Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVU2_LEIDO

TriTrypDb:

LdBPK_200240.1 , LdCL_200007200 , LDHU3_20.0260

Length:

949

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WVU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.584
CLV_C14_Caspase3-7	742	746	PF00656	0.508
CLV_C14_Caspase3-7	832	836	PF00656	0.534
CLV_MEL_PAP_1	602	608	PF00089	0.469
CLV_NRD_NRD_1	120	122	PF00675	0.500
CLV_NRD_NRD_1	174	176	PF00675	0.451
CLV_NRD_NRD_1	182	184	PF00675	0.368
CLV_NRD_NRD_1	187	189	PF00675	0.339
CLV_NRD_NRD_1	727	729	PF00675	0.475
CLV_NRD_NRD_1	838	840	PF00675	0.478
CLV_NRD_NRD_1	95	97	PF00675	0.535
CLV_PCSK_FUR_1	725	729	PF00082	0.485
CLV_PCSK_KEX2_1	120	122	PF00082	0.500
CLV_PCSK_KEX2_1	174	176	PF00082	0.451
CLV_PCSK_KEX2_1	182	184	PF00082	0.368
CLV_PCSK_KEX2_1	187	189	PF00082	0.339
CLV_PCSK_KEX2_1	727	729	PF00082	0.475
CLV_PCSK_KEX2_1	838	840	PF00082	0.478
CLV_PCSK_KEX2_1	95	97	PF00082	0.535
CLV_PCSK_PC7_1	183	189	PF00082	0.479
CLV_PCSK_SKI1_1	121	125	PF00082	0.477
CLV_PCSK_SKI1_1	158	162	PF00082	0.433
CLV_PCSK_SKI1_1	182	186	PF00082	0.483
CLV_PCSK_SKI1_1	220	224	PF00082	0.442
CLV_PCSK_SKI1_1	420	424	PF00082	0.453
CLV_PCSK_SKI1_1	503	507	PF00082	0.423
CLV_PCSK_SKI1_1	55	59	PF00082	0.444
DEG_APCC_DBOX_1	204	212	PF00400	0.425
DEG_APCC_DBOX_1	219	227	PF00400	0.318
DEG_SCF_FBW7_1	618	623	PF00400	0.430
DEG_SCF_FBW7_2	381	388	PF00400	0.536
DEG_SPOP_SBC_1	541	545	PF00917	0.549
DOC_ANK_TNKS_1	173	180	PF00023	0.508
DOC_ANK_TNKS_1	452	459	PF00023	0.526
DOC_CKS1_1	382	387	PF01111	0.541
DOC_CYCLIN_RxL_1	217	224	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.471
DOC_MAPK_MEF2A_6	158	167	PF00069	0.432
DOC_MAPK_MEF2A_6	205	212	PF00069	0.547
DOC_MAPK_MEF2A_6	593	602	PF00069	0.491
DOC_MAPK_NFAT4_5	205	213	PF00069	0.414
DOC_MAPK_RevD_3	161	175	PF00069	0.451
DOC_PP2B_LxvP_1	357	360	PF13499	0.525
DOC_PP4_FxxP_1	782	785	PF00568	0.503
DOC_PP4_FxxP_1	803	806	PF00568	0.473
DOC_USP7_MATH_1	110	114	PF00917	0.486
DOC_USP7_MATH_1	177	181	PF00917	0.518
DOC_USP7_MATH_1	258	262	PF00917	0.493
DOC_USP7_MATH_1	410	414	PF00917	0.491
DOC_USP7_MATH_1	550	554	PF00917	0.558
DOC_USP7_MATH_1	581	585	PF00917	0.610
DOC_USP7_MATH_1	620	624	PF00917	0.496
DOC_USP7_MATH_1	63	67	PF00917	0.470
DOC_USP7_MATH_1	827	831	PF00917	0.418
DOC_WW_Pin1_4	197	202	PF00397	0.473
DOC_WW_Pin1_4	259	264	PF00397	0.563
DOC_WW_Pin1_4	381	386	PF00397	0.548
DOC_WW_Pin1_4	40	45	PF00397	0.569
DOC_WW_Pin1_4	616	621	PF00397	0.514
DOC_WW_Pin1_4	684	689	PF00397	0.540
DOC_WW_Pin1_4	807	812	PF00397	0.481
LIG_14-3-3_CanoR_1	120	130	PF00244	0.434
LIG_14-3-3_CanoR_1	182	190	PF00244	0.384
