ATP-dependent RNA helicase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WVZ5_LEIDO

TriTrypDb:

LdBPK_200880.1 , LdCL_200013500 , LDHU3_20.1090

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WVZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVZ5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	10
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016787	hydrolase activity	2	9
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.509
CLV_C14_Caspase3-7	174	178	PF00656	0.622
CLV_C14_Caspase3-7	179	183	PF00656	0.579
CLV_C14_Caspase3-7	655	659	PF00656	0.754
CLV_MEL_PAP_1	148	154	PF00089	0.542
CLV_NRD_NRD_1	145	147	PF00675	0.466
CLV_NRD_NRD_1	270	272	PF00675	0.284
CLV_NRD_NRD_1	366	368	PF00675	0.595
CLV_NRD_NRD_1	434	436	PF00675	0.547
CLV_NRD_NRD_1	443	445	PF00675	0.433
CLV_NRD_NRD_1	531	533	PF00675	0.224
CLV_NRD_NRD_1	689	691	PF00675	0.600
CLV_NRD_NRD_1	739	741	PF00675	0.638
CLV_PCSK_KEX2_1	145	147	PF00082	0.473
CLV_PCSK_KEX2_1	270	272	PF00082	0.284
CLV_PCSK_KEX2_1	436	438	PF00082	0.532
CLV_PCSK_KEX2_1	443	445	PF00082	0.454
CLV_PCSK_KEX2_1	530	532	PF00082	0.223
CLV_PCSK_KEX2_1	621	623	PF00082	0.470
CLV_PCSK_KEX2_1	689	691	PF00082	0.583
CLV_PCSK_KEX2_1	741	743	PF00082	0.664
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.544
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.503
CLV_PCSK_PC1ET2_1	741	743	PF00082	0.664
CLV_PCSK_PC7_1	141	147	PF00082	0.458
CLV_PCSK_SKI1_1	146	150	PF00082	0.426
CLV_PCSK_SKI1_1	531	535	PF00082	0.237
CLV_PCSK_SKI1_1	625	629	PF00082	0.406
CLV_PCSK_SKI1_1	637	641	PF00082	0.419
CLV_PCSK_SKI1_1	73	77	PF00082	0.303
CLV_Separin_Metazoa	142	146	PF03568	0.448
DEG_APCC_DBOX_1	624	632	PF00400	0.315
DEG_SPOP_SBC_1	746	750	PF00917	0.512
DOC_CKS1_1	213	218	PF01111	0.423
DOC_CKS1_1	722	727	PF01111	0.601
DOC_CYCLIN_RxL_1	221	233	PF00134	0.516
DOC_CYCLIN_RxL_1	529	538	PF00134	0.455
DOC_CYCLIN_RxL_1	621	630	PF00134	0.378
DOC_CYCLIN_RxL_1	85	95	PF00134	0.457
DOC_MAPK_DCC_7	23	33	PF00069	0.501
DOC_MAPK_gen_1	108	117	PF00069	0.499
DOC_MAPK_gen_1	227	236	PF00069	0.516
DOC_MAPK_gen_1	343	352	PF00069	0.596
DOC_MAPK_gen_1	443	451	PF00069	0.412
DOC_MAPK_gen_1	592	601	PF00069	0.513
DOC_MAPK_MEF2A_6	204	213	PF00069	0.484
DOC_MAPK_MEF2A_6	230	238	PF00069	0.516
DOC_MAPK_MEF2A_6	414	421	PF00069	0.347
DOC_MAPK_MEF2A_6	595	603	PF00069	0.368
DOC_PP2B_LxvP_1	55	58	PF13499	0.425
DOC_PP4_FxxP_1	396	399	PF00568	0.371
DOC_USP7_MATH_1	166	170	PF00917	0.773
DOC_USP7_MATH_1	292	296	PF00917	0.464
DOC_USP7_MATH_1	424	428	PF00917	0.486
