Pre-mRNA-splicing factor 38

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pre-mRNA-splicing factor 38, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WW05_LEIDO

TriTrypDb:

LdBPK_201170.1 , LdCL_200016400 , LDHU3_20.1440

Length:

269

Annotations

LeishMANIAdb annotations

A conserved eukaryotic pre-mRNA-splicing factor 38 protein. Non-TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0071011	precatalytic spliceosome	4	8
GO:0140513	nuclear protein-containing complex	2	8
GO:1990904	ribonucleoprotein complex	2	8

Expansion

Sequence features

A0A3S7WW05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW05

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	8
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	8
GO:0000398	mRNA splicing, via spliceosome	8	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006396	RNA processing	6	8
GO:0006397	mRNA processing	7	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0008380	RNA splicing	7	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0016071	mRNA metabolic process	6	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.265
CLV_PCSK_KEX2_1	166	168	PF00082	0.465
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.465
CLV_PCSK_SKI1_1	34	38	PF00082	0.475
CLV_PCSK_SKI1_1	80	84	PF00082	0.308
DEG_COP1_1	189	200	PF00400	0.630
DEG_SPOP_SBC_1	134	138	PF00917	0.625
DOC_CYCLIN_RxL_1	30	41	PF00134	0.274
DOC_CYCLIN_yCln2_LP_2	262	268	PF00134	0.585
DOC_MAPK_gen_1	89	99	PF00069	0.465
DOC_MAPK_MEF2A_6	30	39	PF00069	0.307
DOC_MAPK_MEF2A_6	92	101	PF00069	0.508
DOC_PP1_RVXF_1	111	117	PF00149	0.450
DOC_PP1_RVXF_1	32	39	PF00149	0.308
DOC_PP2B_LxvP_1	14	17	PF13499	0.323
DOC_USP7_MATH_1	10	14	PF00917	0.426
DOC_USP7_MATH_1	149	153	PF00917	0.725
DOC_USP7_MATH_1	219	223	PF00917	0.693
DOC_USP7_MATH_1	242	246	PF00917	0.747
DOC_USP7_MATH_1	247	251	PF00917	0.709
DOC_WW_Pin1_4	236	241	PF00397	0.704
LIG_14-3-3_CanoR_1	113	122	PF00244	0.487
LIG_14-3-3_CanoR_1	153	162	PF00244	0.678
LIG_14-3-3_CanoR_1	192	200	PF00244	0.656
LIG_Actin_WH2_2	76	94	PF00022	0.339
LIG_BIR_II_1	1	5	PF00653	0.335
LIG_Clathr_ClatBox_1	205	209	PF01394	0.535
LIG_FHA_1	210	216	PF00498	0.503
LIG_GSK3_LRP6_1	240	246	PF00069	0.698
LIG_LIR_Nem_3	117	122	PF02991	0.465
LIG_LIR_Nem_3	18	23	PF02991	0.287
LIG_LIR_Nem_3	209	214	PF02991	0.542
LIG_LIR_Nem_3	258	262	PF02991	0.579
LIG_PDZ_Class_2	264	269	PF00595	0.553
LIG_SH2_CRK	119	123	PF00017	0.465
LIG_SH2_CRK	20	24	PF00017	0.287
LIG_SH2_STAT5	214	217	PF00017	0.555
LIG_SH2_STAT5	48	51	PF00017	0.357
LIG_SH2_STAT5	61	64	PF00017	0.304
LIG_SH2_STAT5	90	93	PF00017	0.508
LIG_SH3_3	194	200	PF00018	0.660
LIG_SH3_3	234	240	PF00018	0.712
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.333
LIG_TRAF2_1	129	132	PF00917	0.589
LIG_UBA3_1	159	166	PF00899	0.655
LIG_WW_1	200	203	PF00397	0.626
MOD_CK1_1	187	193	PF00069	0.715
MOD_CK1_1	220	226	PF00069	0.713
MOD_CK1_1	243	249	PF00069	0.723
MOD_CK1_1	250	256	PF00069	0.647
MOD_CK2_1	165	171	PF00069	0.634
MOD_GlcNHglycan	175	178	PF01048	0.483
MOD_GlcNHglycan	182	185	PF01048	0.558
MOD_GlcNHglycan	186	189	PF01048	0.534
MOD_GlcNHglycan	193	196	PF01048	0.448
MOD_GlcNHglycan	219	222	PF01048	0.419
MOD_GlcNHglycan	245	248	PF01048	0.600
MOD_GlcNHglycan	52	55	PF01048	0.461
MOD_GSK3_1	133	140	PF00069	0.737
MOD_GSK3_1	145	152	PF00069	0.668
MOD_GSK3_1	180	187	PF00069	0.684
MOD_GSK3_1	22	29	PF00069	0.269
MOD_GSK3_1	236	243	PF00069	0.713
MOD_NEK2_1	133	138	PF00069	0.624
MOD_NEK2_1	155	160	PF00069	0.659
MOD_PIKK_1	222	228	PF00454	0.733
MOD_PKA_2	191	197	PF00069	0.667
MOD_Plk_4	155	161	PF00069	0.678
MOD_Plk_4	255	261	PF00069	0.627
MOD_ProDKin_1	236	242	PF00069	0.704
TRG_DiLeu_BaEn_4	41	47	PF01217	0.308
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.268
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.303
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.450
TRG_ENDOCYTIC_2	119	122	PF00928	0.465
TRG_ENDOCYTIC_2	20	23	PF00928	0.287
TRG_ENDOCYTIC_2	203	206	PF00928	0.538
TRG_NES_CRM1_1	71	84	PF08389	0.333
TRG_NLS_MonoExtC_3	165	171	PF00514	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I3	Leptomonas seymouri	55%	100%
A0A422NLL2	Trypanosoma rangeli	43%	100%
A4HYV7	Leishmania infantum	100%	100%
E9AIG4	Leishmania braziliensis	79%	100%
E9AUQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCT1	Leishmania major	93%	100%