Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WVX7_LEIDO

TriTrypDb:

LdBPK_200640.1 , LdCL_200011100 , LDHU3_20.0780

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7WVX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.462
CLV_C14_Caspase3-7	557	561	PF00656	0.667
CLV_NRD_NRD_1	428	430	PF00675	0.673
CLV_NRD_NRD_1	54	56	PF00675	0.670
CLV_NRD_NRD_1	554	556	PF00675	0.786
CLV_NRD_NRD_1	691	693	PF00675	0.790
CLV_NRD_NRD_1	699	701	PF00675	0.718
CLV_NRD_NRD_1	780	782	PF00675	0.746
CLV_NRD_NRD_1	790	792	PF00675	0.706
CLV_NRD_NRD_1	86	88	PF00675	0.681
CLV_PCSK_FUR_1	84	88	PF00082	0.788
CLV_PCSK_KEX2_1	553	555	PF00082	0.796
CLV_PCSK_KEX2_1	691	693	PF00082	0.790
CLV_PCSK_KEX2_1	790	792	PF00082	0.787
CLV_PCSK_KEX2_1	84	86	PF00082	0.683
CLV_PCSK_SKI1_1	235	239	PF00082	0.765
CLV_PCSK_SKI1_1	247	251	PF00082	0.637
CLV_PCSK_SKI1_1	353	357	PF00082	0.337
CLV_PCSK_SKI1_1	672	676	PF00082	0.739
DEG_APCC_DBOX_1	352	360	PF00400	0.337
DEG_Kelch_actinfilin_1	209	213	PF01344	0.494
DEG_Nend_UBRbox_2	1	3	PF02207	0.650
DEG_ODPH_VHL_1	342	354	PF01847	0.415
DEG_SCF_FBW7_1	147	154	PF00400	0.541
DEG_SCF_TRCP1_1	560	566	PF00400	0.593
DOC_CDC14_PxL_1	227	235	PF14671	0.602
DOC_CKS1_1	464	469	PF01111	0.513
DOC_CYCLIN_RxL_1	371	384	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	807	810	PF00134	0.546
DOC_MAPK_gen_1	400	410	PF00069	0.678
DOC_MAPK_MEF2A_6	400	408	PF00069	0.746
DOC_PP2B_LxvP_1	304	307	PF13499	0.512
DOC_PP2B_LxvP_1	615	618	PF13499	0.560
DOC_PP2B_LxvP_1	807	810	PF13499	0.546
DOC_PP4_FxxP_1	491	494	PF00568	0.650
DOC_USP7_MATH_1	120	124	PF00917	0.565
DOC_USP7_MATH_1	145	149	PF00917	0.585
DOC_USP7_MATH_1	151	155	PF00917	0.525
DOC_USP7_MATH_1	157	161	PF00917	0.478
DOC_USP7_MATH_1	254	258	PF00917	0.474
DOC_USP7_MATH_1	305	309	PF00917	0.497
DOC_USP7_MATH_1	313	317	PF00917	0.461
DOC_USP7_MATH_1	328	332	PF00917	0.498
DOC_USP7_MATH_1	336	340	PF00917	0.532
DOC_USP7_MATH_1	388	392	PF00917	0.774
DOC_USP7_MATH_1	474	478	PF00917	0.579
DOC_USP7_MATH_1	520	524	PF00917	0.576
DOC_USP7_MATH_1	544	548	PF00917	0.573
DOC_USP7_MATH_1	556	560	PF00917	0.494
DOC_USP7_MATH_1	576	580	PF00917	0.459
DOC_USP7_MATH_1	594	598	PF00917	0.478
DOC_USP7_MATH_1	599	603	PF00917	0.504
