Potassium_voltage-gated_channel_putative/GeneDB:L mjF.19.1620

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

potassium voltage-gated channel, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WVV0_LEIDO

TriTrypDb:

LdBPK_191650.1 , LdCL_190022300 , LDHU3_19.1990

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0008076	voltage-gated potassium channel complex	4	1
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034705	potassium channel complex	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098797	plasma membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A0A3S7WVV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVV0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043933	protein-containing complex organization	4	12
GO:0051259	protein complex oligomerization	6	12
GO:0051260	protein homooligomerization	7	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006813	potassium ion transport	7	1
GO:0030001	metal ion transport	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005216	monoatomic ion channel activity	4	1
GO:0005242	inward rectifier potassium channel activity	7	1
GO:0005244	voltage-gated monoatomic ion channel activity	4	1
GO:0005249	voltage-gated potassium channel activity	6	1
GO:0005261	monoatomic cation channel activity	5	1
GO:0005267	potassium channel activity	6	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015079	potassium ion transmembrane transporter activity	6	1
GO:0015267	channel activity	4	1
GO:0015272	ATP-activated inward rectifier potassium channel activity	8	1
GO:0015276	ligand-gated monoatomic ion channel activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022803	passive transmembrane transporter activity	3	1
GO:0022832	voltage-gated channel activity	6	1
GO:0022834	ligand-gated channel activity	6	1
GO:0022836	gated channel activity	5	1
GO:0022843	voltage-gated monoatomic cation channel activity	5	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1
GO:0046873	metal ion transmembrane transporter activity	5	1
GO:0099094	ligand-gated monoatomic cation channel activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.684
CLV_NRD_NRD_1	159	161	PF00675	0.415
CLV_NRD_NRD_1	167	169	PF00675	0.375
CLV_NRD_NRD_1	249	251	PF00675	0.412
CLV_NRD_NRD_1	285	287	PF00675	0.544
CLV_PCSK_KEX2_1	144	146	PF00082	0.392
CLV_PCSK_KEX2_1	167	169	PF00082	0.439
CLV_PCSK_KEX2_1	249	251	PF00082	0.412
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.392
CLV_PCSK_SKI1_1	160	164	PF00082	0.386
CLV_PCSK_SKI1_1	187	191	PF00082	0.355
CLV_PCSK_SKI1_1	3	7	PF00082	0.391
DEG_APCC_DBOX_1	249	257	PF00400	0.596
DOC_CKS1_1	43	48	PF01111	0.466
DOC_CYCLIN_RxL_1	66	76	PF00134	0.415
DOC_MAPK_gen_1	144	150	PF00069	0.375
DOC_MAPK_gen_1	75	83	PF00069	0.418
DOC_MAPK_MEF2A_6	75	83	PF00069	0.433
DOC_PP1_RVXF_1	284	291	PF00149	0.661
DOC_PP1_RVXF_1	67	74	PF00149	0.433
DOC_USP7_MATH_1	25	29	PF00917	0.479
DOC_USP7_MATH_1	37	41	PF00917	0.401
DOC_USP7_MATH_1	52	56	PF00917	0.485
DOC_WW_Pin1_4	228	233	PF00397	0.417
