Tubulin/FtsZ family, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin/FtsZ family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WVZ9_LEIDO

TriTrypDb:

LdBPK_200790.1 , LdCL_200012600 , LDHU3_20.0980

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WVZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.745
CLV_C14_Caspase3-7	291	295	PF00656	0.453
CLV_C14_Caspase3-7	91	95	PF00656	0.732
CLV_NRD_NRD_1	186	188	PF00675	0.808
CLV_NRD_NRD_1	204	206	PF00675	0.577
CLV_NRD_NRD_1	345	347	PF00675	0.428
CLV_NRD_NRD_1	55	57	PF00675	0.412
CLV_NRD_NRD_1	80	82	PF00675	0.614
CLV_PCSK_FUR_1	202	206	PF00082	0.553
CLV_PCSK_FUR_1	343	347	PF00082	0.544
CLV_PCSK_KEX2_1	186	188	PF00082	0.786
CLV_PCSK_KEX2_1	204	206	PF00082	0.447
CLV_PCSK_KEX2_1	345	347	PF00082	0.428
CLV_PCSK_KEX2_1	55	57	PF00082	0.412
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.560
CLV_PCSK_SKI1_1	129	133	PF00082	0.677
CLV_PCSK_SKI1_1	205	209	PF00082	0.561
CLV_PCSK_SKI1_1	555	559	PF00082	0.488
CLV_PCSK_SKI1_1	61	65	PF00082	0.390
CLV_PCSK_SKI1_1	612	616	PF00082	0.625
CLV_PCSK_SKI1_1	664	668	PF00082	0.498
DEG_APCC_DBOX_1	611	619	PF00400	0.569
DEG_Nend_Nbox_1	1	3	PF02207	0.595
DOC_CDC14_PxL_1	478	486	PF14671	0.625
DOC_CDC14_PxL_1	628	636	PF14671	0.456
DOC_CKS1_1	314	319	PF01111	0.539
DOC_CYCLIN_RxL_1	199	210	PF00134	0.570
DOC_CYCLIN_RxL_1	55	66	PF00134	0.536
DOC_MAPK_DCC_7	55	64	PF00069	0.524
DOC_MAPK_gen_1	343	352	PF00069	0.440
DOC_MAPK_gen_1	441	451	PF00069	0.516
DOC_MAPK_gen_1	55	65	PF00069	0.520
DOC_MAPK_MEF2A_6	363	372	PF00069	0.427
DOC_MAPK_MEF2A_6	444	451	PF00069	0.517
DOC_MAPK_MEF2A_6	5	12	PF00069	0.360
DOC_MAPK_MEF2A_6	55	64	PF00069	0.524
DOC_MAPK_NFAT4_5	5	13	PF00069	0.481
DOC_PP2B_LxvP_1	327	330	PF13499	0.428
DOC_PP2B_LxvP_1	65	68	PF13499	0.421
DOC_PP4_FxxP_1	586	589	PF00568	0.529
DOC_USP7_MATH_1	247	251	PF00917	0.525
DOC_USP7_MATH_1	445	449	PF00917	0.477
DOC_USP7_MATH_1	491	495	PF00917	0.752
DOC_USP7_MATH_1	614	618	PF00917	0.397
DOC_USP7_MATH_1	68	72	PF00917	0.603
DOC_USP7_UBL2_3	84	88	PF12436	0.599
DOC_WW_Pin1_4	100	105	PF00397	0.776
DOC_WW_Pin1_4	313	318	PF00397	0.526
DOC_WW_Pin1_4	386	391	PF00397	0.654
LIG_14-3-3_CanoR_1	211	218	PF00244	0.641
LIG_14-3-3_CanoR_1	263	270	PF00244	0.494
LIG_14-3-3_CanoR_1	363	372	PF00244	0.463
LIG_14-3-3_CanoR_1	401	407	PF00244	0.533
LIG_14-3-3_CanoR_1	561	566	PF00244	0.524
LIG_Actin_WH2_2	403	421	PF00022	0.526
LIG_Actin_WH2_2	539	557	PF00022	0.491
LIG_APCC_ABBA_1	671	676	PF00400	0.535
LIG_APCC_ABBAyCdc20_2	204	210	PF00400	0.583
LIG_BIR_III_4	240	244	PF00653	0.584
LIG_BRCT_BRCA1_1	576	580	PF00533	0.431