DOC_USP7_MATH_1	718	722	PF00917	0.565
DOC_USP7_MATH_1	769	773	PF00917	0.550
DOC_USP7_MATH_1	834	838	PF00917	0.534
DOC_WW_Pin1_4	147	152	PF00397	0.555
DOC_WW_Pin1_4	153	158	PF00397	0.521
DOC_WW_Pin1_4	172	177	PF00397	0.428
DOC_WW_Pin1_4	463	468	PF00397	0.548
DOC_WW_Pin1_4	497	502	PF00397	0.569
DOC_WW_Pin1_4	645	650	PF00397	0.569
DOC_WW_Pin1_4	672	677	PF00397	0.550
DOC_WW_Pin1_4	686	691	PF00397	0.505
DOC_WW_Pin1_4	744	749	PF00397	0.532
DOC_WW_Pin1_4	790	795	PF00397	0.583
DOC_WW_Pin1_4	796	801	PF00397	0.542
LIG_14-3-3_CanoR_1	220	227	PF00244	0.523
LIG_14-3-3_CanoR_1	235	244	PF00244	0.501
LIG_14-3-3_CanoR_1	276	282	PF00244	0.434
LIG_14-3-3_CanoR_1	429	438	PF00244	0.566
LIG_Actin_WH2_2	352	370	PF00022	0.463
LIG_BRCT_BRCA1_1	238	242	PF00533	0.581
LIG_BRCT_BRCA1_1	411	415	PF00533	0.523
LIG_BRCT_BRCA1_1	547	551	PF00533	0.512
LIG_BRCT_BRCA1_1	746	750	PF00533	0.531
LIG_Clathr_ClatBox_1	377	381	PF01394	0.692
LIG_deltaCOP1_diTrp_1	260	265	PF00928	0.572
LIG_Dynein_DLC8_1	428	434	PF01221	0.481
LIG_EH1_1	349	357	PF00400	0.415
LIG_eIF4E_1	350	356	PF01652	0.463
LIG_eIF4E_1	361	367	PF01652	0.561
LIG_FHA_1	159	165	PF00498	0.576
LIG_FHA_1	236	242	PF00498	0.585
LIG_FHA_1	396	402	PF00498	0.724
LIG_FHA_1	411	417	PF00498	0.321
LIG_FHA_1	430	436	PF00498	0.416
LIG_FHA_1	610	616	PF00498	0.562
LIG_FHA_1	7	13	PF00498	0.630
LIG_FHA_1	734	740	PF00498	0.524
LIG_FHA_2	102	108	PF00498	0.637
LIG_FHA_2	330	336	PF00498	0.447
LIG_FHA_2	444	450	PF00498	0.512
LIG_FHA_2	718	724	PF00498	0.564
LIG_FHA_2	761	767	PF00498	0.517
LIG_FHA_2	824	830	PF00498	0.552
LIG_FXI_DFP_1	250	254	PF00024	0.708
LIG_IRF3_LxIS_1	615	622	PF10401	0.559
LIG_LIR_Apic_2	206	210	PF02991	0.508
LIG_LIR_Apic_2	489	494	PF02991	0.644
LIG_LIR_Gen_1	260	269	PF02991	0.565
LIG_LIR_Gen_1	412	423	PF02991	0.523
LIG_LIR_Gen_1	531	541	PF02991	0.519
LIG_LIR_Gen_1	72	83	PF02991	0.521
LIG_LIR_Gen_1	845	853	PF02991	0.521
LIG_LIR_Nem_3	260	265	PF02991	0.570
LIG_LIR_Nem_3	412	418	PF02991	0.523
LIG_LIR_Nem_3	529	535	PF02991	0.562
LIG_LIR_Nem_3	53	57	PF02991	0.440
LIG_LIR_Nem_3	72	78	PF02991	0.513
LIG_LIR_Nem_3	845	851	PF02991	0.521
LIG_NRBOX	362	368	PF00104	0.678
LIG_SH2_NCK_1	62	66	PF00017	0.577
LIG_SH2_PTP2	421	424	PF00017	0.361
LIG_SH2_PTP2	534	537	PF00017	0.560
