Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WVV8_LEIDO

TriTrypDb:

LdBPK_200020.1 , LdCL_200005100 , LDHU3_20.0030

Length:

412

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	6
GO:0032991	protein-containing complex	1	6
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:1990904	ribonucleoprotein complex	2	6
GO:0005634	nucleus	5	1
GO:0005656	nuclear pre-replicative complex	3	1
GO:0005730	nucleolus	5	1
GO:0032993	protein-DNA complex	2	1
GO:0036387	pre-replicative complex	3	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097344	Rix1 complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S7WVV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVV8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006261	DNA-templated DNA replication	6	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.547
CLV_C14_Caspase3-7	374	378	PF00656	0.636
CLV_NRD_NRD_1	355	357	PF00675	0.598
CLV_NRD_NRD_1	400	402	PF00675	0.509
CLV_PCSK_KEX2_1	355	357	PF00082	0.602
CLV_PCSK_KEX2_1	359	361	PF00082	0.589
CLV_PCSK_KEX2_1	400	402	PF00082	0.567
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.645
CLV_PCSK_PC7_1	355	361	PF00082	0.694
CLV_PCSK_SKI1_1	155	159	PF00082	0.338
CLV_PCSK_SKI1_1	198	202	PF00082	0.555
CLV_PCSK_SKI1_1	224	228	PF00082	0.475
CLV_PCSK_SKI1_1	297	301	PF00082	0.498
CLV_PCSK_SKI1_1	32	36	PF00082	0.462
CLV_PCSK_SKI1_1	356	360	PF00082	0.661
CLV_PCSK_SKI1_1	66	70	PF00082	0.458
DEG_APCC_DBOX_1	9	17	PF00400	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.369
DOC_ANK_TNKS_1	22	29	PF00023	0.554
DOC_CKS1_1	273	278	PF01111	0.348
DOC_PP2B_LxvP_1	254	257	PF13499	0.626
DOC_USP7_MATH_1	122	126	PF00917	0.504
DOC_USP7_MATH_1	128	132	PF00917	0.485
DOC_USP7_MATH_1	240	244	PF00917	0.583
DOC_WW_Pin1_4	261	266	PF00397	0.487
DOC_WW_Pin1_4	272	277	PF00397	0.567
DOC_WW_Pin1_4	301	306	PF00397	0.570
DOC_WW_Pin1_4	35	40	PF00397	0.503
DOC_WW_Pin1_4	66	71	PF00397	0.486
LIG_14-3-3_CanoR_1	198	203	PF00244	0.560
LIG_14-3-3_CanoR_1	343	349	PF00244	0.621
LIG_14-3-3_CanoR_1	403	411	PF00244	0.454
LIG_Clathr_ClatBox_1	13	17	PF01394	0.429
LIG_DCNL_PONY_1	1	4	PF03556	0.492
LIG_FHA_1	16	22	PF00498	0.421
LIG_FHA_1	183	189	PF00498	0.504
LIG_FHA_1	197	203	PF00498	0.416
LIG_FHA_1	273	279	PF00498	0.526
LIG_FHA_1	67	73	PF00498	0.358
LIG_FHA_1	81	87	PF00498	0.485
LIG_FHA_1	91	97	PF00498	0.483
LIG_FHA_2	127	133	PF00498	0.482
LIG_FHA_2	199	205	PF00498	0.445
LIG_FHA_2	279	285	PF00498	0.449
LIG_FHA_2	349	355	PF00498	0.613
LIG_Integrin_isoDGR_2	295	297	PF01839	0.507
LIG_NRP_CendR_1	409	412	PF00754	0.642
LIG_SH2_CRK	37	41	PF00017	0.543
LIG_SH2_NCK_1	37	41	PF00017	0.510
LIG_SH2_SRC	233	236	PF00017	0.579
LIG_SH2_SRC	25	28	PF00017	0.545
LIG_SH3_1	270	276	PF00018	0.476
LIG_SH3_2	334	339	PF14604	0.636
LIG_SH3_3	270	276	PF00018	0.431
LIG_SH3_3	331	337	PF00018	0.581
LIG_SUMO_SIM_par_1	12	18	PF11976	0.468
LIG_SUMO_SIM_par_1	198	204	PF11976	0.368
LIG_SUMO_SIM_par_1	387	393	PF11976	0.469
LIG_TRAF2_1	372	375	PF00917	0.706
LIG_TRAF2_1	380	383	PF00917	0.596