LIG_CAP-Gly_1	692	696	PF01302	0.724
LIG_Clathr_ClatBox_1	62	66	PF01394	0.396
LIG_deltaCOP1_diTrp_1	376	381	PF00928	0.490
LIG_deltaCOP1_diTrp_1	467	471	PF00928	0.424
LIG_FHA_1	220	226	PF00498	0.542
LIG_FHA_1	314	320	PF00498	0.517
LIG_FHA_1	356	362	PF00498	0.392
LIG_FHA_1	363	369	PF00498	0.414
LIG_FHA_1	401	407	PF00498	0.421
LIG_FHA_1	580	586	PF00498	0.487
LIG_FHA_2	289	295	PF00498	0.483
LIG_LIR_Apic_2	583	589	PF02991	0.488
LIG_LIR_Gen_1	323	332	PF02991	0.543
LIG_LIR_Gen_1	375	385	PF02991	0.519
LIG_LIR_Gen_1	437	447	PF02991	0.520
LIG_LIR_Gen_1	466	477	PF02991	0.426
LIG_LIR_Gen_1	71	80	PF02991	0.651
LIG_LIR_Nem_3	214	220	PF02991	0.594
LIG_LIR_Nem_3	323	327	PF02991	0.412
LIG_LIR_Nem_3	366	372	PF02991	0.453
LIG_LIR_Nem_3	375	380	PF02991	0.469
LIG_LIR_Nem_3	437	442	PF02991	0.524
LIG_LIR_Nem_3	466	472	PF02991	0.415
LIG_LIR_Nem_3	562	568	PF02991	0.405
LIG_LIR_Nem_3	71	76	PF02991	0.653
LIG_LIR_Nem_3	9	15	PF02991	0.445
LIG_NRBOX	351	357	PF00104	0.380
LIG_Pex14_1	377	381	PF04695	0.418
LIG_Pex14_1	79	83	PF04695	0.645
LIG_SH2_CRK	15	19	PF00017	0.366
LIG_SH2_CRK	556	560	PF00017	0.417
LIG_SH2_NCK_1	628	632	PF00017	0.463
LIG_SH2_NCK_1	677	681	PF00017	0.558
LIG_SH2_NCK_1	69	73	PF00017	0.582
LIG_SH2_PTP2	369	372	PF00017	0.432
LIG_SH2_SRC	369	372	PF00017	0.494
LIG_SH2_STAP1	15	19	PF00017	0.353
LIG_SH2_STAP1	69	73	PF00017	0.634
LIG_SH2_STAT5	220	223	PF00017	0.475
LIG_SH2_STAT5	257	260	PF00017	0.607
LIG_SH2_STAT5	369	372	PF00017	0.362
LIG_SH2_STAT5	565	568	PF00017	0.390
LIG_SH2_STAT5	652	655	PF00017	0.506
LIG_SH2_STAT5	656	659	PF00017	0.494
LIG_SH3_3	311	317	PF00018	0.569
LIG_SH3_3	328	334	PF00018	0.327
LIG_SH3_3	365	371	PF00018	0.364
LIG_SH3_3	439	445	PF00018	0.491
LIG_SH3_3	473	479	PF00018	0.546
LIG_SH3_3	54	60	PF00018	0.522
LIG_SH3_3	569	575	PF00018	0.539
LIG_SUMO_SIM_par_1	61	66	PF11976	0.383
LIG_SxIP_EBH_1	211	221	PF03271	0.433
LIG_TRAF2_1	112	115	PF00917	0.739
LIG_TRAF2_1	666	669	PF00917	0.552
LIG_TRAF2_1	89	92	PF00917	0.664
LIG_TRAF2_2	235	240	PF00917	0.655
LIG_UBA3_1	633	640	PF00899	0.551
LIG_WRC_WIRS_1	248	253	PF05994	0.454
MOD_CDK_SPxxK_3	102	109	PF00069	0.752
MOD_CK1_1	100	106	PF00069	0.776
MOD_CK1_1	229	235	PF00069	0.554
MOD_CK1_1	362	368	PF00069	0.387
MOD_CK1_1	422	428	PF00069	0.630
MOD_CK1_1	463	469	PF00069	0.538
MOD_CK1_1	516	522	PF00069	0.569
MOD_CK1_1	602	608	PF00069	0.669
MOD_CK2_1	386	392	PF00069	0.624
MOD_CK2_1	680	686	PF00069	0.591
MOD_CK2_1	86	92	PF00069	0.630
MOD_GlcNHglycan	188	191	PF01048	0.740
MOD_GlcNHglycan	365	368	PF01048	0.426
MOD_GlcNHglycan	42	45	PF01048	0.585
MOD_GlcNHglycan	424	427	PF01048	0.682
MOD_GlcNHglycan	462	465	PF01048	0.543
