CTP_transf_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WVU1_LEIDO

TriTrypDb:

LdBPK_200570.1 , LdCL_200010400 , LDHU3_20.0680

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WVU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVU1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009117	nucleotide metabolic process	5	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009435	NAD biosynthetic process	8	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019359	nicotinamide nucleotide biosynthetic process	7	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019363	pyridine nucleotide biosynthetic process	6	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway	9	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:0072525	pyridine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	6	1
GO:0003824	catalytic activity	1	3
GO:0016462	pyrophosphatase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0070566	adenylyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.473
CLV_NRD_NRD_1	30	32	PF00675	0.463
CLV_NRD_NRD_1	384	386	PF00675	0.426
CLV_NRD_NRD_1	421	423	PF00675	0.423
CLV_NRD_NRD_1	428	430	PF00675	0.466
CLV_NRD_NRD_1	501	503	PF00675	0.419
CLV_NRD_NRD_1	546	548	PF00675	0.497
CLV_PCSK_FUR_1	127	131	PF00082	0.538
CLV_PCSK_FUR_1	382	386	PF00082	0.418
CLV_PCSK_FUR_1	544	548	PF00082	0.437
CLV_PCSK_KEX2_1	129	131	PF00082	0.473
CLV_PCSK_KEX2_1	30	32	PF00082	0.443
CLV_PCSK_KEX2_1	384	386	PF00082	0.426
CLV_PCSK_KEX2_1	421	423	PF00082	0.423
CLV_PCSK_KEX2_1	428	430	PF00082	0.466
CLV_PCSK_KEX2_1	546	548	PF00082	0.445
CLV_PCSK_SKI1_1	221	225	PF00082	0.521
CLV_PCSK_SKI1_1	281	285	PF00082	0.563
CLV_PCSK_SKI1_1	30	34	PF00082	0.508
CLV_PCSK_SKI1_1	40	44	PF00082	0.368
DEG_APCC_DBOX_1	280	288	PF00400	0.511
DOC_CKS1_1	394	399	PF01111	0.412
DOC_CYCLIN_RxL_1	34	44	PF00134	0.435
DOC_CYCLIN_yCln2_LP_2	394	400	PF00134	0.400
DOC_MAPK_DCC_7	243	253	PF00069	0.589
DOC_MAPK_gen_1	127	137	PF00069	0.448
DOC_MAPK_gen_1	428	435	PF00069	0.432
DOC_MAPK_MEF2A_6	130	139	PF00069	0.452
DOC_MAPK_RevD_3	534	547	PF00069	0.362
DOC_PP1_RVXF_1	81	88	PF00149	0.492
DOC_PP2B_LxvP_1	198	201	PF13499	0.379
DOC_PP2B_LxvP_1	516	519	PF13499	0.379
DOC_USP7_MATH_1	147	151	PF00917	0.761
DOC_USP7_MATH_1	264	268	PF00917	0.691
DOC_USP7_MATH_1	290	294	PF00917	0.574
DOC_USP7_MATH_1	297	301	PF00917	0.557
DOC_USP7_MATH_1	348	352	PF00917	0.659
DOC_USP7_MATH_1	36	40	PF00917	0.432
DOC_USP7_UBL2_3	407	411	PF12436	0.541
DOC_WW_Pin1_4	10	15	PF00397	0.346
DOC_WW_Pin1_4	154	159	PF00397	0.657
DOC_WW_Pin1_4	244	249	PF00397	0.746
DOC_WW_Pin1_4	317	322	PF00397	0.605
DOC_WW_Pin1_4	393	398	PF00397	0.432
LIG_14-3-3_CanoR_1	16	20	PF00244	0.377
LIG_14-3-3_CanoR_1	243	248	PF00244	0.643
LIG_14-3-3_CanoR_1	259	264	PF00244	0.502
LIG_14-3-3_CanoR_1	432	442	PF00244	0.426
LIG_14-3-3_CanoR_1	502	507	PF00244	0.619
LIG_14-3-3_CanoR_1	51	58	PF00244	0.607
LIG_Actin_WH2_2	300	317	PF00022	0.501
LIG_Actin_WH2_2	412	430	PF00022	0.445
LIG_BIR_II_1	1	5	PF00653	0.432
LIG_CaM_IQ_9	371	387	PF13499	0.457
LIG_Clathr_ClatBox_1	454	458	PF01394	0.404
LIG_CtBP_PxDLS_1	248	252	PF00389	0.586
LIG_eIF4E_1	368	374	PF01652	0.480
LIG_FHA_1	108	114	PF00498	0.475
LIG_FHA_1	118	124	PF00498	0.324
LIG_FHA_1	193	199	PF00498	0.490
LIG_FHA_1	369	375	PF00498	0.474
LIG_FHA_1	376	382	PF00498	0.412
LIG_FHA_1	394	400	PF00498	0.334
LIG_FHA_1	437	443	PF00498	0.494