LIG_SH2_SRC	534	537	PF00017	0.637
LIG_SH2_SRC	60	63	PF00017	0.561
LIG_SH2_STAP1	350	354	PF00017	0.401
LIG_SH2_STAP1	431	435	PF00017	0.556
LIG_SH2_STAP1	62	66	PF00017	0.497
LIG_SH2_STAT3	274	277	PF00017	0.570
LIG_SH2_STAT3	361	364	PF00017	0.514
LIG_SH2_STAT5	19	22	PF00017	0.639
LIG_SH2_STAT5	232	235	PF00017	0.605
LIG_SH2_STAT5	421	424	PF00017	0.442
LIG_SH2_STAT5	431	434	PF00017	0.501
LIG_SH2_STAT5	534	537	PF00017	0.637
LIG_SH2_STAT5	60	63	PF00017	0.561
LIG_SH2_STAT5	848	851	PF00017	0.526
LIG_SH3_3	338	344	PF00018	0.430
LIG_SH3_3	461	467	PF00018	0.504
LIG_SH3_3	546	552	PF00018	0.545
LIG_SH3_3	806	812	PF00018	0.587
LIG_SUMO_SIM_par_1	616	623	PF11976	0.558
LIG_SUMO_SIM_par_1	66	72	PF11976	0.514
LIG_SUMO_SIM_par_1	99	104	PF11976	0.621
LIG_TRAF2_1	122	125	PF00917	0.641
LIG_TRAF2_1	507	510	PF00917	0.532
LIG_TYR_ITIM	419	424	PF00017	0.361
LIG_UBA3_1	392	400	PF00899	0.724
LIG_ULM_U2AF65_1	84	89	PF00076	0.556
LIG_Vh1_VBS_1	345	363	PF01044	0.415
LIG_WW_3	808	812	PF00397	0.548
MOD_CDK_SPK_2	686	691	PF00069	0.585
MOD_CDK_SPxK_1	686	692	PF00069	0.585
MOD_CDK_SPxxK_3	796	803	PF00069	0.580
MOD_CK1_1	146	152	PF00069	0.584
MOD_CK1_1	155	161	PF00069	0.502
MOD_CK1_1	284	290	PF00069	0.583
MOD_CK1_1	295	301	PF00069	0.509
MOD_CK1_1	323	329	PF00069	0.562
MOD_CK1_1	437	443	PF00069	0.468
MOD_CK1_1	481	487	PF00069	0.626
MOD_CK1_1	539	545	PF00069	0.569
MOD_CK1_1	547	553	PF00069	0.618
MOD_CK1_1	558	564	PF00069	0.495
MOD_CK1_1	607	613	PF00069	0.571
MOD_CK1_1	635	641	PF00069	0.616
MOD_CK1_1	658	664	PF00069	0.572
MOD_CK1_1	684	690	PF00069	0.584
MOD_CK1_1	717	723	PF00069	0.565
MOD_CK1_1	77	83	PF00069	0.593
MOD_CK1_1	837	843	PF00069	0.485
MOD_CK1_1	844	850	PF00069	0.487
MOD_CK2_1	181	187	PF00069	0.493
MOD_CK2_1	254	260	PF00069	0.475
MOD_CK2_1	443	449	PF00069	0.511
MOD_CK2_1	504	510	PF00069	0.535
MOD_CK2_1	520	526	PF00069	0.441
MOD_CK2_1	568	574	PF00069	0.587
MOD_CK2_1	760	766	PF00069	0.493
MOD_CK2_1	823	829	PF00069	0.557
MOD_CMANNOS	285	288	PF00535	0.786
MOD_DYRK1A_RPxSP_1	645	649	PF00069	0.530
MOD_GlcNHglycan	215	218	PF01048	0.791
MOD_GlcNHglycan	288	291	PF01048	0.726
MOD_GlcNHglycan	294	297	PF01048	0.788
MOD_GlcNHglycan	315	318	PF01048	0.782
MOD_GlcNHglycan	325	328	PF01048	0.667
MOD_GlcNHglycan	33	36	PF01048	0.800
MOD_GlcNHglycan	338	341	PF01048	0.697
MOD_GlcNHglycan	43	46	PF01048	0.739
MOD_GlcNHglycan	480	483	PF01048	0.746
MOD_GlcNHglycan	485	488	PF01048	0.688
MOD_GlcNHglycan	502	505	PF01048	0.648
MOD_GlcNHglycan	522	525	PF01048	0.620
MOD_GlcNHglycan	560	563	PF01048	0.844
MOD_GlcNHglycan	571	574	PF01048	0.735
MOD_GlcNHglycan	627	630	PF01048	0.750
MOD_GlcNHglycan	637	640	PF01048	0.717
MOD_GlcNHglycan	651	654	PF01048	0.664
MOD_GlcNHglycan	684	687	PF01048	0.788
MOD_GlcNHglycan	716	719	PF01048	0.768
MOD_GlcNHglycan	726	729	PF01048	0.694
MOD_GlcNHglycan	771	774	PF01048	0.754
MOD_GlcNHglycan	79	82	PF01048	0.688
MOD_GlcNHglycan	821	824	PF01048	0.730
MOD_GSK3_1	120	127	PF00069	0.550
MOD_GSK3_1	143	150	PF00069	0.579
MOD_GSK3_1	151	158	PF00069	0.508
MOD_GSK3_1	159	166	PF00069	0.453
MOD_GSK3_1	179	186	PF00069	0.419
MOD_GSK3_1	277	284	PF00069	0.510
MOD_GSK3_1	31	38	PF00069	0.593
MOD_GSK3_1	388	395	PF00069	0.772
MOD_GSK3_1	474	481	PF00069	0.593
MOD_GSK3_1	483	490	PF00069	0.514
MOD_GSK3_1	496	503	PF00069	0.510
MOD_GSK3_1	509	516	PF00069	0.498
MOD_GSK3_1	556	563	PF00069	0.572
MOD_GSK3_1	595	602	PF00069	0.617
MOD_GSK3_1	607	614	PF00069	0.532
MOD_GSK3_1	631	638	PF00069	0.579
MOD_GSK3_1	645	652	PF00069	0.460
MOD_GSK3_1	654	661	PF00069	0.503
MOD_GSK3_1	677	684	PF00069	0.581
MOD_GSK3_1	714	721	PF00069	0.536
MOD_GSK3_1	817	824	PF00069	0.580
MOD_GSK3_1	837	844	PF00069	0.381
MOD_GSK3_1	99	106	PF00069	0.585
MOD_N-GLC_1	166	171	PF02516	0.769
MOD_N-GLC_1	220	225	PF02516	0.814
MOD_N-GLC_1	260	265	PF02516	0.695
MOD_N-GLC_1	313	318	PF02516	0.798
MOD_N-GLC_1	635	640	PF02516	0.777
MOD_N-GLC_1	658	663	PF02516	0.772
MOD_NEK2_1	108	113	PF00069	0.627
MOD_NEK2_1	292	297	PF00069	0.481
MOD_NEK2_1	320	325	PF00069	0.496
MOD_NEK2_1	33	38	PF00069	0.615
MOD_NEK2_1	380	385	PF00069	0.701
MOD_NEK2_1	409	414	PF00069	0.523
MOD_NEK2_1	47	52	PF00069	0.509
MOD_NEK2_1	478	483	PF00069	0.563
MOD_NEK2_1	495	500	PF00069	0.433
MOD_NEK2_1	513	518	PF00069	0.437
MOD_NEK2_1	611	616	PF00069	0.518
MOD_NEK2_1	625	630	PF00069	0.475
MOD_NEK2_1	632	637	PF00069	0.540
MOD_NEK2_1	655	660	PF00069	0.571
MOD_NEK2_1	702	707	PF00069	0.544
MOD_NEK2_1	743	748	PF00069	0.512
MOD_NEK2_2	269	274	PF00069	0.556
