Cysteine peptidase, Clan CA, family C2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calpain-like cysteine peptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WW18_LEIDO

TriTrypDb:

LdBPK_040430.1 , LdBPK_201220.1 , LdCL_200016700 , LDHU3_20.1530

Length:

821

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 16

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 20

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 102
NetGPI	no	yes: 0, no: 104

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	5
GO:0005815	microtubule organizing center	2	1
GO:0005856	cytoskeleton	5	1
GO:0020016	ciliary pocket	2	1
GO:0020038	subpellicular network	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0005930	axoneme	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7WW18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW18

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	105
GO:0006807	nitrogen compound metabolic process	2	105
GO:0008152	metabolic process	1	105
GO:0019538	protein metabolic process	3	105
GO:0043170	macromolecule metabolic process	3	105
GO:0044238	primary metabolic process	2	105
GO:0071704	organic substance metabolic process	2	105
GO:1901564	organonitrogen compound metabolic process	3	105

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	105
GO:0004175	endopeptidase activity	4	105
GO:0004197	cysteine-type endopeptidase activity	5	105
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	105
GO:0008233	peptidase activity	3	105
GO:0008234	cysteine-type peptidase activity	4	105
GO:0016787	hydrolase activity	2	105
GO:0140096	catalytic activity, acting on a protein	2	105

