NADH-ubiquinone_oxidoreductase_complex_I_subunit_ putative/GeneDB:LmjF.20.0120

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WVT1_LEIDO

TriTrypDb:

LdBPK_200130.1 , LdCL_200006200 , LDHU3_20.0150

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A0A3S7WVT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WVT1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.557
CLV_C14_Caspase3-7	280	284	PF00656	0.393
CLV_C14_Caspase3-7	546	550	PF00656	0.415
CLV_NRD_NRD_1	124	126	PF00675	0.464
CLV_NRD_NRD_1	2	4	PF00675	0.620
CLV_NRD_NRD_1	237	239	PF00675	0.580
CLV_NRD_NRD_1	348	350	PF00675	0.421
CLV_PCSK_FUR_1	235	239	PF00082	0.363
CLV_PCSK_KEX2_1	2	4	PF00082	0.650
CLV_PCSK_KEX2_1	234	236	PF00082	0.511
CLV_PCSK_KEX2_1	237	239	PF00082	0.542
CLV_PCSK_KEX2_1	348	350	PF00082	0.421
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.511
CLV_PCSK_SKI1_1	128	132	PF00082	0.372
CLV_PCSK_SKI1_1	229	233	PF00082	0.375
CLV_PCSK_SKI1_1	267	271	PF00082	0.466
CLV_PCSK_SKI1_1	389	393	PF00082	0.343
CLV_PCSK_SKI1_1	6	10	PF00082	0.629
DEG_APCC_DBOX_1	266	274	PF00400	0.481
DEG_Kelch_Keap1_1	15	20	PF01344	0.652
DEG_Nend_UBRbox_1	1	4	PF02207	0.696
DEG_ODPH_VHL_1	475	488	PF01847	0.375
DEG_SPOP_SBC_1	164	168	PF00917	0.570
DOC_CDC14_PxL_1	203	211	PF14671	0.407
DOC_CDC14_PxL_1	41	49	PF14671	0.503
DOC_CYCLIN_RxL_1	432	443	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.457
DOC_MAPK_gen_1	123	133	PF00069	0.399
DOC_MAPK_gen_1	234	244	PF00069	0.532
DOC_MAPK_gen_1	452	460	PF00069	0.313
DOC_MAPK_MEF2A_6	125	134	PF00069	0.382
DOC_MAPK_MEF2A_6	184	192	PF00069	0.358
DOC_MAPK_MEF2A_6	499	507	PF00069	0.524
DOC_PP1_RVXF_1	434	441	PF00149	0.349
DOC_PP2B_LxvP_1	535	538	PF13499	0.528
DOC_USP7_MATH_1	110	114	PF00917	0.518
DOC_USP7_MATH_1	12	16	PF00917	0.584
DOC_USP7_MATH_1	180	184	PF00917	0.533
DOC_WW_Pin1_4	136	141	PF00397	0.498
DOC_WW_Pin1_4	171	176	PF00397	0.463
DOC_WW_Pin1_4	184	189	PF00397	0.555
DOC_WW_Pin1_4	305	310	PF00397	0.448
DOC_WW_Pin1_4	377	382	PF00397	0.469
DOC_WW_Pin1_4	421	426	PF00397	0.490
LIG_14-3-3_CanoR_1	14	22	PF00244	0.630
LIG_14-3-3_CanoR_1	229	236	PF00244	0.421
LIG_14-3-3_CanoR_1	32	40	PF00244	0.379
LIG_14-3-3_CanoR_1	389	394	PF00244	0.384
LIG_14-3-3_CanoR_1	499	504	PF00244	0.406
LIG_14-3-3_CanoR_1	98	105	PF00244	0.365
LIG_BRCT_BRCA1_1	389	393	PF00533	0.393
LIG_BRCT_BRCA1_1	95	99	PF00533	0.397
LIG_Clathr_ClatBox_1	131	135	PF01394	0.349
LIG_FHA_1	239	245	PF00498	0.419
LIG_FHA_1	276	282	PF00498	0.414
LIG_FHA_1	28	34	PF00498	0.698
LIG_FHA_1	363	369	PF00498	0.308
LIG_FHA_1	378	384	PF00498	0.341
LIG_FHA_1	516	522	PF00498	0.347
LIG_FHA_2	260	266	PF00498	0.501
LIG_FHA_2	383	389	PF00498	0.461
LIG_LIR_Gen_1	152	162	PF02991	0.433
LIG_LIR_Gen_1	518	524	PF02991	0.354
LIG_LIR_Gen_1	60	66	PF02991	0.414
LIG_LIR_Gen_1	96	105	PF02991	0.367
LIG_LIR_LC3C_4	129	134	PF02991	0.429
LIG_LIR_Nem_3	197	203	PF02991	0.431
LIG_LIR_Nem_3	518	523	PF02991	0.330
LIG_LIR_Nem_3	60	65	PF02991	0.407
LIG_LIR_Nem_3	96	102	PF02991	0.372
LIG_NRP_CendR_1	553	556	PF00754	0.611
LIG_Pex14_1	409	413	PF04695	0.414
LIG_Pex14_1	516	520	PF04695	0.456
LIG_Pex14_2	307	311	PF04695	0.489
LIG_PTB_Apo_2	199	206	PF02174	0.456
LIG_PTB_Phospho_1	199	205	PF10480	0.458
LIG_SH2_CRK	42	46	PF00017	0.518
LIG_SH2_CRK	71	75	PF00017	0.419
LIG_SH2_NCK_1	366	370	PF00017	0.344
LIG_SH2_PTP2	205	208	PF00017	0.378
LIG_SH2_SRC	478	481	PF00017	0.383
LIG_SH2_STAP1	413	417	PF00017	0.467
LIG_SH2_STAT5	154	157	PF00017	0.382
LIG_SH2_STAT5	205	208	PF00017	0.396
LIG_SH2_STAT5	366	369	PF00017	0.337
LIG_SH2_STAT5	478	481	PF00017	0.383
LIG_SH3_3	134	140	PF00018	0.402
LIG_SH3_3	174	180	PF00018	0.407
LIG_SH3_3	474	480	PF00018	0.342
LIG_SUMO_SIM_anti_2	129	136	PF11976	0.357
LIG_SUMO_SIM_anti_2	141	149	PF11976	0.395
LIG_SUMO_SIM_anti_2	484	491	PF11976	0.486
LIG_SUMO_SIM_anti_2	502	507	PF11976	0.519
LIG_SUMO_SIM_par_1	129	136	PF11976	0.357
LIG_SUMO_SIM_par_1	239	245	PF11976	0.389
LIG_TRAF2_1	139	142	PF00917	0.396
LIG_TRAF2_1	418	421	PF00917	0.563
LIG_TRAF2_1	508	511	PF00917	0.533
LIG_TYR_ITIM	203	208	PF00017	0.400
LIG_UBA3_1	437	442	PF00899	0.491
LIG_UBA3_1	519	526	PF00899	0.407
MOD_CDK_SPK_2	305	310	PF00069	0.448
MOD_CK1_1	15	21	PF00069	0.611
MOD_CK1_1	176	182	PF00069	0.537
MOD_CK1_1	25	31	PF00069	0.688
MOD_CK1_1	34	40	PF00069	0.425
MOD_CK1_1	424	430	PF00069	0.504
MOD_CK1_1	465	471	PF00069	0.517
MOD_CK2_1	136	142	PF00069	0.435
MOD_CK2_1	14	20	PF00069	0.631
MOD_CK2_1	25	31	PF00069	0.650
MOD_CK2_1	461	467	PF00069	0.484
MOD_CK2_1	484	490	PF00069	0.490
MOD_GlcNHglycan	14	17	PF01048	0.657
MOD_GlcNHglycan	159	162	PF01048	0.458
MOD_GlcNHglycan	244	247	PF01048	0.490
MOD_GlcNHglycan	388	392	PF01048	0.370
MOD_GlcNHglycan	464	467	PF01048	0.405
MOD_GSK3_1	176	183	PF00069	0.501
MOD_GSK3_1	184	191	PF00069	0.542
MOD_GSK3_1	238	245	PF00069	0.419
MOD_GSK3_1	27	34	PF00069	0.674
MOD_GSK3_1	271	278	PF00069	0.354
MOD_GSK3_1	295	302	PF00069	0.503
MOD_GSK3_1	461	468	PF00069	0.406
MOD_GSK3_1	89	96	PF00069	0.399
MOD_N-GLC_1	162	167	PF02516	0.547
MOD_N-GLC_1	484	489	PF02516	0.443
MOD_NEK2_1	118	123	PF00069	0.434
MOD_NEK2_1	156	161	PF00069	0.364
MOD_NEK2_1	242	247	PF00069	0.405
MOD_NEK2_1	259	264	PF00069	0.309
MOD_NEK2_1	387	392	PF00069	0.365
MOD_NEK2_1	515	520	PF00069	0.295
MOD_NEK2_1	89	94	PF00069	0.498
MOD_NEK2_2	295	300	PF00069	0.533
MOD_PIKK_1	110	116	PF00454	0.512
MOD_PIKK_1	190	196	PF00454	0.541
MOD_PIKK_1	299	305	PF00454	0.439
MOD_PK_1	499	505	PF00069	0.485
MOD_PKA_2	31	37	PF00069	0.648
MOD_PKA_2	352	358	PF00069	0.448
MOD_PKA_2	97	103	PF00069	0.392
MOD_Plk_1	188	194	PF00069	0.525
MOD_Plk_1	238	244	PF00069	0.526
MOD_Plk_1	259	265	PF00069	0.561
MOD_Plk_1	295	301	PF00069	0.491
MOD_Plk_1	484	490	PF00069	0.493
MOD_Plk_2-3	31	37	PF00069	0.648
MOD_Plk_2-3	484	490	PF00069	0.391
MOD_Plk_4	149	155	PF00069	0.439
MOD_Plk_4	195	201	PF00069	0.441
MOD_Plk_4	211	217	PF00069	0.453
MOD_Plk_4	246	252	PF00069	0.467
MOD_Plk_4	341	347	PF00069	0.401
MOD_Plk_4	389	395	PF00069	0.341
MOD_Plk_4	484	490	PF00069	0.521
MOD_Plk_4	515	521	PF00069	0.374
MOD_ProDKin_1	136	142	PF00069	0.505
MOD_ProDKin_1	171	177	PF00069	0.467
MOD_ProDKin_1	184	190	PF00069	0.547
MOD_ProDKin_1	305	311	PF00069	0.465
MOD_ProDKin_1	377	383	PF00069	0.463
MOD_ProDKin_1	421	427	PF00069	0.481
MOD_SUMO_for_1	309	312	PF00179	0.562
MOD_SUMO_rev_2	546	555	PF00179	0.469
TRG_DiLeu_BaEn_1	127	132	PF01217	0.376
TRG_DiLeu_BaEn_1	142	147	PF01217	0.384
TRG_DiLeu_BaEn_1	433	438	PF01217	0.354
TRG_DiLeu_BaEn_4	510	516	PF01217	0.329
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.352
TRG_DiLeu_LyEn_5	36	41	PF01217	0.619
TRG_DiLeu_LyEn_5	433	438	PF01217	0.354
TRG_ENDOCYTIC_2	154	157	PF00928	0.353
TRG_ENDOCYTIC_2	205	208	PF00928	0.385
TRG_ENDOCYTIC_2	359	362	PF00928	0.468
TRG_ENDOCYTIC_2	71	74	PF00928	0.417
TRG_ER_diArg_1	1	3	PF00400	0.665
TRG_ER_diArg_1	235	238	PF00400	0.552
TRG_ER_diArg_1	347	349	PF00400	0.405
TRG_ER_diArg_1	350	353	PF00400	0.441
TRG_ER_diLys_1	553	556	PF00400	0.546
TRG_NES_CRM1_1	484	497	PF08389	0.468
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P560	Leptomonas seymouri	71%	100%
A0A0S4JGE1	Bodo saltans	34%	94%
A0A1X0NY36	Trypanosomatidae	44%	98%
A0A422N7U6	Trypanosoma rangeli	38%	100%
A4HBI0	Leishmania braziliensis	86%	100%
A4HYK2	Leishmania infantum	100%	100%
C9ZHV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
E9AUF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QD32	Leishmania major	94%	100%
V5BAF5	Trypanosoma cruzi	45%	99%