCSK_KEX2_1	189	191	PF00082	0.444
CLV_PCSK_KEX2_1	248	250	PF00082	0.559
CLV_PCSK_SKI1_1	162	166	PF00082	0.434
CLV_PCSK_SKI1_1	178	182	PF00082	0.388
CLV_PCSK_SKI1_1	207	211	PF00082	0.360
CLV_PCSK_SKI1_1	249	253	PF00082	0.574
CLV_PCSK_SKI1_1	63	67	PF00082	0.449
DEG_APCC_DBOX_1	206	214	PF00400	0.386
DEG_COP1_1	264	274	PF00400	0.507
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DOC_CDC14_PxL_1	268	276	PF14671	0.403
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.432
DOC_MAPK_DCC_7	160	170	PF00069	0.514
DOC_MAPK_MEF2A_6	162	171	PF00069	0.546
DOC_PP2B_LxvP_1	195	198	PF13499	0.433
DOC_PP4_MxPP_1	97	100	PF00568	0.541
DOC_USP7_MATH_1	13	17	PF00917	0.573
DOC_USP7_MATH_1	76	80	PF00917	0.520
DOC_WW_Pin1_4	135	140	PF00397	0.458
DOC_WW_Pin1_4	190	195	PF00397	0.511
DOC_WW_Pin1_4	278	283	PF00397	0.493
LIG_14-3-3_CanoR_1	321	331	PF00244	0.475
LIG_Clathr_ClatBox_1	168	172	PF01394	0.533
LIG_FHA_1	109	115	PF00498	0.575
LIG_FHA_1	26	32	PF00498	0.491
LIG_FHA_1	279	285	PF00498	0.426
LIG_FHA_1	315	321	PF00498	0.518
LIG_LIR_Gen_1	121	131	PF02991	0.405
LIG_LIR_Gen_1	141	152	PF02991	0.431
LIG_LIR_Gen_1	231	238	PF02991	0.563
LIG_LIR_Gen_1	266	276	PF02991	0.550
LIG_LIR_Nem_3	121	127	PF02991	0.406
LIG_LIR_Nem_3	141	147	PF02991	0.423
LIG_LIR_Nem_3	172	176	PF02991	0.424
LIG_LIR_Nem_3	231	235	PF02991	0.511
LIG_LIR_Nem_3	266	271	PF02991	0.499
LIG_LIR_Nem_3	44	48	PF02991	0.501
LIG_LIR_Nem_3	5	9	PF02991	0.664
LIG_MYND_1	272	276	PF01753	0.364
LIG_NRBOX	183	189	PF00104	0.498
LIG_PCNA_PIPBox_1	180	189	PF02747	0.523
LIG_PCNA_yPIPBox_3	177	190	PF02747	0.493
LIG_Pex14_1	247	251	PF04695	0.658
LIG_Pex14_2	333	337	PF04695	0.487
LIG_SH2_CRK	144	148	PF00017	0.501
LIG_SH2_CRK	232	236	PF00017	0.560
LIG_SH2_CRK	268	272	PF00017	0.451
LIG_SH2_GRB2like	143	146	PF00017	0.506
LIG_SH2_STAP1	232	236	PF00017	0.504
LIG_SH2_STAT5	124	127	PF00017	0.383
LIG_SH2_STAT5	232	235	PF00017	0.519
LIG_SH3_3	133	139	PF00018	0.473
LIG_SH3_3	161	167	PF00018	0.423
LIG_SH3_3	191	197	PF00018	0.548
LIG_SH3_3	279	285	PF00018	0.461
LIG_SH3_5	139	143	PF00018	0.544
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.528
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.411
LIG_SUMO_SIM_par_1	166	172	PF11976	0.542
LIG_TRAF2_1	52	55	PF00917	0.505
LIG_TRFH_1	144	148	PF08558	0.501
LIG_TRFH_1	268	272	PF08558	0.435
LIG_TYR_ITIM	201	206	PF00017	0.467
LIG_TYR_ITIM	230	235	PF00017	0.515
MOD_CDK_SPK_2	135	140	PF00069	0.571
MOD_CK1_1	138	144	PF00069	0.468
MOD_CK1_1	17	23	PF00069	0.582
MOD_CK1_1	228	234	PF00069	0.591
MOD_CK1_1	253	259	PF00069	0.677
MOD_GlcNHglycan	16	19	PF01048	0.561
MOD_GlcNHglycan	227	230	PF01048	0.648
MOD_GSK3_1	13	20	PF00069	0.553
MOD_GSK3_1	250	257	PF00069	0.652
MOD_GSK3_1	67	74	PF00069	0.399
MOD_GSK3_1	76	83	PF00069	0.357
MOD_N-GLC_1	322	327	PF02516	0.418
MOD_NEK2_1	108	113	PF00069	0.534
MOD_NEK2_1	2	7	PF00069	0.622
MOD_NEK2_1	230	235	PF00069	0.529
MOD_NEK2_1	322	327	PF00069	0.418
MOD_PIKK_1	322	328	PF00454	0.452
MOD_PK_1	250	256	PF00069	0.627
MOD_PKA_2	7	13	PF00069	0.630
MOD_PKB_1	248	256	PF00069	0.690
MOD_Plk_4	179	185	PF00069	0.409
MOD_Plk_4	250	256	PF00069	0.601
MOD_Plk_4	270	276	PF00069	0.393
MOD_Plk_4	68	74	PF00069	0.379
MOD_ProDKin_1	135	141	PF00069	0.455
MOD_ProDKin_1	190	196	PF00069	0.504
MOD_ProDKin_1	278	284	PF00069	0.496
TRG_DiLeu_BaEn_1	266	271	PF01217	0.519
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.544
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.362
TRG_ENDOCYTIC_2	124	127	PF00928	0.413
TRG_ENDOCYTIC_2	143	146	PF00928	0.395
TRG_ENDOCYTIC_2	203	206	PF00928	0.432
TRG_ENDOCYTIC_2	232	235	PF00928	0.487
TRG_ENDOCYTIC_2	268	271	PF00928	0.467
TRG_ER_diArg_1	188	190	PF00400	0.446
TRG_ER_diArg_1	247	250	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5T0	Leptomonas seymouri	75%	100%
A0A0S4INP7	Bodo saltans	38%	88%
A0A1X0NW56	Trypanosomatidae	54%	98%
A0A3R7RG23	Trypanosoma rangeli	52%	99%
A4HYY6	Leishmania infantum	100%	100%
C9ZIJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
E9AIK0	Leishmania braziliensis	89%	100%
E9AUT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QCQ1	Leishmania major	95%	100%
V5BDU9	Trypanosoma cruzi	50%	100%