Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WW17_LEIDO

TriTrypDb:

LdBPK_200990.1 , LdCL_200014600 , LDHU3_20.1220

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WW17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.582
CLV_NRD_NRD_1	226	228	PF00675	0.429
CLV_NRD_NRD_1	304	306	PF00675	0.394
CLV_NRD_NRD_1	335	337	PF00675	0.416
CLV_NRD_NRD_1	35	37	PF00675	0.623
CLV_NRD_NRD_1	350	352	PF00675	0.477
CLV_NRD_NRD_1	353	355	PF00675	0.511
CLV_NRD_NRD_1	435	437	PF00675	0.378
CLV_NRD_NRD_1	465	467	PF00675	0.416
CLV_NRD_NRD_1	468	470	PF00675	0.437
CLV_NRD_NRD_1	613	615	PF00675	0.643
CLV_PCSK_FUR_1	351	355	PF00082	0.448
CLV_PCSK_FUR_1	433	437	PF00082	0.373
CLV_PCSK_FUR_1	466	470	PF00082	0.437
CLV_PCSK_KEX2_1	11	13	PF00082	0.585
CLV_PCSK_KEX2_1	304	306	PF00082	0.394
CLV_PCSK_KEX2_1	35	37	PF00082	0.623
CLV_PCSK_KEX2_1	350	352	PF00082	0.516
CLV_PCSK_KEX2_1	353	355	PF00082	0.550
CLV_PCSK_KEX2_1	435	437	PF00082	0.467
CLV_PCSK_KEX2_1	465	467	PF00082	0.413
CLV_PCSK_KEX2_1	468	470	PF00082	0.439
CLV_PCSK_KEX2_1	613	615	PF00082	0.643
CLV_PCSK_KEX2_1	88	90	PF00082	0.412
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.412
CLV_PCSK_PC7_1	461	467	PF00082	0.426
CLV_PCSK_SKI1_1	155	159	PF00082	0.398
CLV_PCSK_SKI1_1	179	183	PF00082	0.479
CLV_PCSK_SKI1_1	202	206	PF00082	0.355
CLV_PCSK_SKI1_1	405	409	PF00082	0.400
CLV_PCSK_SKI1_1	448	452	PF00082	0.415
CLV_PCSK_SKI1_1	481	485	PF00082	0.454
CLV_PCSK_SKI1_1	592	596	PF00082	0.492
CLV_Separin_Metazoa	339	343	PF03568	0.464
DEG_APCC_DBOX_1	563	571	PF00400	0.547
DEG_APCC_DBOX_1	591	599	PF00400	0.484
DEG_Nend_Nbox_1	1	3	PF02207	0.557
DEG_SPOP_SBC_1	364	368	PF00917	0.560
DEG_SPOP_SBC_1	37	41	PF00917	0.579
DEG_SPOP_SBC_1	98	102	PF00917	0.495
DOC_CDC14_PxL_1	2	10	PF14671	0.473
DOC_CKS1_1	43	48	PF01111	0.512
DOC_CKS1_1	632	637	PF01111	0.593
DOC_CKS1_1	653	658	PF01111	0.556
DOC_CYCLIN_RxL_1	176	185	PF00134	0.467
DOC_CYCLIN_RxL_1	478	487	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	632	638	PF00134	0.583
DOC_MAPK_gen_1	405	413	PF00069	0.399
DOC_MAPK_gen_1	642	650	PF00069	0.593
DOC_MAPK_MEF2A_6	642	650	PF00069	0.593
DOC_PP1_RVXF_1	177	184	PF00149	0.464
DOC_PP1_RVXF_1	396	403	PF00149	0.527
DOC_PP2B_LxvP_1	361	364	PF13499	0.621
DOC_PP4_FxxP_1	194	197	PF00568	0.414