MOD_GlcNHglycan	493	496	PF01048	0.750
MOD_GlcNHglycan	500	503	PF01048	0.759
MOD_GlcNHglycan	51	54	PF01048	0.577
MOD_GlcNHglycan	601	604	PF01048	0.647
MOD_GlcNHglycan	70	73	PF01048	0.650
MOD_GlcNHglycan	88	91	PF01048	0.563
MOD_GlcNHglycan	99	102	PF01048	0.730
MOD_GSK3_1	188	195	PF00069	0.737
MOD_GSK3_1	355	362	PF00069	0.361
MOD_GSK3_1	36	43	PF00069	0.494
MOD_GSK3_1	422	429	PF00069	0.613
MOD_GSK3_1	458	465	PF00069	0.549
MOD_GSK3_1	509	516	PF00069	0.432
MOD_GSK3_1	518	525	PF00069	0.490
MOD_GSK3_1	570	577	PF00069	0.419
MOD_GSK3_1	602	609	PF00069	0.645
MOD_GSK3_1	623	630	PF00069	0.388
MOD_N-GLC_1	13	18	PF02516	0.409
MOD_N-GLC_1	211	216	PF02516	0.632
MOD_N-GLC_1	24	29	PF02516	0.384
MOD_N-GLC_1	491	496	PF02516	0.724
MOD_NEK2_1	119	124	PF00069	0.618
MOD_NEK2_1	355	360	PF00069	0.362
MOD_NEK2_1	511	516	PF00069	0.458
MOD_NEK2_1	560	565	PF00069	0.479
MOD_NEK2_2	607	612	PF00069	0.607
MOD_PIKK_1	426	432	PF00454	0.670
MOD_PKA_1	186	192	PF00069	0.662
MOD_PKA_2	186	192	PF00069	0.763
MOD_PKA_2	210	216	PF00069	0.592
MOD_PKA_2	262	268	PF00069	0.493
MOD_PKA_2	362	368	PF00069	0.470
MOD_PKA_2	400	406	PF00069	0.522
MOD_PKA_2	422	428	PF00069	0.660
MOD_PKA_2	560	566	PF00069	0.519
MOD_Plk_1	13	19	PF00069	0.454
MOD_Plk_1	211	217	PF00069	0.601
MOD_Plk_1	570	576	PF00069	0.502
MOD_Plk_4	14	20	PF00069	0.378
MOD_Plk_4	33	39	PF00069	0.360
MOD_Plk_4	542	548	PF00069	0.538
MOD_Plk_4	561	567	PF00069	0.522
MOD_ProDKin_1	100	106	PF00069	0.775
MOD_ProDKin_1	313	319	PF00069	0.522
MOD_ProDKin_1	386	392	PF00069	0.654
MOD_SUMO_rev_2	85	89	PF00179	0.676
TRG_DiLeu_BaEn_1	115	120	PF01217	0.537
TRG_DiLeu_BaEn_2	466	472	PF01217	0.516
TRG_DiLeu_BaEn_4	115	121	PF01217	0.614
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.455
TRG_DiLeu_BaLyEn_6	564	569	PF01217	0.460
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.488
TRG_ENDOCYTIC_2	15	18	PF00928	0.354
TRG_ENDOCYTIC_2	369	372	PF00928	0.362
TRG_ENDOCYTIC_2	565	568	PF00928	0.390
TRG_ER_diArg_1	345	347	PF00400	0.470
TRG_ER_diArg_1	55	58	PF00400	0.573
TRG_NLS_Bipartite_1	186	208	PF00514	0.619
TRG_NLS_MonoExtC_3	203	209	PF00514	0.665
TRG_NLS_MonoExtN_4	202	208	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U7	Leptomonas seymouri	53%	94%
A0A0S4J688	Bodo saltans	31%	100%
A0A1X0NWM5	Trypanosomatidae	42%	100%
A0A3R7MKD9	Trypanosoma rangeli	41%	100%
A4HYP0	Leishmania infantum	99%	100%
C9ZI95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AIC9	Leishmania braziliensis	79%	100%
E9AUL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QCW8	Leishmania major	91%	100%
V5C080	Trypanosoma cruzi	42%	100%