LeishMANIAdb
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Phosphopantetheinyl transferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphopantetheinyl transferase-like protein
Gene product:
phosphopantetheinyl transferase-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7WW00_LEIDO
TriTrypDb:
LdBPK_200840.1 , LdCL_200013100 , LDHU3_20.1050
Length:
273

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0005829 cytosol 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A3S7WW00
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WW00

Function

Biological processes
TermNameLevelCount
GO:0006082 organic acid metabolic process 3 1
GO:0006520 amino acid metabolic process 3 1
GO:0006553 lysine metabolic process 6 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008652 amino acid biosynthetic process 4 1
GO:0009058 biosynthetic process 2 1
GO:0009066 aspartate family amino acid metabolic process 5 1
GO:0009067 aspartate family amino acid biosynthetic process 6 1
GO:0009085 lysine biosynthetic process 7 1
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Molecular functions
TermNameLevelCount
GO:0000287 magnesium ion binding 5 7
GO:0003824 catalytic activity 1 7
GO:0005488 binding 1 7
GO:0008897 holo-[acyl-carrier-protein] synthase activity 5 7
GO:0016740 transferase activity 2 7
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 7
GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 254 258 PF00656 0.334
CLV_NRD_NRD_1 156 158 PF00675 0.266
CLV_NRD_NRD_1 271 273 PF00675 0.359
CLV_NRD_NRD_1 33 35 PF00675 0.466
CLV_PCSK_KEX2_1 33 35 PF00082 0.431
CLV_PCSK_KEX2_1 78 80 PF00082 0.534
CLV_PCSK_KEX2_1 83 85 PF00082 0.425
CLV_PCSK_PC1ET2_1 78 80 PF00082 0.531
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.428
CLV_PCSK_PC7_1 79 85 PF00082 0.480
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I553 Leptomonas seymouri 38% 100%
A4HYS5 Leishmania infantum 99% 100%
E9AID4 Leishmania braziliensis 64% 100%
E9AUM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QCW3 Leishmania major 89% 100%
Q5NVE1 Pongo abelii 24% 88%
Q9NRN7 Homo sapiens 24% 88%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS