Cyclophilin 15, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 15, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WVY2_LEIDO

TriTrypDb:

LdBPK_200950.1 , LdCL_200014200 , LDHU3_20.1160

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVY2

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018208	peptidyl-proline modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016859	cis-trans isomerase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	257	259	PF00675	0.697
CLV_NRD_NRD_1	316	318	PF00675	0.630
CLV_NRD_NRD_1	377	379	PF00675	0.495
CLV_NRD_NRD_1	387	389	PF00675	0.568
CLV_PCSK_FUR_1	254	258	PF00082	0.734
CLV_PCSK_FUR_1	427	431	PF00082	0.496
CLV_PCSK_KEX2_1	183	185	PF00082	0.526
CLV_PCSK_KEX2_1	256	258	PF00082	0.679
CLV_PCSK_KEX2_1	314	316	PF00082	0.551
CLV_PCSK_KEX2_1	387	389	PF00082	0.569
CLV_PCSK_KEX2_1	429	431	PF00082	0.596
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.433
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.551
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.780
CLV_PCSK_SKI1_1	382	386	PF00082	0.560
CLV_PCSK_SKI1_1	98	102	PF00082	0.363
DEG_Nend_UBRbox_3	1	3	PF02207	0.322
DEG_SPOP_SBC_1	391	395	PF00917	0.577
DOC_CKS1_1	157	162	PF01111	0.444
DOC_CKS1_1	62	67	PF01111	0.476
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.382
DOC_MAPK_FxFP_2	7	10	PF00069	0.307
DOC_MAPK_gen_1	28	37	PF00069	0.371
DOC_MAPK_gen_1	83	92	PF00069	0.340
DOC_PP2B_LxvP_1	140	143	PF13499	0.540
DOC_PP2B_LxvP_1	43	46	PF13499	0.486
DOC_PP4_FxxP_1	20	23	PF00568	0.458
DOC_PP4_FxxP_1	7	10	PF00568	0.343
DOC_USP7_MATH_1	125	129	PF00917	0.556
DOC_USP7_MATH_1	222	226	PF00917	0.659
DOC_USP7_MATH_1	23	27	PF00917	0.494
DOC_USP7_MATH_1	244	248	PF00917	0.528
DOC_USP7_MATH_1	287	291	PF00917	0.746
DOC_USP7_MATH_1	309	313	PF00917	0.644
DOC_USP7_MATH_1	389	393	PF00917	0.672
DOC_USP7_MATH_1	412	416	PF00917	0.662
DOC_USP7_MATH_2	46	52	PF00917	0.349
DOC_USP7_UBL2_3	420	424	PF12436	0.737
DOC_USP7_UBL2_3	425	429	PF12436	0.647
DOC_WW_Pin1_4	156	161	PF00397	0.556
DOC_WW_Pin1_4	266	271	PF00397	0.525
DOC_WW_Pin1_4	334	339	PF00397	0.459
DOC_WW_Pin1_4	61	66	PF00397	0.511
LIG_14-3-3_CanoR_1	109	113	PF00244	0.546
LIG_14-3-3_CanoR_1	119	124	PF00244	0.445
LIG_14-3-3_CanoR_1	184	193	PF00244	0.458
LIG_14-3-3_CanoR_1	28	37	PF00244	0.330
LIG_14-3-3_CanoR_1	332	338	PF00244	0.643
LIG_14-3-3_CanoR_1	54	62	PF00244	0.426
LIG_Actin_WH2_2	168	185	PF00022	0.504
LIG_BRCT_BRCA1_1	289	293	PF00533	0.613
LIG_BRCT_BRCA1_1	296	300	PF00533	0.585
LIG_BRCT_BRCA1_1	414	418	PF00533	0.546
LIG_BRCT_BRCA1_1	5	9	PF00533	0.444
LIG_BRCT_BRCA1_2	289	295	PF00533	0.645
LIG_BRCT_BRCA1_2	296	302	PF00533	0.612
LIG_BRCT_BRCA1_2	414	420	PF00533	0.543
LIG_FHA_1	174	180	PF00498	0.413
LIG_FHA_1	331	337	PF00498	0.561
LIG_FHA_1	95	101	PF00498	0.386
LIG_FHA_2	156	162	PF00498	0.531
LIG_FHA_2	54	60	PF00498	0.468
LIG_LIR_Apic_2	19	23	PF02991	0.457
LIG_LIR_Apic_2	4	10	PF02991	0.321
LIG_LIR_Apic_2	59	65	PF02991	0.471
LIG_LIR_Gen_1	148	157	PF02991	0.355
LIG_LIR_Gen_1	212	221	PF02991	0.395
LIG_LIR_Gen_1	349	356	PF02991	0.491
LIG_LIR_Nem_3	134	140	PF02991	0.472
LIG_LIR_Nem_3	148	154	PF02991	0.343
LIG_LIR_Nem_3	165	169	PF02991	0.549
LIG_LIR_Nem_3	19	24	PF02991	0.489
LIG_LIR_Nem_3	212	216	PF02991	0.618
LIG_LIR_Nem_3	290	296	PF02991	0.626
LIG_LIR_Nem_3	349	354	PF02991	0.569
LIG_LIR_Nem_3	99	104	PF02991	0.329
LIG_MLH1_MIPbox_1	290	294	PF16413	0.603
LIG_REV1ctd_RIR_1	291	299	PF16727	0.549
LIG_REV1ctd_RIR_1	351	359	PF16727	0.610
LIG_SH2_CRK	137	141	PF00017	0.499
LIG_SH2_NCK_1	62	66	PF00017	0.482
LIG_SH2_PTP2	151	154	PF00017	0.340
LIG_SH2_STAT5	151	154	PF00017	0.378
LIG_SH2_STAT5	213	216	PF00017	0.537
LIG_SH3_3	154	160	PF00018	0.472
LIG_SUMO_SIM_par_1	88	97	PF11976	0.337
LIG_TYR_ITIM	135	140	PF00017	0.476
LIG_TYR_ITIM	211	216	PF00017	0.589
LIG_WRC_WIRS_1	216	221	PF05994	0.393
MOD_CK1_1	113	119	PF00069	0.412
MOD_CK1_1	217	223	PF00069	0.686
MOD_CK1_1	269	275	PF00069	0.647
MOD_CK1_1	392	398	PF00069	0.673
MOD_CK1_1	407	413	PF00069	0.512
MOD_CK1_1	94	100	PF00069	0.390
MOD_CK2_1	155	161	PF00069	0.478
MOD_CK2_1	334	340	PF00069	0.588
MOD_CK2_1	53	59	PF00069	0.448
MOD_CK2_1	85	91	PF00069	0.463
MOD_GlcNHglycan	112	115	PF01048	0.561
MOD_GlcNHglycan	176	179	PF01048	0.385
MOD_GlcNHglycan	224	227	PF01048	0.690
MOD_GlcNHglycan	271	274	PF01048	0.704
MOD_GlcNHglycan	290	293	PF01048	0.614
MOD_GlcNHglycan	296	299	PF01048	0.609
MOD_GlcNHglycan	306	309	PF01048	0.654
MOD_GlcNHglycan	39	42	PF01048	0.463
MOD_GlcNHglycan	395	398	PF01048	0.655
MOD_GlcNHglycan	407	410	PF01048	0.688
MOD_GlcNHglycan	414	417	PF01048	0.738
MOD_GlcNHglycan	50	53	PF01048	0.343
MOD_GlcNHglycan	78	81	PF01048	0.345
MOD_GSK3_1	119	126	PF00069	0.502
MOD_GSK3_1	211	218	PF00069	0.582
MOD_GSK3_1	327	334	PF00069	0.579
MOD_GSK3_1	389	396	PF00069	0.710
MOD_GSK3_1	399	406	PF00069	0.586
MOD_GSK3_1	412	419	PF00069	0.668
MOD_GSK3_1	92	99	PF00069	0.364
MOD_NEK2_1	123	128	PF00069	0.362
MOD_NEK2_1	174	179	PF00069	0.393
MOD_NEK2_1	211	216	PF00069	0.515
MOD_NEK2_1	288	293	PF00069	0.560
MOD_NEK2_1	294	299	PF00069	0.493
MOD_NEK2_1	331	336	PF00069	0.542
MOD_NEK2_1	37	42	PF00069	0.355
MOD_NEK2_1	418	423	PF00069	0.741
MOD_NEK2_1	76	81	PF00069	0.342
MOD_NEK2_2	327	332	PF00069	0.430
MOD_PIKK_1	142	148	PF00454	0.475
MOD_PIKK_1	184	190	PF00454	0.565
MOD_PIKK_1	23	29	PF00454	0.328
MOD_PIKK_1	399	405	PF00454	0.768
MOD_PKA_2	108	114	PF00069	0.536
MOD_PKA_2	242	248	PF00069	0.754
MOD_PKA_2	331	337	PF00069	0.537
MOD_PKA_2	53	59	PF00069	0.417
MOD_Plk_1	211	217	PF00069	0.426
MOD_Plk_1	3	9	PF00069	0.430
MOD_Plk_2-3	85	91	PF00069	0.469
MOD_Plk_4	131	137	PF00069	0.355
MOD_Plk_4	16	22	PF00069	0.483
MOD_Plk_4	3	9	PF00069	0.461
MOD_Plk_4	85	91	PF00069	0.389
MOD_Plk_4	96	102	PF00069	0.308
MOD_ProDKin_1	156	162	PF00069	0.556
MOD_ProDKin_1	266	272	PF00069	0.526
MOD_ProDKin_1	334	340	PF00069	0.458
MOD_ProDKin_1	61	67	PF00069	0.510
MOD_SUMO_rev_2	177	185	PF00179	0.396
TRG_ENDOCYTIC_2	137	140	PF00928	0.473
TRG_ENDOCYTIC_2	150	153	PF00928	0.312
TRG_ENDOCYTIC_2	213	216	PF00928	0.600
TRG_ER_diArg_1	206	209	PF00400	0.432
TRG_ER_diArg_1	254	257	PF00400	0.656
TRG_ER_diArg_1	315	317	PF00400	0.704
TRG_NLS_Bipartite_1	183	203	PF00514	0.440
TRG_NLS_MonoCore_2	313	318	PF00514	0.605
TRG_NLS_MonoExtC_3	313	319	PF00514	0.543
TRG_NLS_MonoExtC_3	423	428	PF00514	0.743
TRG_NLS_MonoExtN_4	198	203	PF00514	0.427
TRG_NLS_MonoExtN_4	311	318	PF00514	0.579
TRG_NLS_MonoExtN_4	423	428	PF00514	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC45	Leptomonas seymouri	57%	100%
A0A0S4KRJ3	Bodo saltans	32%	100%
A0A1X0NWC9	Trypanosomatidae	34%	100%
A0A422NPI7	Trypanosoma rangeli	35%	100%
A4HYT6	Leishmania infantum	99%	100%
C9ZIB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AIE5	Leishmania braziliensis	76%	100%
E9AUN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QCV2	Leishmania major	90%	100%
V5DRZ7	Trypanosoma cruzi	38%	100%