DOC_USP7_MATH_1	238	242	PF00917	0.423
DOC_USP7_MATH_1	294	298	PF00917	0.504
DOC_USP7_MATH_1	364	368	PF00917	0.572
DOC_USP7_MATH_1	370	374	PF00917	0.519
DOC_USP7_MATH_1	526	530	PF00917	0.630
DOC_USP7_MATH_1	554	558	PF00917	0.780
DOC_USP7_MATH_1	80	84	PF00917	0.472
DOC_WW_Pin1_4	124	129	PF00397	0.405
DOC_WW_Pin1_4	137	142	PF00397	0.364
DOC_WW_Pin1_4	281	286	PF00397	0.505
DOC_WW_Pin1_4	365	370	PF00397	0.671
DOC_WW_Pin1_4	374	379	PF00397	0.669
DOC_WW_Pin1_4	39	44	PF00397	0.600
DOC_WW_Pin1_4	531	536	PF00397	0.624
DOC_WW_Pin1_4	582	587	PF00397	0.515
DOC_WW_Pin1_4	631	636	PF00397	0.756
DOC_WW_Pin1_4	652	657	PF00397	0.622
DOC_WW_Pin1_4	683	688	PF00397	0.596
LIG_14-3-3_CanoR_1	11	15	PF00244	0.647
LIG_14-3-3_CanoR_1	216	226	PF00244	0.338
LIG_14-3-3_CanoR_1	35	43	PF00244	0.521
LIG_14-3-3_CanoR_1	461	465	PF00244	0.515
LIG_14-3-3_CanoR_1	564	574	PF00244	0.549
LIG_14-3-3_CanoR_1	628	633	PF00244	0.632
LIG_Actin_WH2_2	317	335	PF00022	0.422
LIG_BRCT_BRCA1_1	222	226	PF00533	0.447
LIG_BRCT_BRCA1_1	74	78	PF00533	0.465
LIG_BRCT_BRCA1_2	222	228	PF00533	0.462
LIG_CaM_IQ_9	661	677	PF13499	0.552
LIG_FHA_1	314	320	PF00498	0.405
LIG_FHA_1	384	390	PF00498	0.343
LIG_FHA_1	438	444	PF00498	0.638
LIG_FHA_1	627	633	PF00498	0.708
LIG_FHA_2	404	410	PF00498	0.554
LIG_FHA_2	421	427	PF00498	0.405
LIG_FHA_2	465	471	PF00498	0.594
LIG_FHA_2	620	626	PF00498	0.760
LIG_HCF-1_HBM_1	151	154	PF13415	0.420
LIG_LIR_Apic_2	122	128	PF02991	0.380
LIG_LIR_Apic_2	191	197	PF02991	0.427
LIG_LIR_Apic_2	65	71	PF02991	0.390
LIG_LIR_Gen_1	127	138	PF02991	0.450
LIG_LIR_Gen_1	241	250	PF02991	0.502
LIG_LIR_Gen_1	273	283	PF02991	0.353
LIG_LIR_Gen_1	335	345	PF02991	0.462
LIG_LIR_Gen_1	426	434	PF02991	0.448
LIG_LIR_Gen_1	645	653	PF02991	0.652
LIG_LIR_Nem_3	127	133	PF02991	0.427
LIG_LIR_Nem_3	151	157	PF02991	0.349
LIG_LIR_Nem_3	223	229	PF02991	0.411
LIG_LIR_Nem_3	241	246	PF02991	0.288
LIG_LIR_Nem_3	273	278	PF02991	0.457
LIG_LIR_Nem_3	335	341	PF02991	0.460
LIG_LIR_Nem_3	521	525	PF02991	0.555
LIG_LIR_Nem_3	645	650	PF02991	0.657
LIG_MYND_1	281	285	PF01753	0.446
LIG_NRBOX	200	206	PF00104	0.297
LIG_NRBOX	479	485	PF00104	0.480
LIG_Rb_LxCxE_1	392	409	PF01857	0.401
LIG_SH2_CRK	154	158	PF00017	0.457
LIG_SH2_CRK	327	331	PF00017	0.463