DOC_USP7_MATH_1	44	48	PF00917	0.474
DOC_USP7_MATH_1	476	480	PF00917	0.585
DOC_USP7_MATH_1	513	517	PF00917	0.548
DOC_USP7_MATH_1	548	552	PF00917	0.503
DOC_USP7_MATH_1	58	62	PF00917	0.372
DOC_USP7_MATH_1	650	654	PF00917	0.746
DOC_USP7_MATH_1	710	714	PF00917	0.602
DOC_USP7_MATH_1	729	733	PF00917	0.595
DOC_USP7_MATH_1	757	761	PF00917	0.526
DOC_USP7_MATH_2	576	582	PF00917	0.516
DOC_WW_Pin1_4	212	217	PF00397	0.427
DOC_WW_Pin1_4	302	307	PF00397	0.497
DOC_WW_Pin1_4	721	726	PF00397	0.607
DOC_WW_Pin1_4	734	739	PF00397	0.660
LIG_14-3-3_CanoR_1	197	206	PF00244	0.548
LIG_14-3-3_CanoR_1	23	28	PF00244	0.448
LIG_14-3-3_CanoR_1	230	235	PF00244	0.484
LIG_14-3-3_CanoR_1	353	358	PF00244	0.399
LIG_14-3-3_CanoR_1	435	445	PF00244	0.568
LIG_14-3-3_CanoR_1	586	596	PF00244	0.423
LIG_14-3-3_CanoR_1	622	628	PF00244	0.498
LIG_14-3-3_CanoR_1	689	695	PF00244	0.538
LIG_14-3-3_CanoR_1	716	723	PF00244	0.691
LIG_14-3-3_CanoR_1	73	82	PF00244	0.503
LIG_14-3-3_CanoR_1	744	754	PF00244	0.652
LIG_Actin_WH2_2	216	232	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BRCT_BRCA1_1	287	291	PF00533	0.447
LIG_CaM_NSCaTE_8	691	698	PF13499	0.552
LIG_Clathr_ClatBox_1	236	240	PF01394	0.455
LIG_deltaCOP1_diTrp_1	670	679	PF00928	0.601
LIG_DLG_GKlike_1	230	237	PF00625	0.447
LIG_DLG_GKlike_1	353	360	PF00625	0.501
LIG_eIF4E_1	413	419	PF01652	0.365
LIG_FHA_1	224	230	PF00498	0.455
LIG_FHA_1	489	495	PF00498	0.481
LIG_FHA_1	628	634	PF00498	0.453
LIG_FHA_1	93	99	PF00498	0.429
LIG_FHA_2	129	135	PF00498	0.547
LIG_FHA_2	392	398	PF00498	0.570
LIG_FHA_2	399	405	PF00498	0.447
LIG_FHA_2	4	10	PF00498	0.499
LIG_FHA_2	497	503	PF00498	0.455
LIG_FHA_2	653	659	PF00498	0.754
LIG_LIR_Apic_2	26	30	PF02991	0.491
LIG_LIR_Apic_2	394	399	PF02991	0.420
LIG_LIR_Apic_2	64	70	PF02991	0.423
LIG_LIR_Gen_1	520	528	PF02991	0.454
LIG_LIR_Nem_3	356	360	PF02991	0.502
LIG_LIR_Nem_3	479	485	PF02991	0.607
LIG_LIR_Nem_3	520	524	PF02991	0.460
LIG_LIR_Nem_3	636	642	PF02991	0.462
LIG_LYPXL_yS_3	482	485	PF13949	0.555
LIG_NRP_CendR_1	765	768	PF00754	0.540
LIG_PCNA_yPIPBox_3	270	283	PF02747	0.526
LIG_PTB_Apo_2	351	358	PF02174	0.495
LIG_PTB_Phospho_1	351	357	PF10480	0.496
LIG_REV1ctd_RIR_1	637	645	PF16727	0.611
LIG_RPA_C_Fungi	423	435	PF08784	0.456
LIG_RPA_C_Fungi	439	451	PF08784	0.342
LIG_RPA_C_Fungi	499	511	PF08784	0.392
LIG_SH2_CRK	620	624	PF00017	0.492
LIG_SH2_SRC	67	70	PF00017	0.347
LIG_SH2_STAP1	261	265	PF00017	0.392
LIG_SH2_STAT5	205	208	PF00017	0.414
LIG_SH2_STAT5	358	361	PF00017	0.528
LIG_SH2_STAT5	583	586	PF00017	0.297
LIG_SH2_STAT5	67	70	PF00017	0.262
LIG_SH3_3	144	150	PF00018	0.522
LIG_SH3_3	210	216	PF00018	0.306
LIG_SUMO_SIM_anti_2	207	215	PF11976	0.341
LIG_SUMO_SIM_par_1	235	241	PF11976	0.301
LIG_SUMO_SIM_par_1	89	95	PF11976	0.262
LIG_TRAF2_1	401	404	PF00917	0.465
LIG_TRAF2_1	499	502	PF00917	0.306
LIG_TRAF2_1	662	665	PF00917	0.697
LIG_TRFH_1	396	400	PF08558	0.371
LIG_UBA3_1	74	80	PF00899	0.233
LIG_WRC_WIRS_1	247	252	PF05994	0.204
MOD_CDC14_SPxK_1	737	740	PF00782	0.527
MOD_CDK_SPxK_1	212	218	PF00069	0.262
MOD_CDK_SPxK_1	721	727	PF00069	0.597
MOD_CDK_SPxK_1	734	740	PF00069	0.490
MOD_CDK_SPxxK_3	734	741	PF00069	0.531
MOD_CK1_1	249	255	PF00069	0.361
MOD_CK1_1	294	300	PF00069	0.391
MOD_CK1_1	3	9	PF00069	0.524
MOD_CK1_1	477	483	PF00069	0.522
MOD_CK1_1	61	67	PF00069	0.268
MOD_CK1_1	653	659	PF00069	0.722
MOD_CK1_1	697	703	PF00069	0.572
MOD_CK1_1	745	751	PF00069	0.700
MOD_CK2_1	130	136	PF00069	0.531
MOD_CK2_1	162	168	PF00069	0.710
MOD_CK2_1	290	296	PF00069	0.443
MOD_CK2_1	359	365	PF00069	0.538
MOD_CK2_1	391	397	PF00069	0.601
MOD_CK2_1	398	404	PF00069	0.453
MOD_CK2_1	496	502	PF00069	0.281
MOD_CK2_1	514	520	PF00069	0.213
MOD_CK2_1	523	529	PF00069	0.223
MOD_CK2_1	543	549	PF00069	0.127
MOD_CK2_1	690	696	PF00069	0.501
MOD_CK2_1	729	735	PF00069	0.739
MOD_Cter_Amidation	738	741	PF01082	0.664
MOD_GlcNHglycan	158	161	PF01048	0.691
MOD_GlcNHglycan	164	167	PF01048	0.687
MOD_GlcNHglycan	318	321	PF01048	0.361
MOD_GlcNHglycan	336	339	PF01048	0.190
MOD_GlcNHglycan	379	382	PF01048	0.530
MOD_GlcNHglycan	438	441	PF01048	0.492
MOD_GlcNHglycan	46	49	PF01048	0.269
MOD_GlcNHglycan	476	479	PF01048	0.622
MOD_GlcNHglycan	545	548	PF01048	0.307
MOD_GlcNHglycan	60	63	PF01048	0.241
MOD_GlcNHglycan	608	611	PF01048	0.471
MOD_GlcNHglycan	646	649	PF01048	0.665
MOD_GlcNHglycan	652	655	PF01048	0.700
MOD_GlcNHglycan	667	670	PF01048	0.521
MOD_GlcNHglycan	696	699	PF01048	0.492
MOD_GlcNHglycan	759	762	PF01048	0.569
MOD_GSK3_1	107	114	PF00069	0.288
MOD_GSK3_1	152	159	PF00069	0.682
MOD_GSK3_1	162	169	PF00069	0.716
MOD_GSK3_1	195	202	PF00069	0.522
MOD_GSK3_1	286	293	PF00069	0.377
MOD_GSK3_1	334	341	PF00069	0.299
MOD_GSK3_1	474	481	PF00069	0.586
MOD_GSK3_1	519	526	PF00069	0.273
MOD_GSK3_1	601	608	PF00069	0.516
MOD_GSK3_1	623	630	PF00069	0.411
MOD_GSK3_1	649	656	PF00069	0.595
MOD_GSK3_1	690	697	PF00069	0.506
MOD_GSK3_1	706	713	PF00069	0.545
MOD_GSK3_1	742	749	PF00069	0.527
MOD_N-GLC_1	199	204	PF02516	0.606
MOD_N-GLC_1	353	358	PF02516	0.492
MOD_NEK2_1	223	228	PF00069	0.386
MOD_NEK2_1	246	251	PF00069	0.204
MOD_NEK2_1	372	377	PF00069	0.699
MOD_NEK2_1	535	540	PF00069	0.280
MOD_NEK2_1	601	606	PF00069	0.482
MOD_NEK2_1	623	628	PF00069	0.499
MOD_NEK2_1	680	685	PF00069	0.484
MOD_PIKK_1	372	378	PF00454	0.660
MOD_PIKK_1	391	397	PF00454	0.554
MOD_PIKK_1	578	584	PF00454	0.330
MOD_PIKK_1	680	686	PF00454	0.486
MOD_PIKK_1	729	735	PF00454	0.748
MOD_PIKK_1	92	98	PF00454	0.322
MOD_PK_1	111	117	PF00069	0.341
MOD_PK_1	690	696	PF00069	0.612
MOD_PK_1	742	748	PF00069	0.667
MOD_PKA_1	436	442	PF00069	0.446
MOD_PKA_1	621	627	PF00069	0.499
MOD_PKA_2	107	113	PF00069	0.267
MOD_PKA_2	128	134	PF00069	0.661
MOD_PKA_2	198	204	PF00069	0.518
MOD_PKA_2	345	351	PF00069	0.429
MOD_PKA_2	436	442	PF00069	0.527
MOD_PKA_2	621	627	PF00069	0.499
MOD_PKA_2	715	721	PF00069	0.621
MOD_PKB_1	197	205	PF00069	0.478
MOD_PKB_1	740	748	PF00069	0.711
MOD_Plk_1	199	205	PF00069	0.534
MOD_Plk_1	295	301	PF00069	0.294
MOD_Plk_1	353	359	PF00069	0.499
MOD_Plk_1	409	415	PF00069	0.446
MOD_Plk_1	471	477	PF00069	0.463
MOD_Plk_1	51	57	PF00069	0.392
MOD_Plk_1	519	525	PF00069	0.281
MOD_Plk_1	548	554	PF00069	0.275
MOD_Plk_1	729	735	PF00069	0.778
MOD_Plk_1	742	748	PF00069	0.532
MOD_Plk_4	353	359	PF00069	0.498
MOD_Plk_4	37	43	PF00069	0.347
MOD_Plk_4	514	520	PF00069	0.408
MOD_Plk_4	690	696	PF00069	0.612
MOD_ProDKin_1	212	218	PF00069	0.267
MOD_ProDKin_1	302	308	PF00069	0.365
MOD_ProDKin_1	721	727	PF00069	0.610
MOD_ProDKin_1	734	740	PF00069	0.659
TRG_DiLeu_BaEn_1	139	144	PF01217	0.406
TRG_DiLeu_BaEn_2	403	409	PF01217	0.348
TRG_DiLeu_BaEn_3	170	176	PF01217	0.601
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.262
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.262
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.332
TRG_ENDOCYTIC_2	103	106	PF00928	0.256
TRG_ENDOCYTIC_2	357	360	PF00928	0.508
TRG_ENDOCYTIC_2	482	485	PF00928	0.555
TRG_ENDOCYTIC_2	620	623	PF00928	0.494
TRG_ER_diArg_1	144	146	PF00400	0.453
TRG_ER_diArg_1	425	428	PF00400	0.520
TRG_ER_diArg_1	443	445	PF00400	0.465
TRG_ER_diArg_1	530	532	PF00400	0.281
TRG_ER_diArg_1	689	691	PF00400	0.629
TRG_ER_diArg_1	762	765	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.262
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKF6	Leptomonas seymouri	65%	100%
A0A0S4JIC9	Bodo saltans	34%	100%
A0A3R7NJH7	Trypanosoma rangeli	44%	100%
A4HYS9	Leishmania infantum	100%	100%
A4QX49	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	93%
C9ZIA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AID8	Leishmania braziliensis	79%	100%
E9AUM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QCV9	Leishmania major	92%	100%
V5DS01	Trypanosoma cruzi	43%	100%