Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVW3_LEIDO

TriTrypDb:

LdBPK_200660.1 , LdCL_200011300 , LDHU3_20.0800

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WVW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.718
CLV_C14_Caspase3-7	584	588	PF00656	0.692
CLV_NRD_NRD_1	32	34	PF00675	0.494
CLV_NRD_NRD_1	38	40	PF00675	0.465
CLV_NRD_NRD_1	524	526	PF00675	0.569
CLV_PCSK_KEX2_1	32	34	PF00082	0.494
CLV_PCSK_KEX2_1	38	40	PF00082	0.465
CLV_PCSK_KEX2_1	523	525	PF00082	0.583
CLV_PCSK_SKI1_1	332	336	PF00082	0.587
CLV_PCSK_SKI1_1	381	385	PF00082	0.540
CLV_PCSK_SKI1_1	485	489	PF00082	0.409
CLV_PCSK_SKI1_1	495	499	PF00082	0.426
DEG_Nend_Nbox_1	1	3	PF02207	0.372
DEG_SPOP_SBC_1	298	302	PF00917	0.682
DOC_ANK_TNKS_1	37	44	PF00023	0.683
DOC_ANK_TNKS_1	523	530	PF00023	0.640
DOC_CDC14_PxL_1	127	135	PF14671	0.666
DOC_CDC14_PxL_1	487	495	PF14671	0.607
DOC_CYCLIN_RxL_1	167	177	PF00134	0.654
DOC_MAPK_gen_1	417	425	PF00069	0.642
DOC_MAPK_gen_1	483	492	PF00069	0.592
DOC_MAPK_MEF2A_6	417	425	PF00069	0.692
DOC_MAPK_MEF2A_6	485	494	PF00069	0.532
DOC_MAPK_RevD_3	8	23	PF00069	0.389
DOC_PP4_FxxP_1	103	106	PF00568	0.710
DOC_PP4_FxxP_1	488	491	PF00568	0.603
DOC_USP7_MATH_1	221	225	PF00917	0.743
DOC_USP7_MATH_1	354	358	PF00917	0.813
DOC_USP7_MATH_1	361	365	PF00917	0.819
DOC_USP7_MATH_1	474	478	PF00917	0.595
DOC_USP7_MATH_1	528	532	PF00917	0.775
DOC_USP7_MATH_1	551	555	PF00917	0.746
DOC_USP7_MATH_1	597	601	PF00917	0.818
DOC_USP7_MATH_1	607	611	PF00917	0.688
DOC_USP7_MATH_1	80	84	PF00917	0.841
DOC_WW_Pin1_4	195	200	PF00397	0.733
DOC_WW_Pin1_4	257	262	PF00397	0.797
DOC_WW_Pin1_4	449	454	PF00397	0.698
DOC_WW_Pin1_4	81	86	PF00397	0.727
LIG_14-3-3_CanoR_1	299	304	PF00244	0.770
LIG_14-3-3_CanoR_1	381	390	PF00244	0.760
LIG_14-3-3_CanoR_1	438	444	PF00244	0.619
LIG_14-3-3_CanoR_1	598	608	PF00244	0.758
LIG_Actin_WH2_2	11	29	PF00022	0.436
LIG_Actin_WH2_2	426	442	PF00022	0.614
LIG_Actin_WH2_2	487	502	PF00022	0.612
LIG_BIR_III_4	571	575	PF00653	0.715
LIG_BRCT_BRCA1_1	401	405	PF00533	0.610
LIG_BRCT_BRCA1_1	609	613	PF00533	0.724
LIG_BRCT_BRCA1_1	99	103	PF00533	0.767
LIG_FHA_1	385	391	PF00498	0.690
LIG_FHA_1	42	48	PF00498	0.617
LIG_FHA_1	460	466	PF00498	0.590
LIG_FHA_1	553	559	PF00498	0.818
LIG_FHA_2	110	116	PF00498	0.773
LIG_FHA_2	543	549	PF00498	0.684
LIG_GBD_Chelix_1	2	10	PF00786	0.391
LIG_LIR_Apic_2	100	106	PF02991	0.711
LIG_LIR_Apic_2	266	272	PF02991	0.738
LIG_LIR_Apic_2	486	491	PF02991	0.607