DOC_WW_Pin1_4	290	295	PF00397	0.635
DOC_WW_Pin1_4	42	47	PF00397	0.428
LIG_14-3-3_CanoR_1	17	22	PF00244	0.401
LIG_BIR_III_2	61	65	PF00653	0.389
LIG_EVH1_1	42	46	PF00568	0.407
LIG_FHA_1	161	167	PF00498	0.390
LIG_FHA_1	17	23	PF00498	0.240
LIG_FHA_1	191	197	PF00498	0.389
LIG_FHA_1	203	209	PF00498	0.411
LIG_FHA_1	214	220	PF00498	0.443
LIG_FHA_1	223	229	PF00498	0.243
LIG_FHA_1	37	43	PF00498	0.450
LIG_FHA_1	74	80	PF00498	0.359
LIG_FHA_2	51	57	PF00498	0.415
LIG_LIR_Gen_1	225	235	PF02991	0.417
LIG_LIR_Gen_1	26	37	PF02991	0.363
LIG_LIR_Gen_1	273	283	PF02991	0.621
LIG_LIR_Gen_1	65	74	PF02991	0.363
LIG_LIR_Nem_3	176	182	PF02991	0.378
LIG_LIR_Nem_3	225	230	PF02991	0.405
LIG_LIR_Nem_3	273	278	PF02991	0.624
LIG_LIR_Nem_3	65	70	PF02991	0.363
LIG_MYND_3	253	257	PF01753	0.621
LIG_NRBOX	17	23	PF00104	0.433
LIG_PCNA_yPIPBox_3	12	22	PF02747	0.433
LIG_Pex14_2	29	33	PF04695	0.389
LIG_PTB_Apo_2	242	249	PF02174	0.347
LIG_SH2_GRB2like	275	278	PF00017	0.616
LIG_SH2_GRB2like	95	98	PF00017	0.240
LIG_SH2_PTP2	227	230	PF00017	0.397
LIG_SH2_SRC	95	98	PF00017	0.240
LIG_SH2_STAT5	13	16	PF00017	0.433
LIG_SH2_STAT5	227	230	PF00017	0.402
LIG_SH2_STAT5	95	98	PF00017	0.253
LIG_SH3_2	282	287	PF14604	0.626
LIG_SH3_3	248	254	PF00018	0.520
LIG_SH3_3	279	285	PF00018	0.574
LIG_SH3_3	291	297	PF00018	0.649
LIG_SH3_3	40	46	PF00018	0.436
LIG_SH3_4	296	303	PF00018	0.426
LIG_SUMO_SIM_par_1	121	127	PF11976	0.580
MOD_CDC14_SPxK_1	293	296	PF00782	0.655
MOD_CDK_SPxK_1	290	296	PF00069	0.661
MOD_CK1_1	226	232	PF00069	0.412
MOD_CK2_1	50	56	PF00069	0.441
MOD_GlcNHglycan	108	111	PF01048	0.605
MOD_GlcNHglycan	39	42	PF01048	0.423
MOD_GSK3_1	13	20	PF00069	0.297
MOD_GSK3_1	202	209	PF00069	0.399
MOD_GSK3_1	222	229	PF00069	0.245
MOD_NEK2_1	148	153	PF00069	0.396
MOD_NEK2_1	174	179	PF00069	0.392
MOD_NEK2_1	190	195	PF00069	0.379
MOD_NEK2_1	204	209	PF00069	0.376
MOD_NEK2_1	223	228	PF00069	0.531
MOD_NEK2_1	36	41	PF00069	0.418
MOD_NEK2_1	73	78	PF00069	0.310
MOD_PIKK_1	160	166	PF00454	0.372
MOD_PIKK_1	206	212	PF00454	0.394
MOD_PKA_1	160	166	PF00069	0.405
MOD_PKA_2	16	22	PF00069	0.433
MOD_Plk_1	25	31	PF00069	0.383
MOD_Plk_1	260	266	PF00069	0.641
MOD_Plk_4	17	23	PF00069	0.303
MOD_Plk_4	174	180	PF00069	0.388
MOD_Plk_4	223	229	PF00069	0.410
MOD_Plk_4	260	266	PF00069	0.680
MOD_ProDKin_1	228	234	PF00069	0.420
MOD_ProDKin_1	290	296	PF00069	0.629
MOD_ProDKin_1	42	48	PF00069	0.428
TRG_DiLeu_BaEn_1	118	123	PF01217	0.568
TRG_ENDOCYTIC_2	227	230	PF00928	0.402
TRG_ENDOCYTIC_2	275	278	PF00928	0.616
TRG_ER_diArg_1	166	168	PF00400	0.447
TRG_ER_diArg_1	248	250	PF00400	0.370
TRG_NES_CRM1_1	124	135	PF08389	0.394
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A6	Leptomonas seymouri	79%	97%
A0A0S4JGQ4	Bodo saltans	52%	89%
A0A1X0P666	Trypanosomatidae	59%	100%
A0A3R7KT76	Trypanosoma rangeli	58%	100%
A4HAB1	Leishmania braziliensis	92%	100%
A4HYJ1	Leishmania infantum	99%	100%
D0A0W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ASB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QD47	Leishmania major	97%	100%
V5AP17	Trypanosoma cruzi	56%	100%