LIG_TYR_ITIM	35	40	PF00017	0.527
LIG_Vh1_VBS_1	72	90	PF01044	0.564
LIG_WRC_WIRS_1	349	354	PF05994	0.501
MOD_CDC14_SPxK_1	304	307	PF00782	0.556
MOD_CDK_SPxK_1	301	307	PF00069	0.531
MOD_CK1_1	131	137	PF00069	0.499
MOD_CK1_1	182	188	PF00069	0.485
MOD_CK1_1	274	280	PF00069	0.538
MOD_CK1_1	38	44	PF00069	0.503
MOD_CK1_1	57	63	PF00069	0.259
MOD_CK2_1	126	132	PF00069	0.475
MOD_CK2_1	278	284	PF00069	0.461
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.550
MOD_GlcNHglycan	100	103	PF01048	0.490
MOD_GlcNHglycan	120	123	PF01048	0.128
MOD_GlcNHglycan	257	260	PF01048	0.571
MOD_GlcNHglycan	56	59	PF01048	0.486
MOD_GSK3_1	118	125	PF00069	0.484
MOD_GSK3_1	159	166	PF00069	0.528
MOD_GSK3_1	178	185	PF00069	0.351
MOD_GSK3_1	274	281	PF00069	0.470
MOD_GSK3_1	403	410	PF00069	0.530
MOD_GSK3_1	72	79	PF00069	0.479
MOD_GSK3_1	86	93	PF00069	0.506
MOD_N-GLC_1	90	95	PF02516	0.334
MOD_NEK2_1	104	109	PF00069	0.526
MOD_NEK2_1	126	131	PF00069	0.474
MOD_NEK2_1	163	168	PF00069	0.499
MOD_NEK2_1	171	176	PF00069	0.436
MOD_NEK2_1	188	193	PF00069	0.487
MOD_NEK2_1	278	283	PF00069	0.434
MOD_NEK2_1	54	59	PF00069	0.443
MOD_NEK2_1	64	69	PF00069	0.398
MOD_NEK2_1	72	77	PF00069	0.385
MOD_PIKK_1	15	21	PF00454	0.501
MOD_PIKK_1	219	225	PF00454	0.467
MOD_PIKK_1	342	348	PF00454	0.599
MOD_PIKK_1	38	44	PF00454	0.470
MOD_PIKK_1	57	63	PF00454	0.272
MOD_PKA_1	403	409	PF00069	0.598
MOD_PKA_2	342	348	PF00069	0.620
MOD_PKB_1	401	409	PF00069	0.615
MOD_Plk_1	122	128	PF00069	0.484
MOD_Plk_1	131	137	PF00069	0.493
MOD_Plk_1	214	220	PF00069	0.404
MOD_Plk_1	64	70	PF00069	0.324
MOD_Plk_4	122	128	PF00069	0.473
MOD_Plk_4	166	172	PF00069	0.513
MOD_Plk_4	17	23	PF00069	0.496
MOD_Plk_4	214	220	PF00069	0.412
MOD_Plk_4	274	280	PF00069	0.479
MOD_Plk_4	80	86	PF00069	0.503
MOD_Plk_4	90	96	PF00069	0.513
MOD_ProDKin_1	261	267	PF00069	0.484
MOD_ProDKin_1	272	278	PF00069	0.561
MOD_ProDKin_1	301	307	PF00069	0.579
MOD_ProDKin_1	35	41	PF00069	0.507
MOD_ProDKin_1	66	72	PF00069	0.482
MOD_SUMO_rev_2	406	411	PF00179	0.425
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.518
TRG_ENDOCYTIC_2	37	40	PF00928	0.540
TRG_ER_diArg_1	147	150	PF00400	0.574
TRG_ER_diArg_1	400	403	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVD5	Leptomonas seymouri	65%	99%
A0A0S4IM90	Bodo saltans	30%	88%
A0A0S4J5T5	Bodo saltans	21%	76%
A0A1X0NWV7	Trypanosomatidae	34%	92%
A0A422N846	Trypanosoma rangeli	36%	96%
A4HBH0	Leishmania braziliensis	83%	100%
A4HGX7	Leishmania braziliensis	23%	100%
A4HYJ4	Leishmania infantum	100%	100%
C9ZHT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
E8NHN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AUE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P62884	Leishmania infantum	23%	100%
Q0P593	Bos taurus	23%	99%
Q4Q7Y7	Leishmania major	23%	100%
Q4QD42	Leishmania major	93%	100%
Q4R8E7	Macaca fascicularis	23%	99%
Q6C953	Yarrowia lipolytica (strain CLIB 122 / E 150)	23%	97%
Q76LS6	Leishmania donovani	23%	100%
Q8N136	Homo sapiens	21%	99%
Q9M3B4	Arabidopsis thaliana	26%	94%