LIG_LIR_Gen_1	155	161	PF02991	0.623
LIG_LIR_Gen_1	590	601	PF02991	0.735
LIG_LIR_Nem_3	155	159	PF02991	0.622
LIG_LIR_Nem_3	486	490	PF02991	0.611
LIG_LIR_Nem_3	590	596	PF02991	0.744
LIG_MLH1_MIPbox_1	609	613	PF16413	0.724
LIG_NRBOX	14	20	PF00104	0.392
LIG_NRBOX	5	11	PF00104	0.471
LIG_PCNA_PIPBox_1	481	490	PF02747	0.609
LIG_PCNA_yPIPBox_3	481	495	PF02747	0.602
LIG_Pex14_1	46	50	PF04695	0.702
LIG_Pex14_2	471	475	PF04695	0.586
LIG_Pex14_2	497	501	PF04695	0.605
LIG_SH2_CRK	269	273	PF00017	0.716
LIG_SH2_GRB2like	269	272	PF00017	0.771
LIG_SH2_NCK_1	445	449	PF00017	0.675
LIG_SH2_PTP2	424	427	PF00017	0.663
LIG_SH2_SRC	445	448	PF00017	0.674
LIG_SH2_STAT5	175	178	PF00017	0.742
LIG_SH2_STAT5	269	272	PF00017	0.738
LIG_SH2_STAT5	420	423	PF00017	0.604
LIG_SH2_STAT5	424	427	PF00017	0.590
LIG_SH2_STAT5	458	461	PF00017	0.620
LIG_SH2_STAT5	612	615	PF00017	0.755
LIG_SH3_1	269	275	PF00018	0.686
LIG_SH3_3	196	202	PF00018	0.800
LIG_SH3_3	250	256	PF00018	0.761
LIG_SH3_3	269	275	PF00018	0.648
LIG_SH3_3	331	337	PF00018	0.688
LIG_SH3_3	357	363	PF00018	0.747
LIG_SH3_3	447	453	PF00018	0.696
LIG_SH3_3	576	582	PF00018	0.718
LIG_SH3_3	79	85	PF00018	0.808
LIG_SUMO_SIM_anti_2	389	394	PF11976	0.677
LIG_SUMO_SIM_par_1	260	266	PF11976	0.754
LIG_SxIP_EBH_1	29	39	PF03271	0.677
LIG_UBA3_1	15	23	PF00899	0.364
LIG_Vh1_VBS_1	1	19	PF01044	0.299
LIG_WRC_WIRS_1	153	158	PF05994	0.691
LIG_WRC_WIRS_1	264	269	PF05994	0.816
MOD_CK1_1	120	126	PF00069	0.660
MOD_CK1_1	184	190	PF00069	0.746
MOD_CK1_1	195	201	PF00069	0.782
MOD_CK1_1	212	218	PF00069	0.762
MOD_CK1_1	260	266	PF00069	0.765
MOD_CK1_1	279	285	PF00069	0.776
MOD_CK1_1	287	293	PF00069	0.780
MOD_CK1_1	305	311	PF00069	0.788
MOD_CK1_1	345	351	PF00069	0.714
MOD_CK1_1	477	483	PF00069	0.620
MOD_CK1_1	570	576	PF00069	0.742
MOD_CK1_1	81	87	PF00069	0.778
MOD_CK2_1	119	125	PF00069	0.789
MOD_CK2_1	312	318	PF00069	0.789
MOD_CK2_1	542	548	PF00069	0.684
MOD_CK2_1	597	603	PF00069	0.744
MOD_GlcNHglycan	107	110	PF01048	0.526
MOD_GlcNHglycan	122	125	PF01048	0.487
MOD_GlcNHglycan	144	147	PF01048	0.488
MOD_GlcNHglycan	183	186	PF01048	0.608
MOD_GlcNHglycan	194	197	PF01048	0.528
MOD_GlcNHglycan	223	226	PF01048	0.587
MOD_GlcNHglycan	241	244	PF01048	0.570
MOD_GlcNHglycan	281	284	PF01048	0.601
MOD_GlcNHglycan	288	292	PF01048	0.529
MOD_GlcNHglycan	314	317	PF01048	0.527
MOD_GlcNHglycan	318	321	PF01048	0.501
MOD_GlcNHglycan	347	350	PF01048	0.571
MOD_GlcNHglycan	364	367	PF01048	0.477
MOD_GlcNHglycan	400	404	PF01048	0.397