LIG_FHA_1	485	491	PF00498	0.514
LIG_FHA_2	39	45	PF00498	0.407
LIG_FHA_2	469	475	PF00498	0.495
LIG_LIR_Gen_1	222	232	PF02991	0.512
LIG_LIR_Nem_3	222	227	PF02991	0.486
LIG_LIR_Nem_3	362	366	PF02991	0.387
LIG_SH2_NCK_1	322	326	PF00017	0.481
LIG_SH2_SRC	402	405	PF00017	0.340
LIG_SH2_STAP1	342	346	PF00017	0.660
LIG_SH2_STAP1	402	406	PF00017	0.345
LIG_SH2_STAT5	496	499	PF00017	0.331
LIG_SH3_3	141	147	PF00018	0.443
LIG_SH3_3	460	466	PF00018	0.434
LIG_Sin3_3	224	231	PF02671	0.536
LIG_SUMO_SIM_anti_2	185	190	PF11976	0.482
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.599
LIG_SUMO_SIM_anti_2	250	257	PF11976	0.578
LIG_SUMO_SIM_par_1	396	401	PF11976	0.467
MOD_CDC14_SPxK_1	13	16	PF00782	0.350
MOD_CDK_SPxK_1	10	16	PF00069	0.345
MOD_CK1_1	128	134	PF00069	0.663
MOD_CK1_1	151	157	PF00069	0.646
MOD_CK1_1	208	214	PF00069	0.592
MOD_CK1_1	247	253	PF00069	0.650
MOD_CK1_1	262	268	PF00069	0.597
MOD_CK1_1	317	323	PF00069	0.502
MOD_CK2_1	128	134	PF00069	0.535
MOD_CK2_1	142	148	PF00069	0.508
MOD_CK2_1	173	179	PF00069	0.672
MOD_CK2_1	227	233	PF00069	0.582
MOD_CK2_1	264	270	PF00069	0.727
MOD_CK2_1	38	44	PF00069	0.432
MOD_CK2_1	467	473	PF00069	0.531
MOD_CK2_1	536	542	PF00069	0.460
MOD_Cter_Amidation	500	503	PF01082	0.395
MOD_GlcNHglycan	120	123	PF01048	0.427
MOD_GlcNHglycan	153	156	PF01048	0.617
MOD_GlcNHglycan	229	232	PF01048	0.641
MOD_GlcNHglycan	235	238	PF01048	0.755
MOD_GlcNHglycan	256	259	PF01048	0.623
MOD_GlcNHglycan	266	269	PF01048	0.706
MOD_GlcNHglycan	292	295	PF01048	0.536
MOD_GlcNHglycan	316	319	PF01048	0.665
MOD_GlcNHglycan	322	325	PF01048	0.603
MOD_GlcNHglycan	343	347	PF01048	0.648
MOD_GlcNHglycan	66	69	PF01048	0.485
MOD_GSK3_1	118	125	PF00069	0.439
MOD_GSK3_1	147	154	PF00069	0.592
MOD_GSK3_1	215	222	PF00069	0.555
MOD_GSK3_1	243	250	PF00069	0.699
MOD_GSK3_1	389	396	PF00069	0.608
MOD_GSK3_1	50	57	PF00069	0.430
MOD_N-GLC_1	233	238	PF02516	0.570
MOD_N-GLC_2	548	550	PF02516	0.509
MOD_NEK2_1	314	319	PF00069	0.558
MOD_NEK2_1	79	84	PF00069	0.505
MOD_NEK2_2	297	302	PF00069	0.522
MOD_PIKK_1	51	57	PF00454	0.493
MOD_PK_1	259	265	PF00069	0.576
MOD_PKA_1	30	36	PF00069	0.462
MOD_PKA_1	502	508	PF00069	0.542
MOD_PKA_2	128	134	PF00069	0.526
MOD_PKA_2	15	21	PF00069	0.377
MOD_PKA_2	208	214	PF00069	0.587
MOD_PKA_2	242	248	PF00069	0.638
MOD_PKA_2	30	36	PF00069	0.489
MOD_PKA_2	314	320	PF00069	0.572
MOD_PKA_2	50	56	PF00069	0.417
MOD_Plk_1	389	395	PF00069	0.581
MOD_Plk_1	511	517	PF00069	0.427
MOD_Plk_4	249	255	PF00069	0.603
MOD_Plk_4	436	442	PF00069	0.388
MOD_ProDKin_1	10	16	PF00069	0.345
MOD_ProDKin_1	154	160	PF00069	0.652
MOD_ProDKin_1	244	250	PF00069	0.745
MOD_ProDKin_1	317	323	PF00069	0.609
MOD_ProDKin_1	393	399	PF00069	0.422
TRG_DiLeu_BaEn_1	415	420	PF01217	0.417
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.436
TRG_ENDOCYTIC_2	166	169	PF00928	0.466
TRG_ENDOCYTIC_2	496	499	PF00928	0.331
TRG_ER_diArg_1	127	130	PF00400	0.489
TRG_ER_diArg_1	29	31	PF00400	0.446
TRG_ER_diArg_1	381	384	PF00400	0.472
TRG_ER_diArg_1	420	422	PF00400	0.434
TRG_ER_diArg_1	427	429	PF00400	0.463
TRG_ER_diArg_1	543	546	PF00400	0.425
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7H4	Leptomonas seymouri	54%	100%
A0A0S4ILY4	Bodo saltans	34%	100%
A4HYR1	Leishmania infantum	99%	100%
E9AIA7	Leishmania braziliensis	79%	100%
E9AUJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCZ0	Leishmania major	92%	100%