LIG_14-3-3_CanoR_1	433	439	PF00244	0.548
LIG_14-3-3_CanoR_1	480	488	PF00244	0.470
LIG_14-3-3_CanoR_1	539	549	PF00244	0.544
LIG_14-3-3_CanoR_1	593	600	PF00244	0.377
LIG_14-3-3_CanoR_1	780	785	PF00244	0.532
LIG_14-3-3_CanoR_1	914	923	PF00244	0.549
LIG_14-3-3_CanoR_1	932	940	PF00244	0.302
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_BIR_III_4	887	891	PF00653	0.639
LIG_CaM_NSCaTE_8	929	936	PF13499	0.548
LIG_Clathr_ClatBox_1	131	135	PF01394	0.440
LIG_Clathr_ClatBox_1	195	199	PF01394	0.428
LIG_eIF4E_1	674	680	PF01652	0.471
LIG_FHA_1	122	128	PF00498	0.454
LIG_FHA_1	241	247	PF00498	0.445
LIG_FHA_1	327	333	PF00498	0.439
LIG_FHA_1	376	382	PF00498	0.434
LIG_FHA_1	403	409	PF00498	0.450
LIG_FHA_1	425	431	PF00498	0.423
LIG_FHA_1	480	486	PF00498	0.517
LIG_FHA_1	593	599	PF00498	0.340
LIG_FHA_1	60	66	PF00498	0.527
LIG_FHA_1	617	623	PF00498	0.502
LIG_FHA_1	628	634	PF00498	0.413
LIG_FHA_1	673	679	PF00498	0.470
LIG_FHA_1	685	691	PF00498	0.469
LIG_FHA_1	758	764	PF00498	0.528
LIG_FHA_1	790	796	PF00498	0.453
LIG_FHA_1	860	866	PF00498	0.482
LIG_FHA_2	18	24	PF00498	0.563
LIG_FHA_2	234	240	PF00498	0.506
LIG_FHA_2	264	270	PF00498	0.513
LIG_FHA_2	474	480	PF00498	0.349
LIG_FHA_2	566	572	PF00498	0.525
LIG_FHA_2	649	655	PF00498	0.435
LIG_FHA_2	740	746	PF00498	0.501
LIG_FHA_2	830	836	PF00498	0.517
LIG_FHA_2	893	899	PF00498	0.720
LIG_FHA_2	96	102	PF00498	0.412
LIG_GBD_Chelix_1	649	657	PF00786	0.440
LIG_LIR_Apic_2	224	230	PF02991	0.424
LIG_LIR_Apic_2	779	785	PF02991	0.467
LIG_LIR_Apic_2	800	806	PF02991	0.485
LIG_LIR_Gen_1	236	246	PF02991	0.474
LIG_LIR_Gen_1	311	321	PF02991	0.480
LIG_LIR_Gen_1	396	402	PF02991	0.471
LIG_LIR_Gen_1	476	485	PF02991	0.384
LIG_LIR_Gen_1	623	633	PF02991	0.525
LIG_LIR_Gen_1	938	946	PF02991	0.508
LIG_LIR_Nem_3	236	241	PF02991	0.408
LIG_LIR_Nem_3	311	317	PF02991	0.514
LIG_LIR_Nem_3	396	401	PF02991	0.477
LIG_LIR_Nem_3	442	447	PF02991	0.603
LIG_LIR_Nem_3	476	481	PF02991	0.372
LIG_LIR_Nem_3	623	629	PF02991	0.433
LIG_LIR_Nem_3	71	75	PF02991	0.417
LIG_LIR_Nem_3	779	784	PF02991	0.469
LIG_MYND_1	387	391	PF01753	0.463
LIG_MYND_3	386	390	PF01753	0.455
LIG_NRBOX	352	358	PF00104	0.513
LIG_NRBOX	480	486	PF00104	0.376
LIG_NRBOX	648	654	PF00104	0.469
LIG_NRBOX	739	745	PF00104	0.503
LIG_NRBOX	99	105	PF00104	0.472
LIG_PTAP_UEV_1	923	928	PF05743	0.490
LIG_PTB_Apo_2	74	81	PF02174	0.347
LIG_SH2_PTP2	72	75	PF00017	0.423
LIG_SH2_SRC	569	572	PF00017	0.489
LIG_SH2_STAP1	674	678	PF00017	0.454
LIG_SH2_STAT5	107	110	PF00017	0.346
LIG_SH2_STAT5	450	453	PF00017	0.422
LIG_SH2_STAT5	674	677	PF00017	0.453
LIG_SH2_STAT5	72	75	PF00017	0.423
LIG_SH3_3	297	303	PF00018	0.497