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.407
CLV_C14_Caspase3-7	303	307	PF00656	0.496
CLV_C14_Caspase3-7	378	382	PF00656	0.450
CLV_C14_Caspase3-7	617	621	PF00656	0.528
CLV_NRD_NRD_1	284	286	PF00675	0.443
CLV_NRD_NRD_1	621	623	PF00675	0.397
CLV_PCSK_KEX2_1	284	286	PF00082	0.417
CLV_PCSK_KEX2_1	674	676	PF00082	0.406
CLV_PCSK_KEX2_1	774	776	PF00082	0.476
CLV_PCSK_KEX2_1	804	806	PF00082	0.475
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.416
CLV_PCSK_PC1ET2_1	774	776	PF00082	0.505
CLV_PCSK_PC1ET2_1	804	806	PF00082	0.521
CLV_PCSK_SKI1_1	127	131	PF00082	0.612
CLV_PCSK_SKI1_1	285	289	PF00082	0.553
CLV_PCSK_SKI1_1	340	344	PF00082	0.259
CLV_PCSK_SKI1_1	431	435	PF00082	0.323
CLV_PCSK_SKI1_1	447	451	PF00082	0.183
CLV_PCSK_SKI1_1	569	573	PF00082	0.269
CLV_PCSK_SKI1_1	716	720	PF00082	0.472
DEG_SCF_FBW7_2	156	161	PF00400	0.523
DEG_SIAH_1	117	125	PF03145	0.390
DOC_PP1_RVXF_1	419	425	PF00149	0.478
DOC_PP1_RVXF_1	577	584	PF00149	0.540
DOC_PP4_FxxP_1	189	192	PF00568	0.295
DOC_PP4_FxxP_1	322	325	PF00568	0.521
DOC_PP4_FxxP_1	402	405	PF00568	0.482
DOC_USP7_MATH_1	389	393	PF00917	0.480
DOC_USP7_MATH_1	47	51	PF00917	0.786
DOC_USP7_MATH_2	355	361	PF00917	0.533
DOC_USP7_UBL2_3	465	469	PF12436	0.477
DOC_USP7_UBL2_3	619	623	PF12436	0.505
DOC_WW_Pin1_4	113	118	PF00397	0.693
DOC_WW_Pin1_4	154	159	PF00397	0.458
DOC_WW_Pin1_4	49	54	PF00397	0.706
DOC_WW_Pin1_4	525	530	PF00397	0.483
DOC_WW_Pin1_4	658	663	PF00397	0.400
LIG_14-3-3_CanoR_1	127	133	PF00244	0.611
LIG_14-3-3_CanoR_1	284	292	PF00244	0.531
LIG_14-3-3_CanoR_1	421	425	PF00244	0.463
LIG_14-3-3_CanoR_1	711	720	PF00244	0.532
LIG_Actin_WH2_2	257	274	PF00022	0.330
LIG_Actin_WH2_2	432	449	PF00022	0.562
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_BIR_III_2	595	599	PF00653	0.383
LIG_BRCT_BRCA1_1	769	773	PF00533	0.469
LIG_Clathr_ClatBox_1	793	797	PF01394	0.566
LIG_CtBP_PxDLS_1	355	359	PF00389	0.385
LIG_deltaCOP1_diTrp_1	582	587	PF00928	0.472
LIG_deltaCOP1_diTrp_1	715	719	PF00928	0.429
LIG_eIF4E_1	544	550	PF01652	0.496
LIG_FHA_1	124	130	PF00498	0.619
LIG_FHA_1	266	272	PF00498	0.333
LIG_FHA_1	286	292	PF00498	0.483
LIG_FHA_1	645	651	PF00498	0.427
LIG_FHA_1	664	670	PF00498	0.451
LIG_FHA_2	252	258	PF00498	0.413
LIG_FHA_2	301	307	PF00498	0.494
LIG_FHA_2	4	10	PF00498	0.500
LIG_FHA_2	554	560	PF00498	0.490
LIG_FHA_2	590	596	PF00498	0.559
LIG_LIR_Apic_2	187	192	PF02991	0.289
LIG_LIR_Gen_1	464	475	PF02991	0.483
LIG_LIR_Gen_1	490	497	PF02991	0.493
LIG_LIR_Gen_1	508	519	PF02991	0.491
LIG_LIR_Gen_1	542	550	PF02991	0.497
LIG_LIR_Gen_1	663	669	PF02991	0.369
LIG_LIR_Gen_1	714	725	PF02991	0.424
LIG_LIR_Nem_3	205	209	PF02991	0.303
LIG_LIR_Nem_3	436	441	PF02991	0.507
LIG_LIR_Nem_3	457	462	PF02991	0.475
LIG_LIR_Nem_3	464	470	PF02991	0.478
LIG_LIR_Nem_3	473	477	PF02991	0.466
LIG_LIR_Nem_3	508	514	PF02991	0.464
LIG_LIR_Nem_3	542	547	PF02991	0.465
LIG_LIR_Nem_3	663	668	PF02991	0.407
