Cysteine peptidase, Clan CA, family C2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calpain-like cysteine peptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WW18_LEIDO

TriTrypDb:

LdBPK_040430.1 , LdBPK_201220.1 , LdCL_200016700 , LDHU3_20.1530

Length:

821

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 16

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 20

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 102
NetGPI	no	yes: 0, no: 104

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005815	microtubule organizing center	2	1
GO:0005856	cytoskeleton	5	1
GO:0005930	axoneme	2	1
GO:0016020	membrane	2	1
GO:0020016	ciliary pocket	2	1
GO:0020038	subpellicular network	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1

Previous1 2Next

Expansion

Sequence features

A0A3S7WW18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW18

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	105
GO:0006807	nitrogen compound metabolic process	2	105
GO:0008152	metabolic process	1	105
GO:0019538	protein metabolic process	3	105
GO:0043170	macromolecule metabolic process	3	105
GO:0044238	primary metabolic process	2	105
GO:0071704	organic substance metabolic process	2	105
GO:1901564	organonitrogen compound metabolic process	3	105

Previous1Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	105
GO:0004175	endopeptidase activity	4	105
GO:0004197	cysteine-type endopeptidase activity	5	105
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	105
GO:0008233	peptidase activity	3	105
GO:0008234	cysteine-type peptidase activity	4	105
GO:0016787	hydrolase activity	2	105
GO:0140096	catalytic activity, acting on a protein	2	105

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.407
CLV_C14_Caspase3-7	303	307	PF00656	0.496
CLV_C14_Caspase3-7	378	382	PF00656	0.450
CLV_C14_Caspase3-7	617	621	PF00656	0.528
CLV_NRD_NRD_1	284	286	PF00675	0.443
CLV_NRD_NRD_1	621	623	PF00675	0.397
CLV_PCSK_KEX2_1	284	286	PF00082	0.417
CLV_PCSK_KEX2_1	674	676	PF00082	0.406
CLV_PCSK_KEX2_1	774	776	PF00082	0.476
CLV_PCSK_KEX2_1	804	806	PF00082	0.475

Previous1 2 3 4 5…21Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T6	Leptomonas seymouri	33%	100%
A0A0N1I8N2	Leptomonas seymouri	29%	83%
A0A0N1IGQ2	Leptomonas seymouri	32%	100%
A0A0N1ILF1	Leptomonas seymouri	40%	100%
A0A0N1IMH1	Leptomonas seymouri	34%	100%
A0A0N1P9P1	Leptomonas seymouri	40%	96%
A0A0N1PCA9	Leptomonas seymouri	35%	100%
A0A0N1PE91	Leptomonas seymouri	28%	92%
A0A0N1PFI4	Leptomonas seymouri	36%	100%
A0A0S4JLK6	Bodo saltans	28%	100%

Previous1 2 3 4 5…11Next