LIG_SH3_3	357	363	PF00018	0.525
LIG_SH3_3	630	636	PF00018	0.601
LIG_SH3_3	760	766	PF00018	0.383
LIG_SH3_3	921	927	PF00018	0.474
LIG_Sin3_3	289	296	PF02671	0.485
LIG_Sin3_3	524	531	PF02671	0.422
LIG_SUMO_SIM_par_1	129	137	PF11976	0.359
LIG_SUMO_SIM_par_1	194	200	PF11976	0.447
LIG_SUMO_SIM_par_1	857	864	PF11976	0.407
LIG_TRAF2_1	26	29	PF00917	0.549
LIG_TRAF2_1	440	443	PF00917	0.569
LIG_TRAF2_1	568	571	PF00917	0.531
LIG_TRAF2_1	707	710	PF00917	0.625
LIG_Vh1_VBS_1	470	488	PF01044	0.424
LIG_WRC_WIRS_1	111	116	PF05994	0.412
MOD_CK1_1	200	206	PF00069	0.573
MOD_CK1_1	308	314	PF00069	0.465
MOD_CK1_1	375	381	PF00069	0.442
MOD_CK1_1	542	548	PF00069	0.627
MOD_CK1_1	577	583	PF00069	0.668
MOD_CK1_1	638	644	PF00069	0.540
MOD_CK1_1	686	692	PF00069	0.577
MOD_CK1_1	787	793	PF00069	0.577
MOD_CK1_1	810	816	PF00069	0.508
MOD_CK1_1	917	923	PF00069	0.563
MOD_CK2_1	150	156	PF00069	0.605
MOD_CK2_1	23	29	PF00069	0.574
MOD_CK2_1	233	239	PF00069	0.522
MOD_CK2_1	263	269	PF00069	0.550
MOD_CK2_1	473	479	PF00069	0.328
MOD_CK2_1	565	571	PF00069	0.527
MOD_CK2_1	648	654	PF00069	0.450
MOD_CK2_1	704	710	PF00069	0.602
MOD_CK2_1	788	794	PF00069	0.488
MOD_CK2_1	857	863	PF00069	0.475
MOD_CK2_1	95	101	PF00069	0.363
MOD_GlcNHglycan	152	155	PF01048	0.514
MOD_GlcNHglycan	2	5	PF01048	0.593
MOD_GlcNHglycan	293	296	PF01048	0.434
MOD_GlcNHglycan	307	310	PF01048	0.559
MOD_GlcNHglycan	321	324	PF01048	0.361
MOD_GlcNHglycan	347	350	PF01048	0.434
MOD_GlcNHglycan	374	377	PF01048	0.515
MOD_GlcNHglycan	413	416	PF01048	0.532
MOD_GlcNHglycan	512	515	PF01048	0.428
MOD_GlcNHglycan	529	532	PF01048	0.521
MOD_GlcNHglycan	544	547	PF01048	0.574
MOD_GlcNHglycan	552	555	PF01048	0.470
MOD_GlcNHglycan	576	579	PF01048	0.582
MOD_GlcNHglycan	581	584	PF01048	0.556
MOD_GlcNHglycan	622	625	PF01048	0.491
MOD_GlcNHglycan	630	633	PF01048	0.540
MOD_GlcNHglycan	637	640	PF01048	0.545
MOD_GlcNHglycan	65	68	PF01048	0.401
MOD_GlcNHglycan	794	798	PF01048	0.502
MOD_GlcNHglycan	878	881	PF01048	0.547
MOD_GlcNHglycan	916	919	PF01048	0.515
MOD_GlcNHglycan	924	927	PF01048	0.486
MOD_GlcNHglycan	934	937	PF01048	0.328
MOD_GSK3_1	17	24	PF00069	0.562
MOD_GSK3_1	259	266	PF00069	0.540
MOD_GSK3_1	304	311	PF00069	0.513
MOD_GSK3_1	315	322	PF00069	0.346
MOD_GSK3_1	331	338	PF00069	0.511
MOD_GSK3_1	540	547	PF00069	0.594
MOD_GSK3_1	577	584	PF00069	0.707
MOD_GSK3_1	59	66	PF00069	0.438
MOD_GSK3_1	616	623	PF00069	0.521
MOD_GSK3_1	679	686	PF00069	0.434
MOD_GSK3_1	739	746	PF00069	0.505
MOD_GSK3_1	776	783	PF00069	0.533
MOD_GSK3_1	784	791	PF00069	0.379
MOD_GSK3_1	857	864	PF00069	0.422
MOD_GSK3_1	910	917	PF00069	0.492
MOD_NEK2_1	345	350	PF00069	0.402
MOD_NEK2_1	434	439	PF00069	0.560