LIG_LIR_Nem_3	681	686	PF02991	0.431
LIG_LIR_Nem_3	697	702	PF02991	0.455
LIG_LIR_Nem_3	714	720	PF02991	0.445
LIG_LIR_Nem_3	770	776	PF02991	0.380
LIG_LIR_Nem_3	784	789	PF02991	0.477
LIG_LIR_Nem_3	9	13	PF02991	0.504
LIG_PDZ_Class_3	816	821	PF00595	0.497
LIG_Pex14_2	614	618	PF04695	0.475
LIG_SH2_CRK	467	471	PF00017	0.475
LIG_SH2_CRK	474	478	PF00017	0.475
LIG_SH2_CRK	522	526	PF00017	0.492
LIG_SH2_CRK	544	548	PF00017	0.477
LIG_SH2_CRK	683	687	PF00017	0.402
LIG_SH2_CRK	699	703	PF00017	0.478
LIG_SH2_CRK	86	90	PF00017	0.806
LIG_SH2_GRB2like	280	283	PF00017	0.532
LIG_SH2_GRB2like	624	627	PF00017	0.441
LIG_SH2_NCK_1	544	548	PF00017	0.492
LIG_SH2_NCK_1	86	90	PF00017	0.511
LIG_SH2_NCK_1	93	97	PF00017	0.520
LIG_SH2_PTP2	736	739	PF00017	0.393
LIG_SH2_SRC	438	441	PF00017	0.491
LIG_SH2_STAP1	215	219	PF00017	0.317
LIG_SH2_STAP1	448	452	PF00017	0.505
LIG_SH2_STAP1	638	642	PF00017	0.341
LIG_SH2_STAP1	70	74	PF00017	0.796
LIG_SH2_STAP1	93	97	PF00017	0.524
LIG_SH2_STAT5	245	248	PF00017	0.360
LIG_SH2_STAT5	438	441	PF00017	0.487
LIG_SH2_STAT5	522	525	PF00017	0.510
LIG_SH2_STAT5	555	558	PF00017	0.455
LIG_SH2_STAT5	56	59	PF00017	0.495
LIG_SH2_STAT5	624	627	PF00017	0.472
LIG_SH2_STAT5	736	739	PF00017	0.336
LIG_SH2_STAT5	754	757	PF00017	0.351
LIG_SH3_3	247	253	PF00018	0.318
LIG_SH3_3	322	328	PF00018	0.520
LIG_SH3_3	338	344	PF00018	0.555
LIG_SH3_3	656	662	PF00018	0.379
LIG_SH3_3	745	751	PF00018	0.597
LIG_SH3_3	793	799	PF00018	0.471
LIG_SH3_3	92	98	PF00018	0.683
LIG_SH3_5	636	640	PF00018	0.413
LIG_SUMO_SIM_anti_2	724	729	PF11976	0.375
LIG_SUMO_SIM_par_1	652	658	PF11976	0.397
LIG_SUMO_SIM_par_1	684	689	PF11976	0.380
LIG_TRAF2_1	69	72	PF00917	0.810
LIG_TRAF2_1	74	77	PF00917	0.764
LIG_TYR_ITIM	194	199	PF00017	0.331
LIG_UBA3_1	194	202	PF00899	0.349
LIG_UBA3_1	613	619	PF00899	0.383
LIG_UBA3_1	727	735	PF00899	0.447
LIG_WRPW_2	342	345	PF00400	0.383
MOD_CDK_SPxK_1	525	531	PF00069	0.489
MOD_CK1_1	387	393	PF00069	0.497
MOD_CK1_1	767	773	PF00069	0.371
MOD_CK2_1	143	149	PF00069	0.474
MOD_CK2_1	251	257	PF00069	0.490
MOD_CK2_1	3	9	PF00069	0.745
MOD_CK2_1	387	393	PF00069	0.468
MOD_CK2_1	553	559	PF00069	0.536
MOD_CK2_1	686	692	PF00069	0.371
MOD_CMANNOS	615	618	PF00535	0.276
MOD_GlcNHglycan	118	121	PF01048	0.636
MOD_GlcNHglycan	317	320	PF01048	0.510
MOD_GlcNHglycan	441	444	PF01048	0.308
MOD_GlcNHglycan	450	453	PF01048	0.311
MOD_GlcNHglycan	478	481	PF01048	0.270
MOD_GlcNHglycan	582	586	PF01048	0.330
MOD_GlcNHglycan	651	654	PF01048	0.495
MOD_GlcNHglycan	705	708	PF01048	0.433
MOD_GSK3_1	150	157	PF00069	0.488
MOD_GSK3_1	487	494	PF00069	0.472
MOD_GSK3_1	520	527	PF00069	0.491
MOD_GSK3_1	663	670	PF00069	0.434
MOD_N-GLC_1	209	214	PF02516	0.320
MOD_N-GLC_1	233	238	PF02516	0.336
MOD_N-GLC_1	3	8	PF02516	0.503
MOD_N-GLC_1	678	683	PF02516	0.564
MOD_N-GLC_1	703	708	PF02516	0.391
MOD_NEK2_1	150	155	PF00069	0.508
MOD_NEK2_1	232	237	PF00069	0.277
