LeishMANIAdb
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DUF1935 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF1935 domain-containing protein
Gene product:
Domain of unknown function (DUF1935), putative
Species:
Leishmania donovani
UniProt:
A0A3S7WW30_LEIDO
TriTrypDb:
LdBPK_201310.1 , LdCL_200017700 , LDHU3_20.1630
Length:
189

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WW30
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW30

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 139 143 PF00656 0.736
CLV_PCSK_SKI1_1 48 52 PF00082 0.792
DOC_CYCLIN_yClb1_LxF_4 135 140 PF00134 0.671
DOC_PP1_RVXF_1 135 141 PF00149 0.671
DOC_PP1_RVXF_1 46 52 PF00149 0.798
DOC_PP4_FxxP_1 67 70 PF00568 0.825
DOC_USP7_MATH_1 10 14 PF00917 0.830
DOC_USP7_MATH_1 148 152 PF00917 0.751
DOC_USP7_MATH_1 177 181 PF00917 0.625
DOC_USP7_UBL2_3 42 46 PF12436 0.757
DOC_WW_Pin1_4 131 136 PF00397 0.813
LIG_14-3-3_CanoR_1 20 25 PF00244 0.746
LIG_14-3-3_CanoR_1 97 101 PF00244 0.730
LIG_APCC_ABBA_1 38 43 PF00400 0.816
LIG_APCC_ABBAyCdc20_2 97 103 PF00400 0.698
LIG_deltaCOP1_diTrp_1 94 101 PF00928 0.712
LIG_FHA_1 14 20 PF00498 0.656
LIG_FHA_1 54 60 PF00498 0.713
LIG_LIR_Apic_2 64 70 PF02991 0.815
LIG_LIR_Gen_1 28 38 PF02991 0.719
LIG_LIR_Gen_1 95 103 PF02991 0.701
LIG_LIR_Nem_3 28 33 PF02991 0.714
LIG_LIR_Nem_3 95 101 PF02991 0.705
LIG_REV1ctd_RIR_1 112 120 PF16727 0.746
LIG_SH3_3 147 153 PF00018 0.828
LIG_SH3_3 158 164 PF00018 0.819
LIG_SH3_3 171 177 PF00018 0.656
LIG_SH3_3 34 40 PF00018 0.816
LIG_SH3_4 69 76 PF00018 0.771
LIG_TRAF2_1 15 18 PF00917 0.865
LIG_TRAF2_1 92 95 PF00917 0.810
MOD_CDC14_SPxK_1 134 137 PF00782 0.671
MOD_CDK_SPxK_1 131 137 PF00069 0.672
MOD_CK1_1 106 112 PF00069 0.791
MOD_CK1_1 13 19 PF00069 0.694
MOD_CK2_1 12 18 PF00069 0.801
MOD_CK2_1 177 183 PF00069 0.610
MOD_CK2_1 88 94 PF00069 0.793
MOD_GlcNHglycan 11 15 PF01048 0.720
MOD_GlcNHglycan 43 46 PF01048 0.694
MOD_GlcNHglycan 5 8 PF01048 0.791
MOD_GlcNHglycan 90 93 PF01048 0.768
MOD_GSK3_1 106 113 PF00069 0.791
MOD_GSK3_1 9 16 PF00069 0.820
MOD_NMyristoyl 1 7 PF02799 0.731
MOD_PK_1 20 26 PF00069 0.758
MOD_PKA_2 96 102 PF00069 0.770
MOD_Plk_1 106 112 PF00069 0.710
MOD_Plk_4 110 116 PF00069 0.705
MOD_ProDKin_1 131 137 PF00069 0.815
MOD_SPalmitoyl_4 1 7 PF01529 0.731
MOD_SUMO_for_1 136 139 PF00179 0.698
MOD_SUMO_for_1 74 77 PF00179 0.685
MOD_SUMO_rev_2 23 28 PF00179 0.731
MOD_SUMO_rev_2 80 90 PF00179 0.814
TRG_DiLeu_BaEn_4 17 23 PF01217 0.727
TRG_Pf-PMV_PEXEL_1 20 25 PF00026 0.746

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE64 Leptomonas seymouri 43% 100%
A4HYX0 Leishmania infantum 100% 100%
E9AII2 Leishmania braziliensis 74% 100%
E9AUR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QCR9 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS