UDP-galactose transporter, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-galactose transporter

Species:

Leishmania donovani

UniProt:

A0A3S7WVZ3_LEIDO

TriTrypDb:

LdBPK_180400.1 , LdCL_200015400 , LDHU3_24.0430

Length:

358

Annotations

LeishMANIAdb annotations

Homologous to animal UDP-N-acetylglucosamine, UDP-galactose and CMP-sialic acid transporters. Only expanded in the Leptomonas lineage. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0098588	bounding membrane of organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7WVZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVZ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	10
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	10
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	10
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	10
GO:0022857	transmembrane transporter activity	2	10
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.569
CLV_C14_Caspase3-7	54	58	PF00656	0.633
CLV_NRD_NRD_1	72	74	PF00675	0.321
CLV_PCSK_KEX2_1	232	234	PF00082	0.296
CLV_PCSK_KEX2_1	74	76	PF00082	0.296
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.296
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.325
CLV_PCSK_SKI1_1	133	137	PF00082	0.353
CLV_PCSK_SKI1_1	142	146	PF00082	0.353
CLV_PCSK_SKI1_1	68	72	PF00082	0.371
DEG_Nend_UBRbox_3	1	3	PF02207	0.586
DEG_ODPH_VHL_1	101	114	PF01847	0.174
DOC_CKS1_1	11	16	PF01111	0.636
DOC_CKS1_1	332	337	PF01111	0.324
DOC_MAPK_gen_1	73	81	PF00069	0.535
DOC_MAPK_gen_1	93	101	PF00069	0.354
DOC_MAPK_MEF2A_6	133	141	PF00069	0.269
DOC_MAPK_MEF2A_6	153	162	PF00069	0.241
DOC_PP1_RVXF_1	131	137	PF00149	0.353
DOC_PP1_RVXF_1	283	290	PF00149	0.254
DOC_PP1_RVXF_1	66	72	PF00149	0.469
DOC_PP4_FxxP_1	332	335	PF00568	0.261
DOC_USP7_MATH_1	186	190	PF00917	0.278
DOC_USP7_MATH_1	20	24	PF00917	0.774
DOC_USP7_MATH_1	39	43	PF00917	0.696
DOC_WW_Pin1_4	10	15	PF00397	0.694
DOC_WW_Pin1_4	147	152	PF00397	0.519
DOC_WW_Pin1_4	31	36	PF00397	0.715
DOC_WW_Pin1_4	331	336	PF00397	0.392
LIG_14-3-3_CanoR_1	242	249	PF00244	0.504
LIG_14-3-3_CanoR_1	5	11	PF00244	0.655
LIG_AP2alpha_1	279	283	PF02296	0.296
LIG_BRCT_BRCA1_1	221	225	PF00533	0.353
LIG_BRCT_BRCA1_1	276	280	PF00533	0.296
LIG_BRCT_BRCA1_1	315	319	PF00533	0.349
LIG_EH1_1	106	114	PF00400	0.353
LIG_eIF4E_1	107	113	PF01652	0.353
LIG_eIF4E_1	130	136	PF01652	0.327
LIG_eIF4E_1	94	100	PF01652	0.496
LIG_FHA_1	13	19	PF00498	0.677
LIG_FHA_1	282	288	PF00498	0.293
LIG_FHA_1	324	330	PF00498	0.351
LIG_FHA_1	337	343	PF00498	0.293
LIG_FHA_1	62	68	PF00498	0.418
LIG_FHA_2	172	178	PF00498	0.296
LIG_FHA_2	276	282	PF00498	0.301
LIG_GBD_Chelix_1	105	113	PF00786	0.324
LIG_HCF-1_HBM_1	91	94	PF13415	0.519
LIG_LIR_Gen_1	124	134	PF02991	0.316
LIG_LIR_Gen_1	222	230	PF02991	0.384
LIG_LIR_Gen_1	281	291	PF02991	0.301
LIG_LIR_Gen_1	316	327	PF02991	0.349
LIG_LIR_Gen_1	344	353	PF02991	0.333
LIG_LIR_Nem_3	124	129	PF02991	0.316
LIG_LIR_Nem_3	219	224	PF02991	0.350
LIG_LIR_Nem_3	250	256	PF02991	0.312
LIG_LIR_Nem_3	277	283	PF02991	0.262
LIG_LIR_Nem_3	316	322	PF02991	0.366
LIG_LIR_Nem_3	344	348	PF02991	0.311
LIG_MLH1_MIPbox_1	276	280	PF16413	0.296
LIG_Pex14_2	217	221	PF04695	0.340
LIG_Pex14_2	254	258	PF04695	0.378
LIG_Pex14_2	275	279	PF04695	0.296
LIG_Pex14_2	315	319	PF04695	0.349
LIG_Pex14_2	76	80	PF04695	0.465
LIG_SH2_STAP1	116	120	PF00017	0.310
LIG_SH2_STAT3	107	110	PF00017	0.293
LIG_SH2_STAT5	253	256	PF00017	0.363
LIG_SH2_STAT5	307	310	PF00017	0.509
LIG_SH2_STAT5	354	357	PF00017	0.440
LIG_SUMO_SIM_par_1	111	117	PF11976	0.324
LIG_TRFH_1	147	151	PF08558	0.519
LIG_TYR_ITIM	251	256	PF00017	0.384
LIG_UBA3_1	112	119	PF00899	0.324
LIG_Vh1_VBS_1	38	56	PF01044	0.570
LIG_WRC_WIRS_1	312	317	PF05994	0.514
LIG_WRC_WIRS_1	342	347	PF05994	0.310
MOD_CDC14_SPxK_1	150	153	PF00782	0.519
MOD_CDK_SPxK_1	147	153	PF00069	0.519
MOD_CK1_1	202	208	PF00069	0.366
MOD_CK1_1	219	225	PF00069	0.186
MOD_CK1_1	23	29	PF00069	0.680
MOD_CK1_1	314	320	PF00069	0.353
MOD_CK1_1	7	13	PF00069	0.623
MOD_CK2_1	186	192	PF00069	0.383
MOD_GlcNHglycan	21	25	PF01048	0.363
MOD_GlcNHglycan	218	221	PF01048	0.367
MOD_GlcNHglycan	239	242	PF01048	0.265
MOD_GlcNHglycan	323	326	PF01048	0.259
MOD_GlcNHglycan	6	9	PF01048	0.499
MOD_GSK3_1	194	201	PF00069	0.307
MOD_GSK3_1	202	209	PF00069	0.278
MOD_GSK3_1	237	244	PF00069	0.509
MOD_GSK3_1	321	328	PF00069	0.295
MOD_GSK3_1	39	46	PF00069	0.685
MOD_GSK3_1	57	64	PF00069	0.458
MOD_N-GLC_1	336	341	PF02516	0.519
MOD_NEK2_1	114	119	PF00069	0.410
MOD_NEK2_1	162	167	PF00069	0.458
MOD_NEK2_1	178	183	PF00069	0.187
MOD_NEK2_1	206	211	PF00069	0.284
MOD_NEK2_1	237	242	PF00069	0.468
MOD_NEK2_1	275	280	PF00069	0.311
MOD_NEK2_1	323	328	PF00069	0.343
MOD_NEK2_1	336	341	PF00069	0.261
MOD_NEK2_1	346	351	PF00069	0.269
MOD_NEK2_1	43	48	PF00069	0.551
MOD_NEK2_1	61	66	PF00069	0.467
MOD_NEK2_2	325	330	PF00069	0.345
MOD_NEK2_2	39	44	PF00069	0.600
MOD_PKA_2	241	247	PF00069	0.431
MOD_PKA_2	4	10	PF00069	0.653
MOD_Plk_1	39	45	PF00069	0.525
MOD_Plk_1	61	67	PF00069	0.441
MOD_Plk_2-3	57	63	PF00069	0.404
MOD_Plk_4	121	127	PF00069	0.270
MOD_Plk_4	275	281	PF00069	0.275
MOD_Plk_4	325	331	PF00069	0.314
MOD_Plk_4	336	342	PF00069	0.277
MOD_Plk_4	94	100	PF00069	0.553
MOD_ProDKin_1	10	16	PF00069	0.695
MOD_ProDKin_1	147	153	PF00069	0.519
MOD_ProDKin_1	31	37	PF00069	0.707
MOD_ProDKin_1	331	337	PF00069	0.392
TRG_ENDOCYTIC_2	253	256	PF00928	0.302
TRG_ER_diArg_1	65	68	PF00400	0.510
TRG_ER_diArg_1	73	76	PF00400	0.518
TRG_NES_CRM1_1	110	122	PF08389	0.314
TRG_NES_CRM1_1	294	309	PF08389	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R3	Leptomonas seymouri	24%	88%
A0A0N0P7L9	Leptomonas seymouri	60%	81%
A0A0N1HVQ8	Leptomonas seymouri	29%	66%
A0A0S4JAS7	Bodo saltans	30%	89%
A0A0S4JHP4	Bodo saltans	30%	75%
A0A0S4JJ51	Bodo saltans	31%	83%
A0A1X0NTD6	Trypanosomatidae	34%	83%
A0A1X0P6Y4	Trypanosomatidae	31%	100%
A0A3Q8IES0	Leishmania donovani	98%	66%
A0A3S5IS46	Trypanosoma rangeli	31%	100%
A0A422P321	Trypanosoma rangeli	31%	87%
A0JMG9	Danio rerio	25%	100%
A4HD92	Leishmania braziliensis	72%	100%
A4HDA0	Leishmania braziliensis	71%	100%
A4IHW3	Xenopus tropicalis	26%	100%
A6QPI1	Bos taurus	23%	84%
B8B350	Oryza sativa subsp. indica	25%	100%
B8B7Q4	Oryza sativa subsp. indica	27%	100%
D0A047	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0AAP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	81%
E9AH47	Leishmania infantum	98%	66%
E9AWM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AWM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F4JN00	Arabidopsis thaliana	29%	100%
O08520	Cricetulus griseus	30%	100%
O77592	Canis lupus familiaris	31%	100%
P78381	Homo sapiens	31%	90%
P78382	Homo sapiens	33%	100%
P87041	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q02334	Caenorhabditis elegans	28%	100%
Q58DA6	Bos taurus	30%	91%
Q5R4D7	Pongo abelii	24%	84%
Q61420	Mus musculus	31%	100%
Q654D9	Oryza sativa subsp. japonica	25%	100%
Q6AXR5	Rattus norvegicus	30%	100%
Q6DCG9	Xenopus laevis	24%	87%
Q6YC49	Bos taurus	31%	100%
Q6ZL17	Oryza sativa subsp. japonica	27%	100%
Q8GY97	Arabidopsis thaliana	25%	88%
Q8LES0	Arabidopsis thaliana	26%	100%
Q8LGE9	Arabidopsis thaliana	24%	100%
Q8R1T4	Mus musculus	30%	100%
Q8WMS0	Canis lupus familiaris	31%	90%
Q93890	Caenorhabditis elegans	28%	97%
Q9BS91	Homo sapiens	24%	84%
Q9C5H6	Arabidopsis thaliana	25%	88%
Q9R0M8	Mus musculus	31%	92%
Q9VMU8	Drosophila melanogaster	23%	92%
Q9Y2D2	Homo sapiens	32%	100%
V5B4K3	Trypanosoma cruzi	23%	100%
V5BLB8	Trypanosoma cruzi	30%	87%
V5BRN3	Trypanosoma cruzi	31%	100%