MOD_NEK2_1	260	265	PF00069	0.392
MOD_NEK2_1	379	384	PF00069	0.496
MOD_NEK2_1	434	439	PF00069	0.511
MOD_NEK2_1	470	475	PF00069	0.483
MOD_NEK2_1	497	502	PF00069	0.540
MOD_NEK2_1	614	619	PF00069	0.482
MOD_NEK2_1	703	708	PF00069	0.427
MOD_NEK2_2	491	496	PF00069	0.562
MOD_OFUCOSY	181	188	PF10250	0.192
MOD_PIKK_1	357	363	PF00454	0.541
MOD_PIKK_1	667	673	PF00454	0.362
MOD_PIKK_1	811	817	PF00454	0.545
MOD_PKA_2	420	426	PF00069	0.459
MOD_PKA_2	710	716	PF00069	0.553
MOD_Plk_1	169	175	PF00069	0.581
MOD_Plk_1	209	215	PF00069	0.327
MOD_Plk_1	232	238	PF00069	0.289
MOD_Plk_1	497	503	PF00069	0.504
MOD_Plk_1	723	729	PF00069	0.377
MOD_Plk_1	767	773	PF00069	0.431
MOD_Plk_2-3	499	505	PF00069	0.524
MOD_Plk_4	169	175	PF00069	0.587
MOD_Plk_4	379	385	PF00069	0.478
MOD_Plk_4	434	440	PF00069	0.512
MOD_Plk_4	520	526	PF00069	0.519
MOD_Plk_4	553	559	PF00069	0.494
MOD_Plk_4	723	729	PF00069	0.430
MOD_ProDKin_1	113	119	PF00069	0.694
MOD_ProDKin_1	154	160	PF00069	0.461
MOD_ProDKin_1	49	55	PF00069	0.708
MOD_ProDKin_1	525	531	PF00069	0.483
MOD_ProDKin_1	658	664	PF00069	0.403
MOD_SUMO_for_1	787	790	PF00179	0.429
MOD_SUMO_rev_2	498	507	PF00179	0.480
MOD_SUMO_rev_2	559	568	PF00179	0.524
MOD_SUMO_rev_2	681	686	PF00179	0.458
TRG_DiLeu_BaEn_2	254	260	PF01217	0.257
TRG_DiLeu_BaEn_4	15	21	PF01217	0.510
TRG_ENDOCYTIC_2	196	199	PF00928	0.308
TRG_ENDOCYTIC_2	438	441	PF00928	0.504
TRG_ENDOCYTIC_2	467	470	PF00928	0.482
TRG_ENDOCYTIC_2	474	477	PF00928	0.479
TRG_ENDOCYTIC_2	522	525	PF00928	0.477
TRG_ENDOCYTIC_2	544	547	PF00928	0.486
TRG_ENDOCYTIC_2	555	558	PF00928	0.501
TRG_ENDOCYTIC_2	683	686	PF00928	0.379
TRG_ENDOCYTIC_2	699	702	PF00928	0.390
TRG_ENDOCYTIC_2	736	739	PF00928	0.328
TRG_ENDOCYTIC_2	93	96	PF00928	0.739
TRG_ER_diArg_1	124	127	PF00400	0.653
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T6	Leptomonas seymouri	33%	100%
A0A0N1I8N2	Leptomonas seymouri	29%	83%
A0A0N1IGQ2	Leptomonas seymouri	32%	100%
A0A0N1ILF1	Leptomonas seymouri	40%	100%
A0A0N1IMH1	Leptomonas seymouri	34%	100%
A0A0N1P9P1	Leptomonas seymouri	40%	96%
A0A0N1PCA9	Leptomonas seymouri	35%	100%
A0A0N1PE91	Leptomonas seymouri	28%	92%
A0A0N1PFI4	Leptomonas seymouri	36%	100%
A0A0S4JLK6	Bodo saltans	28%	100%
A0A0S4KGT2	Bodo saltans	40%	100%
A0A0S4KKP7	Bodo saltans	24%	100%
A0A1X0NJ19	Trypanosomatidae	29%	67%
A0A1X0NJK2	Trypanosomatidae	31%	100%
A0A1X0NJX8	Trypanosomatidae	36%	100%
A0A1X0NKT7	Trypanosomatidae	32%	100%
A0A1X0NKX8	Trypanosomatidae	32%	100%
A0A1X0NMT3	Trypanosomatidae	41%	96%
A0A1X0NW84	Trypanosomatidae	39%	100%
A0A1X0NW85	Trypanosomatidae	38%	100%
A0A1X0NW89	Trypanosomatidae	55%	95%
A0A1X0NWA6	Trypanosomatidae	30%	94%
A0A1X0NWW1	Trypanosomatidae	40%	100%
A0A3Q8IBS3	Leishmania donovani	99%	100%
A0A3Q8IDD4	Leishmania donovani	34%	100%
A0A3Q8IJT4	Leishmania donovani	26%	100%
A0A3S5H5A5	Leishmania donovani	41%	100%
A0A3S5ISG2	Trypanosoma rangeli	32%	100%