MOD_NEK2_2	474	479	PF00069	0.528
MOD_NEK2_2	576	581	PF00069	0.538
MOD_NEK2_2	823	828	PF00069	0.559
MOD_PIKK_1	120	126	PF00454	0.559
MOD_PIKK_1	166	172	PF00454	0.569
MOD_PIKK_1	429	435	PF00454	0.430
MOD_PIKK_1	566	572	PF00454	0.597
MOD_PKA_1	429	435	PF00069	0.559
MOD_PKA_1	700	706	PF00069	0.538
MOD_PKA_2	179	185	PF00069	0.574
MOD_PKA_2	219	225	PF00069	0.483
MOD_PKA_2	443	449	PF00069	0.511
MOD_PKA_2	769	775	PF00069	0.553
MOD_PKA_2	810	816	PF00069	0.553
MOD_PKB_1	427	435	PF00069	0.557
MOD_PKB_1	553	561	PF00069	0.589
MOD_PKB_1	698	706	PF00069	0.578
MOD_Plk_1	260	266	PF00069	0.569
MOD_Plk_1	509	515	PF00069	0.536
MOD_Plk_1	528	534	PF00069	0.491
MOD_Plk_1	563	569	PF00069	0.666
MOD_Plk_1	665	671	PF00069	0.583
MOD_Plk_1	761	767	PF00069	0.502
MOD_Plk_1	844	850	PF00069	0.514
MOD_Plk_2-3	181	187	PF00069	0.493
MOD_Plk_2-3	560	566	PF00069	0.555
MOD_Plk_4	159	165	PF00069	0.576
MOD_Plk_4	269	275	PF00069	0.557
MOD_Plk_4	281	287	PF00069	0.441
MOD_Plk_4	388	394	PF00069	0.739
MOD_Plk_4	528	534	PF00069	0.601
MOD_Plk_4	563	569	PF00069	0.597
MOD_Plk_4	837	843	PF00069	0.496
MOD_Plk_4	844	850	PF00069	0.471
MOD_ProDKin_1	147	153	PF00069	0.549
MOD_ProDKin_1	172	178	PF00069	0.575
MOD_ProDKin_1	463	469	PF00069	0.549
MOD_ProDKin_1	497	503	PF00069	0.569
MOD_ProDKin_1	645	651	PF00069	0.568
MOD_ProDKin_1	672	678	PF00069	0.551
MOD_ProDKin_1	686	692	PF00069	0.504
MOD_ProDKin_1	744	750	PF00069	0.533
MOD_ProDKin_1	790	796	PF00069	0.578
MOD_SUMO_for_1	537	540	PF00179	0.515
MOD_SUMO_rev_2	531	539	PF00179	0.521
TRG_DiLeu_BaEn_1	245	250	PF01217	0.571
TRG_DiLeu_BaEn_1	845	850	PF01217	0.519
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.639
TRG_ENDOCYTIC_2	421	424	PF00928	0.361
TRG_ENDOCYTIC_2	534	537	PF00928	0.560
TRG_ENDOCYTIC_2	848	851	PF00928	0.526
TRG_ER_diArg_1	459	462	PF00400	0.580
TRG_ER_diArg_1	552	555	PF00400	0.589
TRG_ER_diArg_1	580	583	PF00400	0.587
TRG_ER_diArg_1	690	692	PF00400	0.581
TRG_ER_diArg_1	697	700	PF00400	0.523
TRG_ER_diArg_1	84	87	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.776
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HYQ4	Leishmania infantum	97%	100%
E9AIB4	Leishmania braziliensis	55%	99%
E9AUK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%