MOD_GlcNHglycan	459	462	PF01048	0.489
MOD_GlcNHglycan	530	533	PF01048	0.629
MOD_GlcNHglycan	542	545	PF01048	0.502
MOD_GlcNHglycan	548	552	PF01048	0.431
MOD_GlcNHglycan	571	575	PF01048	0.446
MOD_GlcNHglycan	609	612	PF01048	0.579
MOD_GSK3_1	105	112	PF00069	0.705
MOD_GSK3_1	263	270	PF00069	0.788
MOD_GSK3_1	294	301	PF00069	0.794
MOD_GSK3_1	302	309	PF00069	0.730
MOD_GSK3_1	312	319	PF00069	0.690
MOD_GSK3_1	338	345	PF00069	0.724
MOD_GSK3_1	370	377	PF00069	0.753
MOD_GSK3_1	384	391	PF00069	0.797
MOD_GSK3_1	399	406	PF00069	0.514
MOD_GSK3_1	507	514	PF00069	0.696
MOD_GSK3_1	547	554	PF00069	0.754
MOD_N-GLC_1	239	244	PF02516	0.542
MOD_N-GLC_1	294	299	PF02516	0.596
MOD_N-GLC_1	332	337	PF02516	0.555
MOD_N-GLC_1	403	408	PF02516	0.397
MOD_NEK2_1	1	6	PF00069	0.378
MOD_NEK2_1	174	179	PF00069	0.706
MOD_NEK2_1	267	272	PF00069	0.757
MOD_NEK2_1	276	281	PF00069	0.712
MOD_NEK2_1	306	311	PF00069	0.791
MOD_NEK2_1	338	343	PF00069	0.766
MOD_NEK2_1	344	349	PF00069	0.766
MOD_NEK2_1	405	410	PF00069	0.601
MOD_NEK2_1	459	464	PF00069	0.599
MOD_NEK2_1	475	480	PF00069	0.634
MOD_NEK2_1	501	506	PF00069	0.678
MOD_PIKK_1	245	251	PF00454	0.761
MOD_PIKK_1	477	483	PF00454	0.620
MOD_PIKK_1	507	513	PF00454	0.709
MOD_PK_1	388	394	PF00069	0.686
MOD_PKA_2	284	290	PF00069	0.714
MOD_PKA_2	298	304	PF00069	0.604
MOD_PKA_2	31	37	PF00069	0.699
MOD_PKA_2	312	318	PF00069	0.746
MOD_PKA_2	342	348	PF00069	0.817
MOD_PKA_2	439	445	PF00069	0.626
MOD_PKA_2	506	512	PF00069	0.684
MOD_PKA_2	597	603	PF00069	0.816
MOD_PKB_1	330	338	PF00069	0.758
MOD_Plk_1	294	300	PF00069	0.795
MOD_Plk_1	403	409	PF00069	0.597
MOD_Plk_2-3	446	452	PF00069	0.688
MOD_Plk_4	1	7	PF00069	0.411
MOD_Plk_4	302	308	PF00069	0.837
MOD_Plk_4	388	394	PF00069	0.686
MOD_Plk_4	41	47	PF00069	0.650
MOD_Plk_4	459	465	PF00069	0.593
MOD_ProDKin_1	195	201	PF00069	0.732
MOD_ProDKin_1	257	263	PF00069	0.796
MOD_ProDKin_1	449	455	PF00069	0.696
MOD_ProDKin_1	81	87	PF00069	0.728
MOD_SUMO_rev_2	145	153	PF00179	0.707
TRG_ENDOCYTIC_2	420	423	PF00928	0.604
TRG_ENDOCYTIC_2	424	427	PF00928	0.590
TRG_ER_diArg_1	37	39	PF00400	0.750
TRG_ER_diArg_1	417	420	PF00400	0.653
TRG_ER_diArg_1	437	440	PF00400	0.445
TRG_ER_diArg_1	482	485	PF00400	0.579
TRG_ER_diArg_1	523	525	PF00400	0.783

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B3	Leptomonas seymouri	49%	99%
A4HYQ2	Leishmania infantum	99%	100%
E9AIB6	Leishmania braziliensis	72%	98%
E9AUK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QCY1	Leishmania major	88%	100%