MOD_NEK2_1	508	513	PF00069	0.511
MOD_NEK2_1	527	532	PF00069	0.457
MOD_NEK2_1	574	579	PF00069	0.576
MOD_NEK2_1	58	63	PF00069	0.432
MOD_NEK2_1	589	594	PF00069	0.318
MOD_NEK2_1	679	684	PF00069	0.483
MOD_NEK2_1	696	701	PF00069	0.494
MOD_NEK2_1	743	748	PF00069	0.436
MOD_NEK2_1	759	764	PF00069	0.259
MOD_NEK2_1	861	866	PF00069	0.454
MOD_NEK2_2	177	182	PF00069	0.514
MOD_PIKK_1	121	127	PF00454	0.467
MOD_PIKK_1	182	188	PF00454	0.425
MOD_PIKK_1	331	337	PF00454	0.573
MOD_PIKK_1	375	381	PF00454	0.442
MOD_PIKK_1	672	678	PF00454	0.460
MOD_PIKK_1	822	828	PF00454	0.495
MOD_PKA_1	182	188	PF00069	0.425
MOD_PKA_1	95	101	PF00069	0.426
MOD_PKA_2	182	188	PF00069	0.404
MOD_PKA_2	432	438	PF00069	0.540
MOD_PKA_2	479	485	PF00069	0.457
MOD_PKA_2	508	514	PF00069	0.441
MOD_PKA_2	592	598	PF00069	0.367
MOD_PKA_2	95	101	PF00069	0.343
MOD_Plk_1	134	140	PF00069	0.413
MOD_Plk_1	34	40	PF00069	0.516
MOD_Plk_2-3	457	463	PF00069	0.489
MOD_Plk_2-3	648	654	PF00069	0.431
MOD_Plk_4	134	140	PF00069	0.445
MOD_Plk_4	233	239	PF00069	0.482
MOD_Plk_4	242	248	PF00069	0.323
MOD_Plk_4	280	286	PF00069	0.388
MOD_Plk_4	648	654	PF00069	0.366
MOD_Plk_4	68	74	PF00069	0.366
MOD_Plk_4	739	745	PF00069	0.479
MOD_Plk_4	861	867	PF00069	0.457
MOD_ProDKin_1	197	203	PF00069	0.483
MOD_ProDKin_1	259	265	PF00069	0.560
MOD_ProDKin_1	381	387	PF00069	0.554
MOD_ProDKin_1	40	46	PF00069	0.555
MOD_ProDKin_1	616	622	PF00069	0.511
MOD_ProDKin_1	684	690	PF00069	0.535
MOD_ProDKin_1	807	813	PF00069	0.474
MOD_SUMO_for_1	901	904	PF00179	0.488
TRG_DiLeu_BaEn_1	648	653	PF01217	0.486
TRG_DiLeu_BaEn_4	101	107	PF01217	0.406
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.505
TRG_ENDOCYTIC_2	478	481	PF00928	0.347
TRG_ENDOCYTIC_2	72	75	PF00928	0.423
TRG_ENDOCYTIC_2	940	943	PF00928	0.510
TRG_ER_diArg_1	174	176	PF00400	0.447
TRG_ER_diArg_1	181	183	PF00400	0.389
TRG_ER_diArg_1	725	728	PF00400	0.458
TRG_ER_diArg_1	837	839	PF00400	0.431
TRG_ER_diArg_1	95	97	PF00400	0.535
TRG_NES_CRM1_1	122	136	PF08389	0.383
TRG_NES_CRM1_1	479	492	PF08389	0.448
TRG_NES_CRM1_1	647	662	PF08389	0.445
TRG_NES_CRM1_1	753	768	PF08389	0.341
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	720	724	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	841	845	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	848	852	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N6	Leptomonas seymouri	53%	100%
A0A3R7KCN8	Trypanosoma rangeli	28%	100%
A4HYL3	Leishmania infantum	100%	100%
E9AI76	Leishmania braziliensis	78%	100%
E9AUG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QD22	Leishmania major	93%	100%
V5BAE6	Trypanosoma cruzi	27%	100%