LIG_SH2_NCK_1	473	477	PF00017	0.435
LIG_SH2_PTP2	647	650	PF00017	0.558
LIG_SH2_STAP1	174	178	PF00017	0.323
LIG_SH2_STAP1	259	263	PF00017	0.338
LIG_SH2_STAP1	522	526	PF00017	0.502
LIG_SH2_STAT5	117	120	PF00017	0.477
LIG_SH2_STAT5	218	221	PF00017	0.360
LIG_SH2_STAT5	245	248	PF00017	0.303
LIG_SH2_STAT5	647	650	PF00017	0.558
LIG_SH2_STAT5	689	692	PF00017	0.670
LIG_SH3_3	40	46	PF00018	0.710
LIG_SH3_3	472	478	PF00018	0.504
LIG_SH3_3	536	542	PF00018	0.693
LIG_SH3_3	581	587	PF00018	0.546
LIG_SH3_3	604	610	PF00018	0.523
LIG_SH3_3	61	67	PF00018	0.430
LIG_SH3_3	632	638	PF00018	0.701
LIG_SUMO_SIM_anti_2	376	384	PF11976	0.356
LIG_TRAF2_1	189	192	PF00917	0.417
LIG_TRAF2_1	452	455	PF00917	0.470
LIG_TRAF2_1	637	640	PF00917	0.616
LIG_UBA3_1	329	337	PF00899	0.460
MOD_CK1_1	13	19	PF00069	0.644
MOD_CK1_1	221	227	PF00069	0.354
MOD_CK1_1	38	44	PF00069	0.590
MOD_CK1_1	529	535	PF00069	0.609
MOD_CK1_1	566	572	PF00069	0.702
MOD_CK1_1	626	632	PF00069	0.715
MOD_CK1_1	657	663	PF00069	0.642
MOD_CK1_1	99	105	PF00069	0.632
MOD_CK2_1	370	376	PF00069	0.691
MOD_CK2_1	38	44	PF00069	0.598
MOD_CK2_1	403	409	PF00069	0.367
MOD_CK2_1	449	455	PF00069	0.406
MOD_CK2_1	619	625	PF00069	0.714
MOD_GlcNHglycan	103	106	PF01048	0.564
MOD_GlcNHglycan	18	21	PF01048	0.752
MOD_GlcNHglycan	220	223	PF01048	0.461
MOD_GlcNHglycan	235	238	PF01048	0.252
MOD_GlcNHglycan	240	243	PF01048	0.168
MOD_GlcNHglycan	358	361	PF01048	0.585
MOD_GlcNHglycan	372	375	PF01048	0.438
MOD_GlcNHglycan	451	454	PF01048	0.431
MOD_GlcNHglycan	489	492	PF01048	0.704
MOD_GlcNHglycan	496	501	PF01048	0.559
MOD_GlcNHglycan	52	55	PF01048	0.571
MOD_GlcNHglycan	556	559	PF01048	0.685
MOD_GlcNHglycan	570	573	PF01048	0.715
MOD_GlcNHglycan	58	62	PF01048	0.413
MOD_GlcNHglycan	615	618	PF01048	0.809
MOD_GlcNHglycan	659	662	PF01048	0.690
MOD_GlcNHglycan	81	85	PF01048	0.392
MOD_GSK3_1	217	224	PF00069	0.388
MOD_GSK3_1	328	335	PF00069	0.462
MOD_GSK3_1	35	42	PF00069	0.619
MOD_GSK3_1	370	377	PF00069	0.705
MOD_GSK3_1	460	467	PF00069	0.500
MOD_GSK3_1	525	532	PF00069	0.591
MOD_GSK3_1	609	616	PF00069	0.609
MOD_GSK3_1	619	626	PF00069	0.739
MOD_GSK3_1	97	104	PF00069	0.578
MOD_N-GLC_1	529	534	PF02516	0.641
MOD_N-GLC_1	623	628	PF02516	0.651
MOD_NEK2_1	181	186	PF00069	0.509
MOD_NEK2_1	217	222	PF00069	0.443
