NUDIX domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WVU6_LEIDO

TriTrypDb:

LdBPK_200450.1 , LdCL_200009200 , LDHU3_20.0530

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVU6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.538
CLV_C14_Caspase3-7	368	372	PF00656	0.529
CLV_C14_Caspase3-7	398	402	PF00656	0.702
CLV_NRD_NRD_1	138	140	PF00675	0.612
CLV_NRD_NRD_1	277	279	PF00675	0.449
CLV_NRD_NRD_1	350	352	PF00675	0.568
CLV_PCSK_KEX2_1	138	140	PF00082	0.612
CLV_PCSK_KEX2_1	277	279	PF00082	0.449
CLV_PCSK_KEX2_1	350	352	PF00082	0.568
CLV_PCSK_KEX2_1	50	52	PF00082	0.485
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.505
CLV_PCSK_SKI1_1	173	177	PF00082	0.660
CLV_PCSK_SKI1_1	24	28	PF00082	0.625
CLV_PCSK_SKI1_1	31	35	PF00082	0.709
CLV_PCSK_SKI1_1	95	99	PF00082	0.758
DEG_Nend_UBRbox_3	1	3	PF02207	0.573
DEG_ODPH_VHL_1	288	301	PF01847	0.570
DEG_SIAH_1	58	66	PF03145	0.378
DOC_CKS1_1	174	179	PF01111	0.552
DOC_MAPK_MEF2A_6	40	48	PF00069	0.584
DOC_PP2B_LxvP_1	288	291	PF13499	0.472
DOC_PP4_FxxP_1	355	358	PF00568	0.565
DOC_USP7_MATH_1	169	173	PF00917	0.734
DOC_USP7_MATH_1	185	189	PF00917	0.385
DOC_USP7_MATH_1	198	202	PF00917	0.427
DOC_USP7_MATH_1	217	221	PF00917	0.491
DOC_USP7_MATH_1	331	335	PF00917	0.708
DOC_USP7_UBL2_3	50	54	PF12436	0.531
DOC_WW_Pin1_4	173	178	PF00397	0.650
DOC_WW_Pin1_4	194	199	PF00397	0.521
DOC_WW_Pin1_4	268	273	PF00397	0.483
DOC_WW_Pin1_4	315	320	PF00397	0.726
LIG_14-3-3_CanoR_1	11	17	PF00244	0.485
LIG_14-3-3_CanoR_1	142	150	PF00244	0.509
LIG_14-3-3_CanoR_1	199	204	PF00244	0.463
LIG_Actin_WH2_2	176	192	PF00022	0.523
LIG_BRCT_BRCA1_1	282	286	PF00533	0.546
LIG_deltaCOP1_diTrp_1	146	152	PF00928	0.613
LIG_eIF4E_1	208	214	PF01652	0.453
LIG_FHA_1	13	19	PF00498	0.462
LIG_FHA_1	290	296	PF00498	0.460
LIG_FHA_1	76	82	PF00498	0.559
LIG_FHA_2	342	348	PF00498	0.730
LIG_FHA_2	396	402	PF00498	0.688
LIG_Integrin_isoDGR_2	348	350	PF01839	0.508
LIG_LIR_Apic_2	266	272	PF02991	0.486
LIG_LIR_Apic_2	354	358	PF02991	0.538
LIG_LIR_Apic_2	371	377	PF02991	0.651
LIG_LIR_Gen_1	207	218	PF02991	0.486
LIG_LIR_Gen_1	292	301	PF02991	0.467
LIG_LIR_Gen_1	304	313	PF02991	0.519
LIG_LIR_Nem_3	202	208	PF02991	0.506
LIG_LIR_Nem_3	292	296	PF02991	0.453
LIG_MYND_3	255	259	PF01753	0.612
LIG_Pex14_2	387	391	PF04695	0.658
LIG_Rb_LxCxE_1	333	354	PF01857	0.603
LIG_SH2_CRK	210	214	PF00017	0.450
LIG_SH2_NCK_1	74	78	PF00017	0.492
LIG_SH2_PTP2	62	65	PF00017	0.466
LIG_SH2_STAP1	181	185	PF00017	0.418
LIG_SH2_STAP1	205	209	PF00017	0.472
LIG_SH2_STAP1	210	214	PF00017	0.450
LIG_SH2_STAT5	208	211	PF00017	0.452
LIG_SH2_STAT5	293	296	PF00017	0.556