A0A3S7WW13	Leishmania donovani	27%	100%
A0A3S7WW41	Leishmania donovani	35%	100%
A0A3S7WW71	Leishmania donovani	40%	100%
A0A3S7X430	Leishmania donovani	34%	100%
A0A3S7X438	Leishmania donovani	30%	87%
A0A3S7X460	Leishmania donovani	35%	100%
A0A3S7X463	Leishmania donovani	27%	88%
A0A3S7X470	Leishmania donovani	36%	100%
A0A422MYU1	Trypanosoma rangeli	52%	89%
A0A422MYX0	Trypanosoma rangeli	38%	100%
A4H3W4	Leishmania braziliensis	40%	100%
A4HE81	Leishmania braziliensis	34%	100%
A4HJ14	Leishmania braziliensis	34%	100%
A4HJ22	Leishmania braziliensis	32%	100%
A4HJ24	Leishmania braziliensis	34%	100%
A4HS39	Leishmania infantum	41%	100%
A4HYN0	Leishmania infantum	100%	100%
A4HYW1	Leishmania infantum	99%	100%
A4HYW2	Leishmania infantum	40%	100%
A4HYW3	Leishmania infantum	35%	100%
A4HYW4	Leishmania infantum	28%	100%
A4I1J4	Leishmania infantum	34%	100%
A4I6E4	Leishmania infantum	36%	100%
A4I6E6	Leishmania infantum	35%	100%
A4I6F0	Leishmania infantum	30%	100%
A4I6K4	Leishmania infantum	33%	100%
A4I6K5	Leishmania infantum	27%	100%
A4I6K6	Leishmania infantum	26%	100%
C9ZIE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	76%
C9ZIE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZIE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZN52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZN53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	96%
C9ZWY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZY36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	96%
E8NHG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AIH1	Leishmania braziliensis	84%	99%
E9AIH3	Leishmania braziliensis	40%	100%
E9AIH4	Leishmania braziliensis	35%	100%
E9AIH6	Leishmania braziliensis	28%	100%
E9AK26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AUQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AUQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AUR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AUR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AXM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B1J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B1J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B1J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q4Q6L7	Leishmania major	35%	100%
Q4Q6L9	Leishmania major	35%	100%
Q4Q6M0	Leishmania major	30%	100%
Q4Q6M2	Leishmania major	26%	100%
Q4Q6M3	Leishmania major	27%	100%
Q4Q6M4	Leishmania major	33%	100%
Q4Q9U3	Leishmania major	34%	100%
Q4QCS6	Leishmania major	36%	100%
Q4QCS7	Leishmania major	40%	100%
Q4QCS8	Leishmania major	95%	100%
Q4QCS9	Leishmania major	95%	100%
Q9U0T9	Leishmania major	41%	100%
V5AYJ1	Trypanosoma cruzi	31%	100%
V5B5I4	Trypanosoma cruzi	54%	98%
V5BA05	Trypanosoma cruzi	41%	100%
V5BEL3	Trypanosoma cruzi	37%	100%
V5BII7	Trypanosoma cruzi	29%	67%
V5BN20	Trypanosoma cruzi	33%	100%
V5D9Y2	Trypanosoma cruzi	41%	97%
V5DES7	Trypanosoma cruzi	32%	100%