MOD_NEK2_1	332	337	PF00069	0.377
MOD_NEK2_1	389	394	PF00069	0.449
MOD_NEK2_1	460	465	PF00069	0.585
MOD_NEK2_1	515	520	PF00069	0.510
MOD_NEK2_1	623	628	PF00069	0.703
MOD_PIKK_1	308	314	PF00454	0.452
MOD_PKA_1	35	41	PF00069	0.586
MOD_PKA_1	613	619	PF00069	0.697
MOD_PKA_2	10	16	PF00069	0.651
MOD_PKA_2	332	338	PF00069	0.450
MOD_PKA_2	35	41	PF00069	0.671
MOD_PKA_2	460	466	PF00069	0.532
MOD_PKA_2	543	549	PF00069	0.519
MOD_PKA_2	563	569	PF00069	0.547
MOD_PKA_2	602	608	PF00069	0.582
MOD_PKA_2	613	619	PF00069	0.620
MOD_PKA_2	72	78	PF00069	0.567
MOD_PKB_1	354	362	PF00069	0.518
MOD_Plk_1	529	535	PF00069	0.571
MOD_Plk_1	73	79	PF00069	0.467
MOD_Plk_4	108	114	PF00069	0.680
MOD_Plk_4	221	227	PF00069	0.373
MOD_Plk_4	389	395	PF00069	0.452
MOD_Plk_4	602	608	PF00069	0.586
MOD_Plk_4	73	79	PF00069	0.467
MOD_ProDKin_1	124	130	PF00069	0.407
MOD_ProDKin_1	137	143	PF00069	0.369
MOD_ProDKin_1	281	287	PF00069	0.512
MOD_ProDKin_1	365	371	PF00069	0.671
MOD_ProDKin_1	374	380	PF00069	0.650
MOD_ProDKin_1	39	45	PF00069	0.600
MOD_ProDKin_1	531	537	PF00069	0.626
MOD_ProDKin_1	582	588	PF00069	0.498
MOD_ProDKin_1	631	637	PF00069	0.750
MOD_ProDKin_1	652	658	PF00069	0.621
MOD_ProDKin_1	683	689	PF00069	0.599
TRG_DiLeu_BaEn_1	455	460	PF01217	0.463
TRG_DiLeu_BaEn_2	408	414	PF01217	0.543
TRG_DiLeu_BaEn_4	191	197	PF01217	0.384
TRG_DiLeu_BaEn_4	671	677	PF01217	0.540
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.449
TRG_ENDOCYTIC_2	130	133	PF00928	0.393
TRG_ENDOCYTIC_2	154	157	PF00928	0.402
TRG_ENDOCYTIC_2	174	177	PF00928	0.179
TRG_ENDOCYTIC_2	327	330	PF00928	0.412
TRG_ENDOCYTIC_2	647	650	PF00928	0.664
TRG_ER_diArg_1	304	306	PF00400	0.394
TRG_ER_diArg_1	34	36	PF00400	0.624
TRG_ER_diArg_1	350	353	PF00400	0.438
TRG_ER_diArg_1	432	435	PF00400	0.378
TRG_ER_diArg_1	464	466	PF00400	0.454
TRG_Pf-PMV_PEXEL_1	155	160	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P3	Leptomonas seymouri	55%	94%
A0A0S4JGL0	Bodo saltans	31%	100%
A0A1X0NTL4	Trypanosomatidae	39%	100%
A0A422N5G0	Trypanosoma rangeli	37%	100%
A4HYU0	Leishmania infantum	100%	100%
C9ZQ69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AIE9	Leishmania braziliensis	80%	100%
E9AUN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCU8	Leishmania major	93%	100%