LIG_SH2_STAT5	361	364	PF00017	0.575
LIG_SH2_STAT5	374	377	PF00017	0.724
LIG_SH2_STAT5	62	65	PF00017	0.466
LIG_SH2_STAT5	80	83	PF00017	0.520
LIG_SH3_3	171	177	PF00018	0.593
LIG_SH3_3	313	319	PF00018	0.709
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.475
LIG_TRAF2_1	110	113	PF00917	0.615
LIG_TRAF2_1	251	254	PF00917	0.636
LIG_TRFH_1	286	290	PF08558	0.471
LIG_WW_1	290	293	PF00397	0.567
MOD_CDK_SPK_2	194	199	PF00069	0.521
MOD_CK1_1	184	190	PF00069	0.583
MOD_CK1_1	262	268	PF00069	0.604
MOD_CK1_1	304	310	PF00069	0.571
MOD_CK1_1	343	349	PF00069	0.626
MOD_CK2_1	107	113	PF00069	0.655
MOD_CK2_1	142	148	PF00069	0.493
MOD_CK2_1	234	240	PF00069	0.758
MOD_CK2_1	268	274	PF00069	0.523
MOD_CK2_1	315	321	PF00069	0.601
MOD_CK2_1	341	347	PF00069	0.656
MOD_CMANNOS	149	152	PF00535	0.626
MOD_Cter_Amidation	348	351	PF01082	0.595
MOD_DYRK1A_RPxSP_1	173	177	PF00069	0.585
MOD_GlcNHglycan	109	112	PF01048	0.698
MOD_GlcNHglycan	165	168	PF01048	0.687
MOD_GlcNHglycan	182	186	PF01048	0.444
MOD_GlcNHglycan	215	218	PF01048	0.552
MOD_GlcNHglycan	219	222	PF01048	0.624
MOD_GlcNHglycan	236	239	PF01048	0.562
MOD_GSK3_1	159	166	PF00069	0.699
MOD_GSK3_1	169	176	PF00069	0.764
MOD_GSK3_1	181	188	PF00069	0.370
MOD_GSK3_1	194	201	PF00069	0.454
MOD_GSK3_1	213	220	PF00069	0.402
MOD_GSK3_1	229	236	PF00069	0.537
MOD_GSK3_1	280	287	PF00069	0.488
MOD_GSK3_1	297	304	PF00069	0.488
MOD_NEK2_1	102	107	PF00069	0.689
MOD_NEK2_1	12	17	PF00069	0.475
MOD_NEK2_1	213	218	PF00069	0.522
MOD_NEK2_1	362	367	PF00069	0.690
MOD_NEK2_2	185	190	PF00069	0.595
MOD_PIKK_1	230	236	PF00454	0.786
MOD_PIKK_1	96	102	PF00454	0.759
MOD_PKA_1	95	101	PF00069	0.726
MOD_PKA_2	198	204	PF00069	0.558
MOD_Plk_1	181	187	PF00069	0.419
MOD_Plk_4	12	18	PF00069	0.475
MOD_Plk_4	204	210	PF00069	0.409
MOD_Plk_4	289	295	PF00069	0.464
MOD_Plk_4	331	337	PF00069	0.594
MOD_Plk_4	407	413	PF00069	0.635
MOD_ProDKin_1	173	179	PF00069	0.638
MOD_ProDKin_1	194	200	PF00069	0.527
MOD_ProDKin_1	268	274	PF00069	0.489
MOD_ProDKin_1	315	321	PF00069	0.736
MOD_SUMO_rev_2	91	98	PF00179	0.685
TRG_DiLeu_BaEn_1	263	268	PF01217	0.517
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.566
TRG_ENDOCYTIC_2	210	213	PF00928	0.452
TRG_ENDOCYTIC_2	293	296	PF00928	0.514
TRG_ER_diArg_1	137	139	PF00400	0.591
TRG_ER_diArg_1	276	278	PF00400	0.506
TRG_ER_diArg_1	350	352	PF00400	0.595
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ0	Leptomonas seymouri	49%	100%
A4HYN2	Leishmania infantum	99%	100%
E9AI97	Leishmania braziliensis	73%	100%
E9AUI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QD02	Leishmania major	93%	100%